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Joana Soares et al.
Pharmacological research, 95-96, 42-52 (2015-03-31)
Inactivation of the p53 tumor suppressor protein by interaction with murine double minute (MDM) proteins, MDM2 and MDMX, is a common event in human tumors expressing wild-type p53. In these tumors, the simultaneous inhibition of these interactions with MDMs, for...
Rúbia Carvalho Gomes Corrêa et al.
Food & function, 6(7), 2155-2164 (2015-06-13)
Pleurotus ostreatoroseus is a Brazilian edible mushroom whose chemical characterization and bioactivity still remain underexplored. In this study, the hydrophilic and lipophilic compounds as well as the antioxidant, anti-inflammatory and antimicrobial activities of formulations (ethanol extracts) prepared with its fruiting...
Joan Eilstein et al.
Archives of toxicology, 88(9), 1681-1694 (2014-03-25)
Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been developed to replace limited ex vivo normal human skin...
Jie Zhang et al.
PloS one, 9(9), e107478-e107478 (2014-09-13)
To interrogate why redox homeostasis and glutathione S-transferase P (GSTP) are important in regulating bone marrow cell proliferation and migration, we isolated crude bone marrow, lineage negative and bone marrow derived-dendritic cells (BMDDCs) from both wild type (WT) and knockout...
Nadia B Hassounah et al.
Cancer immunology, immunotherapy : CII, 68(3), 407-420 (2018-12-20)
Therapeutic blockade of the PD-1/PD-L1 axis is recognized as an effective treatment for numerous cancer types. However, only a subset of patients respond to this treatment, warranting a greater understanding of the biological mechanisms driving immune evasion via PD-1/PD-L1 signaling...
Narcy Arizmendi et al.
Respiratory research, 15, 71-71 (2014-06-28)
Pulmonary fibrotic diseases induce significant morbidity and mortality, for which there are limited therapeutic options available. Rac2, a ras-related guanosine triphosphatase expressed mainly in hematopoietic cells, is a crucial molecule regulating a diversity of mast cell, macrophage, and neutrophil functions....
Valentino Ruggieri et al.
BMC plant biology, 14, 337-337 (2014-12-04)
Genome Wide Association Studies (GWAS) have been recently used to dissect complex quantitative traits and identify candidate genes affecting phenotype variation of polygenic traits. In order to map loci controlling variation in tomato marketable and nutritional fruit traits, we used...
Yoshiteru Kai et al.
Journal of assisted reproduction and genetics, 32(11), 1589-1595 (2015-09-24)
Normally fertilized zygotes generally show two pronuclei (2PN) and the extrusion of the second polar body. Conventional in vitro fertilization (c-IVF) and intracytoplasmic sperm injection (ICSI) often result in abnormal monopronuclear (1PN), tripronuclear (3PN), or other polypronuclear zygotes. In this...
Fakhrozaman Pezeshkpoor et al.
Journal of drugs in dermatology : JDD, 11(11), e66-e69 (2012-11-09)
Common warts caused by the human papillomavirus (HPV) are considered to be the most common infectious skin disease. No individual treatment for common warts is effective as monotherapy in eradicating the lesions. The aim of this study is to evaluate...
Keyvan Amirshahrokhi et al.
Chemico-biological interactions, 225, 63-69 (2014-12-06)
Excessive ethanol ingestion causes gastric mucosal damage through the inflammatory and oxidative processes. The present study was aimed to evaluate the protective effect of thalidomide on ethanol-induced gastric mucosal damage in mice. The animals were pretreated with vehicle or thalidomide...
Sumonto Mitra et al.
Environmental toxicology, 30(12), 1393-1405 (2014-06-05)
Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other...
C A Whipple et al.
British journal of cancer, 111(8), 1625-1633 (2014-08-15)
Melanoma, the most lethal form of skin cancer, is responsible for over 80% of all skin cancer deaths and is highly metastatic, readily spreading to the lymph nodes or metastasising to other organs. The frequent genetic mutation found in metastatic...
Fei Xu et al.
FEMS microbiology letters, 358(1), 98-105 (2014-07-24)
This study investigated inactivation of bacteria with ultraviolet light A irradiation in combination with vitamin K3 as a photosensitizer. Six bacteria including Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, and Escherichia coli suspended in vitamin K3 aqueous...
Samuel Okwudili Onoja et al.
Journal of basic and clinical physiology and pharmacology, 26(5), 465-470 (2015-04-29)
Daniella oliveri is a deciduous plant that is commonly found in savanna and open grassland. Various parts of the plant is used by herbalist in the management of different ailments. The present study aims at investigating the hepatoprotective and antioxidant...
Mingyi Zhao et al.
American journal of physiology. Cell physiology, 308(8), C665-C672 (2015-02-06)
Hydrogen peroxide (H2O2) causes cell damage via oxidative stress. Heme oxygenase-1 (HO-1) is an antioxidant enzyme that can protect cardiomyocytes against oxidative stress. In this study, we investigated whether the heme precursor 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC)...
Verena Pfahler et al.
The New phytologist, 197(1), 186-193 (2012-10-31)
The objective of this study was to investigate the isotopic composition of oxygen bound to phosphate (δ(18)O-PO(4)) in different phosphorus (P) pools in plant leaves. As a model plant we used soybean (Glycine max cv Toliman) grown in the presence...
T E Lewis et al.
Environment international, 30(8), 1119-1150 (2004-09-01)
Trichloroacetic acid (TCAA) is a member of the family of compounds known as chloroacetic acids, which includes mono-, di- and trichloroacetic acid. The significant property these compounds share is that they are all phytotoxic. TCAA once was widely used as...
Jonathan I Silverberg et al.
Journal of drugs in dermatology : JDD, 11(10), 1228-1230 (2012-11-09)
Squaric acid dibutyl ester (SADBE) is a commonly used treatment for verruca vulgaris of childhood. Few studies, however, have examined the role of SADBE in combination with other topical therapies for warts. We sought to determine if trichloroacetic acid 50%...
Hyeong-Geug Kim et al.
World journal of gastroenterology, 20(42), 15703-15714 (2014-11-18)
To evaluate protective effects of Chunggan extract (CGX), a traditional herbal formula, under 4 wk of alcohol consumption-induced liver injury. Male Sprague-Dawley Rats were orally administered 30% ethanol daily for 4 wk with or without CGX. The pharmaceutical properties were...
Manuela E García et al.
European journal of medicinal chemistry, 82, 68-81 (2014-06-01)
Two new and five known withanolides (jaborosalactones 2, 3, 4, 5, and 24) were isolated from the leaves of Jaborosa runcinata Lam. We also obtained some derivatives from jaborosalactone 5, which resulted to be the major isolated metabolite. The natural...
Peng Shi et al.
Journal of hazardous materials, 285, 53-60 (2014-12-08)
This study aimed to compare the toxicity reduction performance of conventional drinking water treatment (CT) and a treatment (NT) with quaternized magnetic microspheres (NDMP) based on chemical analyses. Fluorescence excitation-emission-matrix combined with parallel factor analysis identified four components in source...
Huang Ying et al.
International journal of molecular sciences, 15(11), 20240-20253 (2014-11-08)
Pressure overload induces cardiac hypertrophy through activation of Janus kinase 2 (Jak2), however, the underlying mechanisms remain largely unknown. In the current study, we tested whether histone deacetylase 2 (HDAC2) was involved in the process. We found that angiotensin II...
Is office-based myringoplasty a suitable alternative to surgical tympanoplasty?
Peter L Santa Maria et al.
The Laryngoscope, 124(5), 1053-1054 (2013-10-12)
Victorien Decoin et al.
BMC microbiology, 15, 72-72 (2015-04-18)
Pseudomonas fluorescens strain MFE01 secretes in abundance two Hcp proteins (haemolysin co-regulated proteins) Hcp1 and Hcp2, characteristic of a functional type 6 secretion system. Phenotypic studies have shown that MFE01 has antibacterial activity against a wide range of competitor bacteria...
Yuichiro Maeda et al.
Autophagy, 11(8), 1247-1258 (2015-06-11)
Lipid droplets (LDs) are the conserved organelles for the deposit of neutral lipids, and function as reservoirs of membrane and energy sources. To date, functional links between autophagy and LD dynamics have not been fully elucidated. Here, we report that...
Ou Huang et al.
Oncology reports, 32(2), 627-634 (2014-06-13)
A771726, an orally available anti-inflammatory agent, has been approved for the treatment of multiple sclerosis by diminishing entire inflammatory responses through multiple signaling pathways. Recently, a few emerging studies have focused on the potential application of A771726 in cancer therapy...
Justin I Montgomery et al.
The Journal of antibiotics, 68(6), 361-367 (2014-12-04)
A high-throughput phenotypic screen for novel antibacterial agents led to the discovery of a novel pyrazolopyrimidinedione, PPD-1, with preferential activity against methicillin-resistant Staphylococcus aureus (MRSA). Resistance mapping revealed the likely target of inhibition to be lysyl tRNA synthetase (LysRS). Preliminary...
Chutima Talabnin et al.
Oncology letters, 20(3), 2483-2492 (2020-08-13)
Piperlongumine (PL) produces reactive oxygen species (ROS) and induces G2/M-phase arrest in cholangiocarcinoma (CCA) cells via the JNK/ERK pathway. A differential response to PL was observed among all CCA cell lines However, the underlying mechanisms have remained to be fully...
Michael S Young et al.
Journal of AOAC International, 97(6), 1737-1741 (2015-01-30)
An SPE-based cleanup protocol was developed for ultra-performance LC (UPLC)/MS/MS determination of residues of the common aminoglycoside antibiotics streptomycin, dihydrostreptomycin, neomycin, and gentamicin in bovine milk, kidney, and muscle. Recoveries for all compounds except neomycin ranged from 80 to 104%...
Jiun-Nong Lin et al.
Zebrafish, 12(4), 271-280 (2015-04-30)
Alcoholic liver disease (ALD) continues to be a major cause of liver-related morbidity and mortality worldwide. To date, no zebrafish animal model has demonstrated the characteristic manifestations of ALD in the setting of chronic alcohol exposure. The aim of this...
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