Sylviane Lagarrigue et al.
The Journal of clinical investigation, 126(1), 335-348 (2015-12-15)
Insulin resistance is a fundamental pathogenic factor that characterizes various metabolic disorders, including obesity and type 2 diabetes. Adipose tissue contributes to the development of obesity-related insulin resistance through increased release of fatty acids, altered adipokine secretion, and/or macrophage infiltration