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Sunwoo Park et al.
Journal of hazardous materials, 386, 121639-121639 (2019-12-04)
Aflatoxin B1 is one of the well-known mycotoxins and mainly found in contaminated animal feed and various agricultural products inducing acute and chronic toxicology, tumor, and abnormal neural development. However, the effects of aflatoxin B1 on the human brain, especially...
Min Wang et al.
Frontiers in pharmacology, 8, 353-353 (2017-06-24)
Modulation of oxidative stress is therapeutically effective in ischemia/reperfusion (I/R) injury. Myricitrin, a naturally occurring phenolic compound, is a potent antioxidant. However, little is known about its effect on I/R injury to cardiac myocytes. The present study was performed to...
Mohammed H A Almarzoug et al.
Environmental toxicology, 35(9), 930-941 (2020-04-21)
Platinum nanoparticles (PtNPs) attract much attention due to their excellent biocompatibility and catalytic properties, but their toxic effects on normal (CHANG) and cancerous (HuH-7) human liver cells are meagre. The cytotoxic and apoptotic effects of PtNPs (average size, 3 nm) were...
Lele Guo et al.
PloS one, 10(4), e0124002-e0124002 (2015-04-14)
Treatment of systemic lupus erythematosus (SLE), a chronic inflammatory disease, involves the long-term use of immunosuppressive agents with significant side effects. New therapeutic approaches are being explored to find better treatment possibilities. In this study, age-matched female MRL/lpr mice were...
Maria C Franco et al.
The Journal of biological chemistry, 290(31), 19055-19066 (2015-06-19)
Peroxynitrite production and tyrosine nitration are present in several pathological conditions, including neurodegeneration, stroke, aging, and cancer. Nitration of the pro-survival chaperone heat shock protein 90 (Hsp90) in position 33 and 56 induces motor neuron death through a toxic gain-of-function....
Seyma Aydinlik et al.
Biochimica et biophysica acta. General subjects, 1863(5), 903-916 (2019-03-03)
It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces autophagy in cancer cells. This study aimed to investigate...
Jayme P Coyle et al.
Particle and fibre toxicology, 17(1), 40-40 (2020-08-14)
Engineered nanomaterials are increasingly being incorporated into synthetic materials as fillers and additives. The potential pathological effects of end-of-lifecycle recycling and disposal of virgin and nano-enabled composites have not been adequately addressed, particularly following incineration. The current investigation aims to...
Wei Hong et al.
Scientific reports, 7, 42465-42465 (2017-02-15)
Pluronic L61 unimers, which are biomacromolecular modulators, and curcumin, a small-molecule modulator, were co-formulated into pH-sensitive micelles to reveal the full synergistic potential of combination drug treatments to reverse multidrug resistance (MDR). Compared to monotherapy, combined therapy significantly improved the...
Xueliang Su et al.
OncoTargets and therapy, 13, 277-289 (2020-02-06)
Colorectal cancer is a leading cause of cancer-related death in the world. Despite cisplatin is a commonly used chemotherapeutic drug for the colorectal cancer treatment, resistance of cancer cells to cisplatin restricts its clinical efficacy. It is important to explore...
Chunxiao Zhang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 50, 217-224 (2018-03-24)
Hematotoxicity of benzene is derived mainly from its active metabolite, 1,4-Benzoquinone (1,4-BQ), which induces cell apoptosis and mitochondrial damage. Damaged mitochondria are degraded through a specialized autophagy pathway, called mitophagy, which is driven by PINK1/Parkin signaling. However, whether mitophagy is...
Williams Bravo et al.
Animal reproduction science, 216, 106344-106344 (2020-05-18)
The aim of this study was to evaluate effects of selection using the Percoll density gradient method on motility, mitochondrial membrane potential (ΔΨMit) and fertility in a subpopulation of testicular spermatozoa obtained from Atlantic salmon (Salmo salar). Samples were divided...
Zhiqiang Ren et al.
Animal reproduction science, 210, 106178-106178 (2019-10-23)
Liquid preservation of boar semen is a preferred method in pig husbandry, and antioxidants to protect against sperm oxidative stress during periods of storage have become the focus of recent research. Through its antioxidant activity, Isatis root polysaccharide (IRPS), a...
Yael Haberman et al.
Nature communications, 10(1), 38-38 (2019-01-04)
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We...
Tauane G Soyer et al.
Experimental parasitology, 199, 30-37 (2019-03-01)
The treatment against leishmaniasis presents problems, since the currently used drugs are toxic and/or have high costs. In addition, parasite resistance has increased. As a consequence, in this study, a chloroquinolin derivative, namely 7-chloro-N,N-dimethylquinolin-4-amine or GF1059, was in vitro and...
Xin Zhou et al.
Toxicology in vitro : an international journal published in association with BIBRA, 44, 392-402 (2017-08-15)
A high‑zinc (Zn) diet has been found to promote growth performance in pigs, but causes cell apoptosis in the intestinal epithelium. To investigate the mechanism underlying the high dietary Zn-induced apoptosis in porcine small intestinal epithelium, IPEC-J2 cells (intestinal porcine...
Takahito Miyake et al.
Glia, 63(10), 1870-1882 (2015-05-27)
Microglia, the resident immune cells in the brain, survey the environment of the healthy brain. Microglial migration is essential for many physiological and pathophysiological processes. Although microglia express some members of the transient receptor potential (TRP) channel family, there is...
Xunmin Ji et al.
Toxicology, 334, 22-32 (2015-05-20)
Heavy metals are common environmental toxicants with adverse effects on steroid biosynthesis. The importance of mitochondria has been recognized in cytotoxic mechanism of heavy metals on Leydig cells these years. But it is still poorly known. Our previous study reported...
Microcystin-LR exposure results in aberrant spindles and induces apoptosis in porcine oocytes.
Shi, et al.
Theriogenology, 158, 358-367 (2020)
Toshiyuki Matsunaga et al.
Chemico-biological interactions, 279, 10-20 (2017-11-08)
9,10-Phenanthrenequinone (PQ), a major quinone component in diesel exhaust particles, is considered to provoke damage of respiratory and vascular cells through highly producing reactive oxygen species (ROS), but little is known about its pathophysiological role in neuronal cell damage. In...
Xiaoyang Kong et al.
Oncology reports, 37(6), 3423-3432 (2017-05-13)
Although the patients with t(8;21) acute myeloid leukemia (AML) have a favorable prognosis compared with other non-acute promyelocytic leukemia AML patients, only ~50% patients with this relatively favorable subtype can survive for 5 years and refractory/relapse is common in clinical practice....
Zong-Ze Wu et al.
Marine drugs, 16(4) (2018-04-13)
Anthopleura anjunae anti-tumor peptide (AAP-H) is a pentapeptide from the sea anemone Anthopleura anjunae with an amino acid sequence of Tyr-Val-Pro-Gly-Pro that is obtained by alkaline protease enzymatic hydrolysis extraction. In this study, we investigated the inhibitory effects of AAP-H...
You-Jun Zhang et al.
Basic research in cardiology, 115(5), 57-57 (2020-08-12)
Microvascular damage is a key pathological change in myocardial ischemia/reperfusion (I/R) injury. Using a rat model of myocardial I/R, our current study has provided the first evidence that nicotinamide adenine dinucleotide (NAD+) administration can significantly attenuate myocardial I/R-induced microvascular damage...
Yali Zhang et al.
Oncology reports, 38(6), 3319-3326 (2017-10-19)
Finding effective strategies against colorectal cancer (CRC) is still an emergent health problem. In the present study, we investigated the anticancer activity of quercetrin from Toona sinensis leaves (QTL) and explored the underlying mechanism in human CRC cell line SW620. The...
Yang Huang et al.
Experimental eye research, 169, 68-78 (2018-02-07)
Mitochondrial components are of great importance for the maintenance of lens transparency. In our previous work, we confirmed that carbon monoxide (CO) can protect human and rabbit lens epithelial cells (LECs) from hydrogen peroxide (H2O2)-mediated apoptosis, while the mechanism remains...
Yajing Liu et al.
Scientific reports, 10(1), 18515-18515 (2020-10-30)
Several literature has shown that salinomycin (Sal) is able to kill various types of cancer cells through different signaling pathways. However, its effect on melanoma has seldom been reported. We examined the anti-cancer efficacy of Sal in melanoma cell lines...
Ozge Cevik et al.
The Journal of biological chemistry, 292(52), 21676-21689 (2017-10-29)
Hepatitis C virus (HCV) infection is a major risk factor for the development of chronic liver disease. The disease typically progresses from chronic HCV to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and death. Chronic inflammation associated with HCV infection is implicated...
Erhong Zhang et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 74(5), 457-466 (2015-08-20)
Male obesity has been linked to subfecundity. This study is to investigate the effects of GLP-1 receptor (GLP-1R) agonist exenatide on sperm quality in high-fat diet (HFD)-induced obese mice. After 12 weeks of chow diet (CD) or HFD challenge, mice...
Mei-Jia Lin et al.
Stem cell research & therapy, 11(1), 225-225 (2020-06-10)
Acetaminophen (APAP) overdose is the common cause of acute liver failure (ALF) due to the oxidative damage of multiple cellular components. This study aimed to investigate whether plasma membrane vesicles (PMVs) from human umbilical cord mesenchymal stem cells (hUCMSCs) could...
Meng Shao et al.
Evidence-based complementary and alternative medicine : eCAM, 2018, 6049498-6049498 (2018-07-27)
Xihuang pill (XHP), a traditional Chinese herbal formula, has long been used as an effective agent against multiple tumors. The aim of this study is to evaluate the effects of XHP on the growth inhibition and apoptosis in glioblastoma U-87...
Yanjun Wang et al.
OncoTargets and therapy, 12, 1867-1880 (2019-03-19)
Chemotherapy after surgery can prolong the survival of patients with gliomas. Dimethylaminomicheliolide (DMAMCL), a novel chemotherapeutic agent, exhibited antitumor properties in acute myeloid leukemia stem cells and showed an increased drug concentration in the brain. This study aims to investigate...
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