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Showing 1-30 of 976 results for "T6508" within Papers
Jonathan Ashby et al.
ACS applied materials & interfaces, 6(17), 15412-15419 (2014-08-22)
Nanoparticles (NPs) adsorb proteins when in the biological matrix, and the resulted protein corona could affect NP-cell interactions. The corona has a dynamic nature with the adsorbed proteins constantly exchanging with the free proteins in the matrix at various rates.
Houman Savoji et al.
Macromolecular bioscience, 14(8), 1084-1095 (2014-04-18)
In the quest to reduce risk of thrombosis in vascular grafts, it is essential to provide a surface with morphological and mechanical properties close to those of the extracellular matrix beneath the luminal endothelium, and to favor the growth of
Zhaochuan Liu et al.
Scientific reports, 5, 16468-16468 (2015-11-13)
Fingolimod (FTY720), a novel class of sphingosine 1-phosphate receptor modulators, has received special interest among ophthalmologists, particularly given that oral administration of FTY720 has proven to effectively treat corneal graft rejection in animal models. However, no studies have examined the
Jun Liu et al.
International journal of biological macromolecules, 69, 1-4 (2014-05-17)
A neutral polysaccharide fraction (CGPP) was extracted from Gynostemma pentaphyllum by water extraction and ethanol precipitation. Gas chromatography (GC) analysis showed that the CGPP was mainly composed of mannose, glucose, arabinose, rhamnose, galactose and glucuronic acid in molar ratios of
Dafni K Paspaliari et al.
The FEBS journal, 282(5), 921-936 (2015-01-08)
Chitinases and chitin-active lytic polysaccharide monooxygenases (LPMOs) are most commonly associated with chitin metabolism, but are also reported as virulence factors in pathogenic bacteria. Listeria monocytogenes, a well-known virulent bacterium, possesses two chitinases (ChiA and ChiB) and a multi-modular lytic
AeRyon Kim et al.
Nature communications, 5, 5369-5369 (2014-11-22)
Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-processing system composed of defined components. We use the system to characterize steps in
Martin D Witte et al.
Nature protocols, 8(9), 1808-1819 (2013-08-31)
Chimeric proteins, including bispecific antibodies, are biological tools with therapeutic applications. Genetic fusion and ligation methods allow the creation of N-to-C and C-to-N fused recombinant proteins, but not unnaturally linked N-to-N and C-to-C fusion proteins. This protocol describes a simple
Sergio Alonso-Orgaz et al.
Journal of proteomics, 109, 368-381 (2014-07-30)
Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to
Karita Haapasalo et al.
The Journal of biological chemistry, 290(48), 28977-28987 (2015-10-16)
The alternative pathway of complement is an important part of the innate immunity response against foreign particles invading the human body. To avoid damage to host cells, it needs to be efficiently down-regulated by plasma factor H (FH) as exemplified
Heather Venant et al.
Molecular cancer therapeutics, 14(12), 2744-2752 (2015-10-24)
Despite recent advances in the development of novel therapies against castration-resistant prostate cancer, the advanced form of the disease remains a major treatment challenge. Aberrant sphingolipid signaling through sphingosine kinases and their product, sphingosine-1-phosphate, can promote proliferation, drug resistance, angiogenesis
Julia Kennedy-Darling et al.
Journal of proteome research, 13(8), 3810-3825 (2014-07-08)
DNA-protein interactions play critical roles in the control of genome expression and other fundamental processes. An essential element in understanding how these systems function is to identify their molecular components. We present here a novel strategy, Hybridization Capture of Chromatin
Vincent Delorme et al.
Biochimie, 107 Pt A, 124-134 (2014-07-30)
A synthetic phosphonate inhibitor designed for lipase inhibition but displaying a broader range of activity was covalently immobilized on a solid support to generate a function-directed tool targeting serine hydrolases. To achieve this goal, straightforward and reliable analytical techniques were
AubƩrie Parent et al.
Nature communications, 6, 5686-5686 (2015-01-20)
Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the
Hajer Salem Malitan et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 97(4), 471-479 (2019-01-09)
Embryos of the crustacean Artemia franciscana may arrest as gastrulae, forming cysts that enter diapause, which is a state of reduced metabolism and enhanced stress tolerance. Diapausing cysts survive physiological stresses for years due, in part, to molecular chaperones. p26
Bhawani Chamlagain et al.
Food chemistry, 166, 630-638 (2014-07-24)
A sensitive and selective method is needed to analyse in situ produced vitamin B12 in plant-based materials, potential new dietary sources of vitamin B12. A UHPLC/UV method was developed and validated for the determination of human active vitamin B12 in
Maria-Theresia Gekenidis et al.
Applied and environmental microbiology, 80(14), 4234-4241 (2014-05-06)
A well-accepted method for identification of microorganisms uses matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) coupled to analysis software which identifies and classifies the organism according to its ribosomal protein spectral profile. The method, called MALDI biotyping
Nrupa Borkar et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 216-223 (2014-12-17)
Apomorphine, a subcutaneously administered drug for Parkinson's disease with short half-life requires frequent administration leading to patient non-compliance. This study aimed at synthesising and purifying lipophilic diesters of apomorphine, and investigating their in vitro degradation in biorelevant media before and
Yijie Hu et al.
Food chemistry, 194, 46-54 (2015-10-17)
Purple sweet potato (Ipomoea batatas L.) is rich in anthocyanin pigments, which are valuable constituents of the human diet. Techniques to identify and quantify anthocyanins and their antioxidant potential are desirable for cultivar selection and breeding. In this study, we
Sanghamitra Majumdar et al.
Environmental science & technology, 49(22), 13283-13293 (2015-10-22)
The rapidly growing literature on the response of edible plants to nanoceria has provided evidence of its uptake and bioaccumulation, which delineates a possible route of entry into the food chain. However, little is known about how the residing organic
Natasha Arksey et al.
Bioorganic & medicinal chemistry, 22(15), 3931-3937 (2014-07-16)
The 2-[(18)F]fluoro-3-pent-4-yn-1-yloxypyridine ([(18)F]FPyKYNE) analog of the potent non-peptide angiotensin II type 1 receptor (AT1R) blocker losartan was produced via click chemistry linking [(18)F]FPyKYNE to azide-modified tetrazole-protected losartan followed by TFA deprotection. Preliminary small animal imaging with positron emission tomography (PET)
Binjun Yan et al.
Journal of pharmaceutical and biomedical analysis, 94, 106-110 (2014-02-25)
The concept of quality by design (QbD) is widely applied in the process development of pharmaceuticals. However, the additional cost and time have caused some resistance about QbD implementation. To show a possible solution, this work proposed a rapid process
Colleen S Limegrover et al.
Journal of neurochemistry, 157(4), 1316-1330 (2020-10-08)
Several mutations conferring protection against Alzheimer's disease (AD) have been described, none as profound as the A673T mutation, where carriers are four times less likely to get AD compared to noncarriers. This mutation results in reduced amyloid beta (AĪ²) protein
Rima Ait-Belkacem et al.
mAbs, 6(6), 1385-1393 (2014-12-09)
Bevacizumab induces normalization of abnormal blood vessels, making them less leaky. By binding to vascular endothelial growth factor, it indirectly attacks the vascular tumor mass. The optimal delivery of targeted therapies including monoclonal antibodies or anti-angiogenesis drugs to the target
Dongxin Zhao et al.
Journal of molecular modeling, 21(11), 299-299 (2015-11-03)
Breast cancer susceptibility gene 2 (BRCA2)-a human tumor suppressor gene-is related to various malignancies such as breast and ovarian cancer. This gene can induce the key protein RAD51 recombinase, which is involved in homologous recombination with single-stranded DNA in the
YongCheol Yoo et al.
Journal of proteome research, 14(1), 214-223 (2014-11-11)
Microglial activation in the central nervous system is a key event in the neuroinflammation that accompanies neurodegenerative diseases such as Alzheimer's disease (AD). Among cytokines involved in microglial activation, amyloid Ī² (AĪ²) peptide is known to be a key molecule
Menglin Ma et al.
Journal of bacteriology, 197(10), 1807-1818 (2015-03-18)
The accessory growth regulator (Agr)-like quorum sensing (QS) system of Clostridium perfringens controls the production of many toxins, including beta toxin (CPB). We previously showed (J. E. Vidal, M. Ma, J. Saputo, J. Garcia, F. A. Uzal, and B. A.
Jolanta CzerwiÅska et al.
Nucleic acids research, 42(17), 11119-11135 (2014-08-30)
4-Hydroxy-2-nonenal (HNE) is a reactive Ī±,Ī²-unsaturated aldehyde generated during oxidative stress and subsequent peroxidation of polyunsaturated fatty acids. Here, Werner protein (WRN) was identified as a novel target for modification by HNE. Werner syndrome arises through mutations in the WRN
Aimin Shi et al.
PloS one, 9(10), e111188-e111188 (2014-10-28)
Although a number of bioactive peptides are capable of angiotensin I-converting enzyme (ACE) inhibitory effects, little is known regarding the mechanism of peanut peptides using molecular simulation. The aim of this study was to obtain ACE inhibiting peptide from peanut
Yusuke Miyashita et al.
Biophysical journal, 104(1), 163-172 (2013-01-22)
We investigate the hydration state of horse-heart cytochrome c (hh cyt c) in the unfolding process induced by trifluoroacetic acid (TFA). The conformation of hh cyt c changes from the native (N) state (2.9Ā < pHĀ < 6.0) to the acid-unfolded (U(A))
Paul Dowling et al.
STAR protocols, 1(3), 100196-100196 (2020-12-31)
This protocol describes the comparative proteomic profiling of the spleen of wild type versus mdx-4cv mouse, a model of dystrophinopathy. We detail sample preparation for bottom-up proteomic mass spectrometry experiments, including homogenization of tissue, protein concentration measurements, protein digestion, and
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