Showing 1-21 of 21 results for "T5530"
Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes.
Guthrie, et al.
Journal of Molecular Neuroscience, 45, 32-41 (2018)
Jerel A Fields et al.
Journal of neurovirology, 23(2), 290-303 (2017-01-21)
Despite the success of antiretroviral therapies to control systemic HIV-1 infection, the prevalence of HIV-associated neurocognitive disorders (HANDs) has not decreased among aging patients with HIV. Autophagy pathway alterations, triggered by HIV-1 proteins including gp120, Tat, and Nef, might contribute...
Huishan Guo et al.
The American journal of pathology, 165(2), 523-531 (2004-07-28)
Previously, we have shown that caspase-6 but not caspase-3 is activated by serum deprivation and induces a protracted cell death in primary cultures of human neurons (LeBlanc AC, Liu H, Goodyer C, Bergeron C, Hammond J: Caspase-6 role in apoptosis...
Severity of gliosis in Pick?s disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders
Schofield E, et al.
Brain, 126(4), 827-840 (2003)
S Alladi et al.
Brain : a journal of neurology, 130(Pt 10), 2636-2645 (2007-09-28)
To determine the frequency of Alzheimer's disease (AD) pathology in patients presenting with progressive focal cortical syndromes, notably posterior cortical atrophy (PCA), corticobasal syndrome (CBS), behavioural variant frontotemporal dementia (bvFTD), progressive non-fluent aphasia (PNFA) (or a mixed aphasia) and semantic...
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
Buee L, et al.
Brain Research Reviews, 33(1), 95-130 (2000)
Davide Pintus et al.
Acta veterinaria Scandinavica, 58(1), 37-37 (2016-06-09)
Neuroaxonal dystrophy (NAD) is a neurodegenerative condition affecting humans and animals characterized by the widespread presence of swollen axons (spheroids). Herein, we report the pathological findings in a case of neuroaxonal dystrophy in a Dachshund-cross puppy, which was euthanized because...
Glenda M Halliday et al.
Brain : a journal of neurology, 128(Pt 10), 2272-2280 (2005-07-15)
Changes in motor cortical activation are associated with the major symptoms observed in both Parkinson's disease and progressive supranuclear palsy (PSP). While research has concentrated on basal ganglia abnormalities as central to these cortical changes, several studies in both disorders...
Inhibition of microRNA-203 protects against traumatic brain injury induced neural damages via suppressing neuronal apoptosis and dementia-related molecues.
Zhao, et al.
Physiology & Behavior, 228, 113190-113190 (2021)
K M Cullen et al.
Journal of neurology, neurosurgery, and psychiatry, 63(3), 315-320 (1997-11-05)
The cholinergic nucleus basalis (Ch4) is an exclusive site of neurofibrillary degeneration in alcoholic patients with Wernicke's encephalopathy. To test the hypothesis that the loss of Ch4 neurons contributes to the memory disorder, Korsakoff's psychosis, commonly seen in Wernicke's encephalopathy....
Shiyao Wang et al.
Biotechnology progress, 36(1), e2920-e2920 (2019-10-04)
Microtubule-associated protein tau is an intrinsically disordered, highly soluble protein found primarily in neurons. Under normal conditions, tau regulates the stability of axonal microtubules and intracellular vesicle transport. However, in patients of neurodegeneration such as Alzheimer's disease (AD), tau forms...
Emma C Schofield et al.
Movement disorders : official journal of the Movement Disorder Society, 26(2), 256-263 (2011-03-18)
To determine whether brain atrophy differs between the two subtypes of progressive supranuclear palsy (PSP), Richardson's syndrome (PSP-RS), and PSP parkinsonism (PSP-P), and whether such atrophy directly relates to clinical deficits and the severity of tau deposition. We compared 24...
Lee A Shapiro et al.
Cardiovascular psychiatry and neurology, 2010 (2010-09-10)
S100B promotes development and maturation in the mammalian brain. However, prolonged or extensive exposure can lead to neurodegeneration. Two important functions of S100B in this regard, are its role in the development and plasticity of the serotonergic neurotransmitter system, and...
M A Hely et al.
Journal of neurology, neurosurgery, and psychiatry, 60(5), 531-538 (1996-05-01)
To further elucidate the relation between diffuse Lewy body disease and Parkinson's disease. The clinical features of nine cases of pure diffuse Lewy body disease without pathological evidence of coexisting Alzheimer's neuritic pathology were reported. All patients were aged less...
Helena R Zimmermann et al.
The Journal of clinical investigation, 130(7), 3511-3527 (2020-03-28)
AMPK is a key regulator at the molecular level for maintaining energy metabolism homeostasis. Mammalian AMPK is a heterotrimeric complex, and its catalytic α subunit exists in 2 isoforms: AMPKα1 and AMPKα2. Recent studies suggest a role of AMPKα overactivation...
Nosrat Nourbakhsh et al.
The International journal of developmental biology, 55(2), 189-195 (2011-06-15)
Stem cells from human exfoliated deciduous teeth (SHED) are highly proliferative, clonogenic and multipotent stem cells with a neural crest cell origin. Additionally, they can be collected with minimal invasiveness in comparison with other sources of mesenchymal stem cells (MSCs)....
Anna Mietelska-Porowska et al.
Journal of neuroscience methods, 319, 47-59 (2018-11-19)
Background Tauopathies, including Alzheimer's disease (AD), are multifactorial diseases with strong phenotypic and genetic heterogeneity. Recent evidence revealed that mechanisms of pathogenesis of early (hereditary) and late (sporadic) forms of AD are different. This is not properly reflected in current...
Melissa Broe et al.
Brain : a journal of neurology, 127(Pt 10), 2214-2220 (2004-07-30)
The main unifying feature of cases with frontotemporal dementia (FTD) is the pattern of brain atrophy. Surprisingly, there are a variety of underlying histopathologies in cases with the clinical features and typical pattern of atrophy characterizing FTD. This suggests that...
R Rhys Davies et al.
Brain : a journal of neurology, 128(Pt 9), 1984-1995 (2005-07-08)
Semantic dementia is a syndrome of progressive deterioration in semantic memory (knowledge of objects, people, concepts and words). It falls within the clinical spectrum of frontotemporal dementia but its pathology is yet to be studied systematically. This study included 18...
M Broe et al.
Acta neuropathologica, 101(6), 616-624 (2001-08-23)
This aim of the present study was to identify whether apoptotic features relate to the degree of cortical neuronal loss in cases with variable cortical degeneration. Neuronal apoptosis was assessed using histochemical and morphological criteria in cases with Alzheimer's disease...
S C Papasozomenos et al.
Cell motility and the cytoskeleton, 8(3), 210-226 (1987-01-01)
The monoclonal antibody, Tau-1, which had previously been used to localize tau to the axonal compartment in brain has been reutilized for light and electron microscopic immunohistochemistry following phosphatase treatment of tissue. We report here that a significant quantity of...

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