Showing 1-9 of 9 results for "SRP3251"
D M Anderson et al.
Cell, 63(1), 235-243 (1990-10-05)
We have previously reported the identification of a novel mast cell growth factor (MGF) that was shown to be a ligand for c-kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10. We...
T R Ulich et al.
Blood, 78(3), 645-650 (1991-08-01)
Recombinant rat stem cell factor (rrSCF) administered to rats as a single intravenous injection causes a dose-dependent neutrophilia and lymphocytosis as well as the appearance of immature myeloid cells and occasional blast cells in the circulation. Neutrophilia begins at 2...
Antonija Jurak Begonja et al.
Blood, 126(1), 80-88 (2015-04-04)
Bin-Amphiphysin-Rvs (BAR) and Fes-CIP4 homology BAR (F-BAR) proteins generate tubular membrane invaginations reminiscent of the megakaryocyte (MK) demarcation membrane system (DMS), which provides membranes necessary for future platelets. The F-BAR protein PACSIN2 is one of the most abundant BAR/F-BAR proteins...
Sally Hamour et al.
PloS one, 10(8), e0136238-e0136238 (2015-09-01)
IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney....
Thomas M Seed et al.
International journal of radiation biology, 90(7), 594-604 (2014-03-07)
Amifostine is a highly efficacious cytoprotectant when administered in vivo at high doses. However, at elevated doses, drug toxicity manifests for general, non-clinical radioprotective purposes. Various strategies have been developed to avoid toxic side-effects: The simplest is reducing the dose....
Audrey Pietrzyk-Nivau et al.
PloS one, 10(8), e0136652-e0136652 (2015-08-28)
Hematopoietic stem cells (HSC) differentiate into megakaryocytes (MK), whose function is to release platelets. Attempts to improve in vitro platelet production have been hampered by the low amplification of MK. Providing HSC with an optimal three-dimensional (3D) architecture may favor...
Sang-Goo Lee et al.
Asian-Australasian journal of animal sciences, 28(11), 1565-1572 (2015-11-19)
Porcine embryonic stem cells (pESCs) have become an advantageous experimental tool for developing therapeutic applications and producing transgenic animals. However, despite numerous reports of putative pESC lines, deriving validated pESC lines from embryos produced in vitro remains difficult. Here, we...
Yasuo Mori et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(31), 9638-9643 (2015-07-22)
Determining the developmental pathway leading to erythrocytes and being able to isolate their progenitors are crucial to understanding and treating disorders of red cell imbalance such as anemia, myelodysplastic syndrome, and polycythemia vera. Here we show that the human erythrocyte...
Ramesh C Nayak et al.
The Journal of clinical investigation, 125(8), 3103-3116 (2015-07-21)
Severe congenital neutropenia (SCN) is often associated with inherited heterozygous point mutations in ELANE, which encodes neutrophil elastase (NE). However, a lack of appropriate models to recapitulate SCN has substantially hampered the understanding of the genetic etiology and pathobiology of...

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