Franziska S Hoffmann et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 542-552 (2014-12-17)
BAFF and a proliferation-inducing ligand (APRIL), which control B cell homeostasis, are therapeutic targets in autoimmune diseases. TACI-Fc (atacicept), a soluble fusion protein containing the extracellular domain of the BAFF-APRIL receptor TACI, was applied in clinical trials. However, disease activity