Applied Filters:

Keyword:'t150'

Showing 1-18 of 18 results for "

t150

" within Papers

Isolation, purification, characterization, and antioxidant activity of low-molecular-weight polysaccharides from Sparassis latifolia.

Guo-Liang Duan et al.

International journal of biological macromolecules, 137, 1112-1120 (2019-07-05)

Six polysaccharides (SF-FB11, SF-HW21, SF-CA31, SF-HA41, SF-FF51, and SF-FR61) of similar molecular weights (MW) (30-50 kDa) were extracted from the fermentation liquor, mycelia, and basidiomata of Sparassis latifolia by different methods. Structural analyses of these purified polysaccharides indicated that they were

Taurine prevents memory consolidation deficits in a novel alcohol-induced blackout model in zebrafish.

Kanandra T Bertoncello et al.

Progress in neuro-psychopharmacology & biological psychiatry, 93, 39-45 (2019-03-19)

Ethanol is one of the most consumed substance worldwide that impairs learning and memory processes, resulting in amnesia or blackout. Due to the genetic conservation, rich behavioral repertoire, and high pharmacological tractability, the zebrafish (Danio rerio) has emerged as a

An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme.

John H Sampson et al.

Molecular cancer therapeutics, 8(10), 2773-2779 (2009-10-15)

Conventional therapies for glioblastoma multiforme (GBM) fail to target tumor cells exclusively, such that their efficacy is ultimately limited by nonspecific toxicity. Immunologic targeting of tumor-specific gene mutations, however, may allow more precise eradication of neoplastic cells. The epidermal growth

Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.

Hirotake Furihata et al.

Nature communications, 11(1), 4578-4578 (2020-09-16)

Thalidomide and its derivatives exert not only therapeutic effects as immunomodulatory drugs (IMiDs) but also adverse effects such as teratogenicity, which are due in part to different C2H2 zinc-finger (ZF) transcription factors, IKZF1 (or IKZF3) and SALL4, respectively. Here, we

Enantioselective sensing of (S)-Thalidomide in blood plasma with a chiral naphthalene diimide derivative.

Agata Kowalczyk et al.

Biosensors & bioelectronics, 167, 112446-112446 (2020-08-21)

Fast, simple in use and highly effective voltammetric enantiosensor dedicated for determination of thalidomide (TD) enantiomers (especially towards the toxic (S)-enantiomer) in blood plasma is still desirable. Here we have proven that newly synthesized chiral naphthalene diimide (NDI) derivatives are

Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death.

Jürgen Knobloch et al.

Molecular and cellular biology, 28(2), 529-538 (2008-01-08)

Thalidomide, a drug used for the treatment of multiple myeloma and inflammatory diseases, is also a teratogen that causes birth defects, such as limb truncations and microphthalmia, in humans. Thalidomide-induced limb truncations result from increased cell death during embryonic limb

Origin of Hypoglycemic Benefits of Probiotic-Fermented Carrot Pulp.

Yu-Jun Wan et al.

Journal of agricultural and food chemistry, 67(3), 895-904 (2019-01-05)

It has been found that probiotic-fermented carrot pulp has a beneficial effect in reducing blood glucose, more so than unfermented pulp. This paper explores the reason for this by looking at fermentation-induced changes in nutritional components and hypoglycemic effects of

Thalidomide: the tragedy of birth defects and the effective treatment of disease

Kim JH and Scialli AR

Toxicological Sciences, 122(1) (2011)

Thalidomide-induced teratogenesis: History and mechanisms

Vargesson N

Birth Defects Research Part C: Embryo Today - Reviews, 105(2) (2015)

Thalidomide inhibits the replication of human immunodeficiency virus type 1.

S Makonkawkeyoon et al.

Proceedings of the National Academy of Sciences of the United States of America, 90(13), 5974-5978 (1993-07-01)

Thalidomide, a selective inhibitor of tumor necrosis factor alpha (TNF-alpha) synthesis, suppresses the activation of latent human immunodeficiency virus type 1 (HIV-1) in a monocytoid (U1) line. The inhibition is dose dependent and occurs after exposure of the cells to

Structural characterization, physicochemical properties and α-glucosidase inhibitory activity of polysaccharide from the fruits of wax apple.

Bin-Hui Wang et al.

Carbohydrate polymers, 211, 227-236 (2019-03-03)

In this study, a novel water-soluble polysaccharide fraction (WAFP) was isolated from wax apple fruits. The structural characterization, physicochemical properties and α-glucosidase inhibitory activity of WAFP were investigated. The results indicated that WAFP had average molecular weight of 49.9 kDa, it

Thalidomide is an inhibitor of angiogenesis.

R J D'Amato et al.

Proceedings of the National Academy of Sciences of the United States of America, 91(9), 4082-4085 (1994-04-26)

Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered thalidomide is an inhibitor of angiogenesis induced by basic fibroblast growth factor in a rabbit cornea micropocket assay. Experiments including the analysis

Thalidomide resistance is based on the capacity of the glutathione-dependent antioxidant defense.

Jürgen Knobloch et al.

Molecular pharmaceutics, 5(6), 1138-1144 (2009-05-13)

Thalidomide as an effective treatment for multiple myeloma and leprosy has also caused birth defects in thousands of children five decades ago particularly in Europe. Thus its use in humans remains limited. The rapid and fatal approval of thalidomide at

High Stoichiometry Phosphorylation of Talin at T144/T150 or S446 Produces Contrasting Effects on Calpain-mediated Talin Cleavage and Cell Migration.

Youjun Li et al.

Journal of Cancer, 7(12), 1645-1652 (2016-10-05)

Focal adhesions are large multi-protein complexes that serve as the linkage between extracellular matrix (ECM) and actin cytoskeleton and control the network of signaling cascades underlying cell migration. Talin plays a key role in focal adhesion turnover, and calpain-mediated proteolysis

Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor.

H J Kreienkamp et al.

Neuron, 14(3), 635-644 (1995-03-01)

Through specific intersubunit contacts, the four subunits of the nicotinic acetylcholine receptor assemble into an alpha 2 beta gamma delta pentamer. The specificity of subunit association leads to formation of proper ligand binding sites and to transport of assembled pentamers

Cables1 complex couples survival signaling to the cell death machinery.

Zhi Shi et al.

Cancer research, 75(1), 147-158 (2014-11-02)

Cables1 is a candidate tumor suppressor that negatively regulates cell growth by inhibiting cyclin-dependent kinases. Cables1 expression is lost frequently in human cancer but little is known about its regulation. Here, we report that Cables1 levels are controlled by a

Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells.

I McNiece et al.

Cytotherapy, 6(4), 311-317 (2005-09-09)

Cord blood (CB) cells are being used increasingly as a source of hematopoietic cells to support high dose chemotherapy. However, CB units contain low numbers of cells, including CD34+ cells, and thus their use is associated with significant delays in

The alphaherpesvirus US3/ORF66 protein kinases direct phosphorylation of the nuclear matrix protein matrin 3.

Angela Erazo et al.

Journal of virology, 85(1), 568-581 (2010-10-22)

The protein kinase found in the short region of alphaherpesviruses, termed US3 in herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PRV) and ORF66 in varicella-zoster virus (VZV), affects several viral and host cell processes, and its specific targets

Page 1 of 1