Showing 1-30 of 249 results for "S7401"
O S Goussis et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 22(6), 342-344 (1990-06-01)
Earlier studies have shown that drugs such as dilantin inhibit T4 binding by thyroid hormone binding globulin (TBG) and cause a displacement of T4 from TBG to prealbumin with no change in the albumin-bound T4 fraction. Since recent studies have...
Ashish Ranjan et al.
Functional & integrative genomics, 15(3), 363-373 (2014-12-17)
Xanthomonas oryzae pv. oryzae, the causal agent of bacterial blight of rice, secretes several cell wall degrading enzymes including cellulase (ClsA) and lipase/esterase (LipA). Prior treatment of rice leaves with purified cell wall degrading enzymes such as LipA can confer...
Magda Caban et al.
Journal of chromatography. A, 1346, 107-116 (2014-05-13)
This paper discusses a new silylating reagent - dimethyl(3,3,3-trifluoropropyl)silyldiethylamine (DIMETRIS) - for the derivatisation of non-steroidal anti-inflammatory drugs (NSAIDs) prior to GC-MS analysis. DIMETRIS reacts with seven target compounds (diclofenac, ibuprofen, ketoprofen, naproxen, flurbiprofen and paracetamol, as well as salicylic...
Jose Pedro Fonseca et al.
PloS one, 9(12), e114119-e114119 (2014-12-02)
Nudix hydrolases comprise a large gene family of twenty nine members in Arabidopsis, each containing a conserved motif capable of hydrolyzing specific substrates like ADP-glucose and NADH. Until now only two members of this family, AtNUDX6 and AtNUDX7, have been...
Pankaj Aggarwal et al.
Journal of chromatography. A, 1364, 96-106 (2014-09-07)
Highly cross-linked monolithic networks (i.e., polyethylene glycol diacrylate, PEGDA) synthesized from monomers containing varying ethylene oxide chain lengths were fabricated inside fused silica capillary columns for use in liquid chromatography (LC) of small molecules. Tergitol was used as a surfactant...
Sylwia Magiera et al.
Journal of AOAC International, 97(6), 1526-1537 (2015-01-30)
A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zorbax Rapid Resolution...
Michael Groszmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(46), E6397-E6406 (2015-11-04)
Plant hybrids are extensively used in agriculture to deliver increases in yields, yet the molecular basis of their superior performance (heterosis) is not well understood. Our transcriptome analysis of a number of Arabidopsis F1 hybrids identified changes to defense and...
Mina Heidarian Höckerfelt et al.
International journal of pharmaceutics, 477(1-2), 326-333 (2014-12-03)
The purpose of the research was to investigate the effect of moisture content of cellulose on the degradation of a drug in binary mixtures with cellulose. Physical mixtures of acetylsalicylic acid and two forms of cellulose, either microcrystalline cellulose or...
Vipul Gupta et al.
Molecular pharmacology, 84(6), 824-833 (2013-09-18)
Salicylic acid is a classic nonsteroidal anti-inflammatory drug. Although salicylic acid also induces mitochondrial injury, the mechanism of its antimitochondrial activity is not well understood. In this study, by using a one-step affinity purification scheme with salicylic acid-immobilized beads, ferrochelatase...
J E Baggott et al.
The Biochemical journal, 282 ( Pt 1), 197-202 (1992-02-15)
Many non-steroidal anti-inflammatory drugs (NSAIDs) (including sulphasalazine, sulindac, indomethacin, naproxen, salicylic acid, ibuprofen, piroxicam and mefenamic acid) were found to be competitive inhibitors (with respect to folate) of avian liver phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase, EC and bovine liver dihydrofolate...
[Salicylic acid, aspirin].
Tsuneko Onouchi et al.
Nihon rinsho. Japanese journal of clinical medicine, 62 Suppl 12, 392-394 (2005-01-22)
Miles Trupp et al.
Journal of Parkinson's disease, 4(3), 549-560 (2014-06-15)
Parkinson's disease (PD) is a progressive, multi-focal neurodegenerative disease for which there is no effective disease modifying treatment. A critical requirement for designing successful clinical trials is the development of robust and reproducible biomarkers identifying PD in preclinical stages. To...
Ganesan Karthikeyan et al.
British journal of haematology, 146(2), 142-149 (2009-05-15)
Guidelines differ on whether acetyl salicylic acid (ASA, aspirin) should be used for prophylaxis in patients at high-risk of venous thromboembolism (VTE), principally because of differences in perceptions of its efficacy. ASA is an attractive therapeutic option because it is...
N H Yoshida et al.
The Journal of pharmacy and pharmacology, 47(11), 883-890 (1995-11-01)
Solute concentration, buffer concentration, applied pH and buffer constituents affect the cathodal iontophoresis of salicylate, benzoate and butyrate across excised skin. Experiments were conducted in which the iontophoretic flux of salicylate was measured across excised human skin with variations in...
Carola M Wassvik et al.
Journal of medicinal chemistry, 51(10), 3035-3039 (2008-04-10)
Solubility and solid-state characteristics were determined and multivariate data analysis was used to deduce structural features important for solid-state limited solubility of marketed drugs. Molecules with extended ring structures and large conjugated systems were less soluble, indicating that structural features...
Matthew Di Rago et al.
Forensic science international, 243, 35-43 (2014-05-06)
The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing....
Kyle W Bender et al.
The Biochemical journal, 457(1), 127-136 (2013-10-10)
Many signalling pathways in plants are regulated by the second messenger calcium (Ca(2+)). In the standard model, Ca(2+)-sensor proteins, such as CaM (calmodulin), detect Ca(2+) signals and subsequently regulate downstream targets to advance the signal transduction cascade. In addition to...
Bo Liu et al.
PloS one, 9(7), e102067-e102067 (2014-07-11)
Biotic and abiotic stresses are major unfavorable factors that affect crop productivity worldwide. NAC proteins comprise a large family of transcription factors that play important roles in plant growth and development as well as in responses to biotic and abiotic...
Babasaheb P Bandgar et al.
Bioorganic & medicinal chemistry letters, 20(2), 730-733 (2009-12-17)
A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase. The antioxidant potential was demonstrated using 1,1-diphenyl-2-picryl hydrazine (DPPH) radical scavenging activity. The...
A Kunkel et al.
Archiv der Pharmazie, 332(5), 175-178 (1999-06-15)
Capillary electrophoresis (CE) is often regarded as a separation technique of choice because of its high selectivity and its cost advantages compared to LC.RSD% of 0.5% have become standard for quality control assays. Using CE, sample pretreatment can often be...
Artem O Surov et al.
Molecular pharmaceutics, 12(11), 4154-4165 (2015-10-20)
Salts of the antiviral drug Arbidol (umifenovir) with pharmaceutically relevant benzoate and salicylate anions were obtained, and their crystal structures were described. For Arbidol salicylate, an unstable solvate with acetonitrile was also found and characterized. Analysis of the conformational preferences...
Cristina Avonto et al.
Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13)
Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological and in silico methods are recommended to replace...
Joshua S Mylne et al.
Biopolymers, 94(5), 635-646 (2010-06-22)
Cyclotides are small cysteine-rich plant peptides similar in size and processing to the defensins. Long-term growth of the Rubiaceae family plant Oldenlandia affinis under different conditions reveals a diverse cyclotide gene and peptide expression profile, including tissue specificity, suggesting that...
Thorsten E Fisher et al.
Bioorganic & medicinal chemistry letters, 17(23), 6511-6515 (2007-10-13)
A series of potent novel 8-hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and viral replication in cells. Compound 12 is active against replication of HIV-1 in cell culture with a CIC(95)...
Guozhang Kang et al.
Molecular genetics and genomics : MGG, 288(11), 591-599 (2013-08-15)
Basic transcription factor 3 (BTF3), the β-subunit of the nascent polypeptide-associated complex, is responsible for the transcriptional initiation of RNA polymerase II and is also involved in cell apoptosis, translation initiation regulation, growth, development, and other functions. Here, we report...
[10-year-old boy with blackish brown skin alterations].
C Guarneri et al.
Deutsche medizinische Wochenschrift (1946), 139(50), 2585-2586 (2014-12-04)
Themba T Ndovi et al.
Clinical pharmacology and therapeutics, 80(2), 146-158 (2006-08-08)
The male genital tract is a complex collection of anatomically and biochemically distinct compartments that contribute to the ejaculate. Understanding the pharmacokinetics in these compartments should inform rational therapeutics involving these glands. Nineteen men were administered a single dose of...
Masanori Matsuoka et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(7), 629-634 (2015-07-15)
This paper for the first time reports on novel and non-enzymatic method for studying the free radical-scavenging properties of phenolic compounds against superoxide anion radicals (O2·(-)) by using the cathodic electrochemiluminescence (ECL) of lucigenin (Luc(2+)). The ECL of Luc(2+) at...
Anders Kjær et al.
AoB PLANTS, 2012, pls018-pls018 (2012-07-27)
Glandular trichomes (GT) of Artemisia annua produce valuable compounds for pharmaceutical and industrial uses, most notably the anti-malarial artemisinin. Our aim was to find out whether the density, number and size of GT can be manipulated to advantage by environmental...
Suneela S Dhaneshwar et al.
European journal of medicinal chemistry, 44(10), 3922-3929 (2009-05-16)
Colon-specific mutual azo prodrugs of 5-aminosalicylic acid with essential amino acids were synthesized for the management of inflammatory bowel disease. The structures were confirmed by elemental and spectral analyses. 85-88% release of 5-aminosalicylic acid was achieved in rat fecal matter...

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