Showing 1-30 of 12182 results for "skeletal muscle cells"
Ingrid M Egner et al.
Development (Cambridge, England), 143(16), 2898-2906 (2016-08-18)
The largest mammalian cells are the muscle fibers, and they have multiple nuclei to support their large cytoplasmic volumes. During hypertrophic growth, new myonuclei are recruited from satellite stem cells into the fiber syncytia, but it was recently suggested that...
Lorenzo Giordani et al.
Molecular cell, 74(3), 609-621 (2019-03-30)
Adult tissue repair and regeneration require stem-progenitor cells that can self-renew and generate differentiated progeny. Skeletal muscle regenerative capacity relies on muscle satellite cells (MuSCs) and their interplay with different cell types within the niche. However, our understanding of skeletal...
SiewHui Low et al.
Stem cells (Dayton, Ohio), 36(3), 458-466 (2017-12-13)
Notch signaling is essential to maintain skeletal muscle stem cells in quiescence. However, the precise roles of different Notch receptors are incompletely defined. Here, we demonstrate a role for Notch3 (N3) in the self-renewal of muscle stem cells. We found...
Yoshihiro Nakamura et al.
FEBS letters, 589(11), 1257-1265 (2015-04-12)
Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and...
Fengyuan Chen et al.
The EMBO journal, 38(10) (2019-04-14)
Skeletal muscle satellite cells (SCs) are adult muscle stem cells responsible for muscle regeneration after acute or chronic injuries. The lineage progression of quiescent SC toward activation, proliferation, and differentiation during the regeneration is orchestrated by cascades of transcription factors...
Pengpeng Zhang et al.
Biochemical and biophysical research communications, 463(1-2), 102-108 (2015-05-23)
The serine/threonine kinase mammalian target of rapamycin (mTOR) is a key regulator of protein synthesis, cell proliferation and energy metabolism. As constitutive deletion of Mtor gene results in embryonic lethality, the function of mTOR in muscle stem cells (satellite cells)...
María Laura Messi et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 71(10), 1273-1280 (2015-10-09)
Studies in humans and animal models provide compelling evidence for age-related skeletal muscle denervation, which may contribute to muscle fiber atrophy and loss. Skeletal muscle denervation seems relentless; however, long-term, high-intensity physical activity appears to promote muscle reinnervation. Whether 5-month...
Kristen M Stearns-Reider et al.
Aging cell, 16(3), 518-528 (2017-04-04)
Age-related declines in skeletal muscle regeneration have been attributed to muscle stem cell (MuSC) dysfunction. Aged MuSCs display a fibrogenic conversion, leading to fibrosis and impaired recovery after injury. Although studies have demonstrated the influence of in vitro substrate characteristics on...
Ailian Du et al.
Journal of neuroimmunology, 290, 109-114 (2015-12-30)
After binding by acetylcholine released from a motor neuron, a nicotinic acetylcholine receptor at the neuromuscular junction produces a localized end-plate potential, which leads to muscle contraction. Improper turnover and renewal of acetylcholine receptors contributes to the pathogenesis of myasthenia...
Xiaoling Chen et al.
Journal of agricultural and food chemistry, 66(18), 4734-4740 (2018-04-25)
This study aimed to investigate the effect of arginine on the expression of slow myosin heavy chain (MyHC) I and its underlying mechanism in porcine skeletal muscle satellite cells. Our results showed that arginine upregulated the mRNA (1.54 ± 0.08;...
Ke Ding et al.
Cell biology international, 37(9), 977-987 (2013-04-27)
A cell carrier plays an important role in the maintenance, growth and engraftment of specific cells aimed for defined therapeutic uses in many tissue engineering strategies. A suitable microenvironment for the cells allows for the maximum efficacy of the hybrid...
Guangyan Xiong et al.
eLife, 6 (2017-03-24)
Regeneration of skeletal muscle in adults is mediated by satellite stem cells. Accumulation of misfolded proteins triggers endoplasmic reticulum stress that leads to unfolded protein response (UPR). The UPR is relayed to the cell through the activation of PERK, IRE1/XBP1...
Yang Dai et al.
Molecular and cellular biochemistry, 414(1-2), 37-46 (2016-02-03)
MicroRNAs (miRNAs) play essential roles in muscle cell proliferation and differentiation. The muscle-specific miRNAs miR-1 and miR-206 have been shown to regulate muscle development and promote myogenic differentiation; however, it is likely that a number of other miRNAs play important...
Xiaojuan Quan et al.
Biochemical and biophysical research communications, 463(4), 1102-1107 (2015-06-17)
The prevalence of type 2 diabetes mellitus (T2D) is increasing worldwide. Melatonin possesses various beneficial metabolic actions, decreased levels of which may accelerate T2D. Endoplasmic reticulum stress (ERS) has been linked to insulin resistance in multiple tissues, but the role...
Erik van der Wal et al.
Stem cell reports, 10(6), 1975-1990 (2018-05-08)
Although skeletal muscle cells can be generated from human induced pluripotent stem cells (iPSCs), transgene-free protocols include only limited options for their purification and expansion. In this study, we found that fluorescence-activated cell sorting-purified myogenic progenitors generated from healthy controls...
Ragadeepthi Tunduguru et al.
Biochemical pharmacology, 92(2), 380-388 (2014-09-10)
Skeletal muscle accounts for ∼ 80% of postprandial glucose clearance, and skeletal muscle glucose clearance is crucial for maintaining insulin sensitivity and euglycemia. Insulin-stimulated glucose clearance/uptake entails recruitment of glucose transporter 4 (GLUT4) to the plasma membrane (PM) in a...
Maria A Boldyreva et al.
International journal of molecular sciences, 20(12) (2019-06-27)
Cell therapy remains a promising approach for the treatment of cardiovascular diseases. In this regard, the contemporary trend is the development of methods to overcome low cell viability and enhance their regenerative potential. In the present study, we evaluated the...
Rasmus J O Sjögren et al.
Physiological genomics, 47(3), 45-57 (2014-12-31)
microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through posttranscriptional repression of target genes. miRNAs exert a fundamental level of control over many developmental processes, but their role in the differentiation and development of skeletal muscle from myogenic...
Maximilian Strenzke et al.
International journal of molecular sciences, 21(6) (2020-03-19)
Integrity of the musculoskeletal system is essential for the transfer of muscular contraction force to the associated bones. Tendons and skeletal muscles intertwine, but on a cellular level, the myotendinous junctions (MTJs) display a sharp transition zone with a highly...
Anita Helinska et al.
European journal of cell biology, 96(1), 47-60 (2016-12-27)
Regeneration of skeletal muscle relies on the presence of satellite cells. Satellite cells deficiency accompanying some degenerative diseases is the reason for the search for the "replacement cells" that can be used in the muscle therapies. Due to their unique...
Yang Dai et al.
In vitro cellular & developmental biology. Animal, 52(1), 27-34 (2015-10-02)
MicroRNAs (miRNAs) have been found to play essential roles in muscle cell proliferation and differentiation. MicroRNA-1 (miR-1) and microRNA-206 (miR-206), which are similar and have the same seed sequence, have specific roles in modulating skeletal muscle proliferation and differentiation in...
Paul Knopp et al.
Journal of cell science, 129(20), 3816-3831 (2016-10-17)
Skeletal muscle wasting in facioscapulohumeral muscular dystrophy (FSHD) results in substantial morbidity. On a disease-permissive chromosome 4qA haplotype, genomic and/or epigenetic changes at the D4Z4 macrosatellite repeat allows transcription of the DUX4 retrogene. Analysing transgenic mice carrying a human D4Z4...
Wei Wei Zhang et al.
Biochemical and biophysical research communications, 463(4), 624-631 (2015-06-07)
MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly...
Pengpeng Bi et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(15), 3864-3869 (2018-03-28)
Regeneration of skeletal muscle in response to injury occurs through fusion of a population of stem cells, known as satellite cells, with injured myofibers. Myomixer, a muscle-specific membrane micropeptide, cooperates with the transmembrane protein Myomaker to regulate embryonic myoblast fusion...
Stas Wüst et al.
Cell metabolism, 27(5), 1026-1039 (2018-04-03)
Muscle stem cells undergo a dramatic metabolic switch to oxidative phosphorylation during differentiation, which is achieved by massively increased mitochondrial activity. Since expression of the muscle-specific miR-1/133a gene cluster correlates with increased mitochondrial activity during muscle stem cell (MuSC) differentiation...
William N Addison et al.
Molecular and cellular biology, 39(8) (2019-01-30)
Satellite cells (SCs) are skeletal muscle stem cells that proliferate in response to injury and provide myogenic precursors for growth and repair. Zfp423 is a transcriptional cofactor expressed in multiple immature cell populations, such as neuronal precursors, mesenchymal stem cells...
Wen-Chung Tsai et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(11), 2506-2512 (2017-02-25)
Platelet rich plasma (PRP) contains various cytokines and growth factors which may be beneficial to the healing process of injured muscle. The aim of this study was to investigate the effect and molecular mechanism of PRP on migration of skeletal...
Nicole Y Shen et al.
Bioscience reports, 38(1) (2017-12-07)
Despite the emerging importance of protein arginine methyltransferases (PRMTs) in regulating skeletal muscle plasticity, PRMT biology during muscle development is complex and not completely understood. Therefore, our purpose was to investigate PRMT1, -4, and -5 expression and function in skeletal...
Qian Guo et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 125, 95-105 (2019-01-03)
Glucosamine (GlcN) is a dietary supplement that is widely used to promote joint health. Reports have demonstrated that oral GlcN adversely affects glucose metabolism. Here, we found that oral administration of GlcN induced insulin resistance (IR) and increased plasma glucose...
Paola D'Andrea et al.
Biochimica et biophysica acta. Molecular cell research, 1866(3), 504-517 (2018-10-22)
The biochemical properties of muscle extracellular matrix are essential for stem cell adhesion, motility, proliferation and myogenic development. Recombinant elastin-like polypeptides are synthetic polypeptides that, besides maintaining some properties of the native protein, can be tailored by fusing bioactive sequences...

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