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Véronique Proux-Gillardeaux et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(18), 6362-6367 (2005-04-27)
A role for endocytosis and exocytosis in cell migration has been proposed but not yet demonstrated. Here, we show that cellubrevin (Cb), an early endosomal v-SNARE, mediates trafficking in the lamellipod of migrating epithelial cells and partially colocalizes with markers...
Ana Godinho-Santos et al.
Scientific reports, 6, 30927-30927 (2016-08-05)
HIV-1 relies on the host-cell machinery to accomplish its replication cycle, and characterization of these helper factors contributes to a better understanding of HIV-host interactions and can identify potential novel antiviral targets. Here we explored the contribution of CIB2, previously...
Julia Saez de Guinoa et al.
Journal of immunology (Baltimore, Md. : 1950), 191(5), 2742-2751 (2013-07-23)
Lymphocytes use integrin-based platforms to move and adhere firmly to the surface of other cells. The molecular mechanisms governing lymphocyte adhesion dynamics are however poorly understood. In this study, we show that in mouse B lymphocytes, the actin binding protein...
Samuel J Atkinson et al.
EMBO reports, 19(7) (2018-05-26)
Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which...
David W Erikson et al.
Biology of reproduction, 81(5), 814-825 (2009-07-03)
Conceptus implantation involves pregnancy-specific alterations in extracellular matrix at the conceptus-maternal interface. Secreted phosphoprotein 1 (SPP1, osteopontin) is induced just before implantation and is present at the conceptus-maternal interface in mammals. In the present study, we investigated mechanisms by which...
Hyoungjun Ham et al.
Journal of immunology (Baltimore, Md. : 1950), 190(7), 3661-3669 (2013-03-05)
Recently, patients with mutations in DOCK8 have been reported to have a combined immunodeficiency characterized by cutaneous viral infections and allergies. NK cells represent a first-line defense against viral infections, suggesting that DOCK8 might participate in NK cell function. In...
Guoqiang Zhang et al.
Laboratory investigation; a journal of technical methods and pathology, 91(1), 106-123 (2010-07-28)
The nicotinic acetylcholine receptor α1 (nAChRα1) was investigated as a potential proinflammatory molecule in the kidney, given a recent report that it is an alternative urokinase plasminogen activator (uPA) receptor, in addition to the classical receptor uPAR. Two animal models...
D R Critchley
Biochemical Society transactions, 32(Pt 5), 831-836 (2004-10-21)
The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such...
Sophie Clément et al.
Journal of cell science, 118(Pt 7), 1395-1404 (2005-03-17)
We have previously shown that the N-terminal sequence AcEEED of alpha-smooth-muscle actin causes the loss of alpha-smooth-muscle actin from stress fibers and a decrease in cell contractility when introduced in myofibroblasts as a cell-penetrating fusion peptide. Here, we have investigated...
J A Girón et al.
Infection and immunity, 64(1), 197-208 (1996-01-01)
Mycoplasma penetrans adhered to cultured human cells, forming clusters that localized to specific areas of the host cell surface. Adherence and cluster formation were inhibited by anti-M. penetrans antibodies, suggesting the involvement of specific adhesin-receptor interactions. Ultrastructural studies showed that...
Jana Musilkova et al.
Journal of materials science. Materials in medicine, 26(11), 253-253 (2015-10-10)
Protein-repulsive surfaces modified with ligands for cell adhesion receptors have been widely developed for controlling the cell adhesion and growth in tissue engineering. However, the question of matrix production and deposition by cells on these surfaces has rarely been addressed....
Severin Ruoss et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 36(1), 272-281 (2017-06-03)
Previous studies suggested that degradation of contractile tissue requires cleavage of the costamere, a structural protein complex that holds sarcomeres in place. This study examined if costamere turnover is affected by a rotator cuff tear in a previously established ovine...
Jia Tong Loh et al.
iScience, 10, 23-39 (2018-11-30)
Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive. Here we demonstrate that Ezh2 controls cutaneous tolerance by regulating Langerhans cell (LC) transmigration across the epidermal basement membrane directly via Talin1...
Olga Iendaltseva et al.
Stem cell reports, 14(6), 1107-1122 (2020-05-30)
Pericytes (PCs) have been reported to contribute to the mechanoregulation of the capillary diameter and blood flow in health and disease. How this is realized remains poorly understood. We designed several models representing basement membrane (BM) in between PCs and...
Yingjie Xu et al.
The Journal of experimental medicine, 207(11), 2421-2437 (2010-10-13)
The actin cross-linking protein filamin A (FLNa) functions as a scaffolding protein and couples cell cytoskeleton to extracellular matrix and integrin receptor signaling. In this study, we report that FLNa suppresses invasion of breast cancer cells and regulates focal adhesion...
Bertille Bance et al.
Journal of cell science, 132(7) (2019-03-13)
Microtubules play a crucial role in mesenchymal migration by controlling cell polarity and the turnover of cell adhesive structures on the extracellular matrix. The polarized functions of microtubules imply that microtubules are locally regulated. Here, we investigated the regulation and...
Wan Jun Gan et al.
Cell reports, 24(11), 2819-2826 (2018-09-13)
The extracellular matrix (ECM) critically affects β cell functions via integrin activation. But whether these ECM actions drive the spatial organization of β cells, as they do in epithelial cells, is unknown. Here, we show that within islets of Langerhans...
Amelie Witte et al.
Molecular and cellular biology, 37(7) (2017-01-06)
The β2-integrin lymphocyte function-associated antigen 1 (LFA-1) is needed for the T cell receptor (TCR)-induced activation of LFA-1 to promote T cell adhesion and interaction with antigen-presenting cells (APCs). LFA-1-mediated cell-cell interactions are critical for proper T cell differentiation and...
Yukie Yamahashi et al.
Biomedical microdevices, 17(5), 100-100 (2015-09-12)
Directed neutrophil migration in blood vessels and tissues is critical for proper immune function; however, the mechanisms that regulate three-dimensional neutrophil chemotaxis remain unclear. It has been shown that integrins are dispensable for interstitial three-dimensional (3D) leukocyte migration; however, the...
Abhishek Kumar et al.
The Journal of cell biology, 218(8), 2481-2491 (2019-07-19)
Cell sensing of externally applied mechanical strain through integrin-mediated adhesions is critical in development and physiology of muscle, lung, tendon, and arteries, among others. We examined the effects of strain on force transmission through the essential cytoskeletal linker talin. Using...
Robert C Burghardt et al.
Reproduction (Cambridge, England), 137(3), 567-582 (2008-12-09)
The integrity of the fetal-maternal interface is critical for proper fetal nourishment during pregnancy. Integrins are important adhesion molecules present at the interface during implantation; however, in vivo evidence for integrin activation and focal adhesion formation at the maternal-conceptus interface...
ChangDong Lin et al.
Immunity, 50(1), 137-151 (2019-01-17)
Fever is an evolutionarily conserved response that confers survival benefits during infection. However, the underlying mechanism remains obscure. Here, we report that fever promoted T lymphocyte trafficking through heat shock protein 90 (Hsp90)-induced α4 integrin activation and signaling in T cells....
Louis Tong et al.
Biochimica et biophysica acta, 1833(6), 1304-1315 (2013-03-08)
Migration of cells in the ocular surface underpins physiological wound healing as well as many human diseases. Transglutaminase (TG)-2 is a multifunctional cross-linking enzyme involved in the migration of skin fibroblasts and wound healing, however, its functional role in epithelial...
Aki Stubb et al.
Nature communications, 10(1), 4756-4756 (2019-10-20)
While it is clear that key transcriptional programmes are important for maintaining pluripotency, the requirement for cell adhesion to the extracellular matrix remains poorly defined. Human pluripotent stem cells (hPSCs) form colonies encircled by an actin ring and large stable cornerstone...
Juliette Sauveur et al.
Oncotarget, 9(30), 21141-21155 (2018-05-17)
Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate that specifically targets HER2 thanks to its antibody component trastuzumab. In spite of responses to this novel agent, acquired resistance to treatment remains a major obstacle. Prolonged in vitro exposure of the gastroesophageal junction...
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration
Chiang YJ, et al.
PLoS ONE, 8(4), e61761-e61761 (2013)
Shawn F Bairstow et al.
The Journal of biological chemistry, 281(29), 20632-20642 (2006-05-19)
Clathrin-coated vesicles mediate sorting and intracellular transport of membrane-bound proteins. The formation of these coats is initiated by the assembly of adaptor proteins (AP), which specifically bind to membrane cargo proteins via recognition of endocytic sorting motifs. The lipid signaling...
Koen van den Dries et al.
Nature communications, 10(1), 5171-5171 (2019-11-16)
Basement membrane transmigration during embryonal development, tissue homeostasis and tumor invasion relies on invadosomes, a collective term for invadopodia and podosomes. An adequate structural framework for this process is still missing. Here, we reveal the modular actin nano-architecture that enables...
Hui-Yuan Tseng et al.
Journal of molecular biology, 426(18), 3180-3194 (2014-07-16)
Trafficking of α5β1 integrin to lysosomes and its subsequent degradation is influenced by ligand occupancy and the binding of SNX17 via its protein 4.1, ezrin, radixin, moesin (FERM) domain to the membrane-distal NPxY motif in the cytoplasmic domain of β1...
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