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Showing 1-8 of 8 results for "SRP0212" within Papers
Hanying Ding et al.
Diabetologia, 57(10), 2145-2154 (2014-07-06)
Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signalling. PTP1B deficiency improves obesity-induced insulin resistance and consequently improves type 2 diabetes in mice. Here, the small molecule norathyriol reversed obesity- and high-fat-diet-induced insulin resistance by inhibiting PTP1B. The inhibitory mode
Sisir Kumar Barik et al.
Biochemical pharmacology, 178, 114109-114109 (2020-06-23)
Protein-tyrosine phosphatase 1B (PTP1B, EC 3.1.3.48) is an important regulator of insulin signalling. Herein, we employed experimental and computational biology techniques to investigate the inhibitory properties of phenolics, identified from four in vitro gastrointestinal digested (IVGD) soft fruits, on PTP1B.
PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.
Hughes SK
Molecular Biology of the Cell, 26, 3867-3878 (2015)
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Liu H
Cancer Letters, 359, 218-225 (2015)
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.
Chen PJ
Toxicology, 337, 10-20 (2015)
Mohammad Nasir Uddin et al.
Phytochemistry, 103, 99-106 (2014-05-13)
Protein tyrosine phosphatase 1B (PTP1B) plays a key role in metabolic signaling, thereby making it an exciting drug target for type 2 diabetes and obesity. Besides, there is substantial evidence that shows its overexpression is involved in breast cancer, which
Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients.
Wang N
Cell Cycle, 14, 732-743 (2015)
Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population.
Cheyssac C
BMC Medical Genetics (2006)
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