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Chih-Chao Yang et al.
American journal of translational research, 9(5), 2548-2566 (2017-06-01)
Although chronic kidney disease (CKD) is known to aggravate cardiovascular disease in the setting of cardiorenal syndrome (CRS), the impact of impaired cardiac function on the progression of CKD has seldom been reported. This study tested the impact of acute
Jennifer G Duncan et al.
American journal of physiology. Heart and circulatory physiology, 289(4), H1512-H1518 (2005-05-03)
Heart failure is a clinical syndrome associated with elevated levels of oxygen-derived free radicals. Xanthine oxidase activity is believed to be one source of reactive oxygen species in the failing heart. Interventions designed to reduce oxidative stress are believed to
Elizabeth Rodríguez-Bies et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 70(1), 33-43 (2014-02-06)
Aging affects many biochemical, cellular, and physiological processes in the organisms. Accumulation of damage based on oxidized macromolecules is found in many age-associated diseases. Coenzyme Q (Q) is one of the main molecules involved in metabolic and antioxidant activities in
Chan Yoon Park et al.
Nutrition & metabolism, 14, 14-14 (2017-02-24)
Obesity has been reported to be associated with iron deficiency. However, few studies have investigated iron status in low adiposity. To investigate whether body adiposity was associated with altered hepatic iron status, we compared liver iron levels and markers involved
I A Samjoo et al.
Nutrition & diabetes, 3, e88-e88 (2013-09-18)
Obesity is associated with low-grade systemic inflammation, in part because of secretion of proinflammatory cytokines, resulting into peripheral insulin resistance (IR). Increased oxidative stress is proposed to link adiposity and chronic inflammation. The effects of endurance exercise in modulating these
José B N Moreira et al.
Journal of applied physiology (Bethesda, Md. : 1985), 114(8), 1029-1041 (2013-02-23)
Poor skeletal muscle performance was shown to strongly predict mortality and long-term prognosis in a variety of diseases, including heart failure (HF). Despite the known benefits of aerobic exercise training (AET) in improving the skeletal muscle phenotype in HF, the
Tuoyu Geng et al.
The American journal of pathology, 178(4), 1738-1748 (2011-03-26)
Chronic heart failure often results in catabolic muscle wasting, exercise intolerance, and death. Oxidative muscles, which have greater expression of the metabolic master gene peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and its target genes, are more resistant to catabolic wasting than
Magali Periquet et al.
Journal of neurochemistry, 95(5), 1259-1276 (2005-09-10)
Parkin knockout (KO) mice show behavioural and biochemical changes that reproduce some of the presymptomatic aspects of Parkinson's disease, in the absence of neuronal degeneration. To provide insight into the pathogenic mechanisms underlying the preclinical stages of parkin-related parkinsonism, we
Jiunn-Jye Sheu et al.
Journal of translational medicine, 13, 59-59 (2015-04-19)
We hypothesized that lung cancer patient's circulating microparticles (Lc-MPs) could promote angiogenesis, blood flow in ischemic zone and ischemic recovery in rat critical limb ischemia (CLI). To investigate the impact of MP therapy on reversing the setting of CLI, adult-male
François Le Guerroué et al.
Molecular cell, 68(4), 786-796 (2017-11-18)
Autophagy allows the degradation of cytosolic endogenous and exogenous material in the lysosome. Substrates are engulfed by double-membrane vesicles, coined autophagosomes, which subsequently fuse with lysosomes. Depending on the involvement of specific receptor proteins, autophagy occurs in a selective or
Ronny Lesmana et al.
Endocrinology, 157(1), 23-38 (2015-11-13)
Thyroid hormone (TH) and autophagy share similar functions in regulating skeletal muscle growth, regeneration, and differentiation. Although TH recently has been shown to increase autophagy in liver, the regulation and role of autophagy by this hormone in skeletal muscle is
Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats.
Mohammad Asghar, Emmanuel Monjok, Ghislaine Kouamou, Sunny E Ohia, Debasis Bagchi et al.
Molecular and Cellular Biochemistry null
Emma M Hiolski et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 151-159 (2014-07-18)
Domoic acid is an algal-derived seafood toxin that functions as a glutamate agonist and exerts excitotoxicity via overstimulation of glutamate receptors (AMPA, NMDA) in the central nervous system (CNS). At high (symptomatic) doses, domoic acid is well-known to cause seizures
Protein oxidation implicated as the primary determinant of bacterial radioresistance.
Michael J Daly, Elena K Gaidamakova, Vera Y Matrosova, Alexander Vasilenko, Min Zhai et al.
PLoS Biology null
Expression of the counter-regulatory peptide intermedin is augmented in the presence of oxidative stress in hypertrophied cardiomyocytes.
Bell, David, et al.
Cellular Physiology and Biochemistry, 21, 409-420 (2008)
Hao Wu et al.
Autophagy, 15(11), 1882-1898 (2019-03-23)
There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We
Esther Aguilar et al.
Cell reports, 28(9), 2306-2316 (2019-08-29)
Colorectal cancer (CRC) is associated with metabolic and redox perturbation. The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mechanism in tumors in vivo remains unexplored. Using murine intestinal cancer
James K Fredrickson et al.
The ISME journal, 2(4), 393-403 (2008-02-15)
For extremely ionizing radiation-resistant bacteria, survival has been attributed to protection of proteins from oxidative damage during irradiation, with the result that repair systems survive and function with far greater efficiency during recovery than in sensitive bacteria. Here we examined
Juliane C Campos et al.
Autophagy, 13(8), 1304-1317 (2017-06-10)
We previously reported that facilitating the clearance of damaged mitochondria through macroautophagy/autophagy protects against acute myocardial infarction. Here we characterize the impact of exercise, a safe strategy against cardiovascular disease, on cardiac autophagy and its contribution to mitochondrial quality control
Panos G Ziros et al.
Thyroid : official journal of the American Thyroid Association, 28(6), 780-798 (2018-05-11)
The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation in order to maintain normal function.
Nicolai Treiber et al.
Aging cell, 10(2), 239-254 (2010-11-27)
The free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. Its role in aging of the connective tissue has not yet been established, even though the incidence
Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.
Fussell KC, Udasin RG, Gray JP, Mishin V, Smith PJ, Heck DE, Laskin JD
Free radical biology & medicine null
Lynnette Marcar et al.
Cell reports, 27(12), 3422-3432 (2019-06-20)
Lung cancers with oncogenic mutations in the epidermal growth factor receptor (EGFR) invariably acquire resistance to tyrosine kinase inhibitor (TKI) treatment. Vulnerabilities of EGFR TKI-resistant cancer cells that could be therapeutically exploited are incompletely understood. Here, we describe a poly
Mononuclear iron enzymes are primary targets of hydrogen peroxide stress.
Adil Anjem,James A Imlay
The Journal of Biological Chemistry null
Hui-Ting Wang et al.
Journal of translational medicine, 10, 145-145 (2012-07-13)
Obesity is an important cardiovascular risk factor. This study tested the effect of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice. Eight-week-old C57BL/6 J mice (n=24) were equally divided
Esther van Dam et al.
Cell metabolism, 31(4), 710-725 (2020-03-21)
High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival is complex and difficult to disentangle. Here, we show that
Saurabh Aggarwal et al.
Redox biology, 36, 101684-101684 (2020-08-23)
The prevalence of chronic widespread pain (CWP) in people with HIV is high, yet the underlying mechanisms are elusive. Leukocytes synthesize the endogenous opioid, β-endorphin, within their endoplasmic reticulum (ER). When released into plasma, β-endorphin dampens nociception by binding to
Kuan-Hung Chen et al.
American journal of translational research, 11(9), 6232-6248 (2019-10-22)
We tested the hypothesis that human induced pluripotent stem cell-derived mesenchymal stem cell (iPSC-MSC) therapy could effectively reduce brain-infarct volume (BIV) and improve neurological function in rat after acute intracranial hemorrhage (ICH) induced by a weight-drop device. Adult-male SD rats
Stefan Matecki et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(32), 9069-9074 (2016-07-28)
Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still not fully understood. Here
Christian Giordano et al.
PloS one, 10(6), e0131068-e0131068 (2015-06-25)
Short-term intermittent hypoxia (IH) is common in patients with acute respiratory disorders. Although prolonged exposure to hypoxia induces atrophy and increased fatigability of skeletal muscle, the response to short-term IH is less well known. We hypothesized that the diaphragm and
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