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T-037

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Xi-feng Zhang et al.
Chinese journal of integrative medicine, 20(7), 534-539 (2014-01-15)
To evaluate the effect of a 10-day course of triptolide (TP) on rat cytochrome (CY) P3A4 activity, and on the pharmacokinetics of cyclophosphamide (CPA). In the pharmacokinetics experiment, rats were orally given 0.9% NaCl solution (n=5) and TP [1.2 (mg/kg·d)]
Mariani Carla Prudente Batista et al.
Gene, 550(1), 68-73 (2014-08-12)
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder, of multifactorial etiology, which affects 6-10% of women of reproductive age. It is considered the leading cause of anovulatory infertility, menstrual disorders and hyperandrogenism in this population. The genetic basis of
Y Sato et al.
Andrology, 3(3), 520-525 (2015-04-11)
The association between the Y chromosome haplogroup D2 and risk of azoospermia and low sperm motility has been previously studied, and it was indicated that haplogroups DE (YAP lineage) are associated with prostate cancer risk in Japanese males. Our assumption
[Hazardous endocrine disruptors. Phthalates in our hospital].
Lucie Cordey et al.
Krankenpflege. Soins infirmiers, 106(7), 74-75 (2013-07-31)
Mustafa Kayali et al.
Urology, 84(6), 1448-1452 (2014-10-05)
To investigate the relationship between prostate cancer (PCa), presence of metabolic syndrome (MetS), and late-onset hypogonadism (LOH). One hundred seventy patients who underwent transrectal ultrasonography-guided prostate needle biopsy were included in this study. For the diagnosis of MetS, American Heart
Gema Guedes et al.
ChemMedChem, 10(8), 1403-1412 (2015-06-16)
In this study, a series of new 4,4'-diaminotriphenylmethanes was efficiently synthesized from aromatic aldehydes and 2,5-dimethoxybenzenamine under microwave irradiation in the presence of Sc(OTf)3 as a catalyst. Antiproliferative activity was assessed by using the MCF-7 estrogen receptor (ER)-positive breast cancer
Susan R Davis et al.
The Journal of steroid biochemistry and molecular biology, 142, 107-114 (2013-06-04)
Testosterone is physiologically important for women. Serum testosterone levels decline with age, with the most precipitous fall being prior to menopause. There is no level of testosterone which defines a woman as being testosterone deficient. However, there is substantial high
Aleisha M Moore et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(2), 596-601 (2015-01-01)
Polycystic ovarian syndrome (PCOS), the leading cause of female infertility, is associated with an increase in luteinizing hormone (LH) pulse frequency, implicating abnormal steroid hormone feedback to gonadotropin-releasing hormone (GnRH) neurons. This study investigated whether modifications in the synaptically connected
Ülker Gümüş et al.
Journal of pediatric and adolescent gynecology, 28(4), 249-253 (2015-06-08)
We evaluated the plasma visfatin levels in hirsute female adolescents with polycystic ovary syndrome. This prospective case-control study included 87 female patients who were seen in our adolescence department. Demographic characteristics and hormonal and biochemical parameters were evaluated between patients
Barbara Tschirren
PloS one, 10(7), e0133673-e0133673 (2015-07-21)
Maternal hormones are important mediators of prenatal maternal effects in animals. Although their effects on offspring phenotype are often sex-specific, the reason why sometimes sons are more sensitive to prenatal hormone exposure and sometimes daughters is not well understood. Here
Dong-Sheng Ming et al.
The Journal of steroid biochemistry and molecular biology, 143, 19-28 (2014-02-26)
Castration-resistant prostate cancer (CRPC) remains largely dependent on androgen receptor (AR). Residual tissue androgens are consistently detected within CRPC tumors and play a critical role in facilitating AR-mediated signaling pathways which lead to disease progression. Testosterone and dihydrotestosterone (DHT) are
Hector Mesa et al.
Human pathology, 46(4), 600-606 (2015-02-16)
Reinke crystals (RC) are pathognomonic of Leydig cells (LCs); they are thought to be rare in normal testes and to occur only in approximately one third of LC tumors. We noticed that crystals present in touch imprint and frozen sections
Davina L Hill et al.
Hormones and behavior, 71, 1-9 (2015-04-02)
Alternative reproductive tactics (ARTs), where members of the same sex and population show distinct reproductive phenotypes governed by decision-rules, have been well-documented in males of many species, but are less well understood in females. The relative plasticity hypothesis (RPH) predicts
Rong Chen et al.
Molecular medicine reports, 12(1), 769-775 (2015-03-05)
The present study aimed to assess the effects of aromatase inhibitor anastrozole and testosterone undecanoate, separately and in combination, on proliferation and apoptosis in MCF-7 human breast cancer cells cultured in vitro. The effects of various concentrations of these drugs
Marie Sinclair et al.
Transplantation, 98(7), 788-792 (2014-06-12)
Low pretransplant serum testosterone has recently been associated with increased mortality in men awaiting liver transplantation, but the potential impact on rejection has not yet been investigated. Pretransplantation serum testosterone, SHBG, and other variables were collected on 190 consecutive men
Kristen J Navara et al.
Poultry science, 94(6), 1346-1352 (2015-04-03)
Maximal profit in both the commercial egg and meat industries requires that the quantity of oviposited eggs closely matches the quantity of large yellow follicles maturing in the ovary. While laying hens are genetically selected for maximal egg production and
Amanda K Bolles et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2087-2096 (2014-10-03)
Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of more than half of pharmaceutic drugs, and inactivation of CYP3A4 can lead to adverse drug-drug interactions. The substituted imidazole compounds 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine (SCH 66712) and 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]-4-[4-(trifluoromethyl)-2-pyridinyl]piperazine (EMTPP) have been previously
Paul Kogan et al.
The Urologic clinics of North America, 41(1), 145-161 (2013-11-30)
Although the twentieth century has seen great strides in the development of female contraception, not a single new agent has been introduced as an approved method for common use for male contraception. Condoms (considered uncomfortable by some) and vasectomy (a
Stojan Peric et al.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 32(2), 106-109 (2014-01-09)
Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults. It affects many organs and systems besides muscle. Aim of this study was to assess frequency of erectile dysfunction (ED) and hypogonadism, the correlation between
Kyoko Naramoto et al.
Journal of agricultural and food chemistry, 62(46), 11296-11302 (2014-11-02)
Supplement-drug interaction on CYP enzyme activity is occasionally found to cause clinically adverse events, and no report on interactions of propolis is available either in vitro or clinical. In this study, we tried to estimate the risk of an interaction
Sibel Türedi et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(3), 229-235 (2015-01-03)
The purpose of this study was to evaluate the likely protective effect of resveratrol (RES) on doxorubicin (DOX) induced testicular damage. Rats were divided into five groups: control, RES, dimethyl sulfoxide (DMSO), DOX and DOX+RES. At the end of treatment
E Kostovski et al.
Calcified tissue international, 96(2), 145-154 (2014-12-30)
Spinal cord injury (SCI) leads to severe bone loss, but the associated mechanisms are poorly described in incomplete SCI individuals. The purpose of the study is to compare alterations in bone mineral density (BMD) and serum biomarkers of bone turnover
N Psilander et al.
Scandinavian journal of medicine & science in sports, 25(4), e353-e359 (2014-12-03)
The molecular signaling of mitochondrial biogenesis is enhanced when resistance exercise is added to a bout of endurance exercise. The purpose of the present study was to examine if this mode of concurrent training translates into increased mitochondrial content and
Ning Zhou et al.
Journal of ethnopharmacology, 154(3), 687-695 (2014-05-09)
Shu-Gan-Liang-Xue Decoction (SGLXD), a traditional Chinese herbal formula used to ameliorate the hot flushes in breast cancer patients, was reported to have anti-tumor effect on breast cancer. Estrogen plays a critical role in the genesis and evolution of breast cancer.
Yoshihiko Shimokawa et al.
Biological & pharmaceutical bulletin, 37(11), 1727-1735 (2014-11-05)
Delamanid is a new drug for the treatment of multidrug-resistant tuberculosis. Individuals who are co-infected with human immunodeficiency virus and Mycobacterium tuberculosis may require treatment with a number of medications that might interact significantly with the CYP enzyme system as
Molly M Shores et al.
Archives of internal medicine, 166(15), 1660-1665 (2006-08-16)
Low serum testosterone is a common condition in aging associated with decreased muscle mass and insulin resistance. This study evaluated whether low testosterone levels are a risk factor for mortality in male veterans. We used a clinical database to identify
Ozer Oztekin et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(3), 243-246 (2014-11-19)
This study was designed to determine serum human leukocyte antigen-G (HLA-G) levels and establish whether serum HLA-G level is related with insulin resistance, oxidative stress, dyslipidemia and ovarian hyperandrogenism in women with polycystic ovary syndrome (PCOS). Twenty-five patients with PCOS
Beatrice A Golomb et al.
PloS one, 10(7), e0124451-e0124451 (2015-07-02)
Low/ered cholesterol is linked to aggression in some study designs. Cases/series have reported reproducible aggression increases on statins, but statins also bear mechanisms that could reduce aggression. Usual statin effects on aggression have not been characterized. 1016 adults (692 men
Amar S More et al.
Biology of reproduction, 92(6), 155-155 (2015-05-15)
Prenatal exposure to elevated testosterone levels induces adult life hypertension associated with selective impairments in endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation in mesenteric arteries. We tested whether the angiotensin-converting enzyme inhibitor enalapril restores EDHF function through regulating the activities of small
Asish Kumar Basu et al.
Journal of the Indian Medical Association, 110(8), 573-575 (2013-06-08)
Sexual dysfunction in diabetic men can result from a variety of causes of which late onset hypogonadism is now a recognised entity. The study described here was conducted to determine this entity by comparing diabetic men with age matched controls.
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