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Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system
Scharadin TM, et al.
PLoS ONE (2017)
U S Dinish et al.
Journal of biophotonics, 7(11-12), 956-965 (2013-08-22)
Surface-enhanced Raman scattering (SERS) spectroscopy possesses the most promising advantage of multiplex detection for biosensing applications, which is achieved due to the narrow 'fingerprint' Raman spectra from the analyte molecules. We developed an ultrasensitive platform for the multiplex detection of
Tamara Braut et al.
Applied immunohistochemistry & molecular morphology : AIMM, 22(9), 674-680 (2014-10-04)
Although enhanced epidermal growth factor receptor (EGFR) signaling has been connected with glottic cancerogenesis, the precise mechanisms of its activation still remain unclear. The aim of the present study was to examine EGFR on protein level, confronting cellular pattern of
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab.
Brand TM
Cancer Biology & Therapy, 11(9), 777-792 (2011)
Anna-Maria Stock et al.
Experimental cell research, 326(2), 307-314 (2014-05-09)
Pancreatic cancer is characterized by aggressive local invasion and early metastasis formation. Active migration of the pancreatic cancer cells is essential for these processes. We have shown previously that the pancreatic cancer cells lines CFPAC1 and IMIM-PC2 show high migratory
Christopher N Graham et al.
European journal of cancer (Oxford, England : 1990), 50(16), 2791-2801 (2014-09-16)
To investigate the cost-effectiveness of panitumumab plus mFOLFOX6 (oxaliplatin, 5-fluorouracil and leucovorin) compared with bevacizumab plus mFOLFOX6 in first-line treatment of patients with wild-type RAS metastatic colorectal cancer (mCRC). A semi-Markov model was constructed from a French health collective perspective
EGFR regulates macrophage activation and function in bacterial infection
Hardbower DM, et al.
The Journal of Clinical Investigation (2016)
Yi Zhang et al.
Journal of pharmacological sciences, 126(1), 77-83 (2014-09-23)
Esophageal carcinoma is one of the most virulent malignant diseases and a major cause of cancer-related deaths worldwide. Despite improvements in surgical techniques and perioperative management and surgery combined with chemotherapy and/or radiotherapy, the prognosis of esophageal squamous cell carcinoma
Yong Sang Hong et al.
PloS one, 9(10), e109440-e109440 (2014-10-29)
ERBB2-directed therapy is now a routine component of therapy for ERBB2-amplified metastatic gastroesophageal adenocarcinomas. However, there is little knowledge of the mechanisms by which these tumors develop acquired resistance to ERBB2 inhibition. To investigate this question we sought to characterize
Lakshmi Reddy Bollu et al.
Cell cycle (Georgetown, Tex.), 13(15), 2415-2430 (2014-12-09)
Increased expressions of fatty acid synthase (FASN) and epidermal growth factor receptor (EGFR) are common in cancer cells. De novo synthesis of palmitate by FASN is critical for the survival of cancer cells via mechanisms independent of its role as
Hailing Tang et al.
Molecular pharmaceutics, 11(10), 3242-3250 (2014-09-03)
Targeting ligands displayed on liposome surface had been used to mediate specific interactions and drug delivery to target cells. However, they also affect liposome distribution in vivo, as well as the tissue extravasation processes after IV injection. In this study
Warut Tulalamba et al.
Journal of clinical pathology, 67(8), 667-672 (2014-05-16)
Although the ERBB proteins have been shown to be associated in many types of human tumours and serve as important cancer therapeutic targets, however, data regarding the expression and clinical relevance of ERBBs in nasopharyngeal carcinoma (NPC) are still conflicting.
Tai Kiuchi et al.
Science signaling, 7(339), ra78-ra78 (2014-08-21)
The epidermal growth factor receptor (EGFR) is a member of the ErbB family that can promote the migration and proliferation of breast cancer cells. Therapies that target EGFR can promote the dimerization of EGFR with other ErbB receptors, which is
M Grimm et al.
International journal of oral and maxillofacial surgery, 43(10), 1199-1205 (2014-05-14)
The clinical impact of epidermal growth factor receptor (EGFR) (E746-A750del) mutation and human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) is unclear. EGFR (E746-A750del) expression was analyzed in OSCC specimens (n=161) by immunohistochemistry. The expression results were correlated with
Weishan Wang et al.
Biochemical and biophysical research communications, 452(3), 614-621 (2014-09-03)
Overexpressions of EGFR and HER2 are thought to be prognostic factors of cholangiocarcinoma (CCA). The SOX4 transcription factor is involved in the development and cell fate decision. Although up-regulation of SOX4 has been described in multiple human malignancies, the prognostic
Shizuka Ito et al.
International journal of oncology, 44(3), 685-692 (2014-01-09)
Previously we showed that Akt-suppressing agents, combined with amrubicin, synergistically inhibited the growth of small cell lung cancer cells. The combined effects of chemotherapeutic agents and Akt-suppressing agents, including epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, were evaluated in
Tanusree Paul et al.
European journal of cancer (Oxford, England : 1990), 50(11), 1855-1863 (2014-05-27)
Epidermal growth factor receptor inhibitor (EGFRI) induced skin toxicity has a prognostic value suggesting skin toxicity can be a useful surrogate marker for successful epidermal growth factor receptor (EGFR) inhibition, improved response and survival. But the pathophysiology of EGFRI induced
A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma.
Eley GD
Neuro-Oncology, 4(2), 86-94 (2002)
POPDC1 is suppressed in human breast cancer tissues and is negatively regulated by EGFR in breast cancer cell lines
Amunjela JN and Tucker SJ
Cancer Letters (2017)
Terence Tieu et al.
Biomaterials science, 9(1), 133-147 (2020-11-03)
Targeted delivery of chemotherapeutics to cancer cells has the potential to yield high drug concentrations in cancer cells while minimizing any unwanted side effects. However, the development of multidrug resistance in cancer cells may impede the accumulation of chemotherapy drugs
A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma
Eley GD, et al.
Neuro-Oncology (2002)
Pavel Barta et al.
Journal of pharmacological and toxicological methods, 70(2), 145-151 (2014-08-02)
Competitive binding assays can be used to decipher not only the binding kinetics of studied ligands but also the binding site preference. Such assays are an essential step in the characterization of radioligands. However, the currently used competition assays require
Federica Ganci et al.
Lung cancer (Amsterdam, Netherlands), 85(2), 197-204 (2014-05-28)
Thymic epithelial tumors (TET) are the most frequent human primary mediastinal tumors in adults. A deep biological characterization of the processes at the basis of the transformed phenotype could strongly improve our understanding of the morphological and clinical heterogeneity of
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Min Shi et al.
Current cancer drug targets, 14(2), 217-224 (2014-01-29)
Mutation status of Kirsten rat sarcoma viral oncogene homolog (KRAS) may serve as a negative predictive marker of Cetuximab in treating colorectal cancer. The present study was to determine the role of KRAS status in EGFR antibody treatment for gastric
X Chen et al.
Neoplasma, 61(5), 514-522 (2014-07-18)
Colorectal cancer (CRC) is the third common cancer and most of the chemotherapies of CRC currently used often suffer limited efficacy and large side effects. Targeted small-molecule by anti-tumor drugs are thought a promising strategy for improving the efficacy and reducing
Haruko Ota et al.
Nature communications, 5, 4532-4532 (2014-07-31)
Throughout life, new neurons generated in the ventricular-subventricular zone take the long journey to the olfactory bulb. The intracellular mechanisms that precisely control the neurons' migration speed, enabling their well-organized movement, remain unclear. Rho signalling is known to affect the
Wai Jin Tan et al.
Breast cancer research and treatment, 145(3), 635-645 (2014-05-17)
Phyllodes tumours of the breast are uncommon fibroepithelial neoplasms which pose management challenges due to difficulties in accurate prediction of clinical behaviour, as histological assessment has its limitations. Molecular studies have improved the understanding of these rare tumours but such
Juan Zhou et al.
Oncology reports, 39(4), 1783-1792 (2018-02-03)
Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend
Cui Tang et al.
International journal of clinical and experimental pathology, 7(6), 3213-3223 (2014-07-18)
Clinical and epidemiological studies have shown that estrogen may be involved in the development and progression of papillary thyroid carcinoma (PTC). G protein-coupled estrogen receptor 1 (GPER1) is a novel seven-transmembrane estrogen receptor that functions alongside traditional nuclear estrogen receptors
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