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Tensin is potentially involved in extracellular matrix production in mesangial cells.
Yamashita M
Histochemistry and Cell Biology, 121, 245-254 (2004)
Nuria Barber-Pérez et al.
Journal of cell science, 133(12) (2020-05-13)
Fibrillar adhesions are important structural and adhesive components in fibroblasts, and are required for fibronectin fibrillogenesis. While nascent and focal adhesions are known to respond to mechanical cues, the mechanoresponsive nature of fibrillar adhesions remains unclear. Here, we used ratiometric
Genetic association analyses highlight biological pathways underlying mitral valve prolapse
Dina C
Nature Genetics, 47, 1206?1211-1206?1211 (2015)
Lo S H
The International Journal of Biochemistry & Cell Biology, 36(1), 31-34 (2004)
Maria Georgiadou et al.
The Journal of cell biology, 216(4), 1107-1121 (2017-03-16)
Tight regulation of integrin activity is paramount for dynamic cellular functions such as cell matrix adhesion and mechanotransduction. Integrin activation is achieved through intracellular interactions at the integrin cytoplasmic tails and through integrin-ligand binding. In this study, we identify the
Abhishek Kumar et al.
The Journal of cell biology, 218(8), 2481-2491 (2019-07-19)
Cell sensing of externally applied mechanical strain through integrin-mediated adhesions is critical in development and physiology of muscle, lung, tendon, and arteries, among others. We examined the effects of strain on force transmission through the essential cytoskeletal linker talin. Using
Tensin can induce JNK and p38 activation.
Katz BZ
Biochemical and Biophysical Research Communications, 272, 717-720 (2000)
Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation.
Bernau K
American Journal of Respiratory Cell and Molecular Biology, 56, 465-476 (2017)
Abhishek Kumar et al.
The Journal of cell biology, 213(3), 371-383 (2016-05-11)
Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report the development and validation of a talin tension sensor. We find that talin in focal adhesions
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