Showing 1-30 of 151 results for "SRP3182"
Petros Andrikopoulos et al.
Cellular signalling, 37, 12-30 (2017-05-26)
It has been previously demonstrated that the bi-directional transporter Na
Philippe Foubert et al.
Cell transplantation, 24(7), 1343-1361 (2013-09-28)
Endothelial progenitor cell (EPC) transplantation has beneficial effects for therapeutic neovascularization. We therefore assessed the effect of a therapeutic strategy based on EPC administration in the healing of radiation-induced damage. To improve cell therapy for clinical use, we used pretreatment...
Akiyo Ito et al.
American journal of physiology. Heart and circulatory physiology, 316(4), H900-H910 (2019-02-02)
Although increased levels of reactive oxygen species (ROS) are involved in the pathogenesis of cardiovascular diseases, the importance of physiological ROS has also been emerging. We have previously demonstrated that endothelium-derived H2O2 is an endothelium-dependent hyperpolarization (EDH) factor and that...
Thorsten R Doeppner et al.
Molecular neurobiology, 54(2), 1531-1540 (2016-02-11)
Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral...
Birgit Regenfuß et al.
Lymphatic research and biology, 13(2), 76-84 (2015-06-20)
In the murine cornea, which is an established model for analyzing pathologic lymphatic vessel growth, phenotypic heterogeneity of the endogenous lymphatic vessels in the limbus of the cornea was previously described. In this study, the cornea of BALB/c, C57BL/6, and...
Sadaf Ashraf et al.
JCI insight, 4(6) (2019-02-06)
While anti-VEGF drugs are commonly used to inhibit pathological retinal and choroidal neovascularization, not all patients respond in an optimal manner. Mechanisms underpinning resistance to anti‑VEGF therapy include the upregulation of other proangiogenic factors. Therefore, therapeutic strategies that simultaneously target...
X Jiang et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(7), 1768-1781 (2015-03-03)
The loss of a functional microvascular bed in rejecting solid organ transplants is correlated with fibrotic remodeling and chronic rejection; in lung allografts, this pathology is predicted by bronchoalveolar fluid neutrophilia which suggests a role for polymorphonuclear cells in microcirculatory...
Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle.
Kim, et al.
Cell Metabolism, 32, 629-642 (2020)
Wenjie Zhang et al.
PloS one, 9(7), e102371-e102371 (2014-07-23)
Stem cell-based tissue engineering shows promise for bone regeneration and requires artificial microenvironments to enhance the survival, proliferation and differentiation of the seeded cells. Silk fibroin, as a natural protein polymer, has unique properties for tissue regeneration. The present study...
A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.
Awata T
Diabetes, 51, 1635-1639 (2002)
Abhirup Das et al.
Cell, 173(1), 74-89 (2018-03-24)
A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by activating...
S J Park et al.
Eye (London, England), 29(4), 561-568 (2015-01-17)
To determine intraocular pharmacokinetic properties of intravitreally injected vascular endothelial growth factor (VEGF)-Trap in a rabbit model. VEGF-Trap was intravitreally injected in 18 rabbit eyes. Eyes were enucleated 1 h and 1, 2, 5, 14, and 30 days after injections and...
Da-Hye Lee et al.
Molecules and cells, 41(8), 771-780 (2018-07-25)
Angiogenesis must be precisely controlled because uncontrolled angiogenesis is involved in aggravation of disease symptoms. Vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR-2) signaling is a key pathway leading to angiogenic responses in vascular endothelial cells (ECs). Therefore, targeting VEGF/VEGFR-2...
Ai-Hua Liu et al.
Experimental and therapeutic medicine, 10(3), 1019-1024 (2015-12-02)
The aim of the present study was to investigate the role of vascular endothelial growth factor (VEGF) in cell proliferation under hypoxic conditions. Gene knockdown of VEGF was conducted in the choroid-retinal endothelial RF/6A cell line by transfection with short...
Takehiko Matsuo et al.
Scientific reports, 5, 16842-16842 (2015-11-21)
Poor engraftment of cells after transplantation to the heart is a common and unresolved problem in the cardiac cell therapies. We previously generated cardiovascular cell sheets entirely from pluripotent stem cells with cardiomyocytes, endothelial cells and vascular mural cells. Though...
Wei Yang et al.
Toxicology and applied pharmacology, 327, 1-12 (2017-04-26)
It is well known that liver cancer is a highly aggressive malignancy with poor prognosis. Andrographolide (AD), a major bioactive component of Andrographis paniculata (Burm. F.), is a potential anti-cancer pharmacophore and the synthesis of AD derivatives with better cytotoxicity...
M Kere et al.
Domestic animal endocrinology, 49, 60-69 (2014-07-26)
Vascular endothelial growth factor is a multipotent angiogenic factor implicated in cell survival and proliferation. The objective was to determine effects of exogenous recombinant human VEGFA (or VEGFA165) in culture media on porcine oocyte maturation and parthenote development. Adding 5 ng/mL...
Annapoorna Mohandas et al.
Colloids and surfaces. B, Biointerfaces, 127, 105-113 (2015-02-11)
Reduced levels of endogenous growth factors and diminished angiogenesis are contributory factors for impaired wound healing in diabetic patients. Vascular endothelial growth factor (VEGF) is the most potent angiogenic growth factor which stimulates multiple phases of wound healing angiogenesis and...
Hisanobu Ota et al.
PloS one, 10(4), e0123733-e0123733 (2015-04-16)
Relationship between microalbuminuria and worse outcome of coronary artery disease patients is discussed, but its underlying pathophysiological mechanism remains unclear. We investigated the role of microalbuminuria to the function of endothelial progenitor cells (EPCs), that might affect to outcome of...
Yujeong Gho et al.
Animal cells and systems, 23(2), 72-81 (2019-04-06)
We previously reported that hydrangenol has potent antitumor activity against human bladder cancer EJ cells. Here, we investigated the antiangiogenic activity of hydrangenol using in vitro and ex vivo models. Treatment with hydrangenol significantly inhibited the proliferation of vascular endothelial...
Shota Yamana et al.
PloS one, 10(4), e0124259-e0124259 (2015-04-22)
Contact inhibition of cell movement and proliferation is critical for proper organogenesis and tissue remodeling. We show here a novel regulatory mechanism for this contact inhibition using cultured vascular endothelial cells. When the cells were confluently cultured, Necl-4 was up-regulated...
Alfred C Aplin et al.
Angiogenesis, 22(3), 421-431 (2019-04-11)
Progression of atherosclerotic plaques into life-threatening lesions is associated with angiogenesis which contributes to intraplaque hemorrhages and plaque instability. The lack of adequate models for the study of human plaque-induced angiogenesis has limited progress in this field. We describe here...
Kai Hu et al.
Matrix biology : journal of the International Society for Matrix Biology, 62, 105-114 (2016-12-25)
Our previous studies of Antxr1 knockout mice suggested that fibrotic skin abnormalities in these mice are associated with increased VEGF signaling. Here, based on studies of primary fibroblasts isolated from skin of Antx1+/+ and Antxr1-/- mice at embryonic stage E17.5...
Zhao-Qiu Wu et al.
Nature communications, 5, 3998-3998 (2014-06-05)
Notch1-Delta-like 4 (Dll4) signalling controls vascular development by regulating endothelial cell (EC) targets that modulate vessel wall remodelling and arterial-venous specification. The molecular effectors that modulate Notch signalling during vascular development remain largely undefined. Here we demonstrate that the transcriptional...
Feng Wang et al.
Materials science & engineering. C, Materials for biological applications, 52, 155-162 (2015-05-09)
Inspired from the sophisticated bilayer structures of natural dermis, here, we reported collagen/chitosan based two-compartment and bi-functional dermal scaffolds. Two functions refer to mediating rapid angiogenesis based on recombinant human vascular endothelial growth factor (rhVEGF) and antibacterial from gentamicin, which...
Pedro Torres et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(11), 4946-4958 (2017-07-29)
Saliva is a key factor that contributes to the high efficiency of wound healing in the oral mucosa. This is not only attributed to physical cues but also to the presence of specific peptides in the saliva, such as histatins....
Udi Sarig et al.
Tissue engineering. Part A, 21(9-10), 1507-1519 (2015-01-21)
Functional vascularization is a prerequisite for cardiac tissue engineering of constructs with physiological thicknesses. We previously reported the successful preservation of main vascular conduits in isolated thick acellular porcine cardiac ventricular ECM (pcECM). We now unveil this scaffold's potential in...
Hongyi Yao et al.
Oncotarget, 6(19), 17501-17513 (2015-05-21)
A variety of vasoactive stimuli induce endothelial permeability through Rac1, a membrane of Rho small GTPases. Here, we determine whether tumor-secreted vasoactive stimulant through Rac1 inducing permeability contributes to hematogenous metastasis. Activation of Rac1 was assayed in human umbilical vein...
Hye Jin Jung et al.
Molecules and cells, 38(3), 273-278 (2015-01-06)
The induction of angiogenesis is a crucial step in tumor progression, and therefore, efficient inhibition of angiogenesis is considered a powerful strategy for the treatment of cancer. In the present study, we report that the lipophilic antimicrobial peptides from EML-CAP3...
Bioactivity of Circulatory Factors After Pulmonary Exposure to Mild or Stainless Steel Welding Fumes.
Kodali, et al.
Toxicological Sciences, 177, 108-120 (2020)

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