Showing 1-30 of 245 results for "

T1850000

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L Kakita
Journal of the American Academy of Dermatology, 43(2 Pt 3), S51-S54 (2000-07-18)
The efficacy and tolerability of tazarotene 0.1% gel in the treatment of acne vulgaris have been compared with those of tretinoin 0.025% gel and adapalene 0.1% gel in multicenter, double-blind, randomized, parallel-group trials. Preliminary results from the tazarotene versus tretinoin...
Garry L Coles et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(21), E1898-E1905 (2013-05-08)
Congenital diaphragmatic hernia (CDH) is a common birth defect that results in a high degree of neonatal morbidity and mortality, but its pathological mechanisms are largely unknown. Therefore, we performed a forward genetic screen in mice to identify unique genes...
Nandini Krishnamoorthy et al.
Journal of immunology (Baltimore, Md. : 1950), 194(3), 863-867 (2014-12-30)
Asthma is a chronic inflammatory disease that fails to resolve. Recently, a key role for type 2 innate lymphoid cells (ILC2s) was linked to asthma pathogenesis; however, mechanisms for ILC2 regulation remain to be determined. In this study, metabololipidomics of...
Margot Carocci et al.
Antimicrobial agents and chemotherapy, 59(1), 85-95 (2014-10-15)
Dengue virus (DENV), a member of the Flaviviridae family, is a mosquito-borne pathogen and the cause of dengue fever. The increasing prevalence of DENV worldwide heightens the need for an effective vaccine and specific antivirals. Due to the dependence of...
A K Dhar et al.
The Journal of the Association of Physicians of India, 60, 63-65 (2013-06-19)
Retinoic acid syndrome is a novel complication of therapy with all-trans retinoic acid (ATRA) in patients with acute promyelocytic leukemia (APML). Primarily the syndrome consists of fever and respiratory distress. Additional features include weight gain, oedema over lower extremities, pleural...
Diep Ngoc Thi Pham et al.
The American journal of clinical nutrition, 98(2), 413-422 (2013-06-28)
β,β-Carotene 15,15'-monooxygenase (BCMO1) converts β-carotene to retinaldehyde. Increased β-carotene consumption is linked to antitumor effects. Retinoic acid reduces the invasiveness in cancer, through inhibition of matrix metalloproteinases (MMPs). In our studies of a mouse model that develops intestinal tumors after...
Serge A van de Pavert et al.
Nature, 508(7494), 123-127 (2014-03-29)
The impact of nutritional status during fetal life on the overall health of adults has been recognized; however, dietary effects on the developing immune system are largely unknown. Development of secondary lymphoid organs occurs during embryogenesis and is considered to...
J W Quigley et al.
Journal of the American Academy of Dermatology, 38(4), S5-10 (1998-04-29)
Novel tretinoin cream and gel formulations have been developed that incorporate polyolprepolymer-2, which is a material designed to help retain drug molecules in and on the skin when applied in topical vehicles. The results of preclinical and clinical investigations have...
Dušan Milanović et al.
Anticancer research, 34(4), 1885-1891 (2014-04-03)
13-cis-retinoic acid (RA) and thalidomide have shown a synergistic anti-proliferative effect on U343 glioblastoma (GBM) cells. In the present study, we test if their combined treatment might enhance the radiosensitivity of these cells. The radiosensitivity of U343 GBM cells was...
Sumantha Bhatt et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5098-5108 (2014-05-03)
Hepatic stellate cells (HSC) are a major source of the immunoregulatory metabolite all-trans retinoic acid (ATRA), which may contribute to the generation of tolerogenic dendritic cells (DCs) in the liver. The present study seeks to clarify the mechanism(s) through which...
Andreia Neves-Carvalho et al.
Human molecular genetics, 24(1), 100-117 (2014-08-22)
The physiological function of Ataxin-3 (ATXN3), a deubiquitylase (DUB) involved in Machado-Joseph Disease (MJD), remains elusive. In this study, we demonstrate that ATXN3 is required for neuronal differentiation and for normal cell morphology, cytoskeletal organization, proliferation and survival of SH-SY5Y...
Sung Tae Kim et al.
Developmental biology, 390(2), 160-169 (2014-04-05)
The absence of Discs-large 1 (DLG1), the mouse ortholog of the Drosophila discs-large tumor suppressor, results in congenital hydronephrosis characterized by urinary tract abnormalities, reduced ureteric bud branching, and delayed disconnection of the ureter from the common nephric duct (CND)....
A D Cohen et al.
The Journal of dermatological treatment, 12(3), 171-173 (2002-09-24)
Multiple miliary osteoma cutis of the face represents primary extra-skeletal bone formation that arises within the skin of the face. A 60-year-old woman with multiple miliary osteoma cutis of the face was treated by application of 0.05% tretinoin (all-trans-retinoic acid)...
Adam Jonas et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 283-290 (2014-08-12)
Retinoic acids and their derivatives have been recently identified by chemical analyses in cyanobacteria and algae. Given the essential role of retinoids for vertebrate development this has raised concerns about a potential risk for vertebrates exposed to retinoids during cyanobacterial...
Jurate Savickiene et al.
Leukemia research, 38(7), 822-829 (2014-05-17)
The involvement of histone lysine methyltransferases (HMT) in carcinogenesis is not well understood. Here, we describe a dose-dependent growth and survival inhibitory effects of BIX-01294, a specific inhibitor of euchromatic HMT2, in promyelocytic leukemia HL-60 and NB4 cells. BIX-01294 combined...
Natsuno Suda et al.
Development (Cambridge, England), 141(14), 2885-2894 (2014-07-10)
Apoptosis is an important mechanism for sculpting morphology. However, the molecular cascades that control apoptosis in developing limb buds remain largely unclear. Here, we show that MafB was specifically expressed in apoptotic regions of chick limb buds, and MafB/cFos heterodimers...
Melisa J Hamilton et al.
Journal of immunology (Baltimore, Md. : 1950), 192(1), 512-522 (2013-11-29)
Myeloid-derived suppressor cells (MDSCs) are emerging as potential promoters of metastatic tumor growth, and there is interest in targeting immature MDSCs by inducing their differentiation into more mature myeloid cells. We used all-trans retinoic acid (ATRA) to differentiate MDSCs in...
R J M Hurst et al.
Parasite immunology, 34(7), 351-359 (2012-03-27)
Retinoic acid or vitamin A is important for an extensive range of biological processes, including immunomodulatory functions, however, its role in gastrointestinal parasite infections is not yet clear. Despite this, parasite infected individuals are often supplemented with vitamin A, given...
Yanhong Tan et al.
British journal of haematology, 162(1), 93-97 (2013-05-01)
Alternative splicing is associated with human disease. In acute promyelocytic leukaemia (APL) patients with the long (L)-type promyelocytic leukaemia-retinoic acid receptor α fusion gene (PML-RARA), three alternative splicing isoforms can be detected: E5(+)E6(+), E5(-)E6(+), and E5(-)E6(-). This study is the...
Jace W Jones et al.
Health physics, 106(1), 106-119 (2013-11-28)
Biomarker identification and validation for radiation exposure is a rapidly expanding field encompassing the need for well defined animal models and advanced analytical techniques. The resources within the consortium, Medical Countermeasures Against Radiological Threats (MCART), provide a unique opportunity for...
Luciana Rocha-Viegas et al.
Molecular and cellular biology, 34(19), 3765-3775 (2014-07-30)
Human UTX, a member of the Jumonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes. Stimulation with retinoic acid leads to the recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3 lysine 27...
Topical tretinoin in acne therapy.
G F Webster
Journal of the American Academy of Dermatology, 39(2 Pt 3), S38-S44 (1998-08-14)
Mees lines and Beau lines.
Gregory Chesnut et al.
Cutis, 91(3), 147-147 (2013-04-27)
Anwar J Almzaiel et al.
Life sciences, 93(2-3), 125-131 (2013-06-19)
Neutrophil apoptosis is important in the resolution of inflammation in chronic wounds. Hyperbaric oxygen (HBO) therapy, an intermittent inhalation of 100% oxygen at greater than atmospheric pressure, appears to be an effective treatment for chronic wounds. The aim was to...
Andrea Pelosi et al.
Molecular cancer research : MCR, 12(6), 878-889 (2014-03-19)
Let-7c, an intronic microRNA (miRNA) embedded in the long non-coding gene LINC00478, can act as a tumor suppressor by targeting oncogenes. Previous studies indicated that in acute promyelocytic leukemia (APL), a subtype of acute myelogenous leukemia (AML) bearing the leukemia...
Jinyi Han et al.
Experimental biology and medicine (Maywood, N.J.), 239(3), 272-283 (2014-02-07)
All-trans retinoic acid (ATRA) has been used for the treatment of acute promyelocytic leukemia. It remains unclear, however, whether ATRA affects cyclooxygenase-2 (COX-2; an enzyme involved in prostaglandin production), PGE2, and thromboxane A2 (TXA2) (metabolic products of COX-2) by a...
Theodore J Sanders et al.
Gastroenterology, 146(5), 1278-1288 (2014-02-08)
Reduced generation of all-trans retinoic acid (RA) by CD103(+) intestinal dendritic cells (DCs) is linked to intestinal inflammation in mice. However, the role of RA in intestinal inflammation in humans is unclear. We investigated which antigen-presenting cells (APCs) produce RA...
Birgit Steinmetz et al.
Cell cycle (Georgetown, Tex.), 13(18), 2931-2943 (2014-12-09)
The product of the ecotropic virus integration site 1 (EVI1) gene, whose overexpression is associated with a poor prognosis in myeloid leukemias and some epithelial tumors, regulates gene transcription both through direct DNA binding and through modulation of the activity...
Cathryn A Hogarth et al.
Current opinion in endocrinology, diabetes, and obesity, 20(3), 217-223 (2013-03-21)
Description of new evidence to support the model for how retinoic acid regulates spermatogonial differentiation, male meiosis and the cycle of the seminiferous epithelium. It has been known since the 1920s that vitamin A is essential for spermatogenesis. However, only...
Prerna Kumar et al.
Molecular pharmacology, 85(6), 946-957 (2014-04-10)
The objective of the present study was to delineate the mechanisms of GC-A/natriuretic peptide receptor-A (GC-A/NPRA) gene (Npr1) expression in vivo. We used all-trans retinoic acid (ATRA) and histone deacetylase (HDAC) inhibitor, sodium butyrate (NaBu) to examine the expression and...