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Hilde K Ofte et al.
Cephalalgia : an international journal of headache, 35(6), 469-477 (2014-08-22)
Cluster headache (CH) attacks are accompanied by cranial autonomic symptoms indicative of parasympathetic hyperactivity and sympathetic dysfunction ipsilateral to the pain. We aimed to assess cranial autonomic function in CH patients during the remission phase of cluster headache. During a
Yu Zhang et al.
Journal of molecular neuroscience : MN, 55(4), 830-835 (2014-10-09)
GABAergic neurons within the ventrolateral preoptic area (VLPO) play an important role in sleep-wakefulness regulation. Propofol, a widely used systemic anesthetic, has lately been reported to excite noradrenaline (NA)-inhibited type of VLPO neurons. Present study tested if acetylcholine system takes
Tiffany E Choe et al.
PloS one, 9(11), e113011-e113011 (2014-11-14)
To determine the relationship between longitudinal in vivo measurements of retinal nerve fiber layer thickness (RNFLT) and retinal ganglion cell (RGC) density after unilateral optic nerve transection (ONT). Nineteen adult Brown-Norway rats were studied; N = 10 ONT plus RGC label, N = 3
Rajendra K Gangalum et al.
Investigative ophthalmology & visual science, 55(11), 7227-7240 (2014-08-30)
The clinical management of cataracts in infancy involves surgical removal of the lens to ensure transmission of light to the retina, which is essential for normal neural development of the infant. This surgery, however, entails a lifelong follow-up and impaired
Yuji Odagaki et al.
Journal of pharmacological sciences, 125(2), 157-168 (2014-05-23)
The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5'-O-(3-[(35)S]thio) triphosphate ([(35)S]GTPγS) binding assay in rat brain membranes. The most efficacious stimulation elicited by acetylcholine or carbachol (CCh) was obtained in striatal
S J Park et al.
Eye (London, England), 29(4), 561-568 (2015-01-17)
To determine intraocular pharmacokinetic properties of intravitreally injected vascular endothelial growth factor (VEGF)-Trap in a rabbit model. VEGF-Trap was intravitreally injected in 18 rabbit eyes. Eyes were enucleated 1 h and 1, 2, 5, 14, and 30 days after injections and
Wei Wu et al.
Psychopharmacology, 231(21), 4109-4118 (2014-04-05)
Drug addiction represents a pathological usurpation of neural processes involved in learning and memory. Retrieval of drug-related memories can result in drug craving and relapse. Recently, the insula was identified as part of the neuronal circuit responsible for the processing
Kazutaka Kamiya et al.
American journal of ophthalmology, 158(1), 179-184 (2014-04-05)
To evaluate the factors affecting the long-term regression after posterior chamber phakic intraocular lens (Visian ICL; STAAR Surgical) implantation for myopia. Retrospective observational case series. We retrospectively examined 60 eyes of 35 consecutive patients (age, 38.4 ± 9.3 years [mean
Srinivas Rao Chennamaneni et al.
Pharmaceutical research, 31(11), 3179-3190 (2014-06-21)
To advance therapy for the treatment of concurrent uveitis and post-cataract surgical inflammation; we evaluated pharmacokinetics and pharmacodynamics of Bioerodible Dexamethasone Implant (BDI) containing 0.3 mg of dexamethasone (DXM) in Concanavalin A (Con A) induced uveitis followed by phacoemulsification in
Ke Jiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), E5716-E5723 (2014-12-17)
Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed
Ahmed S Ibrahim et al.
Biochimica et biophysica acta, 1851(3), 290-298 (2015-01-07)
We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal levels of the vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF).
Amany Tawfik et al.
Investigative ophthalmology & visual science, 55(6), 3616-3625 (2014-05-09)
Loss-of-function mutations in hemojuvelin (HJV) cause juvenile hemochromatosis, an iron-overload disease. Deletion of Hjv in mice results in excessive iron accumulation and morphologic changes in the retina. Here, we studied the retinal vasculature in Hjv(-/-) mice. Age-matched wild-type and Hjv(-/-)
Rui Huang et al.
Molecular vision, 20, 1271-1280 (2014-10-30)
The purpose of this study is to evaluate the functional and morphological changes in subretinal xenografts of human retinal progenitor cells (hRPCs) in B6 mice treated with Cyclosporin A (CsA; 210 mg/l in drinking water). The hRPCs from human fetal
Carla J Abbott et al.
PloS one, 9(12), e114546-e114546 (2014-12-17)
To compare in young and old rats longitudinal measurements of retinal nerve fiber layer thickness (RNFLT) and axonal transport 3-weeks after chronic IOP elevation. IOP was elevated unilaterally in 2- and 9.5-month-old Brown-Norway rats by intracameral injections of magnetic microbeads.
Yun Qi et al.
Investigative ophthalmology & visual science, 55(9), 5466-5475 (2014-08-07)
Retinal ischemia/reperfusion (IR) is common in eye disorders. Pattern-recognition receptors (PRRs) are reported to initiate sterile inflammatory response. The role of PRRs in retinal IR injury is currently unknown. Thus, we investigated the expression and function of membrane and cytoplasmic
Kalpana Rose et al.
Investigative ophthalmology & visual science, 55(7), 4266-4276 (2014-05-08)
The aim of this study was to investigate the impact of cigarette smoking in otherwise healthy young individuals on retinal blood flow (RBF) and vascular reactivity (RVR). An automated gas flow controller (RespirAct) was used to achieve normoxic hypercapnia in
Yu-Chieh Ko et al.
Ophthalmic epidemiology, 22(2), 109-115 (2015-03-18)
To determine factors associated with angle-closure disease, particularly in those with structural or functional damage to the eyes, in an elderly Chinese population. A total of 460 individuals aged over 72 years were recruited. The association of angle-closure diseases, including
Shogo Arimura et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(2), 307-312 (2014-10-15)
To identify the determinants of anterior chamber angle narrowing after mydriasis by quantitative assessment of the anterior chamber components using anterior segment optical coherence tomography (AS-OCT). In this intervention study, anterior chamber angle analysis was performed using AS-OCT in patients
Alja Crnej et al.
Investigative ophthalmology & visual science, 56(1), 185-189 (2014-12-18)
To compare corneal inflammation after syngeneic and allogeneic penetrating keratoplasty (PK) with miniature Keratoprosthesis (m-KPro) implantation in mice. BALB/C (syngeneic) or C57BL/6 (allogeneic) corneas were transplanted onto BALB/C host beds as part of PK or m-KPro implantation. Corneal inflammation was
Liangliang Zhao et al.
Investigative ophthalmology & visual science, 55(9), 5979-5988 (2014-08-26)
Oxidative stress and inflammation have key roles in the light damage (LD) model of retinal degeneration as well as in age-related macular degeneration (AMD). We sought to determine if lipoic acid (LA), an antioxidant and iron chelator, protects the retina
Alja Crnej et al.
Investigative ophthalmology & visual science, 55(6), 3681-3685 (2014-05-17)
To establish a murine model for keratoprosthesis. A miniature keratoprosthesis (m-KPro) device was created consisting of a poly[methyl methacrylate] front part and a titanium back plate, designed after the Boston KPro, which is in widespread clinical use. BALB/c mice were
Adam Boretsky et al.
Current eye research, 40(4), 368-377 (2014-06-10)
To investigate the effects of nicotine on retinal alterations in early-stage diabetes in an established rodent model. Sprague-Dawley rats were examined using a combination of confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography to determine changes in retinal
Jen-Pin Sun et al.
Investigative ophthalmology & visual science, 55(12), 8467-8474 (2014-11-20)
We used a rabbit model to evaluate the interface embedded between the recipient corneas and transplanted donor corneal discs after non-Descemet's stripping automated endothelial keratoplasty (nDSAEK). Unilateral DSAEK and nDSAEK surgeries were performed on New Zealand white rabbits. In vivo
Yalong Dang et al.
Drug design, development and therapy, 8, 1441-1449 (2014-09-27)
Our objective was to investigate the efficacy and safety of dexa methasone (DEX) implant for the treatment of pseudophakic cystoid macular edema (PCME) in diabetic patients. This was a prospective, non-randomized, interventional case series of 43 participants. Eighteen patients were
David Sung Hyeon Baek et al.
Journal of pharmacological and toxicological methods, 71, 77-82 (2014-09-10)
Traditional methods of pre-clinical ocular toxicology require that multiple cohorts of animals be sacrificed over time for terminal histological analysis. By contrast, in vivo techniques capable of following the same cohort prospectively have the potential to be efficient and cost-saving.
Jeeyun Ahn et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(7), 612-618 (2013-06-06)
To compare the pharmacokinetics (PKs) of intravitreally injected bevacizumab in vitrectomized versus nonvitrectomized control rabbit eyes. Twenty-five-gauge pars plana vitrectomy without lensectomy was performed in 17 right rabbit eyes (V) and 18 nonvitrectomized right rabbit eyes served as controls (C).
Hui Chen et al.
Investigative ophthalmology & visual science, 56(3), 1971-1984 (2015-02-28)
We investigated the progressive degeneration of retinal and superior collicular functions in a mouse model of sustained ocular hypertension. Focal laser illumination and injection of polystyrene microbeads were used to induce chronic ocular hypertension. Retinal ganglion cell (RGC) loss was
Delu Song et al.
The American journal of pathology, 184(10), 2721-2729 (2014-08-05)
Mutations in the RP1 gene can cause retinitis pigmentosa. We identified a spontaneous L66P mutation caused by two adjacent point mutations in the Rp1 gene in a colony of C57BL/6J mice. Mice homozygous for the L66P mutation exhibited slow, progressive
Delu Song et al.
Investigative ophthalmology & visual science, 55(7), 4525-4532 (2014-06-28)
To investigate the retinal-protective effects of the oral iron chelator deferiprone (DFP) in mice lacking the iron regulatory hormone hepcidin (Hepc). These Hepc knockout (KO) mice have age-dependent systemic and retinal iron accumulation leading to retinal degeneration. Hepc KO mice
Yun Wang et al.
Experimental eye research, 125, 128-134 (2014-06-15)
The purpose of this study is to evaluate the neuroprotective effects of C3 exoenzyme (C3) on N-methyl-d-aspartate (NMDA)-induced retinopathy in rats. C3 was expressed in Escherichia. coli and purified by affinity chromatography. Immunofluorescence was performed in NIH 3T3 cells treated
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