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Showing 1-30 of 33 results for "S9915" within Papers
SCF/c-kit transactivates CXCR4-serine 339 phosphorylation through G protein-coupled receptor kinase 6 and regulates cardiac stem cell migration
Zuo K, et al.
Scientific Reports, 6: 26812, 1-12 (2016)
Huy Tran et al.
Frontiers in cellular neuroscience, 13, 56-56 (2019-03-07)
Endothelial dysfunction underlies the pathobiology of cerebrovascular disease. Mast cells are located in close proximity to the vasculature, and vasoactive mediators released upon their activation can promote endothelial activation leading to blood brain barrier (BBB) dysfunction. We examined the mechanism
Jonathan M Eby et al.
Pigment cell & melanoma research, 27(6), 1075-1085 (2014-06-18)
To generate a mouse model of spontaneous epidermal depigmentation, parental h3TA2 mice, expressing both a human-derived, tyrosinase-reactive T-cell receptor on T cells and the matching HLA-A2 transgene, were crossed to keratin 14-promoter driven, stem cell factor transgenic (K14-SCF) mice with
Sunhee Hwang et al.
Stem cells and development, 23(21), 2661-2671 (2014-06-11)
A hyaluronic-acid-rich node and duct system (HAR-NDS) was found on the surface of internal organs of mice, and inside their blood and lymph vessels. The nodes (HAR-Ns) were filled with immune cells of the innate system and were especially enriched
Maegan L Capitano et al.
Blood cells, molecules & diseases, 55(1), 15-20 (2015-05-16)
Ames hypopituitary dwarf mice are deficient in growth hormone, thyroid-stimulating hormone, and prolactin. The phenotype of these mice demonstrates irregularities in the immune system with skewing of the normal cytokine milieu towards a more anti-inflammatory environment. However, the hematopoietic stem
Santiago Balseiro-Gomez et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2046-2056 (2015-07-24)
The key role of mast cells (MC), either in development of inflammatory pathologies or in response to environmental stress, has been widely reported in recent years. Previous studies have described the effects of corticotropin-releasing hormone (CRH), which is released from
PP2A regulates SCF-induced cardiac stem cell migration through interaction with p38 MAPK
Wang Y, et al.
Life Sciences, 191, 59-67 (2017)
Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
Song H, et al.
Bioorganic & Medicinal Chemistry, 18, 7580-7585 (2010)
Chisa Nakashima et al.
The Journal of allergy and clinical immunology, 134(1), 100-107 (2014-04-10)
Although eosinophils have been detected in several human skin diseases in the vicinity of basophils, how eosinophils infiltrate the skin and the role of eosinophils in the development of skin inflammation have yet to be examined. Using murine irritant contact
Edyta E Wojtowicz et al.
Experimental hematology, 42(10), 909-918 (2014-08-06)
MicroRNAs (miRNAs) are crucial for proper functioning of hematopoietic stem and progenitor cells (HSPCs). Members of the miRNA-125 family (consisting of miR-125a, miR-125b1, and miR-125b2) are known to confer a proliferative advantage on cells upon overexpression, to decrease the rate
Jie Zhang et al.
PloS one, 9(9), e107478-e107478 (2014-09-13)
To interrogate why redox homeostasis and glutathione S-transferase P (GSTP) are important in regulating bone marrow cell proliferation and migration, we isolated crude bone marrow, lineage negative and bone marrow derived-dendritic cells (BMDDCs) from both wild type (WT) and knockout
Jelena Ostojić et al.
Cell reports, 35(7), 109136-109136 (2021-05-20)
The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the cAMP-regulated transcription co-activators 1-3 (CRTC1-3). Differentiation is dysregulated in melanomas, although the contributions of CRTC proteins is unclear. We report a selective differentiation impairment in CRTC3 KO melanocytes
Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis by secreting SCF
Zhou BO, et al.
Nature Cell Biology, 19(8), 891-903 (2017)
Maike Buchner et al.
Nature communications, 6, 6471-6471 (2015-03-11)
Despite recent advances in the cure rate of acute lymphoblastic leukaemia (ALL), the prognosis for patients with relapsed ALL remains poor. Here we identify FOXM1 as a candidate responsible for an aggressive clinical course. We show that FOXM1 levels peak
Antonija Jurak Begonja et al.
Blood, 126(1), 80-88 (2015-04-04)
Bin-Amphiphysin-Rvs (BAR) and Fes-CIP4 homology BAR (F-BAR) proteins generate tubular membrane invaginations reminiscent of the megakaryocyte (MK) demarcation membrane system (DMS), which provides membranes necessary for future platelets. The F-BAR protein PACSIN2 is one of the most abundant BAR/F-BAR proteins
Prabir Ray et al.
Cell cycle (Georgetown, Tex.), 7(18), 2826-2832 (2008-09-13)
The receptor tyrosine kinase, c-kit, and its ligand, stem cell factor (SCF), function in a diverse range of biological functions. The role of c-kit in the maintenance and survival of hematopoietic stem cells and of mast cells is well recognized.
Ramesh C Nayak et al.
The Journal of clinical investigation, 125(8), 3103-3116 (2015-07-21)
Severe congenital neutropenia (SCN) is often associated with inherited heterozygous point mutations in ELANE, which encodes neutrophil elastase (NE). However, a lack of appropriate models to recapitulate SCN has substantially hampered the understanding of the genetic etiology and pathobiology of
Anne-Sophie Bergot et al.
PLoS pathogens, 10(10), e1004466-e1004466 (2014-10-24)
Human Papillomavirus (HPV) 16 E7 protein promotes the transformation of HPV infected epithelium to malignancy. Here, we use a murine model in which the E7 protein of HPV16 is expressed as a transgene in epithelium to show that mast cells
Yasuo Mori et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(31), 9638-9643 (2015-07-22)
Determining the developmental pathway leading to erythrocytes and being able to isolate their progenitors are crucial to understanding and treating disorders of red cell imbalance such as anemia, myelodysplastic syndrome, and polycythemia vera. Here we show that the human erythrocyte
Albert W Cheng et al.
Blood, 124(4), 598-610 (2014-05-30)
The scope and roles of regulated isoform gene expression during erythroid terminal development are poorly understood. We identified hundreds of differentiation-associated isoform changes during terminal erythropoiesis. Sequences surrounding cassette exons of skipped exon events are enriched for motifs bound by
Laura Pitzonka et al.
PloS one, 9(5), e97628-e97628 (2014-05-17)
Co-transcriptionally assembled ribonucleoprotein (RNP) complexes are critical for RNA processing and nuclear export. RNPs have been hypothesized to contribute to the regulation of coordinated gene expression, and defects in RNP biogenesis contribute to genome instability and disease. Despite the large
Sally Hamour et al.
PloS one, 10(8), e0136238-e0136238 (2015-09-01)
IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney.
Shuchismita R Satpathy et al.
Nature communications, 6, 7064-7064 (2015-04-30)
Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study, we demonstrate that in K-ras(LA1) mice, CS exposure markedly enhances the lung tumour burden and genetic deletion
Persistent distention of colon damages interstitial cells of Cajal through Ca2+-ERK-AP-1-miR-34c-SCF deregulation
Yang S, et al.
Journal of Cellular and Molecular Medicine, 21(9), 1881-1892 (2017)
Hebist Berhane et al.
Radiation research, 182(1), 35-49 (2014-06-17)
The altered DNA damage response pathway in patients with Fanconi anemia (FA) may increase the toxicity of clinical radiotherapy. We quantitated oral cavity mucositis in irradiated Fanconi anemia Fancd2(-/-) mice, comparing this to Fancd2(+/-) and Fancd2(+/+) mice, and we measured
Neha Khandelwal et al.
Cell chemical biology, 28(8), 1169-1179 (2021-02-12)
In humans, lysophosphatidylserines (lyso-PSs) are potent lipid regulators of important immunological processes. Given their structural diversity and commercial paucity, here we report the synthesis of methyl esters of lyso-PS (Me-lyso-PSs) containing medium- to very-long-chain (VLC) lipid tails. We show that
Antagonism of Stem Cell Factor/c-kit Signaling Attenuates Neonatal Chronic Hypoxia-Induced Pulmonary Vascular Remodeling
Young KC, et al.
Pediatric Research, 79(4), 637-646 (2016)
Audrey Pietrzyk-Nivau et al.
PloS one, 10(8), e0136652-e0136652 (2015-08-28)
Hematopoietic stem cells (HSC) differentiate into megakaryocytes (MK), whose function is to release platelets. Attempts to improve in vitro platelet production have been hampered by the low amplification of MK. Providing HSC with an optimal three-dimensional (3D) architecture may favor
Sang-Goo Lee et al.
Asian-Australasian journal of animal sciences, 28(11), 1565-1572 (2015-11-19)
Porcine embryonic stem cells (pESCs) have become an advantageous experimental tool for developing therapeutic applications and producing transgenic animals. However, despite numerous reports of putative pESC lines, deriving validated pESC lines from embryos produced in vitro remains difficult. Here, we
Kyu-Tae Jeong et al.
Biomolecules & therapeutics, 23(5), 421-427 (2015-09-04)
Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse bone marrow-derived mast cells (BMMC). Imperatorin inhibited degranulation and the
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