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SAFC Expertise
SAFC Expertise
SAFC® Brand
Our complete portfolio of high-performance cGMP raw material solutions spans cell culture, process chemicals, formulation and HPAPI/ADC contract manufacturing. Whether you need customized or ready-to-use solutions, our team of quality and regulatory experts will tailor solutions to precisely fit...
Biologic APIs and Conjugation Experts – SAFC - St. Louis
SAFC’s St. Louis, Missouri (USA) campus is a key center of manufacturing excellence in cGMP biologics, with over 25 years experience in plant- and animal-based therapeutic protein extraction and purification, bio-conjugation, excipients and adjuvants manufacturing.
Speeding Biosimilar Development using Glycosylation Control Technology from SAFC
The biosimilar market is expected to grow rapidly in the coming years, as many blockbuster monoclonal antibodies lose patent protection by 2020.
Mgat4 May Play a Role in Increased Sialylation by Overexpressing Functional MGAT1 in Mgat1-Disrupted Chinese Hamster Ovary (CHO) Cells
MGAT1 adds N-acetylglucosamine to the Man5GlcNAc2 (Man5) structure. Goh et al. reported increased sialylation after restoring MGAT1 function in MGAT1 deficient CHO cells.
Lab Chemicals
Our vast lab chemicals portfolio includes acids, salts, caustic alkalis, bases, metals, and solvents for a variety of applications, including research, quality control, and other analytical testing.
EX-CELL® Advanced™ CHO Fed-Batch System – Bioprocessing Technology Institute, Singapore Case Study
In this study, nine commercially available, chemically defined media and feed combinations from different vendors were assessed for producing monoclonal antibody in Chinese hamster ovary (CHO) cells.
Development and Manufacturing of ADCs and Bio-Conjugates
As an industry leader in the conjugation of biological molecules with Highly-Active Pharmaceutical Ingredients (HAPIs), SAFC is among a handful of companies that can carry out the complexities of conjugation of biological molecules with HAPIs.
Smart Up Your Lab
Smart up your lab with our EMSURE® premium quality inorganics and solvents, available in safety packaging for smart handling and lab safety, including smart labels for digitalized lab data.
Analytical Reagents
Analytical reagents and solvents for wet chemistry, chromatography, spectroscopy, titration, microbiology, microscopy, gravimetry, water analysis, and ion sensors.
Metals
Choose from our wide selection of metals, metal salts, and metal oxides in various grades, ideal for a variety of applications in R&D, production, and quality control. We guarantee to deliver premium high purity and quality products, with excellent batch-to-batch...
Safety Inside Lab Safety
Discover our lab safety solutions for handling hazardous goods in the lab, risk prevention of lab accidents, and emergency help for quick absorbance of liquid chemical spills to meet all your chemical safety needs.
Acids
Explore a comprehensive range of acids offered under three portfolios for a variety of applications: Supelco® products for analytical chemistry, Sigma-Aldrich® materials for lab and production, SAFC® products for biopharmaceutical and pharmaceutical development and manufacturing.
Caustic Alkalis & Bases
Our three portfolio brands offer caustic alkalis and bases to meet the various requirements of your specific applications. Supelco® products for analytical chemistry, Sigma-Aldrich® materials for lab and production, SAFC® products for biopharmaceutical and pharmaceutical development and manufacturing.
Salts
Explore a comprehensive range of salts offered under three portfolios for a variety of applications: Supelco® for analytical methods and applications, Sigma-Aldrich® for classic research and production, and SAFC® for biopharmaceutical and pharmaceutical applications. Order now.
McCoy's 5A Modified Media Formulation
McCoy's 5A Modified Media Formulation
HPLC Buffers
The selection of a buffer in terms of species, ionic strength and pH range is critical in reversed-phase chromatography. Learn more about high quality HPLC grade buffers and reagents for your lab chromatographic applications. Order now.
Solvents
Browse through our comprehensive range of solvents offered under three portfolio brands for your various applications: Supelco® products for analytical chemistry, SigmaAldrich® materials for lab and production, SAFC® products for biopharmaceutical and pharmaceutical development and manufacturing. Order online.
NCTC 109 Medium Formulation
NCTC 109 Medium Formulation
Protocol for Transducing Mouse Embryonic Fibroblasts (MEF) using MISSION® ExpressMag™ Super Magnetic Kit®
This detailed procedure allows you to transduce Mouse Embryonic Fibroblasts (MEF) using MISSION ExpressMag Super Magnetic Kit.
Selection Process Development in a GS Knock-Out CHO Host Cell Line: The Effects of MSX Addition on Clones Generated in an MSX-Free Process
The Glutamine Synthetase (GS) expression system does not typically require multiple rounds of amplification to isolate high-producing clones (Brown, 1992).
StableCell™ Trypsin Solutions
StableCell™ Trypsin solutions are designed to perform cell detachment as standard trypsin solutions do, without the need to aliquot, freeze, and thaw. This saves significant time before passaging.
MilliporeSigma Accelerates Scale Up of Lipids to Meet Covid-19 Demand
To meet the high demand for lipids, a key component of mRNA-based vaccines and therapeutics, MilliporeSigma has launched a new, high-purity synthetic cholesterol product, nine months ahead of schedule.
Glassware
We offer a complete selection of Aldrich® chemistry glassware including a full range of standard beakers, flasks, tubing, reaction vessels, and chromatography columns as well as custom glassblowing services.
Waymouth MB 752/1 Medium Formulation
Waymouth MB 752/1 Medium Formulation
Sigma-Aldrich® Brand
Sigma-Aldrich®  Lab & Production materials that help you Unleash the Impossible. Explore our range of lab, diagnostic and bulk products, hear stories from inspiring scientists like you, and more.
Milli-Q® Lab Water Solutions
Milli-Q®  Lab Water Solutions that empower you to focus on what matters. Explore our products, services and expertise, and learn about our sustainability goals and more. 
L-15 Media Formulation
L-15 Media Formulation
Cell Culture Media Stability and Testing Services
Our cell culture media stability and testing services can provide an assigned expiration date for custom products, or test for nutritional component data to optimize your bioprocess.
Biodegradable Nanoparticles
Preparation for biodegradable nanoparticles and their use in transfection protocols .

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MilliporeSigma

Research. Development. Production.

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