Showing 1-30 of 116 results for "

SML0534

"
Heena Saini et al.
Cancer cell international, 21(1), 52-52 (2021-01-16)
Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients...
Julie Giraud et al.
International journal of cancer, 146(8), 2255-2267 (2019-09-07)
Gastric carcinomas (GC) are heterogeneous tumors, composed of a subpopulation of cluster of differentiation-44 (CD44)+ tumorigenic and chemoresistant cancer stem cells (CSC). YAP1 and TAZ oncoproteins (Y/T) interact with TEA domain family member 1 (TEAD) transcription factors to promote cell...
Giovanni Sorrentino et al.
Gastroenterology, 159(3), 956-968 (2020-06-03)
Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nutrient availability by activating the...
Focke Ziemssen et al.
Expert opinion on drug metabolism & toxicology, 8(8), 1023-1041 (2012-07-06)
The benzoporphyrine derivative verteporfin has lost its importance to the treatment of the most frequent neovascular eye diseases. Nevertheless, it is still mandatory to define the remaining applications, role, and potential of verteporfin in ocular photodynamic therapy (PDT), including the...
Chee Wai Wong et al.
Retina (Philadelphia, Pa.), 35(8), 1577-1593 (2015-02-27)
To evaluate the 3-year outcome in eyes with polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy with verteporfin. Retrospective study and review of the literature. We performed a retrospective study of patients with PCV who were treated with photodynamic therapy...
Ichiro Maruko
Nippon Ganka Gakkai zasshi, 116(11), 1062-1079 (2013-01-16)
Studies using indocyanine green angiography (ICGA) revealed that the main cause of central serous chorioretionopathy (CSC) stems from choroidal abnormalities such as choroidal vascular hyperpermeability. However, there are no methods to evaluate the choroid except for either the invasive ICGA...
Bruce I Gaynes et al.
Expert opinion on drug safety, 3(4), 345-361 (2004-07-23)
Photodynamic therapy (PDT) is a novel treatment entity that exploits the photophysical properties of various photosensitive chemical entities which, upon light activation, results in targeted photooxidation and subsequent tissue destruction. The antiangiogenic properties of PDT have been adapted for treatment...
Anders Pryds et al.
Retina (Philadelphia, Pa.), 33(1), 128-135 (2012-12-28)
To assess the prognostic effect of subretinal deposits in eyes with central serous chorioretinopathy (CSC). The study included 21 eyes with foveal detachment and subretinal deposits at presentation that underwent photodynamic therapy (PDT). No symptoms or signs of CSC were...
Kyoko Fujita et al.
Ophthalmology, 122(3), 555-561 (2014-12-03)
To assess the 1-year outcome of half-dose verteporfin photodynamic therapy (PDT) for patients with chronic central serous chorioretinopathy (CSC). Retrospective, interventional case series with no controls. A total of 204 eyes of 204 patients with chronic CSC were studied. Fluorescein...
D Vysloužilová et al.
Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 68(3), 98-101 (2012-12-12)
Photodynamic therapy with Verteporfin (Visudyne - Novartis AG, Basel, Switzerland) is a method designed for treatment of the wet form of age-related macular degeneration. Effectiveness of photodynamic therapy with Verteporfin we approved on our department in group of 301 patients...
Sam Razavi et al.
American journal of ophthalmology, 157(4), 852-860 (2014-01-15)
To investigate the relationship between choroidal thickness and angiographic abnormalities in central serous chorioretinopathy (CSC) eyes by swept-source optical coherence tomography (swept-OCT), before and after half-fluence photodynamic therapy (PDT). Prospective interventional case series. Consecutive patients presenting with treatment-naive active CSC...
Lisa Bierbaumer et al.
Oncogenesis, 10(1), 2-2 (2021-01-10)
Ewing sarcoma (EwS) is a highly metastatic bone cancer characterized by the ETS fusion oncoprotein EWS-FLI1. EwS cells are phenotypically highly plastic and switch between functionally distinct cell states dependent on EWS-FLI1 fluctuations. Whereas EWS-FLI1high cells proliferate, EWS-FLI1low cells are...
S Michels et al.
Seminars in ophthalmology, 16(4), 201-206 (2004-10-30)
Photodynamic therapy (PDT) with verteporfin is a new treatment modality in ophthalmology that has previously shown its effectiveness in treatment of a variety of neoplastic pathologies. In this therapeutic approach, the photosensitizer verteporfin is activated by non-thermal laser light to...
Susan J Keam et al.
Drugs & aging, 21(3), 203-209 (2004-02-26)
Verteporfin (Visudyne) therapy (photodynamic therapy with intravenous liposomal verteporfin) is the first treatment to effectively prevent the loss of visual acuity in patients with subfoveal choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD), pathological myopia or presumed ocular histoplasmosis...
Jiro Arita et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 124(6), 435-444 (2004-12-02)
Age-related macular degeneration (AMD) is the leading cause of blindness among people aged over 50 years in the western world. Verteporfin (Visudyne) is the first light-activated drug indicated for the treatment of patients with AMD caused by subfoveal choroidal neovascularization...
Ilse Krebs et al.
Acta ophthalmologica, 91(3), e178-e183 (2012-12-18)
Modern therapy of neovascular age-related macular degeneration consists in intravitreal injections of inhibitors of the vascular endothelial growth factor. An increasing number of these injections is required not only in monthly but also in as-needed treatment regimen. In this study...
Massimo Nicoló et al.
American journal of ophthalmology, 157(5), 1033-1037 (2014-02-04)
To compare the efficacy and safety of half-fluence vs half-dose photodynamic therapy (PDT) in chronic central serous chorioretinopathy (CSC). Multicenter retrospective comparison study. Retrospective review of 56 patients affected by chronic CSC, including 28 patients (31 eyes) who received half-fluence...
Ahmet Selım et al.
Turkish journal of medical sciences, 44(5), 889-895 (2014-12-30)
To compare the effectiveness of photodynamic therapy (PDT) and PDT combined with intravitreal triamcinolone (IVTA) and vascular endothelial growth factor inhibition (anti-VEGF) in age-related macular degeneration (AMD). Eighty eyes of 80 patients diagnosed with choroidal neovascularization (CNV) caused by AMD...
Salwa A Abdelkawi et al.
General physiology and biophysics, 31(4), 449-455 (2012-12-21)
The aim of the present study was to evaluate the change in corneal protein and oxidative stress state after using photodynamic therapy (PDT) for treatment of experimental corneal neovascularization (NV) with benzoporphyrin derivative (BPD). One group was considered as control...
M Sickenberg
Seminars in ophthalmology, 16(4), 207-212 (2004-10-30)
People with choroidal neovascularization (CNV) due to age-related macular degeneration (AMD) are at high risk of central vision loss. Until verteporfin therapy became available, there was no safe and effective treatment for a large majority of these people. The phase...
Margarete K Akens et al.
Photodiagnosis and photodynamic therapy, 11(3), 426-433 (2014-09-02)
Photodynamic therapy (PDT), a non-ionizing, minimally invasive drug-light treatment, has recently been shown to successfully ablate tumor within rat vertebrae with concurrent improvements in bone strength and architecture. The bisphosphonate zoledronic acid (zol), a current drug for patients with skeletal...
Andrea Sodi et al.
Ophthalmic genetics, 36(2), 168-174 (2015-02-13)
To report long-term results of photodynamic therapy (PDT) in young patients affected by Best vitelliform macular dystrophy (VMD) complicated by choroidal neovascularization (CNV). We evaluated a group of 30 VMD patients with confirmed mutations in the BEST1 gene. Five of...
Neil M Bressler et al.
Ophthalmology, 120(1), 160-168 (2012-09-27)
To determine the impact of ranibizumab on driving status, driving ability perception, and having 20/40 vision or better in patients with choroidal neovascularization resulting from age-related macular degeneration (AMD). Phase III, multicenter, randomized clinical trials (Minimally Classic/Occult Trial of the...
Fengjiao Chang et al.
International journal of molecular sciences, 21(10) (2020-05-20)
Actomyosin-mediated contractility is required for the majority of force-driven cellular events such as cell division, adhesion, and migration. Under pathological conditions, the role of actomyosin contractility in malignant phenotypes of various solid tumors has been extensively discussed, but the pathophysiological...
Jan W Buikema et al.
Cell stem cell, 27(1), 50-63 (2020-07-04)
Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (<5-fold). Here, we demonstrate massive expansion of hiPSC-CMs in vitro (i.e., 100-...
Yong-Kyu Kim et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(12), 2063-2073 (2015-01-27)
To compare visual and anatomical outcomes of half-fluence (HF) and half-dose (HD) photodynamic therapy (PDT) in chronic central serous chorioretinopathy (CSC). Particular focus was given to photoreceptor recovery rate following treatment. Retrospective review of 52 chronic CSC patients who underwent...
Xuefan Gu et al.
Journal of nanobiotechnology, 18(1), 87-87 (2020-06-12)
In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen...
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Akio Oishi et al.
American journal of ophthalmology, 156(4), 644-651 (2013-07-24)
To compare the effect of photodynamic therapy (PDT) and intravitreal ranibizumab in patients with polypoidal choroidal vasculopathy (PCV). Randomized clinical trial. Multicenter. Total of 93 patients with treatment-naïve PCV. Patients were randomized to 2 arms. Patients in the PDT arm...
Kamalesh J Ramaiya et al.
Ophthalmic surgery, lasers & imaging retina, 44(1), 17-21 (2013-02-16)
To evaluate the efficacy of ranibizumab in the treatment of choroidal neovascularization secondary to presumed ocular histoplasmosis syndrome. Patients enrolled in the ranibizumab group received a monthly intravitreal injection of 0.5 mg of ranibizumab. Patients in the photodynamic therapy (PDT)...