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Showing 1-18 of 18 results for "SRP3087" within Papers
Jennifer Lee et al.
Immunology, 142(4), 573-580 (2014-02-06)
Systemic lupus erythematosus (SLE) is an autoimmune disease in which abnormal immune responses are mediated by tissue-binding autoantibodies and immune complex deposition. Because most SLE patients are women of child-bearing age, oestrogen has been suggested to play an important role
Elisabeth Salzer et al.
The Journal of allergy and clinical immunology, 133(6), 1651-1659 (2014-04-22)
Alterations of immune homeostasis in the gut can result in development of inflammatory bowel disease (IBD). Recently, Mendelian forms of IBD have been discovered, as exemplified by deficiency of IL-10 or its receptor subunits. In addition, other types of primary
Hamza Loucif et al.
Autophagy, 18(6), 1256-1273 (2021-10-07)
The maintenance of a strong IL21 production in memory CD4 T cells, especially in HIV-1-specific cells, represents a major correlate of natural immune protection against the virus. However, the molecular mechanisms underlying IL21 production during HIV-1 infection, which is only
Hamza Loucif et al.
Autophagy, 17(11), 3408-3423 (2021-01-19)
Although macroautophagy/autophagy has been proposed as a critical defense mechanism against HIV-1 by targeting viral components for degradation, its contribution as a catabolic process in providing optimal anti-HIV-1 immunity has never been addressed. The failure to restore proper antiviral CD8A/CD8
Nayoun Kim et al.
Stem cells and development, 24(23), 2808-2821 (2015-09-29)
Interleukin (IL)-21, a proinflammatory cytokine, has been developed as an immunotherapeutic approach due to its effects on various lymphocytes, including natural killer (NK) cells and T cells; however, the clinical success in cancer patients has been limited. Recently, mesenchymal stem
Biological effects of IL-21 on different immune cells and its role in autoimmune diseases.
Gharibi T, et al.
Immunobiology, 221(2), 357-367 (2016)
Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins.
Wu C, et al.
Oncotarget, 6(30), 28633-28645 (2015)
Melinda Mata et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 37(8), 407-415 (2014-09-10)
Adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has shown promising antitumor activity in early phase clinical studies, especially for hematological malignancies. However, most preclinical models do not reliably mimic human disease. We reasoned that developing an adoptive
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Xing R, et al.
Clinical and Experimental Immunology, 184(2), 147-158 (2016)
Yoshiko Matsuda et al.
Cellular immunology, 295(2), 127-136 (2015-04-17)
Long-lived plasma cells (PCs) contribute to humoral immunity through an undefined mechanism. Memory B cells, but not human naïve B cells, can be induced to differentiate into long-lived PCs in vitro. Because evidence links a proliferation-inducing ligand (APRIL), a tumor
Adria Carbo et al.
mBio, 5(4), e01243-e01214 (2014-07-24)
The development of gastritis during Helicobacter pylori infection is dependent on an activated adaptive immune response orchestrated by T helper (Th) cells. However, the relative contributions of the Th1 and Th17 subsets to gastritis and control of infection are still
Adèle de Masson et al.
Blood, 125(11), 1830-1839 (2015-01-22)
Interleukin 10 (IL-10)-producing B cells (regulatory B cells [Bregs]) regulate autoimmunity in mice and humans, and a regulatory role of IL-10-producing plasma cells has been described in mice. Dysfunction of B cells that maintain homeostasis may play a role in
Janani Krishnamurthy et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(14), 3241-3251 (2015-04-02)
The human endogenous retrovirus (HERV-K) envelope (env) protein is a tumor-associated antigen (TAA) expressed on melanoma but not normal cells. This study was designed to engineer a chimeric antigen receptor (CAR) on T-cell surface, such that they target tumors in
Emily K Moser et al.
PloS one, 10(4), e0120169-e0120169 (2015-04-08)
Influenza A virus (IAV) infection of the respiratory tract elicits a robust immune response, which is required for efficient virus clearance but at the same time can contribute to lung damage and enhanced morbidity. IL-21 is a member of the
Julia Parrish-Novak et al.
Journal of leukocyte biology, 72(5), 856-863 (2002-11-14)
Interleukin (IL)-21 was recently discovered using a functional cloning approach based on expression of its receptor. It is similar in domain organization and primary sequence to IL-2 and IL-15. Like these cytokines, IL-21 uses the common gamma chain of the
Jin Zhang et al.
Immunologic research, 62(2), 163-174 (2015-04-22)
The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases. However, less is known about their role in Graves' disease (GD). This study aimed to investigate the expression of Tfhs
A T Cao et al.
Mucosal immunology, 8(5), 1072-1082 (2015-01-15)
Commensal microbiota-specific T helper type 17 (Th17) cells are enriched in the intestines, which can convert into T follicular helper (Tfh) in Peyer's patches, and are crucial for production of intestinal immunoglobulin A (IgA) against microbiota; however, the role of
Iskra Tuero et al.
PLoS pathogens, 11(8), e1005101-e1005101 (2015-08-13)
Many viral infections, including HIV, exhibit sex-based pathogenic differences. However, few studies have examined vaccine-related sex differences. We compared immunogenicity and protective efficacy of monomeric SIV gp120 with oligomeric SIV gp140 in a pre-clinical rhesus macaque study and explored a
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