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Amichand Dairam et al.
Life sciences, 80(15), 1431-1438 (2007-02-03)
Accumulating evidence suggests that anti-inflammatory agents and antioxidants have neuroprotective properties and may be beneficial in the treatment of neurodegenerative disorders. In the present study, the possible neuroprotective properties of tolmetin and sulindac were investigated using quinolinic acid (QA)-induced neurotoxicity
A Dairam et al.
Life sciences, 79(24), 2269-2274 (2006-09-06)
Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory
R Scott Obach
Drug metabolism and disposition: the biological fate of chemicals, 37(8), 1581-1586 (2009-05-15)
During an investigation of the in vitro glucuronidation of benoxaprofen by human liver S-9 fraction, an unusual drug-related entity possessing a protonated molecular ion that was 74 mass units greater than the parent drug was observed. It was identified as
James E Taylor et al.
Organic letters, 12(24), 5740-5743 (2010-11-17)
1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) has been shown to be an effective catalyst for the regioselective Friedel-Crafts C-acylation of pyrroles and indoles in high yields. A detailed mechanistic study implies that DBN is acting as a nucleophilic organocatalyst, with the X-ray crystal structure
B Suárez et al.
Journal of chromatography. A, 1159(1-2), 203-207 (2007-02-16)
Last years, the usefulness of the use of carbon nanotubes (CNTs) as sorbent material have been demonstrated for a wide variety of compounds. In this work, it has been demonstrated for first time that immobilized carboxylated single-walled carbon nanotubes (c-SWNTs)
Aida Kulo et al.
European journal of drug metabolism and pharmacokinetics, 38(1), 1-4 (2012-11-28)
Compared to female volunteers or postpartum, ketorolac clearance is higher at delivery. To explore the alterations that explain this higher clearance, urinary ketorolac metabolites collected at delivery (n = 40) were compared to female volunteers (unpaired, n = 8) or postpartum (paired, n = 8) following
David R Ely et al.
International journal of pharmaceutics, 414(1-2), 157-160 (2011-05-24)
In this work, near infrared (NIR) hyperspectral imaging was used to quantify the spatial distribution of drug in tablets containing tolmetin sodium dihydrate. Hyperspectral data cubes were generated by imaging the same spatial region of a sample while illuminated by
Jolanda S van Leeuwen et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(2), 197-205 (2011-12-06)
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of pain and inflammation. However, this group of drugs is associated with serious adverse drug reactions. Previously, we studied the mechanisms underlying toxicity of the NSAID diclofenac using Saccharomycescerevisiae as
Jack U Flanagan et al.
PloS one, 7(8), e43965-e43965 (2012-09-01)
Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The enzyme is also over-expressed in prostate and breast cancer and its expression is correlated with the aggressiveness of
Mitra Jelvehgari et al.
Pharmaceutical development and technology, 15(1), 71-79 (2009-06-10)
Ethylcellulose microparticles containing tolmetin sodium, an anti-inflammatory drug, were prepared by a solvent diffusion method based on the formation of multiple W/O(1)/O(2)-emulsion. The drug used was TOL, which is water-soluble and n-hexane was used as the non-solvent. Important parameters in
Cláudia Nunes et al.
The journal of physical chemistry. B, 115(43), 12615-12623 (2011-09-23)
This work focuses on the application of different biophysical techniques to study the interaction of tolmetin with membrane mimetic models of different dimensionality (liposomes, monolayers, and supported lipid bilayers) composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), used as a representative phospholipid of natural
C P Duffy et al.
European journal of cancer (Oxford, England : 1990), 34(8), 1250-1259 (1998-12-16)
The effect on cytotoxicity of combining a range of clinically important non-steroidal anti-inflammatory drugs (NSAIDs) with a variety of chemotherapeutic drugs was examined in the human lung cancer cell lines DLKP, A549, COR L23P and COR L23R and in a
Jørgen Olsen et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(5), 758-764 (2007-02-17)
Carboxylic acids may be metabolized to acyl glucuronides and acyl-coenzyme A thioesters (acyl-CoAs), which are reactive metabolites capable of reacting with proteins in vivo. In this study, the metabolic activation of tolmetin (Tol) to reactive metabolites and the subsequent formation
Maria X Traa et al.
The Cochrane database of systematic reviews, (2)(2), CD007556-CD007556 (2011-02-18)
Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID), available in several different countries, but not widely used. To assess the efficacy of single dose oral fenoprofen in acute postoperative pain, and associated adverse events. We searched Cochrane CENTRAL, MEDLINE, EMBASE and
David Costa et al.
Redox report : communications in free radical research, 13(4), 153-160 (2008-07-24)
It has long been known that singlet oxygen ((1)O2) is generated during inflammatory processes. Once formed in substantial amounts, (1)O2 may have an important role in mediating the destruction of infectious agents during host defense. On the other hand, (1)O2
Jens François et al.
Acta orthopaedica Belgica, 73(5), 653-657 (2007-11-21)
Idiopathic chondrolysis of the hip is a rare condition occurring mainly in adolescents and is characterised by a rapidly progressive destruction of the articular cartilage in the coxofemoral joint. Patients report intense pain, motion restriction and often limping due to
M Kirkova et al.
Autonomic & autacoid pharmacology, 27(2), 99-104 (2007-03-30)
1. The in vivo effects of the non-steroid anti-inflammatory drug (NSAID) amtolmetin guacyl, a pro-drug of the NSAID tolmetin, on lipid peroxidation, glutathione levels and activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) in rat gastric
Rachel Moll et al.
The Cochrane database of systematic reviews, (3)(3), CD007553-CD007553 (2011-03-18)
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID). It is most often used for treating pain of dysmenorrhoea in the short term (seven days or less), as well as mild to moderate pain including headache, dental pain, postoperative and postpartum
Marta Cruz-Vera et al.
Journal of chromatography. A, 1202(1), 1-7 (2008-07-18)
Dynamic liquid-phase microextraction (dLPME) using an ionic liquid as acceptor phase is proposed for the determination of six non-steroidal anti-inflammatory drugs (NSAIDs) in human urine samples for the first time. The extraction is carried out in a simple and automatic
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Glen Stanbaugh
Texas medicine, 101(10), 5-7 (2006-11-11)
Philip Gardiner et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(10), 1930-1938 (2011-07-23)
The disposition of seven marketed and two AstraZeneca acid (organic anion) compounds with a range of volume of distribution at steady state (V(ss)) and clearance have been profiled in rat and dog. Pharmacokinetic (PK) parameters along with liver and muscle
Gregory S Walker et al.
Chemical research in toxicology, 20(6), 876-886 (2007-06-01)
Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs. These toxicities are hypothesized to be a consequence of covalent binding of the reactive forms of the acyl glucuronide to proteins. Reactive intermediates of the acyl
Antonio Tito et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(5), 1000-1006 (2009-02-03)
The formation of tolmetin/N-acetyl-l-tyrosine ethyl ester (ATEE) complex has been reported by means of both theoretical and experimental studies, including quantum mechanical calculations as well as UV-vis absorption, fluorescence and time-resolved spectroscopy measurements. It has been found that the fluorescence
Zhihui Rong et al.
Life sciences, 92(3), 245-251 (2013-01-22)
The purpose of the present study was to investigate the role of efflux transporters on the intestinal absorption of amtolmetin guacyl (MED-15). The effects of P-glycoprotein (P-gp), multiple resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) inhibitors on
Jessica H Kennedy et al.
Reproductive biology and endocrinology : RB&E, 1, 74-74 (2003-11-14)
Turkey reproduction is by artificial insemination using pooled semen so there is interest in storing semen. Fertilizing capacity declines after six hours storage, possibly due to poor sperm mobility. Prostaglandins (PG) affect mammalian sperm motility, but avian sperm has not
Embedded-polar-group bonded phases for high performance liquid chromatography.
O'Gara, J. E., et al.
LC-GC, 19(6), 632-642 (2001)
Kishore Kumar Hotha et al.
Biomedical chromatography : BMC, 24(10), 1100-1107 (2010-09-21)
A highly sensitive, rapid assay method has been developed and validated for the simultaneous estimation of tolmetin (TMT) and MED5 in human plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode. A simple
Z K Krowicki
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 63(6), 581-588 (2013-02-08)
We previously reported that delta-9-tetrahydrocannabinol (delta-9-THC), the primary psychoactive constituent of Cannabis sativa, inhibited gastric motor activity and evoked bradycardia and hypotension upon its parenteral administration in the rat. As prostanoids are important mediators of the actions of cannabinoids, we
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