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Showing 1-15 of 15 results for "sab4600084" within Papers
Pascal Hoffmann et al.
PloS one, 16(8), e0256143-e0256143 (2021-08-24)
Gastrointestinal infectious diseases remain an important issue for human and animal health. Investigations on gastrointestinal infectious diseases are classically performed in laboratory animals leading to the problem that species-specific models are scarcely available, especially when it comes to farm animals.
Line Séguy et al.
Pharmaceutics, 13(10) (2021-10-24)
The activation of 5-HT4 receptors with agonists has emerged as a valuable therapeutic strategy to treat Alzheimer's disease (AD) by enhancing the nonamyloidogenic pathway. Here, the potential therapeutic effects of tegaserod, an effective agent for irritable bowel syndrome, were assessed
Evan C Chen et al.
Gastroenterology, 149(3), 705-717 (2015-06-01)
Receptor tyrosine kinase (RTK) inhibitors have advanced colon cancer treatment. We investigated the role of the RTK KIT in development of human colon cancer. An array of 137 patient-derived colon tumors and their associated xenografts were analyzed by immunohistochemistry to
Christophe Rochais et al.
British journal of pharmacology, 177(9), 1988-2005 (2019-12-28)
We recently identified donecopride as a pleiotropic compound able to inhibit AChE and to activate 5-HT4 receptors. Here, we have assessed the potential therapeutic effects of donecopride in treating Alzheimer's disease (AD). We used two in vivo animal models of
Thomas Prukop et al.
Journal of neuroscience research, 98(10), 1933-1952 (2020-06-27)
Charcot-Marie-Tooth disease 1 A (CMT1A) is caused by an intrachromosomal duplication of the gene encoding for PMP22 leading to peripheral nerve dysmyelination, axonal loss, and progressive muscle weakness. No therapy is available. PXT3003 is a low-dose combination of baclofen, naltrexone
Qinggang Xie et al.
Frontiers in nutrition, 9, 1054431-1054431 (2022-11-29)
During early neurodevelopment of infant, myelination plays an essential role in brain connectivity and emergence of behavioral and cognitive function. Early life nutrition is an important factor to shape myelination and consequently cognitive appearance. To analyze the effects of additive
Fabien Bonini et al.
Brain sciences, 12(4) (2022-04-22)
Recent advances in biomaterials offer new possibilities for brain tissue reconstruction. Biocompatibility, provision of cell adhesion motives and mechanical properties are among the present main design criteria. We here propose a radically new and potentially major element determining biointegration of
Magdalena Ganz et al.
PloS one, 14(8), e0213130-e0213130 (2019-08-14)
DNA replication stress is a major source of genomic instability and is closely linked to tumor formation and progression. Poly(ADP-ribose)polymerases1/2 (PARP1/2) enzymes are activated in response to replication stress resulting in poly(ADP-ribose) (PAR) synthesis. PARylation plays an important role in
Ashrafur Rahman et al.
Cell reports, 39(9), 110903-110903 (2022-06-02)
Selective autophagy receptors and adapters contain short linear motifs called LIR motifs (LC3-interacting region), which are required for the interaction with the Atg8-family proteins. LIR motifs bind to the hydrophobic pockets of the LIR motif docking site (LDS) of the
Yazhou Li et al.
Journal of neurochemistry, 159(5), 867-886 (2021-09-28)
Glucagon-like peptide-1 (GLP-1) is best known for its insulinotropic action following food intake. Its metabolite, GLP-1 (9-36), was assumed biologically inactive because of low GLP-1 receptor (GLP-1R) affinity and non-insulinotropic properties; however, recent studies contradict this assumption. Increased use of
Patricia Richard et al.
PloS one, 16(8), e0253216-e0253216 (2021-08-12)
Growing evidence suggests that human gut bacteria, which comprise the microbiome, are linked to several neurodegenerative disorders. An imbalance in the bacterial population in the gut of Parkinson's disease (PD) and Alzheimer's disease (AD) patients has been detected in several
Yamei Zhang et al.
Viruses, 14(4) (2022-04-24)
Coronaviruses (CoVs) have caused several global outbreaks with relatively high mortality rates, including Middle East Respiratory Syndrome coronavirus (MERS)-CoV, which emerged in 2012, and Severe Acute Respiratory Syndrome (SARS)-CoV-1, which appeared in 2002. The recent emergence of SARS-CoV-2 highlights the
Antibody structure, instability, and formulation.
Wang W
Journal of Pharmaceutical Sciences, 96, 1-26 (2007)
P Casali et al.
Current topics in microbiology and immunology, 210, 167-179 (1996-01-01)
Natural antibodies arise independently of known antigenic stimulation, are mostly IGM, polyreactive, and are generally encoded by V genes in germline configuration. Polyreactive IgM natural antibodies are produced by mainly B-1 cells which account for most of the B cell
Human placental Fc receptors and the transmission of antibodies from mother to fetus
Simister NE and Story CM.
Journal of Reproductive Immunology, 37, 1-23 (1997)
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