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Ronny Lesmana et al.
Endocrinology, 157(1), 23-38 (2015-11-13)
Thyroid hormone (TH) and autophagy share similar functions in regulating skeletal muscle growth, regeneration, and differentiation. Although TH recently has been shown to increase autophagy in liver, the regulation and role of autophagy by this hormone in skeletal muscle is
Gaurav Patki et al.
Brain research, 1539, 73-86 (2013-10-08)
In the present study, we have examined the behavioral and biochemical effect of induction of psychological stress using a modified version of the resident-intruder model for social stress (social defeat). At the end of the social defeat protocol, body weights
I A Samjoo et al.
Nutrition & diabetes, 3, e88-e88 (2013-09-18)
Obesity is associated with low-grade systemic inflammation, in part because of secretion of proinflammatory cytokines, resulting into peripheral insulin resistance (IR). Increased oxidative stress is proposed to link adiposity and chronic inflammation. The effects of endurance exercise in modulating these
Jasmin Awad et al.
Plant physiology, 167(4), 1592-1603 (2015-02-11)
Different peroxidases, including 2-cysteine (2-Cys) peroxiredoxins (PRXs) and thylakoid ascorbate peroxidase (tAPX), have been proposed to be involved in the water-water cycle (WWC) and hydrogen peroxide (H2O2)-mediated signaling in plastids. We generated an Arabidopsis (Arabidopsis thaliana) double-mutant line deficient in
Chih-Chao Yang et al.
American journal of translational research, 9(5), 2548-2566 (2017-06-01)
Although chronic kidney disease (CKD) is known to aggravate cardiovascular disease in the setting of cardiorenal syndrome (CRS), the impact of impaired cardiac function on the progression of CKD has seldom been reported. This study tested the impact of acute
Pei-Hsun Sung et al.
American journal of translational research, 10(9), 2781-2795 (2018-10-17)
This study tested the hypothesis that extracellular matrix accumulation in tPA-/-/MMP-9-/- [double-knockout (DKO)] may be protective against left ventricular (LV) remodeling and dysfunction following transverse aortic constriction (TAC)-induced hypertrophic cardiomyopathy in mice. Wild-type C57BL/6 mice (n = 20) were equally
Yung-Lung Chen et al.
Journal of translational medicine, 10, 86-86 (2012-05-10)
We tested the hypothesis that obesity reduced circulating number of endothelial progenitor cells (EPCs), angiogenic ability, and blood flow in ischemic tissue that could be reversed after obesity control. 8-week-old C57BL/6J mice (n=27) were equally divided into group 1 (fed
Alison Ludzki et al.
Diabetes, 64(8), 2769-2779 (2015-04-08)
Mitochondrial ADP transport may represent a convergence point unifying two prominent working models for the development of insulin resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and subsequently increase mitochondrial reactive oxygen species emissions. In the current
Elizabeth Donohue et al.
PloS one, 9(12), e114964-e114964 (2014-12-11)
Autophagy is a cellular catabolic process responsible for the degradation of cytoplasmic constituents, including organelles and long-lived proteins, that helps maintain cellular homeostasis and protect against various cellular stresses. Verteporfin is a benzoporphyrin derivative used clinically in photodynamic therapy to
Juliane C Campos et al.
Autophagy, 13(8), 1304-1317 (2017-06-10)
We previously reported that facilitating the clearance of damaged mitochondria through macroautophagy/autophagy protects against acute myocardial infarction. Here we characterize the impact of exercise, a safe strategy against cardiovascular disease, on cardiac autophagy and its contribution to mitochondrial quality control
Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats.
Mohammad Asghar, Emmanuel Monjok, Ghislaine Kouamou, Sunny E Ohia, Debasis Bagchi et al.
Molecular and Cellular Biochemistry null
Luciana R Gomes et al.
Autophagy, 13(5), 928-940 (2017-04-15)
Chaperone-mediated autophagy (CMA), a selective form of protein lysosomal degradation, is maximally activated in stress situations to ensure maintenance of cellular homeostasis. CMA activity decreases with age and in several human chronic disorders, but in contrast, in most cancer cells
David J Loane et al.
Journal of neuropathology and experimental neurology, 73(1), 14-29 (2013-12-18)
Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known about the mechanisms underlying such changes. Microglial-mediated neuroinflammationis an important secondary injury mechanism after TBI. In
Adam J Trewin et al.
Antioxidants & redox signaling, 31(9), 594-607 (2019-03-20)
Aims: How mitochondrial reactive oxygen species (ROS) impact physiological function may depend on the quantity of ROS generated or removed, and the subcellular microdomain in which this occurs. However, pharmacological tools currently available to alter ROS production in vivo lack
Protein oxidation implicated as the primary determinant of bacterial radioresistance.
Michael J Daly, Elena K Gaidamakova, Vera Y Matrosova, Alexander Vasilenko, Min Zhai et al.
PLoS Biology null
Emma M Hiolski et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 151-159 (2014-07-18)
Domoic acid is an algal-derived seafood toxin that functions as a glutamate agonist and exerts excitotoxicity via overstimulation of glutamate receptors (AMPA, NMDA) in the central nervous system (CNS). At high (symptomatic) doses, domoic acid is well-known to cause seizures
Expression of the counter-regulatory peptide intermedin is augmented in the presence of oxidative stress in hypertrophied cardiomyocytes.
Bell, David, et al.
Cellular Physiology and Biochemistry, 21, 409-420 (2008)
Patricia Martín-Maestro et al.
Human molecular genetics, 25(4), 792-806 (2016-01-02)
Mitochondrial anomalies have been previously reported in patients' brain and peripheral tissue, suggesting their relevance in sporadic Alzheimer's disease (AD). The present work evaluates mitochondrial function and recycling in human fibroblasts and brain biopsies. Functional studies using patients' skin fibroblasts
Andrew M Pickering et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 70(7), 791-799 (2014-07-30)
Species differ greatly in their rates of aging. Among mammalian species life span ranges from 2 to over 60 years. Here, we test the hypothesis that skin-derived fibroblasts from long-lived species of animals differ from those of short-lived animals in
Naveen Sharma et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 302(1), R126-R136 (2011-10-21)
Calorie restriction [CR; ∼40% below ad libitum (AL) intake] improves the health of many species, including rats, by mechanisms that may be partly related to enhanced insulin sensitivity for glucose disposal by skeletal muscle. Excessive activation of several mitogen-activated protein
Hao Wu et al.
Autophagy, 15(11), 1882-1898 (2019-03-23)
There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We
Esther Aguilar et al.
Cell reports, 28(9), 2306-2316 (2019-08-29)
Colorectal cancer (CRC) is associated with metabolic and redox perturbation. The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mechanism in tumors in vivo remains unexplored. Using murine intestinal cancer
Li Gao et al.
Antioxidants & redox signaling, 20(18), 2936-2948 (2013-11-14)
Dysfunction of myocyte enhancer factor 2D (MEF2D), a key survival protein and transcription factor, underlies the pathogenic loss of dopaminergic (DA) neurons in Parkinson's disease (PD). Both genetic factors and neurotoxins associated with PD impair MEF2D function in vitro and
Chia-Lo Chang et al.
American journal of translational research, 11(5), 2706-2724 (2019-06-21)
This study tested the hypothesis that melatonin (Mel) and adipose-derived mesenchymal stem cell-derived exosomes effectively suppress dextran sulfate sodium (DSS)-induced acute inflammatory colitis (AIC) in rats. To determine whether Mel-exosome treatment could ameliorate the severity of AIC, we treated Sprague
James K Fredrickson et al.
The ISME journal, 2(4), 393-403 (2008-02-15)
For extremely ionizing radiation-resistant bacteria, survival has been attributed to protection of proteins from oxidative damage during irradiation, with the result that repair systems survive and function with far greater efficiency during recovery than in sensitive bacteria. Here we examined
Yen-Ta Chen et al.
Journal of translational medicine, 9, 51-51 (2011-05-07)
Reactive oxygen species are important mediators exerting toxic effects on various organs during ischemia-reperfusion (IR) injury. We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury. Adult
Jaime DeSantiago et al.
Stem cells and development, 22(18), 2497-2507 (2013-04-26)
Mesenchymal stem cell (MSC) transplantation after ischemia/reperfusion (I/R) injury reduces infarct size and improves cardiac function. We used mouse ventricular myocytes (VMs) in an in vitro model of I/R to determine the mechanism by which MSCs prevent reperfusion injury by
Elizabeth Rodríguez-Bies et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 70(1), 33-43 (2014-02-06)
Aging affects many biochemical, cellular, and physiological processes in the organisms. Accumulation of damage based on oxidized macromolecules is found in many age-associated diseases. Coenzyme Q (Q) is one of the main molecules involved in metabolic and antioxidant activities in
Yoon Jin Lee et al.
Annals of dermatology, 27(5), 507-516 (2015-10-30)
Reactive oxygen species (ROS) play an important role in the induction of apoptosis under pathological conditions. Recently, a significant increase in ROS production and disrupted apoptosis mechanisms in keloids have been reported. Nuclear factor erythroid 2-related factor 2 (Nrf2) represents
Jingxing Ou et al.
Cell, 173(4), 851-863 (2018-03-27)
Hibernating mammals survive hypothermia (<10°C) without injury, a remarkable feat of cellular preservation that bears significance for potential medical applications. However, mechanisms imparting cold resistance, such as cytoskeleton stability, remain elusive. Using the first iPSC line from a hibernating mammal
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