Showing 1-30 of 1375 results for "

S7920

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Serafín Pérez-Cerezales et al.
Scientific reports, 5, 16146-16146 (2015-11-06)
A unique characteristic of mammalian sperm thermotaxis is extreme temperature sensitivity, manifested by the capacity of spermatozoa to respond to temperature changes of <0.0006 °C as they swim their body-length distance. The identity of the sensing system that confers this exceptional...
Kimbell L Hetzler et al.
Biochimica et biophysica acta, 1852(5), 816-825 (2015-01-04)
A devastating aspect of cancer cachexia is severe loss of muscle and fat mass. Though cachexia occurs in both sexes, it is not well-defined in the female. The Apc(Min/+) mouse is genetically predisposed to develop intestinal tumors; circulating IL-6 is...
Ji-Youn Youn et al.
Molecular endocrinology (Baltimore, Md.), 29(8), 1123-1133 (2015-06-30)
We have recently shown that angiotensin II-mediated uncoupling of endothelial nitric oxide synthase (eNOS) contributes to endothelial dysfunction in streptozotocin-induced type 1 diabetes mellitus. However, it has remained unclear whether and how eNOS uncoupling occurs in type 2 diabetes mellitus...
Michael K Wong et al.
PloS one, 10(3), e0122295-e0122295 (2015-03-27)
Maternal nicotine exposure has been associated with many adverse fetal and placental outcomes. Although underlying mechanisms remain elusive, recent studies have identified that augmented endoplasmic reticulum (ER) stress is linked to placental insufficiency. Moreover, ER function depends on proper disulfide...
Anita Leocadio Freitas-Mesquita et al.
Experimental parasitology, 137, 8-13 (2013-12-10)
Several ecto-enzymatic activities have been described in the plasma membrane of the protozoan Leishmania amazonensis, which is the major etiological agent of diffuse cutaneous leishmaniasis in South America. These enzymes, including ecto-phosphatases, contribute to the survival of the parasite by...
Shilpa Prabhakar et al.
Neurobiology of disease, 82, 22-31 (2015-05-29)
We examined the potential benefit of gene therapy in a mouse model of tuberous sclerosis complex (TSC) in which there is embryonic loss of Tsc1 (hamartin) in brain neurons. An adeno-associated virus (AAV) vector (serotype rh8) expressing a tagged form...
Masaaki Kawai et al.
Journal of biomedical science, 22, 48-48 (2015-07-05)
Breast cancer is classified into three subtypes by the expression of biomarker receptors such as hormone receptors and human epidermal growth factor receptor 2. Triple-negative breast cancer (TNBC) expresses none of these receptors and has an aggressive phenotype with a...
Christopher M Lucaj et al.
Cytoskeleton (Hoboken, N.J.), 72(5), 225-234 (2015-05-28)
Microtubule plus-end dynamics are regulated by a family of proteins called plus-end tracking proteins (+TIPs). We recently demonstrated that the transforming acidic coiled-coil (TACC) domain family member, TACC3, can function as a +TIP to regulate microtubule dynamics in Xenopus laevis...
Yun-Hee Rhee et al.
Biochemical and biophysical research communications, 447(4), 557-562 (2014-02-15)
Anethole has been known to have chemopreventive activities as a suppressor of the incidence and multiplicity of both invasive and noninvasive carcinomas. The goal of this study was to understand the anti-metastatic effect of anethole through C-X-C chemokine receptor type...
Zhifang Dong et al.
The Journal of clinical investigation, 125(1), 234-247 (2014-12-02)
Long-term potentiation (LTP) of synaptic strength between hippocampal neurons is associated with learning and memory, and LTP dysfunction is thought to underlie memory loss. LTP can be temporally and mechanistically classified into decaying (early-phase) LTP and nondecaying (late-phase) LTP. While...
Ya'an Kang et al.
PloS one, 9(9), e107948-e107948 (2014-09-30)
Expression of the cellular adhesion protein N-cadherin is a critical event during epithelial-mesenchymal transition (EMT). The SMAD4 protein has been identified as a mediator of transforming growth factor-β (TGF-β) superfamily signaling, which regulates EMT, but the mechanisms linking TGF-β signaling...
W-L Wang et al.
Oncogene, 34(9), 1116-1125 (2014-03-26)
The transcriptional repressor Slug is best known to control epithelial-mesenchymal transition (EMT) and promote cancer invasion/metastasis. In this study, we demonstrate that Slug is temporally regulated during cell cycle progression. At G1/S transition, cyclin E-cyclin-dependent kinase 2 mediates the phosphorylation...
Jessica Ohnona et al.
Nuclear medicine communications, 34(5), 417-425 (2013-03-09)
18F-Sodium fluoride is a bone tracer with a high signal-to-noise ratio, but its dosimetry is higher than that of 99mTc-labeled phosphonates at the recommended activities. The study's purpose was to determine whether the reduction by half of F-sodium fluoride-injected activity...
Vidhyalakshmi Arumugam et al.
Journal of leukocyte biology, 98(5), 703-712 (2015-07-15)
DGK-ζ is a negative regulator of TCR signaling that causes degradation of the second messenger DAG, terminating DAG-mediated activation of Ras and PKCθ. Cytotoxic T cells deficient in DGK-ζ demonstrate enhanced effector functions in vitro and antitumor activity in vivo...
Hong Tan et al.
International journal of clinical and experimental medicine, 8(9), 14816-14826 (2015-12-03)
Besides neurotoxic effects, inhaled anesthetics might have other adverse effects on the developing brain. Ribosomal protein S6 (rpS6), the first identified ribosomal protein undergoing phosphorylation, has important physiological functions in regulating protein synthesis, cell proliferation, and glucose homeostasis. To date...
Min Cui et al.
Scientific reports, 5, 16455-16455 (2015-11-13)
OASIS/CREB3L1, an endoplasmic reticulum (ER)-resident transcription factor, plays important roles in osteoblast differentiation. In this study, we identified new crosstalk between OASIS and the hypoxia signaling pathway, which regulates vascularization during bone development. RT-PCR and real-time PCR analyses revealed significant...
Weili Tian et al.
FEBS letters, 589(15), 1847-1854 (2015-05-20)
UNC-51 like kinase (ULK1) translocates to dysfunctional mitochondria and is involved in mitophagy, but the mechanisms responsible for ULK1 activation and translocation remain unclear. Here, we found that hypoxia induces phosphorylation of ULK1 at Serine-555 by Adenosine 5'-monophosphate (AMP)-activated protein...
Shahla Karim Baloch et al.
Chirality, 27(3), 274-280 (2015-02-11)
In this study, a shikonin ester derivative, compound , was selected to evaluate its anticancer activities and we found that compound exhibited better antitubulin activities against the human HepG2 cell line with an IC50 value of 1.097 μM. Furthermore, the inhibition...
Michael K Kiessling et al.
Oncotarget, 6(39), 42183-42196 (2015-11-07)
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung...
Maitea Guridi et al.
Science signaling, 8(402), ra113-ra113 (2015-11-12)
Skeletal muscle is the largest organ, comprising 40% of the total body lean mass, and affects whole-body metabolism in multiple ways. We investigated the signaling pathways involved in this process using TSCmKO mice, which have a skeletal muscle-specific depletion of...
Xiaolong Wang et al.
Oncology reports, 33(6), 3038-3044 (2015-04-16)
Human telomerase reverse transcriptase (hTERT) is upregulated in most cancer cell types as well in immortalized cells. The underlying mechanism for such upregulation, however, remains largely unknown. We report here that bile acids under acidified media increase hTERT expression via...
Xiao-Yun Yang et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 36(11), 2027-2033 (2015-07-15)
Lysophosphatidic acid (LPA) is a bioactive phospholipid that activates at least five known G-protein-coupled receptors (GPCRs): LPA1-LPA5. The nervous system is a major locus for LPA1 expression. LPA has been shown to regulate neuronal proliferation, migration, and differentiation during central...
Maha Abdalla et al.
British journal of pharmacology, 172(16), 4173-4188 (2015-06-03)
Interstitial lung disease accounts for a group of chronic and progressive disorders associated with severe pulmonary vascular remodelling, peripheral vascular rarefaction and fibrosis, thus limiting lung function. We have previously shown that Akt is necessary for myofibroblast differentiation, a critical...
Charles Finsterwald et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(48), 15903-15915 (2015-12-04)
Arousal and stress critically regulate memory formation and retention. Increasing levels of stress produce an inverted U-shaped effect on cognitive performance, including the retention of explicit memories, and experiencing a severe stress during a traumatic event may lead to posttraumatic...
Pawel Leznicki et al.
Journal of cell science, 128(17), 3187-3196 (2015-07-15)
Rpn13 is an intrinsic ubiquitin receptor of the 26S proteasome regulatory subunit that facilitates substrate capture prior to degradation. Here we show that the C-terminal region of Rpn13 binds to the tetratricopeptide repeat (TPR) domain of SGTA, a cytosolic factor...
Jinbin Zhai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(24), 9088-9105 (2015-06-19)
Mutant genes that underlie Mendelian forms of amyotrophic lateral sclerosis (ALS) and biochemical investigations of genetic disease models point to potential driver pathophysiological events involving endoplasmic reticulum (ER) stress and autophagy. Several steps in these cell biological processes are known...
Bianca Kloos et al.
Cell communication and signaling : CCS, 13, 40-40 (2015-09-16)
Pasteurella multocida toxin (PMT) is a potent inducer of osteoclast formation. Pigs suffering from an infection with toxigenic Pasteurella multocida strains develop atrophic rhinitis characterised by a loss of turbinate bones and conchae. However, on the molecular level the process...
Monique Stoffels et al.
Rheumatology (Oxford, England), 54(2), 363-368 (2014-09-01)
The autoinflammatory hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS) is characterized by recurrent episodes of fever and inflammation. As part of the mevalonate kinase deficiency spectrum, it is caused by MVK mutations, resulting in decreased mevalonate kinase activity in the...
E Bertogna et al.
Journal of photochemistry and photobiology. B, Biology, 118, 74-76 (2012-12-19)
The ultra-weak photon emission (biophoton) patterns of wheat germination tests under chemical stress (mercury and fluoride solutions) are presented in comparison to respective control groups run simultaneously in two similar, automatic photon-count chambers. Solutions of Hg (EC(50) and EC(100)) and...
Hiroyasu Sakai et al.
Anesthesiology, 118(5), 1076-1085 (2013-01-29)
Tyrosine (Tyr) kinases and mitogen-activated protein kinases have been thought to participate in the contractile response in various smooth muscles. The aim of the current study was to investigate the involvement of the Tyr kinase pathway in the contraction of...