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Nikoletta A Gkatza et al.
PLoS biology, 17(6), e3000297-e3000297 (2019-06-15)
Posttranscriptional modifications in transfer RNA (tRNA) are often critical for normal development because they adapt protein synthesis rates to a dynamically changing microenvironment. However, the precise cellular mechanisms linking the extrinsic stimulus to the intrinsic RNA modification pathways remain largely...
Gergely Jocsak et al.
Brain sciences, 9(12) (2019-12-11)
The endocrine system of animals consists of fine-tuned self-regulating mechanisms that maintain the hormonal and neuronal milieu during tissue development. This complex system can be influenced by endocrine disruptors (ED)-substances that can alter the hormonal regulation even in small concentrations....
Stefan Reber et al.
Nucleic acids research, 49(13), 7713-7731 (2021-07-08)
Liquid-liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlying the formation of membrane-less organelles. Such biomolecular condensates have various biological functions and have been linked to disease. The protein Fused in Sarcoma (FUS) undergoes...
Anne Monette et al.
Cell reports, 31(3), 107520-107520 (2020-04-23)
The duality of liquid-liquid phase separation (LLPS) of cellular components into membraneless organelles defines the nucleation of both normal and disease processes including stress granule (SG) assembly. From mounting evidence of LLPS utility by viruses, we discover that HIV-1 nucleocapsid...
Ashley Colemon et al.
Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 42, 24-24 (2020-08-08)
Melanoma Antigen Genes (MAGEs) are a family of genes that have piqued the interest of scientists for their unique expression pattern. A subset of MAGEs (Type I) are expressed in spermatogonial cells and in no other somatic tissue, and then...
Shengkui Xu et al.
Veterinary microbiology, 247, 108786-108786 (2020-08-10)
Pseudorabies virus (PRV) is one of the most notorious pathogens in the global pig industry. During infection, viruses may evolve various strategies, such as modulating stress granules (SGs) formation, to create an optimal surroundings for viral replication. However, the interplay...
Ruiqi Wang et al.
Cell death & disease, 10(3), 215-215 (2019-03-06)
Stress granule formation is important for stress response in normal cells and could lead to chemotherapy resistance in cancer cells. Aberrant stress granule dynamics are also known to disrupt proteostasis, affect RNA metabolism, and contribute to neuronal cell death. Meanwhile...
Kevin Klann et al.
Molecular cell, 77(4), 913-925 (2019-12-10)
Regulation of translation is essential during stress. However, the precise sets of proteins regulated by the key translational stress responses-the integrated stress response (ISR) and mTORC1-remain elusive. We developed multiplexed enhanced protein dynamics (mePROD) proteomics, adding signal amplification to dynamic-SILAC...
Haitian Lu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 112(2), 363-373 (2009-09-22)
Rodent models have been extensively utilized to identify putative human immunotoxicants; however, even when immunotoxicity is established, uncertainty remains whether the effects are predictive of human risk. Therefore, the objective of this study was to establish a polyclonal immunoglobulin M...
Ji-Hoon Lee et al.
Molecular cell, 81(7), 1515-1533 (2021-02-12)
Loss of the ataxia-telangiectasia mutated (ATM) kinase causes cerebellum-specific neurodegeneration in humans. We previously demonstrated that deficiency in ATM activation via oxidative stress generates insoluble protein aggregates in human cells, reminiscent of protein dysfunction in common neurodegenerative disorders. Here, we...
Marta Lualdi et al.
Oncotarget, 6(10), 7851-7865 (2015-03-24)
As widely recognized, tumor growth entails a close and complex cross-talk among cancer cells and the surrounding tumor microenvironment. We recently described the human RNASET2 gene as one key player of such microenvironmental cross-talk. Indeed, the protein encoded by this...
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Cui, et al.
Biochemical Pharmacology, 182, 114280-114280 (2021)
S J Tavernier et al.
Nature communications, 10(1), 4779-4779 (2019-10-23)
Hyperinflammatory syndromes are life-threatening disorders caused by overzealous immune cell activation and cytokine release, often resulting from defects in negative feedback mechanisms. In the quintessential hyperinflammatory syndrome familial hemophagocytic lymphohistiocytosis (HLH), inborn errors of cytotoxicity result in effector cell accumulation...
Beibei Cai et al.
Apoptosis : an international journal on programmed cell death, 13(6), 803-810 (2008-05-10)
Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL). However, the relationship between p38 and Bim(EL) in this apoptosis has not been fully defined. Here, we report that...
Taher Alizadeh et al.
Analytica chimica acta, 843, 7-17 (2014-08-26)
In this study, a new strategy was proposed for the preparation of As (III)-imprinted polymer by using arsenic (methacrylate)3 as template. Precipitation polymerization was utilized to synthesize nano-sized As (III)-imprinted polymer. Methacrylic acid and ethylene glycol dimethacrylate were used as...
Andrea Maria Guarino et al.
Genes, 9(10) (2018-10-27)
The prototype cold-shock Y-box binding protein 1 (YB-1) is a multifunctional protein that regulates a variety of fundamental biological processes including cell proliferation and migration, DNA damage, matrix protein synthesis and chemotaxis. The plethora of functions assigned to YB-1 is...
Biwu Liu et al.
ACS applied materials & interfaces, 7(44), 24833-24838 (2015-10-23)
Although DNA has been quite successful in metal cation detection, anion detectioin remains challenging because of the charge repulsion. Metal oxides represent a very important class of materials, and different oxides might interact with anions differently. In this work, a...
Kevin Rhine et al.
Molecular cell, 80(4), 666-681 (2020-11-08)
The RNA-binding protein fused in sarcoma (FUS) can form pathogenic inclusions in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). Over 70 mutations in Fus are linked to ALS/FTLD. In patients, all Fus mutations are heterozygous...
Sofia Zanotti et al.
Scientific reports, 11(1), 14454-14454 (2021-07-16)
MYCN is an oncogenic driver in neural crest-derived neuroblastoma and medulloblastoma. To better understand the early effects of MYCN activation in a neural-crest lineage context, we profiled the transcriptome of immortalized human retina pigment epithelial cells with inducible MYCN activation....
Jasmina Zivanovic et al.
Cell metabolism, 30(6), 1152-1170 (2019-11-19)
Life on Earth emerged in a hydrogen sulfide (H2S)-rich environment eons ago and with it protein persulfidation mediated by H2S evolved as a signaling mechanism. Protein persulfidation (S-sulfhydration) is a post-translational modification of reactive cysteine residues, which modulate protein structure...
Jin-Ho Park et al.
Sensors (Basel, Switzerland), 19(13) (2019-06-30)
A simple and rapid As3+ detection method using 3-nitro-L-tyrosine (N-Tyr) is reported. We discovered the specific property of N-Tyr, which specifically chelates As3+. The reaction between As3+ and N-Tyr induces a prompt color change to vivid yellow, concomitantly increasing the...
Ranya A Amer et al.
BioMed research international, 2015, 981829-981829 (2015-08-15)
Coastal environments worldwide are threatened by the effects of pollution, a risk particularly high in semienclosed basins like the Mediterranean Sea that is poorly studied from bioremediation potential perspective especially in the Southern coast. Here, we investigated the physical, chemical...
Jeanne M Danes et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(12), 16034-16048 (2020-10-14)
Inorganic arsenic (iAs/As2 O3 2- ) is an environmental toxicant found in watersheds around the world including in densely populated areas. iAs is a class I carcinogen known to target the skin, lungs, bladder, and digestive organs, but its role...
Balam Ruiz-Ruiz et al.
ACS omega, 5(21), 12005-12015 (2020-06-18)
Silver nanoparticles (AgNPs) are the most used nanomaterials worldwide due to their excellent antibacterial, antiviral, and antitumor activities, among others. However, there is scarce information regarding their genotoxic potential measured using human peripheral blood lymphocytes. In this work, we present...
Rahul Bhowmick et al.
Virus research, 210, 344-354 (2015-09-20)
Cytoplasmic Processing bodies (P bodies), the RNA-protein aggregation foci of translationally stalled and potentially decaying mRNA, have been reported to be differentially modulated by viruses. Rotavirus, the causative agent of acute infantile gastroenteritis is a double stranded RNA virus which...
Meredith Whitaker et al.
Journal of bacteriology (2020-06-03)
The Mycobacterium tuberculosis H37Rv genome has been sequenced and annotated over 20 years ago, yet roughly half of the protein-coding genes still lack a predicted function. We characterized two genes of unknown function, rv3679 and rv3680, for which inconsistent findings...
Francesca Zappa et al.
The EMBO journal, 38(19), e101704-e101704 (2019-08-21)
The TRAnsport Protein Particle (TRAPP) complex controls multiple membrane trafficking steps and is strategically positioned to mediate cell adaptation to diverse environmental conditions, including acute stress. We have identified the TRAPP complex as a component of a branch of the...
Tyler Matheny et al.
RNA (New York, N.Y.), 27(2), 174-189 (2020-11-18)
Stress granules (SGs) are stress-induced RNA-protein assemblies formed from a complex transcriptome of untranslating ribonucleoproteins (RNPs). Although RNAs can be either enriched or depleted from SGs, the rules that dictate RNA partitioning into SGs are unknown. We demonstrate that the...
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