Showing 1-30 of 62 results for "T-021"
Sandeep Ankolekar et al.
Stroke, 44(11), 3120-3128 (2013-09-05)
The practicalities of doing ambulance-based trials where paramedics perform all aspects of a clinical trial involving patients with ultra-acute stroke have not been assessed. We performed a randomized controlled trial with screening, consent, randomization, and treatment performed by paramedics prior...
Tatsuya Maruhashi et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(6), 1401-1408 (2013-03-23)
Nitroglycerine-induced vasodilation has been used as a control test for flow-mediated vasodilation (FMD) to differentiate endothelium-dependent from endothelium-independent response when evaluating endothelial function in humans. Recently, nitroglycerine-induced vasodilation has also been reported to be impaired in patients with atherosclerosis. The...
Yoshiaki Kubota et al.
Journal of Korean medical science, 27(11), 1364-1370 (2012-11-21)
The vascular endothelial function is impaired in the very early stage of atherosclerosis in diabetic patients. The goal of this study was to identify the mechanism underlying the improvement in vascular endothelial function by sitagliptin in type 2 diabetes mellitus...
Agustín Conde-Agudelo et al.
American journal of obstetrics and gynecology, 209(6), 551-551 (2013-07-31)
The purpose of this study was to evaluate the efficacy and safety of transdermal nitroglycerin as a tocolytic agent in women with preterm labor. We conducted a systematic review and metaanalysis of randomized controlled trials. Thirteen studies were included (1302...
Blood pressure in acute stroke: which questions remain?
Peter M Rothwell
Lancet (London, England), 385(9968), 582-585 (2014-12-04)
Raul A Dulce et al.
The Journal of biological chemistry, 288(9), 6522-6533 (2013-01-16)
Although the combined use of hydralazine and isosorbide dinitrate confers important clinical benefits in patients with heart failure, the underlying mechanism of action is still controversial. We used two models of nitroso-redox imbalance, neuronal NO synthase-deficient (NOS1(-/-)) mice and spontaneously...
Stephen E Gilbert et al.
Experimental physiology, 98(9), 1401-1410 (2013-05-15)
What is the central question of this study? Androgen deprivation therapy (ADT) for prostate cancer has been linked with increased cardiovascular risk, but the mechanisms are unclear. Is there evidence that endothelial dysfunction, as evidenced by reduced flow-mediated dilatation (FMD)...
Lancet (London, England), 385(9968), 617-628 (2014-12-04)
High blood pressure is associated with poor outcome after stroke. Whether blood pressure should be lowered early after stroke, and whether to continue or temporarily withdraw existing antihypertensive drugs, is not known. We assessed outcomes after stroke in patients given...
Duangdee Rummasak et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(12), 2428-2433 (2014-10-14)
To evaluate the advantageous anesthetic properties, such as the decrease of intraoperative analgesic requirement, time to extubation and recovery, and early postoperative pain, of dexmedetomidine used as hypotensive agent compared with nitroglycerin in orthognathic surgery. The authors implemented a prospective...
Farooq Husain Maniyar et al.
Brain : a journal of neurology, 137(Pt 1), 232-241 (2013-11-28)
Our aim was identify brain areas involved in the premonitory phase of migraine using functional neuroimaging. To this end, we performed positron emission tomography scans with H2(15)O to measure cerebral blood flow as a marker of neuronal activity. We conducted...
Lyes Boudechiche et al.
Transplantation, 99(1), 36-40 (2014-10-24)
Hepatocyte transplantation could be an alternative to liver transplantation for the treatment of metabolic diseases. However, rodent models have shown that engraftment of transplanted cells in the liver is low and requires deposition of cells in hepatic sinusoids. Splanchnic vasodilatators...
Geneviève Bordeleau et al.
Chemosphere, 93(1), 14-19 (2013-05-22)
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and nitroglycerin (NG) are two energetic materials commonly found in the environment on military training ranges. They are deposited on the ground in the form of solid particles, which can then dissolve in infiltration water or in surface...
Chie Matsuda et al.
Masui. The Japanese journal of anesthesiology, 62(4), 390-394 (2013-05-24)
Rapid and transient uterine relaxation is sometimes required for fetal distress or difficult delivery due to uterine hyperactivity during cesarean section. For its rapid onset and short duration, intravenous nitroglycerin (NTG) is commonly used for this purpose. But its suitable...
Nuri I Akkus et al.
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 31(12), 825-828 (2012-11-21)
Nebivolol is a novel beta1-selective beta-blocker with vasodilator properties mediated through activation of the l-arginine-nitric oxide pathway. There is no published report of coronary artery spasm associated with nebivolol. We describe a 64-year-old female patient who developed unstable angina secondary...
Chuan-Yaw Chang et al.
American journal of obstetrics and gynecology, 208(2), e3-e6 (2012-12-04)
The antenatal diagnosis of aortic dissection carries a grave prognosis. Although cases of pregnant women with Marfan syndrome have been encountered that resulted either in sudden death or emergency surgery at diagnosis, cesarean section delivery for patients who survive is...
Muhammad Asim et al.
The New Zealand medical journal, 127(1393), 80-86 (2014-05-13)
Chronic anal fissure (CAF) is perpetuated by high sphincter pressures and secondary local ischemia. Pharmacological approaches include topical nitrates and botulinum toxin (BT), which both help to decrease the sphincter pressure. The aims of the present study were to assess...
Angela L Spence et al.
The Journal of physiology, 591(5), 1265-1275 (2012-12-19)
Abstract  This randomized trial evaluated the impact of different exercise training modalities on the function and size of conduit arteries in healthy volunteers. Young (27 ± 5 years) healthy male subjects were randomized to undertake 6 months of either endurance...
Vikram S Kashyap et al.
Journal of vascular surgery, 58(5), 1259-1266 (2013-07-09)
Endothelial function has been measured in preclinical studies in human brachial and coronary arteries but not in lower extremity arteries affected by atherosclerosis. We describe a novel, first-in-man evaluation of endothelial function of the superficial femoral arteries (SFAs) in patients...
Laura K Hummers et al.
Annals of the rheumatic diseases, 72(12), 1962-1967 (2012-12-27)
MQX-503 is a novel nitroglycerine preparation designed to absorb quickly and allow local vasodilatation in the skin. We examined the efficacy and tolerability of this medication in Raynaud phenomenon (RP) in a laboratory-based study. In this multi-centre, double-blind, randomised, placebo-controlled...
Regina Neubauer et al.
Biochemical pharmacology, 93(4), 440-448 (2015-01-13)
The vascular bioactivation of the antianginal drug nitroglycerin (GTN), yielding 1,2-glycerol dinitrate and nitric oxide or a related activator of soluble guanylate cyclase, is catalyzed by aldehyde dehydrogenase-2 (ALDH2) in rodent and human blood vessels. The essential role of ALDH2...
Hosein Kimiaei Asadi et al.
Acta cirurgica brasileira, 28(1), 19-25 (2013-01-23)
To evaluate the effect of nitroglycerine (NTG) on sensory and motor block onset and recovery time as well as the quality of tourniquet pain relief, when added to lidocaine (LID) for intravenous regional anesthesia in elective forearm and hand surgery....
Brian M Clemency et al.
Prehospital and disaster medicine, 28(5), 477-481 (2013-08-22)
High-dose intravenous nitroglycerin is a common in-hospital treatment for respiratory distress due to congestive heart failure (CHF) with hypertension. Intravenous (IV) nitroglycerin administration is impractical in the prehospital setting. In 2011, a new regional Emergency Medical Services (EMS) protocol was...
Chronic arterial hypertension.
Henry Wireman Cook
JAMA, 311(14), 1451-1451 (2014-04-10)
Kate Kleydman et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 38(12), 1889-1897 (2012-12-05)
Skin necrosis after soft tissue augmentation with dermal fillers is a rare but potentially severe complication. Nitroglycerin paste may be an important treatment option for dermal and epidermal ischemia in cosmetic surgery. To summarize the knowledge about nitroglycerin paste in...
Mirco Govoni et al.
The Journal of pharmacology and experimental therapeutics, 346(1), 96-104 (2013-04-19)
Liver first-pass metabolism differs considerably among organic nitrates, but little information exists on the mechanism of denitration of these compounds in hepatic tissue. The metabolism of nitrooxybutyl-esters of flurbiprofen and ferulic-acid, a class of organic nitrates with potential therapeutic implication...
F G Lopes et al.
Microvascular research, 85, 99-103 (2012-11-10)
How cholesterol influences the microcirculation on aging subjects is not well known. This study evaluated moderate hypercholesterolemia effects in, treated or not, lean elderly women on brachial artery reactivity and microcirculatory function using venous occlusion plethysmography (VOP) and nailfold videocapillaroscopy...
Francesco Saverio Mari et al.
Diseases of the colon and rectum, 56(6), 768-773 (2013-05-09)
Postoperative pain after stapled hemorrhoidopexy is cause for considerable concern and may be related to contracture of continence muscles. We compared glyceryl trinitrate 0.4% ointment with lidocaine chlorohydrate 2.5% gel as topical therapy to relieve the pain of anorectal muscular...
Michele Moretti et al.
The American journal of cardiology, 114(11), 1722-1728 (2014-10-16)
The aims of this study were to investigate the clinical outcomes of patients with low-gradient aortic stenosis despite preserved left ventricular ejection fraction and to assess reliable prognostic clinical-instrumental features in patients experiencing or not experiencing aortic valve replacement (AVR)....
Shahram Ala et al.
Acta gastro-enterologica Belgica, 75(4), 438-442 (2013-02-14)
Chemical sphincterotomy is a new way for the treatment of chronic anal fissure which avoids the risk of faecal incontinence associated with traditional surgical methods. The aim of this study was to compare topical Diltiazem with topical Glyceril trinitrate in...
Guillaume Ruel et al.
Nutrition research (New York, N.Y.), 33(1), 41-49 (2013-01-29)
The stiffening of arteries is a key step in atherogenesis leading to cardiovascular disease. It has been suggested that dietary polyphenols may be cardioprotective through possible favorable effects on oxidative stress and vascular function. The present study was undertaken in...

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