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s7920

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Petr Kosztyu et al.
Chemico-biological interactions, 219, 203-210 (2014-06-24)
The effect of ABCB1 (P-gp, (P-glycoprotein), MDR1) and ABCG2 (BCRP1, (breast cancer resistance protein 1)) expressions on cell resistance to daunorubicin (DRN), imatinib, and nilotinib was studied in human leukemia cells. We used a set of cells derived from a...
Andrey V Kuznetsov et al.
Biochimica et biophysica acta, 1853(2), 276-284 (2014-12-03)
Dysfunction of cardiac energy metabolism plays a critical role in many cardiac diseases, including heart failure, myocardial infarction and ischemia-reperfusion injury and organ transplantation. The characteristics of these diseases can be elucidated in vivo, though animal-free in vitro experiments, with...
Yu-Ting Xu et al.
Archives of oral biology, 60(7), 1059-1065 (2015-05-08)
The objective of this study was to investigate the antibacterial effects on a cariogenic biofilm of a bioactive glass (BAG) combined with either sodium fluoride (NaF) or triclosan (TCS). According to minimal bactericidal concentrations, 37.5mg/ml of BAG, 4.69 mg/ml of...
Corina A Schmid et al.
The Journal of experimental medicine, 212(5), 775-792 (2015-04-08)
The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmacological DNA demethylation with functional screening to identify novel tumor suppressors in diffuse large...
J Einwag et al.
Quintessence international (Berlin, Germany : 1985), 26(10), 707-713 (1995-10-01)
A conference concerning the caries-inhibiting efficacy of dentifrices that contain amine and sodium fluorides compared relevant clinical studies and found that both fluoride compounds contribute to the maintenance of dental health. Because of the differing test conditions, the study results...
Caine C Smith et al.
Alcoholism, clinical and experimental research, 39(1), 36-44 (2015-01-28)
Binge-like ethanol (EtOH) exposure during the early rat neonatal period results in acute cell loss in specific brain regions, but such acute cell death has not been well established in the hippocampus. Binge alcohol exposure can also result in protein...
Chang Seok Lee et al.
Skeletal muscle, 5, 4-4 (2015-02-27)
Ca(2+) influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca(2+) permeation through CaV1.1 during sustained muscle activity plays a functional role in mammalian skeletal muscle has not been assessed. We generated a mouse with a...
Sebastien Gingras et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(29), 10510-10522 (2015-07-24)
Neuronal death caused by excessive excitatory signaling, excitotoxicity, plays a central role in neurodegenerative disorders. The mechanisms regulating this process, however, are still incompletely understood. Here we show that the coated vesicle-associated kinase SCYL2/CVAK104 plays a critical role for the...
Najiba Murad et al.
The FEBS journal, 281(23), 5251-5264 (2014-09-25)
MicroRNA 184 (miR-184) is known to play a key role in neurological development and apoptosis and is highly expressed in mouse brain, mouse corneal epithelium, zebrafish lens and human retinal pigment epithelium (RPE). However, the role of miR-184 in RPE...
Ayumi Okamoto et al.
Cell cycle (Georgetown, Tex.), 14(10), 1568-1582 (2015-03-19)
Large tumor suppressor 1 and 2 (Lats1/2) regulate centrosomal integrity, chromosome segregation and cytokinesis. As components of the centralspindlin complex, the kinesin-like protein CHO1 and its splicing variant MKLP1 colocalize with chromosome passenger proteins and GTPases and regulate the formation...
Gaël Ennequin et al.
The Journal of physiology, 593(12), 2665-2677 (2015-03-31)
Some studies suggest that neuregulin 1 (NRG1) could be involved in the regulation of skeletal muscle energy metabolism in rodents. Here we assessed whether unbalanced diet is associated with alterations of the NRG1 signalling pathway and whether exercise and diet...
Seyedeh Farzaneh Omidkhoda et al.
Iranian journal of basic medical sciences, 23(3), 303-310 (2020-05-23)
One of the most important problems of taking nitroglycerin is the nitrate tolerance phenomenon and endothelial dysfunction. Oxidative stress is a high-emphasized one of tolerance mechanisms. The possible effect of crocin, one of the anti-oxidant ingredients of saffron, on the...
Fabian B Fahlbusch et al.
Histochemistry and cell biology, 144(3), 281-291 (2015-06-14)
Gastrokines (GKNs) were originally described as stomach-specific tumor suppressor genes. Recently, we identified GKN1 in extravillous trophoblasts (EVT) of human placenta. GKN1 treatment reduced the migration of the trophoblast cell line JEG-3. GKN2 is known to inhibit the proliferation, migration...
Melissa Togtema et al.
Virology, 485, 274-282 (2015-09-01)
Human papillomavirus type 16 is commonly implicated in HPV-related cancers. However, only a small number of infected individuals progress to this stage. Epidemiological evidence demonstrated that oncogenic risk is population-specific and variations within the viral oncogene, E6, have been suggested...
Noel C Wortham et al.
BMC medical genetics, 16, 64-64 (2015-08-20)
Leukoencephalopathy with Vanishing White Matter (VWM) is an autosomal recessive disorder caused by germline mutations in the genes EIF2B1-5, which encode the 5 subunits of the eukaryotic translation initiation factor eIF2B. To date, analysis of the biochemical effects of mutations...
Julia Hernandez-Rapp et al.
Behavioural brain research, 287, 15-26 (2015-03-31)
The miR-132/212 family is thought to play an important role in neural function and plasticity, while its misregulation has been observed in various neurodegenerative disorders. In this study, we analyzed 6-month-old miR-132/212 knockout mice in a battery of cognitive and...
Shweta Joshi et al.
Cancer chemotherapy and pharmacology, 75(3), 595-608 (2015-01-13)
SF1126 is a vascular-targeted pan-PI-3K inhibitor prodrug with antitumor and antiangiogenic activity and has completed phase I clinical trial in solid tumors and B-cell malignancies. In this study, we investigated the effect of SF1126 on hypoxic HIF-1α/HIF-2α stability as well...
Yuki Yoshino et al.
Biochemical and biophysical research communications, 464(1), 275-280 (2015-06-28)
Cancer cell invasion is a critical phenomenon in cancer pathogenesis. Glycogen synthase kinase-3β (GSK-3β) has been reported to regulate cancer cell invasion both negatively and positively. Thus, the net effect of GSK-3β on invasion is unclear. In this report, we...
Xinlei Yu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(2), 394-407 (2014-11-08)
Induction of autophagy and the integrated stress response is important for amino acid homeostasis. It remains unknown whether the autophagy coregulates both mechanistic target of rapamycin complex 1 (mTORC1) signaling and the integrated stress response. In mouse C2C12 myotubes, we...
Jinsong Li et al.
Oncotarget, 6(9), 6749-6761 (2015-03-03)
The epidermal growth factor receptor (EGFR) is a therapeutic target (oncotarget) in NSCLC. Using in vitro EGFR kinase activity system, we identified a novel small molecule, WB-308, as an inhibitor of EGFR. WB-308 decreased NSCLC cell proliferation and colony formation...
Monica P Rodriguez et al.
The Journal of surgical research, 196(1), 180-189 (2015-03-25)
Nitric oxide (NO) more effectively inhibits neointimal hyperplasia in type 2 diabetic versus nondiabetic and type 1 diabetic rodents. NO also decreases the ubiquitin-conjugating enzyme UbcH10, which is critical to cell-cycle regulation. This study seeks to determine whether UbcH10 levels...
Marcus Trentzsch et al.
Cell death discovery, 6, 8-8 (2020-03-04)
Genetic obesity increases in liver phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio, inducing endoplasmic reticulum (ER) stress without concomitant increase of ER chaperones. Here, it is found that exposing mice to a palm oil-based high fat (HF) diet induced obesity, loss of liver...
Maiwen Caudron-Herger et al.
Nature protocols, 15(4), 1338-1370 (2020-02-26)
Analysis of RNA-protein complexes is central to understanding the molecular circuitry governing cellular processes. In recent years, several proteome-wide studies have been dedicated to the identification of RNA-binding proteins. Here, we describe in detail R-DeeP, an approach built on RNA...
Christopher A Dieni et al.
PeerJ, 2, e558-e558 (2014-09-12)
The wood frog, Rana sylvatica, survives whole-body freezing and thawing each winter. The extensive adaptations required at the biochemical level are facilitated by alterations to signaling pathways, including the insulin/Akt and AMPK pathways. Past studies investigating changing tissue-specific patterns of...
Yu-Xin Xu et al.
Journal of lipid research, 56(2), 266-276 (2014-12-22)
Perlecan is a major heparan sulfate (HS) proteoglycan in the arterial wall. Previous studies have linked it to atherosclerosis. Perlecan contains a core protein and three HS side chains. Its core protein has five domains (DI-DV) with disparate structures and...
Wei-Kai Chen et al.
Biochemical and biophysical research communications, 453(3), 576-581 (2014-10-11)
The c-Jun N-terminal Kinases (JNKs) play important roles in cell responses to stress or growth factor stimulation. The JNK1α1 isoform shares >90% identity with a predominantly neuronal JNK3α1 isoform, but JNK3α1 also includes a distinctive 38 amino acid N-terminal sequence....
K P Sharma et al.
Indian journal of experimental biology, 50(12), 897-903 (2013-08-31)
Protective role of diet supplements (Spirulina, tamarind fruit pulp and their combination) on a freshwater fish G. affinis exposed at sublethal concentration of fluoride (F-) (10 ppm), Al(+3) (3 ppm) and aluminum fluoride (AlF3) (35.4 ppm) in the microcosms (15...
Sheroy Minocherhomji et al.
Nature, 528(7581), 286-290 (2015-12-04)
Oncogene-induced DNA replication stress has been implicated as a driver of tumorigenesis. Many chromosomal rearrangements characteristic of human cancers originate from specific regions of the genome called common fragile sites (CFSs). CFSs are difficult-to-replicate loci that manifest as gaps or...
Jason S L Yu et al.
Nature communications, 6, 7212-7212 (2015-05-23)
Crosstalk between the phosphatidylinositol 3-kinase (PI3K) and the transforming growth factor-β signalling pathways play an important role in regulating many cellular functions. However, the molecular mechanisms underpinning this crosstalk remain unclear. Here, we report that PI3K signalling antagonizes the Activin-induced...
Y Gu et al.
Cell death & disease, 5, e1580-e1580 (2014-12-19)
BRCA1 is a multifunctional protein best known for its role in DNA repair and association with breast and ovarian cancers. To uncover novel biologically significant molecular functions of BRCA1, we tested a panel of 198 approved and experimental drugs to...
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