Showing 1-30 of 759 results for "S5636"
Alex K K Leung et al.
The journal of physical chemistry. B, 119(28), 8698-8706 (2015-06-19)
Previous work has shown that lipid nanoparticles (LNP) composed of an ionizable cationic lipid, a poly(ethylene glycol) (PEG) lipid, distearoylphosphatidylcholine (DSPC), cholesterol, and small interfering RNA (siRNA) can be efficiently manufactured employing microfluidic mixing techniques. Cryo-transmission electron microscopy (cryo-TEM) and...
G Kor-Bicakci et al.
Bioresource technology, 166, 219-228 (2014-06-09)
The study evaluated the chronic impact of sulfamethoxazole on metabolic activities of fast growing microbial culture. It focused on changes induced on utilization kinetics of acetate and composition of the microbial community. The experiments involved a fill and draw reactor...
Nicolae Vaszilcsin et al.
International journal of pharmaceutics, 431(1-2), 241-244 (2012-05-09)
This paper presents a method of expired or unused drugs valorization as corrosion inhibitors for metals in various media. Cyclic voltammograms were drawn on platinum in order to assess the stability of pharmaceutically active substances from drugs at the metal-corrosive...
Aránzazu Mediero et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(5), 837-854 (2014-12-09)
Bone metabolism is a vital process that involves resorption by osteoclasts and formation by osteoblasts, which is closely regulated by immune cells. The neuronal guidance protein Netrin-1 regulates immune cell migration and inflammatory reactions, but its role in bone metabolism...
Tomohiro Torii et al.
Glycoconjugate journal, 31(9), 671-683 (2014-11-25)
Oligosaccharides of glycoproteins expressed on the cell surface play important roles in cell-cell interactions, particularly sialylated N-glycans having a negative charge, which interact with sialic acid-binding immunoglobulin-like lectins (siglecs). The entire structure of sialylated N-glycans expressed in the mouse brain...
Zhengzong Wu et al.
Food chemistry, 194, 671-679 (2015-10-17)
The application of attenuated total reflectance infrared spectroscopy (ATR-IR), Raman spectroscopy (RS) and combination of ATR-IR and RS for measurements of total antioxidant capacity (TAC) and total phenolic content (TPC) of Chinese rice wine (CRW) were investigated in this study....
Aerin Yoon et al.
PloS one, 10(10), e0141312-e0141312 (2015-10-30)
To date, four main mechanisms mediating inhibition of influenza infection by anti-hemagglutinin antibodies have been reported. Anti-globular-head-domain antibodies block either influenza virus receptor binding to the host cell or progeny virion release from the host cell. Anti-stem region antibodies hinder...
Amanda L Hughes et al.
G3 (Bethesda, Md.), 5(9), 1889-1897 (2015-07-16)
Packaging of genomic DNA into nucleosomes is nearly universally conserved in eukaryotes, and many features of the nucleosome landscape are quite conserved. Nonetheless, quantitative aspects of nucleosome packaging differ between species because, for example, the average length of linker DNA...
Guadalupe Chavarría et al.
Food additives & contaminants. Part B, Surveillance, 8(2), 128-135 (2015-06-26)
Aflatoxins are toxic fungal metabolites, which can be found in feed. Aflatoxin M1 (AFM1) is excreted into milk when ruminants ingest aflatoxin B1 contaminated feedstuffs. Due to its carcinogenic potential, contamination of milk and dairy products with AFM1 may pose...
Celalettin Semih Kunak et al.
Oxidative medicine and cellular longevity, 2015, 598162-598162 (2015-08-04)
Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature....
Jung-Hoon Bae et al.
Scientific reports, 5, 12229-12229 (2015-07-22)
To produce rarely secreted recombinant proteins in the yeast Saccharomyces cerevisiae, we developed a novel genome-wide optimal translational fusion partner (TFP) screening system that involves recruitment of an optimal secretion signal and fusion partner. A TFP library was constructed from...
Qingqing Wang et al.
Steroids, 96, 140-152 (2015-02-01)
An ultrasensitive stable isotope dilution liquid chromatography-tandem mass spectrometry method (LC-MS/MS) was developed and validated for multiplexed quantitative analysis of six unconjugated and conjugated estrogens in human serum. The quantification utilized a new derivatization procedure, which formed analytes as pre-ionized...
Kevin C Baldridge et al.
Inhalation toxicology, 27(1), 74-82 (2015-01-21)
RNAs are more susceptible to modifications than DNA, and chemical modifications in RNA have an effect on their structure and function. This study aimed to characterize chemical effects on total RNA in human A549 lung cells after exposure to elevated...
Robert Glaser
Journal of biotechnology, 214, 9-16 (2015-09-02)
The characterization of cellulase performance for industrial-scale processes holds special challenges. A huge gap exists between the enzyme characterization in a laboratory and large-scale process performances. Common cellulase mixtures from Novozymes and enzymes provided by Moscow State University were used...
Noah D Cohen et al.
PloS one, 9(10), e109865-e109865 (2014-10-22)
Neutrophils play an important role in protecting against infection. Foals have age-dependent deficiencies in neutrophil function that may contribute to their predisposition to infection. Thus, we investigated the ability of a CpG-ODN formulated with Emulsigen to modulate functional responses of...
Wioletta M Dynkowska et al.
Journal of the science of food and agriculture, 95(5), 1103-1115 (2014-11-21)
The bread-making process influences bread components, including phenolics that significantly contribute to its antioxidant properties. Five bread model systems made from different rye cultivars were investigated to compare their impact on concentration of ethanol-soluble (free and ester-bound) and insoluble phenolics....
Florian Platten et al.
The journal of physical chemistry. B, 119(48), 14986-14993 (2015-11-07)
Protein phase behavior and protein-protein interactions can be tuned by additives. We experimentally determined the phase behavior of lysozyme solutions, namely, the cloud-point temperature (CPT), in the presence of two additives, sodium chloride (NaCl) and guanidine hydrochloride (GuHCl). Their concentrations...
Justyna Sulej et al.
Applied biochemistry and biotechnology, 176(6), 1638-1658 (2015-05-25)
Cellobiose dehydrogenase (CDH), a secreted flavocytochrome produced by a number of wood-degrading fungi, was detected in the culture supernatant of a biotechnologically important strain of Cerrena unicolor grown in a modified cellulose-based liquid medium. The enzyme was purified as two...
Huili Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 62-70 (2015-02-11)
Herein, we developed a novel integrated device to perform phase separation based on ultrasound-assisted salt-induced liquid-liquid microextraction for determination of five fluoroquinones (FQs) in human body fluids. The integrated device consisted of three simple HDPE components used to separate the...
Karina Lopes Dornelas et al.
Analytica chimica acta, 858, 82-90 (2015-01-20)
This paper presents a simple and low-cost method for patterning poly(dimethylsiloxane) (PDMS) barriers in porous support such as paper for the construction of flexible microfluidic paper-based analytical devices (μPADs). The fabrication method consisted of contact-printing a solution of PDMS and...
Daniel Girma Mulat et al.
Talanta, 143, 56-63 (2015-06-17)
In anaerobic digestion of organic matter, several metabolic pathways are involved during the simultaneous production and consumption of short-chain fatty acids (SCFA) in general and acetate in particular. Understanding the role of each pathway requires both the determination of the...
Tamilselvan Mohan et al.
Colloids and surfaces. B, Biointerfaces, 123, 533-541 (2014-12-03)
In this study, the interaction of fluorescein isothiocyanate functionalized bovine serum albumin (FITC-BSA) with cellulose surfaces decorated with trimethyl chitosan (TMC) is investigated. Two types of TMC, one exhibiting a lower and one with a higher degree of cationization are...
Pamela Romo-Rodríguez et al.
Chemosphere, 134, 563-570 (2015-01-13)
The Cr(VI) reducing capability of growing cells of the environmental A. tubingensis Ed8 strain is remarkably efficient compared to reference strains A. niger FGSC322 and A. tubingensis NRRL593. Extracellular glucose oxidase (GOX) activity levels were clearly higher in colonies developed...
Robert K Huston et al.
PloS one, 10(8), e0136894-e0136894 (2015-09-01)
Previous studies of compatibility of calcium chloride (CaCl2) and phosphates have not included particle counts in the range specified by the United States Pharmacopeia. Micro-flow imaging techniques have been shown to be comparable to light obscuration when determining particle count...
Myra E Flores-Flores et al.
Journal of chromatography. A, 1419, 37-44 (2015-10-04)
An LC-MS/MS (QqQ) method has been developed and validated for simultaneous determination of the following trichothecenes in UHT cow milk: nivalenol (NIV), deoxynivalenol (DON), deepoxy-deoxynivalenol (DOM-1), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), neosolaniol (NEO), diacetoxyscirpenol (DAS), fusarenon X (FUS-X), T-2 and HT-2...
Rushd Khalaf et al.
Journal of chromatography. A, 1407, 169-175 (2015-07-08)
Reversed-phase (RP) chromatography is one of the main tools for the preparative purification of therapeutic peptides. In previous works [1,2], a new type of RP chromatography, doped reversed-phase chromatography (DRP) was presented. By adding small amounts (up to 15% of...
Jianhua Xu et al.
The journal of physical chemistry. B, 119(11), 4230-4239 (2015-02-25)
Time dependent fluorescence Stokes (emission wavelength) shifts (TDFSS) from tryptophan (Trp) following sub-picosecond excitation are increasingly used to investigate protein dynamics, most recently enabling active research interest into water dynamics near the surface of proteins. Unlike many fluorescence probes, both...
T Mahgoub et al.
International journal of oncology, 47(3), 900-908 (2015-07-24)
Despite recent advances in targeted therapies and immunotherapies metastatic melanoma remains only rarely curable. The objective of the present study was to identify novel therapeutic targets for metastatic melanoma. A library of 160 well-characterised and potent protein kinase inhibitors was...
Weiguo Xu et al.
Biomaterials, 54, 72-86 (2015-04-25)
Recently, chemotherapy has been one of the most important therapeutic approaches for malignant tumors. The tumor tissular or intracellular microenvironment-sensitive polymer-doxorubicin (DOX) conjugates demonstrate great potential for improved antitumor efficacy and reduced side effects. In this work, the acid-sensitive dextran-DOX...
Bernice Wright et al.
Journal of biomaterials applications, 30(2), 147-159 (2015-03-21)
Poly (lactic-co-glycolic) acid microspheres are amenable to a number of biomedical procedures that support delivery of cells, drugs, peptides or genes. Hydrophilisation or wetting of poly (lactic-co-glycolic) acid are an important pre-requisites for attachment of cells and can be achieved...

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