sml0322

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Showing 1-8 of 8 results for "sml0322" within Papers

Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B-PKA-Caspase8/9 Pathway.

Jing-Li Tao et al.

Antioxidants (Basel, Switzerland), 10(2) (2021-02-03)

In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum antioxidant that exists

Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination.

Mahesh Kathania et al.

Nature immunology, 17(8), 997-1004 (2016-06-21)

Dysregulated expression of interleukin 17 (IL-17) in the colonic mucosa is associated with colonic inflammation and cancer. However, the cell-intrinsic molecular mechanisms by which IL-17 expression is regulated remain unclear. We found that deficiency in the ubiquitin ligase Itch led

The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through ROR$\alpha$ and SRC-2 coactivator transcriptional activity

Madsen A, et al.

Molecular and Cellular Endocrinology, 419(8) (2016)

The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity.

Andre Madsen et al.

Molecular and cellular endocrinology, 419, 92-101 (2015-10-13)

Fasting hormones activate the cAMP/PKA signaling pathway and stimulate expression of hepatic gluconeogenic enzymes including glucose-6-phosphatase (G6Pase). Previously it was shown that steroid receptor coactivator 2 (SRC-2) knock-out mice exhibit fasting hypoglycemia and that SRC-2 coactivates RAR-related orphan receptor alpha

Nuclear receptor retinoid-related orphan receptor alpha promotes apoptosis but is reduced in human gastric cancer.

Zhengguang Wang et al.

Oncotarget, 8(7), 11105-11113 (2017-01-05)

Retinoid-related orphan receptor α (RORα) is a nuclear receptor, which regulates inflammation and immune responses, lipid metabolism and circadian rhythm. Although RORα suppresses breast tumor invasion, it is unknown whether RORα is dysregulated in gastric cancer leading to cellular survival.

RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis.

Ye Sun et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(10), 4492-4502 (2017-06-25)

Pathological proliferation of retinal blood vessels commonly causes vision impairment in proliferative retinopathies, including retinopathy of prematurity. Dysregulated crosstalk between the vasculature and retinal neurons is increasingly recognized as a major factor contributing to the pathogenesis of vascular diseases. Class

JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.

Patricia R Taylor et al.

Journal of leukocyte biology, 100(1), 213-222 (2016-04-02)

IL-6 and IL-23 (IL-6/23) induce IL-17A (IL-17) production by a subpopulation of murine and human neutrophils, resulting in autocrine IL-17 activation, enhanced production of reactive oxygen species, and increased fungal killing. As IL-6 and IL-23 receptors trigger JAK1, -3/STAT3 and

Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-gammat ubiquitination

Kathania M, et al.

Nature Immunology, 17(8), 997-997 (2016)

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