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A role for APP in Wnt signalling links synapse loss with beta-amyloid production
Elliott C, et al.
Translational Psychiatry, 8(1), 179-179 (2018)
Xiangmei Wu et al.
Molecular neurobiology, 50(3), 839-851 (2014-04-15)
Chronic cerebral hypoperfusion is associated with cognitive decline in aging and age-related neurodegenerative disease. Epigenetic mechanisms are involved in the maintenance of long-term hypoxia-adapted cellular phenotypes. In the present study, the epigenetic signatures such as DNA methylation and histone acetylation
Protective effects of sulforaphane on cognitive impairments and ad-like lesions in diabetic mice are associated with the upregulation of Nrf2 transcription activity
Pu D, et al.
Neuroscience, 381, 35-45 (2018)
Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24. 3
Elliott C, et al.
Translational Psychiatry, 2(4), 179-179 (2018)
C Scuderi et al.
Cell death & disease, 5, e1419-e1419 (2014-09-12)
Given the complex heterogeneity of pathological changes occurring in Alzheimer's disease (AD), any therapeutic effort absolutely requires a multi-targeted approach, because attempts addressing only a single event may result ineffective. Palmitoylethanolamide (PEA), a naturally occurring lipid amide between palmitic acid
Noemí Fabelo et al.
Neurobiology of aging, 35(8), 1801-1812 (2014-03-13)
The presence of lipid alterations in lipid rafts from the frontal cortex in late stages of Alzheimer's disease (AD) has been recently demonstrated. Here, we have isolated and analyzed the lipid composition of lipid rafts from different brain areas from
Novel derivative of Paeonol, Paeononlsilatie sodium, alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's disease concurrent with cofilin1/phosphorylated-cofilin1 and RAC1/CDC42 alterations in rats
Han F, et al.
PLoS ONE, 12(9), e0185102-e0185102 (2017)
Ilaria Zuliani et al.
International journal of molecular sciences, 22(7) (2021-05-01)
The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer's disease (AD), flaws of the cerebral glucose uptake translate into reduced protein O-GlcNAcylation, which
Human brain-derived Abeta oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP
Wang Z, et al.
The Journal of Neuroscience, 37(49), 11947-11966 (2017)
Flaubert Tchantchou et al.
Neuropharmacology, 85, 427-439 (2014-06-18)
Traumatic brain injury (TBI) is the leading cause of death in young adults in the United States, but there is still no effective agent for treatment. N-arachidonoylethanolamine (anandamide, AEA) is a major endocannabinoid in the brain. Its increase after brain
Fei Han et al.
PloS one, 12(9), e0185102-e0185102 (2017-09-22)
Alzheimer's disease (AD) is a typical hippocampal amnesia and the most common senile dementia. Many studies suggest that cognitive impairments are more closely correlated with synaptic loss than the burden of amyloid deposits in AD progression. To date, there is
Kaja Plucińska et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(32), 10710-10728 (2014-08-08)
Key neuropathological hallmarks of Alzheimer's disease (AD) are elevated levels of amyloid β-peptide (Aβ) species generated via amyloid precursor protein (APP) endoproteolysis and cleavage by the rate-limiting β-site enzyme 1 (BACE1). Because rodents do not develop amyloid pathologies, we here
Anne Rovelet-Lecrux et al.
Nature genetics, 38(1), 24-26 (2005-12-22)
We report duplication of the APP locus on chromosome 21 in five families with autosomal dominant early-onset Alzheimer disease (ADEOAD) and cerebral amyloid angiopathy (CAA). Among these families, the duplicated segments had a minimal size ranging from 0.58 to 6.37
Yuan Zhou et al.
PloS one, 9(7), e103187-e103187 (2014-07-23)
Sporadic or late-onset Alzheimer's disease (AD) is expected to affect 50% of individuals reaching 85 years of age. The most significant genetic risk factor for late-onset AD is the e4 allele of APOE gene encoding apolipoprotein E, a lipid carrier
Human brain-derived Abeta oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP
Wang Z, et al.
The Journal of Neuroscience, 8(1), 11947-11966 (2017)
Ilaria Zuliani et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18(1), 340-363 (2020-12-02)
Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discovery some 30 years ago, has been associated with the development of neurodegenerative diseases. As reported in Alzheimer's disease (AD), flaws in the cerebral glucose uptake translate into reduced hexosamine biosynthetic
RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum?induced Alzheimer's disease?like rat model.
Han, et al.
Acta Neurobiologiae Experimentalis, 80, 225-244 (2020)
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