Showing 1-28 of 28 results for "T3126"
Pankaj K Singh et al.
Cytokine, 56(2), 411-421 (2011-09-02)
The purpose of this study was to elucidate the role of granulocyte colony-stimulating factor (G-CSF) induced by α-tocopherol succinate (TS) in protecting mice from total-body irradiation. CD2F1 mice were injected with a radioprotective dose of TS and the levels of...
Xuhui Zhang et al.
The British journal of nutrition, 104(12), 1796-1805 (2010-09-03)
The anti-inflammatory effects of two esters of a-tocopherol (α-TOH), all-rac-α-TOH acetate (DL-α-TOA) and RRR-α-TOH succinate (D-α-TOS), on broilers repeatedly challenged with lipopolysaccharide (LPS) were investigated. Three hundred and twenty 1-d-old broiler chicks were allotted into four treatment groups and fed...
Pengfei Xu et al.
Biomaterials, 64, 10-20 (2015-06-25)
Metastasis is one of the major obstacles for the successful therapy of breast cancer. To inhibit the metastasis and growth of breast cancer simultaneously, a new docetaxel (DTX) loaded shrapnel nano delivery system with the reduction- and enzyme-sensitive properties was...
Liying Hou et al.
PloS one, 10(7), e0132829-e0132829 (2015-07-15)
Vitamin E succinate (VES), a potential cancer therapeutic agent, potently induces apoptosis and inhibits the growth of various cancer cells. Autophagy has been supposed to promote cancer cell survival or trigger cell death, depending on particular cancer types and tumor...
J S Drukteinis et al.
Placenta, 26 Suppl A, S87-S95 (2005-04-20)
Maternal cigarette smoking is known to disrupt placental growth and function. The polyaromatic hydrocarbon benzo[a]pyrene (BaP) is a major toxicant in cigarette smoke that has been shown to alter placental cell function. This study compared the effects of the benzo[a]pyrene...
Myocardial apoptosis and mesenchymal stem cells with acute exercise
Arisi MF, et al.
Physiological Reports, 5(11), e13297-e13297 (2017)
Effects of immunomodulatory nutrients on growth performance and immune-related gene expression in layer chicks challenged with lipopolysaccharide
Wils-Plotz EL and Klasing KC
Poultry Science, 96(3), 548-555 (2017)
K Kluckova et al.
Cell death & disease, 6, e1749-e1749 (2015-05-08)
Respiratory complex II (CII, succinate dehydrogenase, SDH) inhibition can induce cell death, but the mechanistic details need clarification. To elucidate the role of reactive oxygen species (ROS) formation upon the ubiquinone-binding (Qp) site blockade, we substituted CII subunit C (SDHC)...
Wenbin Zhu et al.
PloS one, 9(3), e92992-e92992 (2014-03-26)
Benzo[a]pyrene (BaP), a well-known environmental carcinogen, promotes oxidative stress and DNA damage. Curcumin and vitamin E (VE) have potent antioxidative activity that protects cells from oxidative stress and cellular damage. The objectives of the present study were to investigate the...
Salvatore Rizza et al.
Biochemical pharmacology, 176, 113885-113885 (2020-03-01)
The downregulation of the denitrosylating enzyme S-nitrosoglutathione reductase (GSNOR, EC:, is a feature of hepatocellular carcinoma (HCC). This condition causes mitochondrial rearrangements that sensitize these tumors to mitochondrial toxins, in particular to the mitochondrial complex II inhibitor alpha-tocopheryl succinate (αTOS)....
Maria F Arisi et al.
Physiological reports, 5(11) (2017-06-04)
Aerobic exercise confers many health benefits. However, numerous reports have shown that acute aerobic exercise can injure the heart. We tested the general hypothesis that acute moderate-intensity exercise in rodents induces cardiomyocyte damage and stimulates mesenchymal stem cells (MSCs) to...
Sakthivel Muniyan et al.
Molecular carcinogenesis, 54(8), 618-631 (2014-01-08)
p66Shc functions as a longevity protein in murine and exhibits oxidase activity in regulating diverse biological activities. In this study, we investigated the role of p66Shc protein in regulating ovarian cancer (OCa) cell proliferation. Among three cell lines examined, the...
Vijay K Singh et al.
International immunopharmacology, 9(12), 1423-1430 (2009-09-09)
Vitamin E is composed of a family of eight isomers known as tocols; consisting of four tocopherols and four tocotrienols that exist in four isomeric forms: alpha (alpha), beta (beta), gamma (gamma), and delta (delta). Earlier we have demonstrated the...
Vijay K Singh et al.
International journal of radiation biology, 86(1), 12-21 (2010-01-15)
The purpose of this study was to further elucidate the role of granulocyte-colony stimulating factor (G-CSF)-induced in response to alpha-tocopherol succinate (TS) administration in protecting mice from total body irradiation (TBI). The dose, route, and schedule of TS administration for...
Vitamin E supplementation and cardiovascular events in high-risk patients.
Yusuf S, et al.
The New England Journal of Medicine, 342(3), 154-160 (2000)
Tocopherols, tocotrienols and tocomonoenols: Many similar molecules but only one vitamin E
Azzi A
Redox Biology, 101259-101259 (2019)
Sindhuri Maddineni et al.
AAPS PharmSciTech, 16(2), 444-454 (2014-11-02)
The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the...
Absorption, transport, and tissue delivery of vitamin E
Rigotti A
Molecular Aspects of Medicine, 28(5-6), 423-436 (2007)
Yanyun Xu et al.
International journal of pharmaceutics, 495(2), 792-797 (2015-09-28)
Our recent publication showed that VES-dFdC nanocapsules in pure water could be obtained via the self-assembling of VES-dFdC prodrug synthesized by coupling gemcitabine (dFdC) with vitamin E succinate (VES). To prepare the intravenous injection nanoformulation, we present here a novel...
K L Khanduja et al.
Molecular and cellular biochemistry, 319(1-2), 133-139 (2008-07-22)
We investigated the possible mechanisms of All-trans retinoic acid (ATRA)-promoted apoptosis induced by alpha-tocopherol succinate (alpha-TS) in freshly isolated leukemic cells obtained from chronic myeloid leukemic patients. alpha-TS at 50 microM concentration significantly decreased superoxide dismutase (SOD) activity and reduced...
Tocopherol succinate: modulation of antioxidant enzymes and oncogene expression, and hematopoietic recovery.
Singh VK, Parekh VI, et al.
Int. J. Radiation Oncology Biol. Phys., 79, 571-578 (2011)
alpha-Tocopherol stereoisomers
Jensen S K and Lauridsen C
Vitamins and Hormones, 76, 281-308 (2007)
Richa Bajpai et al.
Nature communications, 11(1), 1228-1228 (2020-03-08)
The BCL-2 antagonist venetoclax is highly effective in multiple myeloma (MM) patients exhibiting the 11;14 translocation, the mechanistic basis of which is unknown. In evaluating cellular energetics and metabolism of t(11;14) and non-t(11;14) MM, we determine that venetoclax-sensitive myeloma has...
Cong-Jun Li et al.
Gene regulation and systems biology, 6, 1-14 (2012-01-24)
To further investigate the potential role of α-tocopherol in maintaining immuno-homeostasis in bovine cells (Madin-Darby bovine kidney epithelial cell line), we undertook in vitro experiments using recombinant TNF-α as an immuno-stimulant to simulate inflammation response in cells with or without...
Pengfei Xu et al.
Biomaterials, 35(26), 7574-7587 (2014-06-06)
Metastasis is one of the major obstacles for the successful therapy of breast cancer. Although increased candidate drugs targeting cancer metastasis are tested, their clinical translation is limited by either serve toxicity or low efficacy. In present work, a nano-drug...
Molecular mechanism of alpha-tocopherol action
Azzi A
Free radical biology & medicine, 43(1), 16-21 (2007)
Dasheng Wang et al.
Journal of medicinal chemistry, 52(18), 5642-5648 (2009-08-28)
This study is aimed at the pharmacological exploitation of alpha-tocopheryl succinate (1) to develop potent antiadhesion agents. Considering the structural cooperativity between the phytyl chain and the carboxylic terminus in determining the antiadhesion activity, our structural optimization led to compound...
Adriana Sampayo-Reyes et al.
Reproductive toxicology (Elmsford, N.Y.), 74, 204-211 (2017-10-23)
Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at...

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