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Iatrogenic androgenetic alopecia in a male phenotype 46XX true hermaphrodite.
S H Paik et al.
The British journal of dermatology, 166(1), 221-222 (2011-07-07)
Jonathan P Jarow et al.
Annals of the New York Academy of Sciences, 1061, 208-220 (2006-02-10)
It is well established for both rat and man that the total testosterone concentration within the testis is far higher than that in serum. We know for the rat that intratesticular testosterone can be reduced by 50-60% without an adverse
Hanna M King et al.
Psychoneuroendocrinology, 37(3), 396-409 (2011-08-09)
Increasing evidence in humans and other animals suggests that testosterone (T) plays an important role in modulating emotion. We previously reported that T treatment in rhesus monkeys undergoing chemically induced hypogonadism results in increased watching time of videos depicting fights
The role of 5α-reductase inhibition in men receiving testosterone replacement therapy.
Ugis Gruntmanis
JAMA, 307(9), 968-970 (2012-03-08)
Agnès Lacreuse et al.
Physiology & behavior, 106(2), 229-237 (2012-03-01)
The role of testosterone (T) in modulating cognitive function and emotion in men remains unclear. The paucity of animal studies has likely contributed to the slow progress in this area. In particular, studies in nonhuman primates have been lacking. Our
J W Kim et al.
International journal of impotence research, 25(1), 29-33 (2012-09-14)
Several studies have suggested combination therapy with testosterone supplementation in patients not responding to PDE5 inhibitors. Considering the pathophysiological basis for testosterone supplementation, the present study aims to identify whether combination therapy allows persistence of treatment effect after testosterone discontinuation.
Jenny J Schulze et al.
The Journal of clinical endocrinology and metabolism, 96(11), 3440-3447 (2011-08-19)
The conspicuous interindividual differences in metabolism and urinary excretion of testosterone and its metabolites make it challenging to reveal testosterone doping. The variation in testosterone glucuronide excretion is strongly associated with a deletion polymorphism in the uridine diphosphate-glucuronosyltranferase (UGT) 2B17
Gerhard Binder et al.
Clinical endocrinology, 82(1), 100-105 (2014-09-11)
The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in
Thomas Reinehr et al.
Hormone research in paediatrics, 76(5), 343-347 (2011-10-26)
High-dose testosterone treatment is a well-known, though still controversial, therapy in boys with tall stature. 161 boys with constitutional tall stature were treated at two different treatment centers (center A 114 patients; center B 47 patients). In center A, boys
Marija M Janjic et al.
Reproductive toxicology (Elmsford, N.Y.), 34(4), 686-693 (2012-10-23)
Anabolic-androgenic steroids (AAS) are synthetic derivatives of testosterone (T) predominantly taken as drugs of abuse. Using in vivo treatment of adult male rats we investigated the effects of testosterone enanthate (TE) a widely abused AAS, on apoptosis of Leydig cells.
Falah Shidaifat et al.
Life sciences, 91(5-6), 194-198 (2012-07-24)
The aim of this study was to investigate the effect of testosterone treatment on the proliferation index and the mRNA expression levels of 5α-reductase, CYP7B1, androgen receptor (AR), and estrogen receptor β (ΕRβ) in the canine prostate. Immature dogs were
A F Radicioni et al.
Clinical endocrinology, 76(1), 72-77 (2011-07-02)
Hypogonadism in Prader-Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or to primary gonadal defect, but pathophysiology is still unclear. To investigate the aetiology of hypothalamic-pituitary-gonadal axis dysfunction in PWS males. Clinical examination and blood sampling for luteinizing hormone
Luigi Di Luigi et al.
The journal of sexual medicine, 9(3), 873-886 (2012-02-11)
A well-tailored testosterone replacement treatment (TRT) in male hypogonadal athletes plays a pivotal role to restore physiological performances, to reduce health risks, and to guarantee the ethic of competition. Few studies evaluated individual androgens profiles during TRT in trained individuals.
Alfio Giuberti et al.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 79(1), 26-29 (2007-05-09)
Testicular malignant tumours represent 1% of neoplasms. The probability of developing a contralateral tumour is between 3% and 7%. We report two cases of complete genital prosthetization in two patients treated with bilateral orchiectomy for metachronous testicular cancer. In our
A Schustack et al.
Clinical nephrology, 23(6), 303-306 (1985-06-01)
Sixteen chronic uremics who showed exhausted bone marrow iron stores and mean hematocrit values of 20.9 +/- 4.2% at the time of starting maintenance hemodialysis (HD) were treated by means of intramuscular iron dextran (IMD) (400 mg/month) for six months.
Markus Schubert et al.
Hormone research, 60(1), 21-28 (2003-06-07)
No randomized study exists comparing the effects of different modes of androgen substitution on bone mineral density (BMD). We performed a prospective, randomized, trial assigning 53 hypogonadal men to the following treatment groups: mesterolone 100 mg p.o. daily, testosterone undecanoate
Shane Rogerson et al.
Journal of strength and conditioning research, 21(2), 354-361 (2007-05-29)
Use of testosterone enanthate has been shown to significantly increase strength within 6-12 weeks of administration (2, 9), however, it is unclear if the ergogenic benefits are evident in less than 6 weeks. Testosterone enanthate is classified as a prohibited
Masashi Iijima et al.
International journal of urology : official journal of the Japanese Urological Association, 18(6), 469-471 (2011-04-01)
We report a case of myelodysplastic syndrome (MDS) treated effectively with testosterone enanthate. A 70-year-old man was diagnosed with low-risk MDS in 1998, and he was first given methenolone acetate orally because of gradual progression of anemia and thrombocytopenia. However
Louis J G Gooren et al.
Drugs, 64(17), 1861-1891 (2004-08-27)
The major goal of androgen substitution is to replace testosterone at levels as close to physiological levels as is possible. For some androgen-dependent functions testosterone is a pro-hormone, peripherally converted to 5alpha-dihydrotestosterone (DHT) and 17beta-estradiol (E2), of which the levels
Séverine Trabado et al.
Fertility and sterility, 95(7), 2324-2329 (2011-05-04)
To evaluate the degree of E2 deficiency in male congenital hypogonadotropic hypogonadism (CHH), and its response to different hormonal treatments. Retrospective and prospective studies. Academic institution. Untreated or treated CHH, healthy men, untreated men with Klinefelter syndrome (KS). Serum sex
Revital Amiaz et al.
Journal of sex & marital therapy, 37(4), 243-254 (2011-06-29)
Testosterone replacement is the most effective treatment for sexual dysfunction in hypogonadal men. Comorbid depression and antidepressant side effects may reduce its influence. The authors conducted a 6-week, double-blind, placebo-controlled clinical trial of testosterone gel versus placebo gel in men
Carole A Samango-Sprouse et al.
American journal of medical genetics. Part A, 161A(3), 501-508 (2013-01-25)
The effects of early androgen treatment on neurodevelopmental performance in pre-pubertal boys with 47,XXY have not been well investigated. The influence of hormones on brain development in humans suggests that a positive effect on neurodevelopmental outcome in young boys with
A Malin et al.
Der Anaesthesist, 61(3), 224-226 (2012-03-21)
A case report of severe rhabdomyolysis in a 33-year-old motorcyclist after multiple trauma is described. The injuries included severe thoracic and abdominal trauma as well as injuries to the extremities and spinal column. During the first 3 days of treatment
Emily Darby et al.
Treatments in endocrinology, 4(5), 293-309 (2005-09-28)
Male hypogonadism is one of the most common endocrinologic syndromes. The diagnosis is based on clinical signs and symptoms plus laboratory confirmation via the measurement of low morning testosterone levels on two different occasions. Serum luteinizing hormone and follicle-stimulating hormone
Christian K Roberts et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(2), R118-R123 (2013-12-07)
Whether exogenous testosterone is proatherogenic remains controversial. We assessed the effects of graded doses of testosterone on serum markers of oxidative stress, chemotaxis, adhesion, and inflammation in healthy younger and older men. In a double-blind, randomized trial, 121 eugonadal men
The dark side of beauty: acne fulminans induced by anabolic steroids in a male bodybuilder.
Sophie L Kraus et al.
Archives of dermatology, 148(10), 1210-1212 (2012-10-17)
Kazunari Nohara et al.
The Journal of endocrinology, 219(3), 259-268 (2013-10-03)
Polycystic ovary syndrome is a common endocrine disorder in females of reproductive age and is believed to have a developmental origin in which gestational androgenization programs reproductive and metabolic abnormalities in offspring. During gestation, both male and female fetuses are
Masato Okano et al.
Drug testing and analysis, 5(3), 166-181 (2012-08-14)
Ethnicity has been found to influence urinary testosterone glucuronide to epitestosterone glucuronide (T/E) ratios among athletes. Uridine diphospho-glucuronosyltransferase 2B17 (UGT2B17) is the most active enzyme in testosterone glucuronidation. UGT2B17 polymorphism analysis is rarely performed in Japanese athletes, and the influence
Akira Tsujimura et al.
Asian journal of andrology, 13(4), 558-562 (2011-04-05)
Androgens, the levels of which decrease with ageing, play many physiological roles in various organs. Testosterone deficiency syndrome (TDS) has received widespread attention in the last several years. First-line treatment for TDS should be testosterone replacement therapy (TRT), which is
Lena Ekström et al.
European journal of clinical investigation, 43(3), 248-255 (2013-01-09)
We investigated the androgen receptor (AR) bioluminescense response in serum and urine before and after testosterone challenge in different genotypes of the UGT2B17 enzyme, which catalyses testosterone glucuronidation. The androgen receptor activity was determined using a yeast-based bioluminescence assay. The
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