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T2900000

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Ju-Hoon So et al.
PloS one, 9(10), e109517-e109517 (2014-10-28)
It has been shown that Mindbomb (Mib), an E3 Ubiquitin ligase, is an essential modulator of Notch signaling during development. However, its effects on vascular development remain largely unknown. We identified a number of novel proteins that physically interact with...
S I Labidi-Galy et al.
Oncogene, 34(3), 373-383 (2014-01-29)
High-grade serous ovarian carcinoma (HGSOC) and basal-like breast cancer (BLBC) share many features including TP53 mutations, genomic instability and poor prognosis. We recently reported that Elafin is overexpressed by HGSOC and is associated with poor overall survival. Here, we confirm...
Michael Peitz et al.
Stem cell research, 12(3), 680-689 (2014-04-01)
A comprehensive understanding of the functional network of transcription factors establishing and maintaining pluripotency is key for the development of biomedical applications of stem cells. Nanog plays an important role in early development and is essential to induce natural pluripotency...
Nadine K Gut et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(12), 4792-4803 (2015-03-27)
The pedunculopontine tegmental nucleus (PPTg) has been proposed as a target for deep brain stimulation (DBS) in parkinsonian patients, particularly for symptoms such as gait and postural difficulties refractory to dopaminergic treatments. Several patients have had electrodes implanted aimed at...
Veronika Dunkl et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 88-92 (2014-12-20)
Experience regarding O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET in children and adolescents with brain tumors is limited. Sixty-nine (18)F-FET PET scans of 48 children and adolescents (median age, 13 y; range, 1-18 y) were analyzed retrospectively. Twenty-six scans to assess newly diagnosed cerebral...
Se Hwan Mun et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(9), 2482-2493 (2014-06-04)
Macrophage migration inhibitory factor (MIF) is an important modulator of innate and adaptive immunity as well as local inflammatory responses. We previously reported that MIF down-regulated osteoclastogenesis through a mechanism that requires CD74. The aim of the current study was...
Xuan Zhuang et al.
Scientific reports, 5, 7922-7922 (2015-01-30)
The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in men with normal versus impaired spermatogenesis. The expression of mRNAs and miRNAs in testicular tissues obtained...
Lutz Tautz et al.
Methods in molecular biology (Clifton, N.J.), 1053, 179-221 (2013-07-19)
Protein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine phosphatases can lead to serious human diseases, including cancer, diabetes, as well as cardiovascular, infectious, autoimmune, and...
Tyler M Basting et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 527-543 (2015-01-16)
In conscious mammals, hypoxia or hypercapnia stimulates breathing while theoretically exerting opposite effects on central respiratory chemoreceptors (CRCs). We tested this theory by examining how hypoxia and hypercapnia change the activity of the retrotrapezoid nucleus (RTN), a putative CRC and...
Emily J Platt et al.
Journal of virology, 88(8), 4304-4318 (2014-01-31)
HIV-1 membranes contain gp120-gp41 trimers. Binding of gp120 to CD4 and a coreceptor (CCR5 or CXCR4) reduces the constraint on metastable gp41, enabling a series of conformational changes that cause membrane fusion. An analytic difficulty occurs because these steps occur...
Gwen McCaffrey et al.
Cancer research, 74(23), 7014-7023 (2014-10-08)
Studies in animals and humans show that blockade of nerve growth factor (NGF) attenuates both malignant and nonmalignant skeletal pain. While reduction of pain is important, a largely unanswered question is what other benefits NGF blockade might confer in patients...
C Lanteri et al.
Molecular psychiatry, 19(7), 823-833 (2013-08-21)
3,4-Methylenedioxymethamphetamine (MDMA or 'ecstasy') is a psychostimulant drug, widely used recreationally among young people in Europe and North America. Although its neurotoxicity has been extensively described, little is known about its ability to strengthen neural circuits when administered in a...
Ritesh Kumar et al.
Biochemistry, 53(13), 2112-2125 (2014-03-15)
Hemophores from Pseudomonas aeruginosa (HasAp), Serratia marcescens (HasAsm), and Yersinia pestis (HasAyp) bind hemin between two loops. One of the loops harbors conserved axial ligand Tyr75 (Y75 loop) in all three structures, whereas the second loop (H32 loop) contains axial...
Florian Noulin et al.
PloS one, 9(11), e112496-e112496 (2014-11-14)
The predilection of Plasmodium vivax (P. vivax) for reticulocytes is a major obstacle for its establishment in a long-term culture system, as this requires a continuous supply of large quantities of reticulocytes, representing only 1-2% of circulating red blood cells....
Zhoumeng Lin et al.
Toxicology, 326, 130-141 (2014-12-03)
Overexposure to the commonly used herbicide atrazine (ATR) affects several organ systems, including the brain. Previously, we demonstrated that short-term oral ATR exposure causes behavioral deficits and dopaminergic and serotonergic dysfunction in the brains of mice. Using adult male C57BL/6...
Kathryn M Nesbitt et al.
ACS chemical neuroscience, 6(1), 163-173 (2014-12-11)
The power of microdialysis for in vivo neurochemical monitoring is a result of intense efforts to enhance microdialysis procedures, the probes themselves, and the analytical systems used for the analysis of dialysate samples. Our goal is to refine microdialysis further...
Ji Ae Lee et al.
British journal of pharmacology, 172(4), 1087-1100 (2014-10-10)
Neuroinflammation through microglial activation is involved in the pathogenesis of neurodegenerative diseases including Parkinson's disease (PD), a major neurodegenerative disorder characterized by dopaminergic neuronal death in the substantia nigra. We examined our novel synthetic compound VSC2 for its anti-inflammatory properties...
Andrii Anatoliyovych Gryshchenko et al.
Journal of enzyme inhibition and medicinal chemistry, 30(1), 126-132 (2014-06-19)
New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been identified. A series of N-phenylnaphthostyril-1-sulfonamides has been synthesized and tested in vitro. It was revealed that the most active compound N-(4-hydroxyphenyl)naphthostyril-1-sulfonamide inhibited FGFR1 with IC50 of 2 µM. In our...
Reihane Seifi Moroudi et al.
Molecular biology reports, 41(12), 8019-8030 (2014-09-07)
One of the important behaviors of dogs is trainability which is affected by learning and memory genes. These kinds of the genes have not yet been identified in dogs. In the current research, these genes were found in animal models...
Alexander P Sobinoff et al.
Biology of reproduction, 92(1), 27-27 (2014-12-05)
Chlamydia trachomatis infections are increasingly prevalent worldwide. Male chlamydial infections are associated with urethritis, epididymitis, and orchitis; however, the role of Chlamydia in prostatitis and male factor infertility remains controversial. Using a model of Chlamydia muridarum infection in male C57BL/6...
Rodrigo A Silva et al.
PloS one, 10(3), e0119020-e0119020 (2015-03-18)
Herein, we provide new contribution to the mechanisms involved in keratinocytes response to hyperosmotic shock showing, for the first time, the participation of Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP) activity in this event. We reported that sorbitol-induced osmotic stress...
Won Seok Yang et al.
Molecular pharmacology, 87(3), 533-542 (2015-01-04)
1,25-Dihydroxyvitamin D3 (1,25D3) has a potential antiatherosclerotic effect through anti-inflammatory actions. We investigated how 1,25D3 regulates tumor necrosis factor-α (TNF-α)-induced lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in cultured human aortic smooth muscle cells. TNF-α activated Rac1/reactive oxygen species/spleen tyrosine...
Almudena Veiga-Lopez et al.
Endocrinology, 156(3), 911-922 (2015-01-21)
Bisphenol A (BPA) is a high production volume chemical and an endocrine disruptor. Developmental exposures to BPA have been linked to adult metabolic pathologies, but the pathways through which these disruptions occur remain unknown. This is a comprehensive interspecies association...
Yun-Hee Lee et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 286-299 (2014-11-14)
This work investigated how cold stress induces the appearance of brown adipocytes (BAs) in brown and white adipose tissues (WATs) of adult mice. In interscapular brown adipose tissue (iBAT), cold exposure increased proliferation of endothelial cells and interstitial cells expressing...
Marina E Emborg et al.
Stereotactic and functional neurosurgery, 92(3), 182-194 (2014-06-20)
The efficacy and safety of intracerebral gene therapy for brain disorders like Parkinson's disease depends on the appropriate distribution of gene expression. To assess whether the distribution of gene expression is affected by vector titer and protein type. Four adult...
O Shimozato et al.
Oncogene, 34(15), 1949-1960 (2014-06-03)
Although CD133 has been considered to be a molecular marker for cancer stem cells, its functional roles in tumorigenesis remain unclear. We here examined the molecular basis behind CD133-mediated signaling. Knockdown of CD133 resulted in the retardation of xenograft tumor...
Jennifer L Anderson et al.
Molecular cancer research : MCR, 12(12), 1740-1754 (2014-08-06)
Members of the Ewing sarcoma family of tumors (ESFT) contain tumor-associated translocations that give rise to oncogenic transcription factors, most commonly EWS/FLI1. EWS/FLI1 plays a dominant role in tumor progression by modulating the expression of hundreds of target genes. Here...
Gabriele Loers et al.
The Biochemical journal, 460(3), 437-446 (2014-03-29)
Lack of permissive mechanisms and abundance of inhibitory molecules in the lesioned central nervous system of adult mammals contribute to the failure of functional recovery, which leads to severe disabilities in motor functions or pain. Previous studies have indicated that...
T-J Park et al.
Oncogene, 33(43), 5121-5132 (2013-10-30)
Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine...
L Schafranek et al.
Leukemia, 29(1), 76-85 (2014-05-13)
Kinase inhibitors block proliferative signals in BCR-ABL1+ leukemic cells, but their capacity to induce apoptosis is poorly understood. Initial studies suggested that very brief exposure to kinase inhibitors was sufficient to induce apoptosis in chronic myeloid leukemia (CML) cells. However...
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