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Jinzhi Duan et al.
Genome biology, 19(1), 192-192 (2018-11-10)
CRISPR/dCas9 is a versatile tool that can be used to recruit various effectors and fluorescent molecules to defined genome regions where it can modulate genetic and epigenetic markers, or track the chromatin dynamics in live cells. In vivo applications of
Kanako Miyabayashi et al.
PloS one, 8(6), e68050-e68050 (2013-07-11)
Development of the testis begins with the expression of the SRY gene in pre-Sertoli cells. Soon after, testis cords containing Sertoli and germ cells are formed and fetal Leydig cells subsequently develop in the interstitial space. Studies using knockout mice
Amandine Cartier-Michaud et al.
PloS one, 7(2), e32204-e32204 (2012-03-01)
The microenvironment of a tumor can influence both the morphology and the behavior of cancer cells which, in turn, can rapidly adapt to environmental changes. Increasing evidence points to the involvement of amoeboid cell migration and thus of cell blebbing
Jaclyn M Fingerhut et al.
The Journal of cell biology, 219(9) (2020-07-25)
Cytoplasmic cilia, a specialized type of cilia in which the axoneme resides within the cytoplasm rather than within the ciliary compartment, are proposed to allow for the efficient assembly of very long cilia. Despite being found diversely in male gametes
Qiji Li et al.
Biochemical and biophysical research communications, 486(4), 872-878 (2017-03-25)
Transforming acidic coiled-coil (TACC3), a member of the TACC family, has been shown to be deregulated in various cancers and involved in tumor progression. However, its biological role and molecular mechanism in prostate cancer (PCa) have not been elucidated. Herein
Anna A W M Sanders et al.
Molecular biology of the cell, 28(23), 3181-3192 (2017-09-22)
Noncentrosomal microtubule (MT) nucleation at the Golgi generates MT network asymmetry in motile vertebrate cells. Investigating the Golgi-derived MT (GDMT) distribution, we find that MT asymmetry arises from nonrandom nucleation sites at the Golgi (hotspots). Using computational simulations, we propose
J T Jamison et al.
Neuroscience, 199, 394-400 (2011-10-08)
Following global brain ischemia and reperfusion, it is well-established that neurons undergo a translation arrest that is reversible in surviving neurons, but irreversible in vulnerable neurons. We previously showed a correlation between translation arrest in reperfused neurons and the presence
E Salas et al.
Oncogene, 35(22), 2913-2922 (2015-10-06)
Despite immense interest in using antimalarials as autophagy inhibitors to treat cancer, it remains unclear whether these agents act predominantly via autophagy inhibition or whether other pathways direct their anti-cancer properties. By comparing the treatment effects of the antimalarials chloroquine
Wanchuan Zhang et al.
Cell reports, 30(3), 725-738 (2020-01-23)
Recent reports have shown the critical role of the mitochondrial antiviral signaling (MAVS) protein in virus-induced apoptosis, but the involvement of MAVS in tumorigenesis is still poorly understood. Herein, we report that MAVS is a key regulator of p53 activation
Liying Liang et al.
Journal of cell science, 132(10) (2019-04-28)
The cancer clinical therapy of doxorubicin (Dox) treatment is limited by its life-threatening cardiotoxic effects. Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad
Kirstin Meyer et al.
Molecular systems biology, 16(2), e8985-e8985 (2020-02-25)
The mechanisms of organ size control remain poorly understood. A key question is how cells collectively sense the overall status of a tissue. We addressed this problem focusing on mouse liver regeneration. Using digital tissue reconstruction and quantitative image analysis
Junxiang Zhou et al.
The Journal of cell biology, 218(2), 580-597 (2018-12-24)
Amino acid catabolism is frequently executed in mitochondria; however, it is largely unknown how aberrant amino acid metabolism affects mitochondria. Here we report the requirement for mitochondrial saccharopine degradation in mitochondrial homeostasis and animal development. In Caenorhbditis elegans, mutations in
Anders P Mutvei et al.
Nature communications, 11(1), 1416-1416 (2020-03-19)
The kinase mTOR complex 1 (mTORC1) promotes cellular growth and is frequently dysregulated in cancers. In response to nutrients, mTORC1 is activated on lysosomes by Rag and Rheb guanosine triphosphatases (GTPases) and drives biosynthetic processes. How limitations in nutrients suppress
E46K I?-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.
????igo-Marco, et al.
Proceedings of the National Academy of Sciences of the USA, 114, E8274-E8283 (2018)
Sylviane Lagarrigue et al.
The Journal of clinical investigation, 126(1), 335-348 (2015-12-15)
Insulin resistance is a fundamental pathogenic factor that characterizes various metabolic disorders, including obesity and type 2 diabetes. Adipose tissue contributes to the development of obesity-related insulin resistance through increased release of fatty acids, altered adipokine secretion, and/or macrophage infiltration
Rubén Aquino-Martínez et al.
Stem cell research & therapy, 8(1), 265-265 (2017-11-18)
Osteoinduction and subsequent bone formation rely on efficient mesenchymal stem cell (MSC) recruitment. It is also known that migration is induced by gradients of growth factors and cytokines. Degradation of Ca A circular calvarial bone defect (5 mm diameter) was created
Xabier L Aranguren et al.
Blood, 122(24), 3982-3992 (2013-10-11)
Endothelial cells (ECs) lining arteries and veins have distinct molecular/functional signatures. The underlying regulatory mechanisms are incompletely understood. Here, we established a specific fingerprint of freshly isolated arterial and venous ECs from human umbilical cord comprising 64 arterial and 12
James A Waschek et al.
ASN neuro, 9(3), 1759091417708720-1759091417708720 (2017-05-20)
New neurons are born throughout the life of mammals in germinal zones of the brain known as neurogenic niches: the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus. These niches contain
Sami Palomäki et al.
Stem cells (Dayton, Ohio), 31(9), 1902-1909 (2013-06-08)
Human mesenchymal stem cells (hMSCs) are multipotent cells that have aroused great expectations in regenerative medicine. They are assumed to originate from hypoxic stem cell niches, especially in the bone marrow. This suggests that O2 is of importance in their
Baoshan Huang et al.
The Journal of biological chemistry, 293(6), 2137-2148 (2017-12-24)
The progenitor cells in the cerebral cortex coordinate proliferation and mitotic exit to generate the correct number of neurons and glial cells during development. However, mechanisms for regulating the mitotic cycle of cortical progenitors are not fully understood. Otx1 is
Marion Robin et al.
Autophagy, 15(5), 771-784 (2018-12-20)
The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activation and
Simone Meidhof et al.
EMBO molecular medicine, 7(6), 831-847 (2015-04-16)
Therapy resistance is a major clinical problem in cancer medicine and crucial for disease relapse and progression. Therefore, the clinical need to overcome it, particularly for aggressive tumors such as pancreatic cancer, is very high. Aberrant activation of an epithelial-mesenchymal
Judit Bigas et al.
Cell death & disease, 9(6), 588-588 (2018-05-24)
Endogenous and synthetic glucocorticoids (GCs) regulate epidermal development and combat skin inflammatory diseases. GC actions can be mediated through the GC receptor (GR) and/or the mineralocorticoid receptor (MR), highly homologous ligand-activated transcription factors. While the role of GR as a
Hui-Zi Chen et al.
Nature cell biology, 14(11), 1192-1202 (2012-10-16)
The endocycle is a variant cell cycle consisting of successive DNA synthesis and gap phases that yield highly polyploid cells. Although essential for metazoan development, relatively little is known about its control or physiologic role in mammals. Using lineage-specific cre
Grégory Ghézali et al.
Cerebral cortex (New York, N.Y. : 1991), 30(2), 753-766 (2019-07-05)
Astrocytes play key roles in brain functions through dynamic interactions with neurons. One of their typical features is to express high levels of connexins (Cxs), Cx43 and Cx30, the gap junction (GJ)-forming proteins. Cx30 is involved in basic cognitive processes
Christine Kim et al.
Toxicology in vitro : an international journal published in association with BIBRA, 67, 104925-104925 (2020-07-01)
The impacts of acute arsenic exposure (i.e. vomiting, diarrhea, and renal failure) are distinct from those brought about by sustained, low level exposure from environmental sources or drinking of contaminated well water. Chronic arsenic exposure is a risk factor for
Antonio Cuevas-Navarro et al.
Current biology : CB, 31(17), 3915-3924 (2021-07-09)
The spindle assembly checkpoint (SAC) functions as a sensor of unattached kinetochores that delays mitotic progression into anaphase until proper chromosome segregation is guaranteed.1,2 Disruptions to this safety mechanism lead to genomic instability and aneuploidy, which serve as the genetic
Eric R Brooks et al.
Methods in cell biology, 127, 131-159 (2015-04-04)
Cilia are key organelles in development and homeostasis. The ever-expanding complement of cilia associated proteins necessitates rapid and tractable models for in vivo functional investigation. Xenopus laevis provides an attractive model for such studies, having multiple ciliated populations, including primary
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