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Christine Burkard et al.
PLoS pathogens, 10(11), e1004502-e1004502 (2014-11-07)
Enveloped viruses need to fuse with a host cell membrane in order to deliver their genome into the host cell. While some viruses fuse with the plasma membrane, many viruses are endocytosed prior to fusion. Specific cues in the endosomal
Diletta Scaccabarozzi et al.
PloS one, 10(12), e0143195-e0143195 (2015-12-02)
Malaria-associated acute lung injury (MA-ALI) and its more severe form malaria-associated acute respiratory distress syndrome (MA-ARDS) are common, often fatal complications of severe malaria infections. However, little is known about their pathogenesis. In this study, biochemical alterations of the lipid
Marco Diociaiuti et al.
Biochimica et biophysica acta, 1842(9), 1622-1629 (2014-06-17)
Many proteins belonging to the amyloid family share the tendency to misfold and aggregate following common steps, and display similar neurotoxicity. In the aggregation pathway different kinds of species are formed, including several types of oligomers and eventually mature fibers.
Christian Nilsson et al.
Electrophoresis, 31(3), 459-464 (2010-02-02)
Totally porous lipid-based liquid crystalline nanoparticles were used as pseudostationary phase for capillary electroseparation with LIF detection of proteins at physiological conditions using unmodified cyclic olefin copolymer capillaries (Topas, 6.7 cm effective length). In the absence of nanoparticles, i.e. in
Irina G Shabalina et al.
Biochimica et biophysica acta, 1837(12), 2017-2030 (2014-04-29)
Whether active UCP1 can reduce ROS production in brown-fat mitochondria is presently not settled. The issue is of principal significance, as it can be seen as a proof- or disproof-of-principle concerning the ability of any protein to diminish ROS production
[Translational molecular imaging: an investment for the future].
I Peñuelas et al.
Revista espanola de medicina nuclear e imagen molecular, 31(2), 59-60 (2012-01-10)
Pierce G Young et al.
Autophagy, 15(6), 941-959 (2019-02-09)
Macroautophagy is a process through which eukaryotic cells degrade large substrates including organelles, protein aggregates, and invading pathogens. Over 40 autophagy-related (ATG) genes have been identified through forward-genetic screens in yeast. Although homology-based analyses have identified conserved ATG genes in
Bao Teng et al.
Bioorganic & medicinal chemistry letters, 17(12), 3440-3444 (2007-04-24)
The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of
Brian T Welsh et al.
Alcoholism, clinical and experimental research, 34(9), 1634-1639 (2010-07-01)
Emerging evidence suggests that taurine acts as a partial agonist on glycine receptors (GlyR) in vitro and in vivo. Ethanol acts as an allosteric modulator on the GlyR producing a leftward shift of the glycine concentration-response curve, with no enhancing
Tingting Li et al.
Acta biochimica et biophysica Sinica, 44(7), 606-613 (2012-05-29)
Sophora alopecuroides lectin (SAL), a novel lectin from the seeds of Sophora alopecuroides, was purified by ion-exchange chromatography on diethylaminoethyl (DEAE)- and carboxymethyl (CM)-Sepharose columns, followed by gel filtration on a Sephadex 75 10/300 GL column. SAL was found to
Kyle E Godden et al.
PloS one, 9(9), e106977-e106977 (2014-09-05)
Hypocretin/Orexin (H/O) neuropeptides are released by a discrete group of neurons in the vertebrate hypothalamus which play a pivotal role in the maintenance of waking behavior and brain state control. Previous studies have indicated that the H/O neuronal development differs
Minal J Menezes et al.
Human molecular genetics, 24(8), 2297-2307 (2015-01-04)
Functional defects of the mitochondrial translation machinery, as a result of mutations in nuclear-encoded genes, have been associated with combined oxidative phosphorylation (OXPHOS) deficiencies. We report siblings with congenital sensorineural deafness and lactic acidemia in association with combined respiratory chain
Thierry Rabilloud
Journal of proteomics, 73(8), 1562-1572 (2010-04-17)
Electrophoretic separations of proteins are widely used in proteomic analyses, and rely heavily on SDS electrophoresis. This mode of separation is almost exclusively used when a single dimension separation is performed, and generally represents the second dimension of two-dimensional separations.
Hana Nůsková et al.
Biochemical and biophysical research communications, 464(3), 787-793 (2015-07-15)
Mitochondrial ATP synthase, ADP/ATP translocase (ANT), and inorganic phosphate carrier (PiC) are supposed to form a supercomplex called ATP synthasome. Our protein and transcript analysis of rat tissues indicates that the expression of ANT and PiC is transcriptionally controlled in
Pin Su et al.
Scientific reports, 5, 16121-16121 (2015-11-05)
Rhodopseudomonas palustris strain JSC-3b isolated from a water canal adjacent to a vegetable field produces a protein that was purified by bioactivity-guided fractionation based on ammonium sulfate precipitation, ion-exchange absorption and size exclusion. The protein was further identified as an
Guolin Ma et al.
Nature communications, 6, 7826-7826 (2015-07-18)
Store-operated Ca(2+) entry mediated by STIM1 and ORAI1 constitutes one of the major Ca(2+) entry routes in mammalian cells. The molecular choreography of STIM1-ORAI1 coupling is initiated by endoplasmic reticulum (ER) Ca(2+) store depletion with subsequent oligomerization of the STIM1
Irina V Mikheyeva et al.
PLoS genetics, 10(10), e1004740-e1004740 (2014-10-31)
Histone modifiers are critical regulators of chromatin-based processes in eukaryotes. The histone methyltransferase Set1, a component of the Set1C/COMPASS complex, catalyzes the methylation at lysine 4 of histone H3 (H3K4me), a hallmark of euchromatin. Here, we show that the fission
Jan Darius Unterlauft et al.
Experimental eye research, 127, 206-214 (2014-08-17)
The death of retinal ganglion cells (RGC) leads to visual impairment and blindness in ocular neurodegenerative diseases, primarily in glaucoma and diabetic retinopathy; hence, mechanisms that contribute to protecting RGC from ischemia/hypoxia are of great interest. We here address the
Duygu Yilmaz et al.
European biophysics journal : EBJ, 44(7), 557-565 (2015-08-20)
A number of techniques developed to investigate protein structure and function depend on chemically modifying and/or labeling of proteins. However, in the case of homooligomeric proteins, the presence of multiple identical subunits obstructs the introduction of residue-specific labels to only
Charbel Eid et al.
Analytical chemistry, 87(13), 6736-6743 (2015-05-30)
We present an on-chip electrophoretic assay for rapid protein detection with a SOMAmer (Slow Off-Rate Modified Aptamer) reagent. We used isotachophoresis (ITP) coupled with an ionic spacer to both react and separate SOMAmer-protein complex from free SOMAmer reagent. ITP accelerates
Ming-Hsuan Ou-Yang et al.
Neurobiology of aging, 36(2), 801-811 (2014-12-03)
Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid-β (Aβ) in the brain. Previously, myelin basic protein (MBP) was identified to be a potent inhibitor to Aβ fibril formation, and this inhibitory activity
Franziska S Hoffmann et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 542-552 (2014-12-17)
BAFF and a proliferation-inducing ligand (APRIL), which control B cell homeostasis, are therapeutic targets in autoimmune diseases. TACI-Fc (atacicept), a soluble fusion protein containing the extracellular domain of the BAFF-APRIL receptor TACI, was applied in clinical trials. However, disease activity
Earle Stellwagen et al.
Analytical biochemistry, 373(2), 407-409 (2007-11-21)
Capillary electrophoresis has been used to determine whether zwitterions contribute to the ionic strength of a solution, by measuring the mobility of a double-stranded DNA oligomer in cacodylate-buffered solutions containing various concentrations of the ionic salt tetraethylammonium chloride (TEA(+)Cl(-)) or
Zhenzhen Huang et al.
Journal of pharmaceutical and biomedical analysis, 100, 175-183 (2014-08-30)
Serum peptidomic approach was applied to investigate the peptidomic signature and discover the clinical biomarkers and biomarker patterns for RCC patients. The holistic orthogonal partial least-squares-discriminant analysis (OPLS-DA) based on qualified profile data successfully classified RCC patients from healthy controls
Kristoffer Graham et al.
Dalton transactions (Cambridge, England : 2003), 40(13), 3125-3127 (2011-02-25)
We describe an enneanuclear Fe(III) complex with an unusual boat-shaped core topology and an S=11/2 ground state, assembled using the ligands tricine {N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine, H(4)L} and 2-phenoxybenzoate.
Henrik Helmfors et al.
Analytical biochemistry, 484, 136-142 (2015-06-07)
An improved assay for screening for the intracellular delivery efficacy of short oligonucleotides using cell-penetrating peptides is suggested. This assay is an improvement over previous assays that use luciferase reporters for cell-penetrating peptides because it has been scaled up from
Nathalie J Plundrich et al.
Food & function, 6(7), 2145-2154 (2015-05-27)
Allergenic peanut proteins are relatively resistant to digestion, and if digested, metabolized peptides tend to remain large and immunoreactive, triggering allergic reactions in sensitive individuals. In this study, the stability of hypoallergenic peanut protein-polyphenol complexes was evaluated during simulated in
Igor Cestari et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(21), E2803-E2812 (2015-05-13)
African trypanosomes evade clearance by host antibodies by periodically changing their variant surface glycoprotein (VSG) coat. They transcribe only one VSG gene at a time from 1 of about 20 telomeric expression sites (ESs). They undergo antigenic variation by switching
Fei Li et al.
Nuclear medicine and biology, 42(3), 256-262 (2014-12-18)
TMTP1 (NVVRQ) is a novel tumor-homing peptide, which specifically targets tumor metastases, even at the early stage of occult metastasis foci. Fusing TMTP1 to therapeutic peptides or proteins can increase its anti-cancer efficacy both in vivo and in vitro. Here
Jeong-Im Woo et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3953-3961 (2015-03-18)
Cochlear inflammatory diseases, such as tympanogenic labyrinthitis, are associated with acquired sensorineural hearing loss. Although otitis media is extremely frequent in children, tympanogenic labyrinthitis is not commonly observed, which suggests the existence of a potent anti-inflammatory mechanism modulating cochlear inflammation.
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