Showing 1-11 of 11 results for "S9200"
Mika Pietilä et al.
Nature communications, 10(1), 2340-2340 (2019-05-30)
The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many other receptor tyrosine kinases is known to regulate their oncogenic signalling, the prevailing view on...
Vanessa Schmidt et al.
Cellular and molecular life sciences : CMLS, 74(8), 1475-1483 (2016-11-11)
Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues...
Michael R Lamprecht et al.
Journal of neurotrauma, 34(1), 97-108 (2016-02-28)
The utility of in vitro models of traumatic brain injury (TBI) depends on their ability to recapitulate the in vivo TBI cascade. In this study, we used a genome-wide approach to compare changes in gene expression at several time points...
Eleonora Ciarlo et al.
Disease models & mechanisms, 6(2), 424-433 (2012-09-22)
Recent studies indicated that sortilin-related receptor 1 (SORL1) is a risk gene for late-onset Alzheimer's disease (AD), although its role in the aetiology and/or progression of this disorder is not fully understood. Here, we report the finding of a non-coding...
Satoru Suwa et al.
International heart journal, 61(3), 470-475 (2020-05-01)
Cardiovascular events still occur despite statin-based lipid-lowering therapy in patients with coronary artery disease (CAD). LR11, a member of the low-density lipoprotein receptor family, is a novel marker for the proliferation of intimal smooth muscle cells, which are critical to...
Coding mutations in SORL 1 and A lzheimer disease
Vardarajan BN, et al.
Annals of Neurology, 77(2), 215-227 (2015)
L Jacobsen et al.
The Journal of biological chemistry, 271(49), 31379-31383 (1996-12-06)
The 39-40-kDa receptor-associated protein (RAP) binds to the members of the low density lipoprotein receptor gene family and functions as a specialized endoplasmic reticulum/Golgi chaperone. Using RAP affinity chromatography, we have purified a novel approximately 250-kDa brain protein and isolated...
Vanessa Schmidt et al.
The Journal of biological chemistry, 282(45), 32956-32964 (2007-09-15)
SorLA has been recognized as a novel sorting receptor that regulates trafficking and processing of the amyloid precursor protein (APP) and that represents a significant risk factor for sporadic Alzheimer disease. Here, we investigated the cellular mechanisms that control intracellular...
Olav M Andersen et al.
Biochemistry, 45(8), 2618-2628 (2006-02-24)
SorLA/LR11 is a sorting receptor that regulates the intracellular transport and processing of the amyloid precursor protein (APP) in neurons. SorLA/LR11-mediated binding results in sequestration of APP in the Golgi and in protection from processing into the amyloid-beta peptide (Abeta)...
Michael L Cuccaro et al.
Neurology. Genetics, 2(6), e116-e116 (2016-11-09)
To characterize the clinical and molecular effect of mutations in the sortilin-related receptor ( We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer disease (LOAD) families followed by functional studies of select variants. The phenotypic consequences associated...
Badri N Vardarajan et al.
Annals of neurology, 77(2), 215-227 (2014-11-11)
Common single nucleotide polymorphisms in the SORL1 gene have been associated with late onset Alzheimer disease (LOAD), but causal variants have not been fully characterized nor has the mechanism been established. The study was undertaken to identify functional SORL1 mutations...

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