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Onsurang Wattanathamsan et al.
Cell death discovery, 7(1), 67-67 (2021-04-08)
The posttranslational modifications (PTMs) of microtubules have been reported to play an important role in cancer aggressiveness, including apoptosis resistance. In this study, we aimed to investigate the biological role of microtubule PTMs in the regulation of paclitaxel responsiveness. The
Shoko Nakamuta et al.
Anatomical record (Hoboken, N.J. : 2007), 295(3), 481-491 (2012-01-25)
Many vertebrates have two anatomically distinct olfactory organs--the olfactory epithelium and the vomeronasal organ--to detect chemicals such as general odorants and pheromones in their environment. The vomeronasal organ is not present in fish but is present in vertebrates of a
Deepti Trivedi et al.
Advances in experimental medicine and biology, 664, 185-191 (2010-03-20)
As part of the renewal of photoreceptor outer segment disk membranes, membrane proteins are transported along the region of the cilium, connecting the inner and outer segments. Genetics studies have indicated the role of motor proteins in this transport. Direct
Xing-Zhen Chen et al.
The FEBS journal, 275(19), 4675-4683 (2008-08-30)
TRPP2, also called polycystin-2, the gene product of PKD2, is a membrane protein defective in 10-15% of cases of autosomal dominant polycystic kidney disease. Mutations in PKD2 are also associated with extrarenal disorders, such as hepatic cystogenesis and cardiovascular abnormalities.
Pengfei Liu et al.
PLoS biology, 18(2), e3000620-e3000620 (2020-02-14)
Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncogenic
Ting Guo et al.
Human genetics, 140(5), 761-773 (2021-01-04)
Genetics-associated asthenoteratozoospermia is often seen in patients with multiple morphological abnormalities of the sperm flagella (MMAF). Although 24 causative genes have been identified, these explain only approximately half of patients with MMAF. Since sperm flagella and motile cilia (especially respiratory
Yu-Han Huang et al.
Genes & development, 32(13-14), 915-928 (2018-06-28)
Small cell lung cancer (SCLC) is widely considered to be a tumor of pulmonary neuroendocrine cells; however, a variant form of this disease has been described that lacks neuroendocrine features. Here, we applied domain-focused CRISPR screening to human cancer cell
Ryan O Walters et al.
Cell reports, 25(3), 663-676 (2018-10-18)
A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of
Natalya G Dulyaninova et al.
Molecular biology of the cell, 29(5), 632-642 (2017-12-29)
S100A4, a member of the S100 family of Ca2+-binding proteins, is a key regulator of cell migration and invasion. Our previous studies showed that bone marrow-derived macrophages from S100A4-/- mice exhibit defects in directional motility and chemotaxis in vitro and
Barbara Tavares et al.
eLife, 6 (2017-09-07)
Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and slow-scan two-photon live imaging capable of identifying the number of motile and immotile cilia, we now established that the final number of motile cilia depends on Notch
Luca Perico et al.
Nature communications, 8(1), 983-983 (2017-10-19)
Mesenchymal stromal cells (MSCs) are renoprotective and drive regeneration following injury, although cellular targets of such an effect are still ill-defined. Here, we show that human umbilical cord (UC)-MSCs transplanted into mice stimulate tubular cells to regain mitochondrial mass and
S Fernandes et al.
Toxicology letters, 234(2), 131-138 (2015-02-24)
Methamphetamine (METH) is a powerful psychostimulant drug used worldwide for its reinforcing properties. In addition to the classic long-lasting monoaminergic-disrupting effects extensively described in the literature, METH has been consistently reported to increase blood brain barrier (BBB) permeability, both in
Andrew Muroyama et al.
eLife, 6 (2017-09-05)
The physiological functions of microtubules (MTs) are poorly understood in many differentiated cell types. We developed a genetic toolkit to study MT dynamics and function in diverse cells. Using TRE-EB1-GFP mice, we found that MT dynamics are strongly suppressed in
Saskia M Jacobson et al.
Aquatic toxicology (Amsterdam, Netherlands), 100(1), 101-111 (2010-08-13)
Organophosphate pesticides (OPs) are environmental toxicants known to inhibit the catalytic activity of acetylcholinesterase (AChE) resulting in hypercholinergic toxicity symptoms. In developing embryos, OPs have been hypothesized to affect both cholinergic and non-cholinergic pathways. In order to understand the neurological
Viviana Barra et al.
Nature communications, 10(1), 175-175 (2019-01-13)
CENP-A is the histone H3 variant necessary to specify the location of all eukaryotic centromeres via its CENP-A targeting domain and either one of its terminal regions. In humans, several post-translational modifications occur on CENP-A, but their role in centromere
Wan Namkung et al.
Molecular biology of the cell, 21(15), 2639-2648 (2010-06-18)
Chloride secretion by airway epithelial cells is defective in cystic fibrosis (CF). The conventional paradigm is that CFTR is activated through cAMP and protein kinase A (PKA), whereas the Ca(2+)-activated chloride channel (CaCC) is activated by Ca(2+) agonists like UTP.
Takashi Umehara et al.
PLoS biology, 17(8), e3000398-e3000398 (2019-08-14)
In most mammals, the male to female sex ratio of offspring is about 50% because half of the sperm contain either the Y chromosome or X chromosome. In mice, the Y chromosome encodes fewer than 700 genes, whereas the X
Bernadette Carroll et al.
The Journal of cell biology, 216(7), 1949-1957 (2017-06-02)
Mammalian target of rapamycin complex 1 (mTORC1) and cell senescence are intimately linked to each other and to organismal aging. Inhibition of mTORC1 is the best-known intervention to extend lifespan, and recent evidence suggests that clearance of senescent cells can
Acetylation: a regulatory modification to rival phosphorylation?
Kouzarides T
The Embo Journal, 19, 1176-1179 (2000)
Maria Lobikin et al.
The International journal of developmental biology, 59(7-9), 303-311 (2015-07-23)
The correct anatomical placement and precise determination of specific cell types is required for the establishment of normal embryonic patterning. Understanding these processes is also important for progress in regenerative medicine and cancer biology. Transmembrane voltage gradients across embryonic tissues
Sophia E Akbareian et al.
Journal of anatomy, 226(6), 560-574 (2015-05-23)
Cranial foramina are holes within the skull, formed during development, allowing entry and exit of blood vessels and nerves. Once formed they must remain open, due to the vital structures they contain, i.e. optic nerves, jugular vein, carotid artery, and
Xiangyang Liu et al.
Science signaling, 11(519) (2018-03-01)
During coronary vasculature development, endothelial cells enclose the embryonic heart to form the primitive coronary plexus. This structure is remodeled upon recruitment of epicardial cells that may undergo epithelial-mesenchymal transition (EMT) to enable migration and that give rise to smooth
Steven Su et al.
Nature methods, 10(11), 1105-1107 (2013-09-24)
Visualization of signal transduction in live primary cilia constitutes a technical challenge owing to the organelle's submicrometer dimensions and close proximity to the cell body. Using a genetically encoded calcium indicator targeted to primary cilia, we visualized calcium signaling in
Peu Santra et al.
Disease models & mechanisms, 14(7) (2021-07-24)
The vacuolar-type H+-ATPase (V-ATPase) is a multi-subunit proton pump that regulates cellular pH. V-ATPase activity modulates several cellular processes, but cell-type-specific functions remain poorly understood. Patients with mutations in specific V-ATPase subunits can develop sensorineural deafness, but the underlying mechanisms
Handan Xiang et al.
Cell discovery, 3, 17019-17019 (2017-06-20)
Cellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for novel senescence regulators in airway basal cells, we discovered that the
Shixuan Wang et al.
Autophagy, 11(4), 607-616 (2015-04-24)
Primary cilium is an organelle that plays significant roles in a number of cellular functions ranging from cell mechanosensation, proliferation, and differentiation to apoptosis. Autophagy is an evolutionarily conserved cellular function in biology and indispensable for cellular homeostasis. Both cilia
Julie K Watson et al.
Cell reports, 12(1), 90-101 (2015-06-30)
Epithelial lineages have been studied at cellular resolution in multiple organs that turn over rapidly. However, many epithelia, including those of the lung, liver, pancreas, and prostate, turn over slowly and may be regulated differently. We investigated the mouse tracheal
Hua Zhang et al.
International journal of molecular sciences, 20(15) (2019-07-28)
Collaterals are unique blood vessels present in the microcirculation of most tissues that, by cross-connecting a small fraction of the outer branches of adjacent arterial trees, provide alternate routes of perfusion. However, collaterals are especially susceptible to rarefaction caused by
Izabela Kowalczyk et al.
Development (Cambridge, England), 148(2) (2021-01-28)
Pathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe neural tube closure defects (NTDs) such as anencephaly and spina bifida. Here, we have combined analysis of neural tube closure in mouse and in the African Clawed
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