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Injae Hwang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2397-2411 (2015-02-26)
Firmicutes and Bacteroidetes, 2 major phyla of gut microbiota, are involved in lipid and bile acid metabolism to maintain systemic energy homeostasis in host. Recently, accumulating evidence has suggested that dietary changes promptly induce the alteration of abundance of both
Mao Taketani et al.
Nature biotechnology, 38(8), 962-969 (2020-04-02)
Bacteroides thetaiotaomicron is a human-associated bacterium that holds promise for delivery of therapies in the gut microbiome1. Therapeutic bacteria would benefit from the ability to turn on different programs of gene expression in response to conditions inside and outside of
Shlomit David et al.
Foods (Basel, Switzerland), 9(9) (2020-09-11)
There is a need to better understand the possible anti-nutritional effect of food stabilizers on the digestibility of important macronutrients, like proteins. This study hypothesized that the anionic nature of κ-, ι-, λ-, Carrageenan (CGN) and xanthan gum directs their
Sebastiaan Bijttebier et al.
Food chemistry, 165, 371-378 (2014-07-21)
Food processing enterprises produce enormous amounts of organic waste that contains valuable phytochemicals (e.g. C17-polyacetylenes). Knowledge on the phytochemicals content is a first step towards valorisation. Quantification of C17-polyacetylenes is however often hampered by the lack of commercially available standards
Jhansi L Leslie et al.
mSphere, 4(1) (2019-02-01)
Clostridium (Clostridioides) difficile, a Gram-positive, anaerobic bacterium, is the leading single cause of nosocomial infections in the United States. A major risk factor for Clostridium difficile infection (CDI) is prior exposure to antibiotics, as they increase susceptibility to CDI by
Studies on the adsorption of bile salts to non-absorbed components of diet.
M A Eastwood et al.
Biochimica et biophysica acta, 152(1), 165-173 (1968-01-10)
Tiantian Lin et al.
Food chemistry, 310, 125699-125699 (2019-12-08)
The capacity of high-fiber foods to sequester BS during digestion is considered a mechanism to lower serum-cholesterol. We investigated the effect of hydrothermal (HT) and high-hydrostatic-pressure (HHP) on the bile salt (BS)-binding ability of dry beans, and how this relates
Sean T Koester et al.
STAR protocols, 2(4), 100938-100938 (2021-11-23)
Gastrointestinal motility is regulated by a variety of environmental factors including gut microbes and metabolites. The ability to interrogate mouse models of gut motility has enabled elucidation of these relationships. Here we describe integration of the red carmine dye and
Lei Li et al.
World journal of gastroenterology, 26(12), 1317-1328 (2020-04-08)
We studied the protective effects of Qingyi decoction (QYD) (a Traditional Chinese Medicine) against severe acute pancreatitis (SAP)-induced myocardial infarction (MI). To study the function and mechanism of QYD in the treatment of myocardial injuries induced by SAP. Ultrasonic cardiography
Amal Salhi et al.
Biochimie, 169, 106-120 (2019-07-10)
Porcine pancreatic extracts (PPE), also named pancreatin, are commonly used as a global source of pancreatic enzymes for enzyme replacement therapy in patients with exocrine pancreatic insufficiency. They are considered as a good substitute of human pancreatic enzymes and they
Ambre Riba et al.
Science translational medicine, 12(565) (2020-10-16)
Although infection with the human enteropathogen Giardia lamblia causes self-limited diarrhea in adults, infant populations in endemic areas experience persistent pathogen carriage in the absence of diarrhea. The persistence of this protozoan parasite in infants has been associated with reduced
Wycliffe O Masanta et al.
Proteomics. Clinical applications, 13(3), e1800083-e1800083 (2018-09-25)
Bile acids are crucial components of the intestinal antimicrobial defense and represent a significant stress factor for enteric pathogens. Adaptation processes of Campylobacter jejuni to this hostile environment are analyzed in this study by a proteomic approach. Proteome profiling by
Pernille Barbre Pedersen et al.
Pharmaceutical research, 31(8), 2044-2053 (2014-02-20)
To develop a minimally-invasive method for direct visualization of drug delivery systems in the human stomach and to compare the obtained results with an established in vitro model. The method should provide the capsule rupture, dispersion characteristics, and knowledge regarding
Jeffrey R Maslanka et al.
Gut microbes, 12(1), 1-15 (2020-12-12)
Clostridioides difficile is an enteric bacterial pathogen that can a cause nosocomial infection leading to debilitating colitis. The development of a murine model of C. difficile infection has led to fundamental discoveries in disease pathogenesis and the host immune response
Sang-Nee Tan et al.
BMC medical genomics, 12(1), 9-9 (2019-01-17)
It has been found that chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC). CRS can be caused by gastro-oesophageal reflux (GOR) that may reach nasopharynx. The major component of refluxate, bile acid (BA) has been found to
Qing-Rui Cui et al.
Shock (Augusta, Ga.), 52(5), e107-e116 (2018-12-19)
Fluid resuscitation is the first-line antishock treatment in severe acute pancreatitis (SAP). Currently, although mentions of complications related to aggressive fluid resuscitation are very frequent, a lack of proper handling of complications remains. One of the most important complications is
Ling Li et al.
Molecular cell, 80(3), 525-540 (2020-10-18)
Well-balanced and timed metabolism is essential for making a high-quality egg. However, the metabolic framework that supports oocyte development remains poorly understood. Here, we obtained the temporal metabolome profiles of mouse oocytes during in vivo maturation by isolating large number of
Xuan Guo et al.
Rejuvenation research, 18(3), 211-224 (2015-01-06)
Pluripotent human hepatic stem cells have broad research and clinical applications, which are, however, restricted by both limited resources and technical difficulties with respect to isolation of stem cells from the adult or fetal liver. In this study, we developed
Paloma Benito-Gallo et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 93, 353-362 (2015-05-06)
Triglycerides (TG) are one of the most common excipients used in oral lipid-based formulations. The chain length of the TG plays an important role in the oral bioavailability of the co-administered drug. Fatty acid (FA) chain-length specificity of porcine pancreatic
Joseph J Orsini et al.
Clinica chimica acta; international journal of clinical chemistry, 413(15-16), 1270-1273 (2012-05-03)
We sought to modify a previously published tandem mass spectrometry method of screening for 5 lysosomal storage disorders (LSDs) in order to make it better suited for high-throughput newborn screening. Two 3-mm dried blood spot (DBS) punches were incubated, each
Tiantian Lin et al.
MethodsX, 8, 101389-101389 (2021-08-26)
Bile salts (BS) play a key role in cholesterol and lipid metabolism as well as in many other key metabolic pathways. High performance liquid chromatography (HPLC) is the most common technique used to analyze BS in diverse type of samples.
Isabel Veloso Alves Pereira et al.
PloS one, 10(2), e0117152-e0117152 (2015-02-04)
The sodium-taurocholate cotransporting polypeptide (NTCP) is both a key bile acid (BA) transporter mediating uptake of BA into hepatocytes and an essential receptor for hepatitis B virus (HBV) and hepatitis D virus (HDV). In this study we aimed to characterize
Patrycja Szumała et al.
Food chemistry, 351, 129356-129356 (2021-03-02)
Nanoemulsions are currently of interest in the functional food sector because their small droplet size (100-500 nm) provides a number of potential advantages over conventional emulsions. This study concerned the behavior of nanoemulsions stabilized with whey proteins and two synthetic emulsifiers
Line Hagner Nielsen et al.
International journal of pharmaceutics, 490(1-2), 334-340 (2015-06-01)
A glass solution of the amorphous sodium salt of furosemide (ASSF) and polyvinylpyrrolidone (PVP) (80:20 w/w%) was prepared by spray drying. It was investigated if PVP was able to stabilise ASSF during storage and dissolution and whether this influenced the
Miguel García-Parra et al.
Plants (Basel, Switzerland), 10(10) (2021-10-24)
The existence of more of 16,000 varieties of quinoa accessions around the world has caused a disregard on their structural and phytochemical characteristics. Most of such accessions belong to cultivars settled in Colombia. The goal of this research was to
Lisa C Lindesmith et al.
Cellular and molecular gastroenterology and hepatology, 10(2), 245-267 (2020-04-15)
Human norovirus infection is the leading cause of acute gastroenteritis. Genetic polymorphisms, mediated by the FUT2 gene (secretor enzyme), define strain susceptibility. Secretors express a diverse set of fucosylated histoblood group antigen carbohydrates (HBGA) on mucosal cells; nonsecretors (FUT2-/-) express
Yanxia Wei et al.
BMC infectious diseases, 19(1), 46-46 (2019-01-13)
Clostridium difficile (C. difficile) is a main cause of antibiotic-associated diarrhoea in humans. Several studies have been performed to reveal the prevalence rate of C. difficile in cats and dogs. However, little is known about the epidemiology of C. difficile
Nermina Vejzagić et al.
Parasitology research, 114(7), 2705-2714 (2015-05-27)
Eggs of the pig whipworm, Trichuris suis ova (TSO), are currently tested in human clinical trials for their potential immunomodulatory capacity. The biological potency of TSO (egg viability and infectivity) is traditionally assessed in Göttingen minipigs as the establishment of
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