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Zachariah M Norman et al.
ACS nano, 8(7), 7513-7521 (2014-06-25)
We report the evolution of electrical transport and grain size during the sintering of thin films spin-cast from soluble phosphine and amine-bound, chloride-terminated cadmium selenide nanocrystals. Sintering of the nanocrystals occurs in three distinct stages as the annealing temperature is
Page C Spiess et al.
Chemical research in toxicology, 21(5), 1074-1085 (2008-04-18)
The significance of free radicals in biology has been established by numerous investigations spanning a period of over 40 years. Whereas there are many intracellular targets for these radical species, the importance of cysteine thiol posttranslational modification has received considerable
Zi-Zhen Zhang et al.
Molecular cancer therapeutics, 14(5), 1162-1170 (2015-01-24)
The objective of this study was to evaluate the role of HOTAIR long noncoding RNA in gastric cancer metastasis. We analyzed HOTAIR expression levels by real-time reverse transcription PCR and Northern blot analysis in 100 gastric tissues (50 gastric cancer
Thi-Ngoc Suong Huynh et al.
Electrophoresis, 36(11-12), 1374-1382 (2015-01-30)
Identification of uranyl transport proteins is key to develop efficient detoxification approaches. Therefore, analytical approaches have to be developed to cope with the complexity of biological media and allow the analysis of metal speciation. CE-ICP/MS was used to combine the
Fangfang Wang et al.
Journal of liposome research, 25(2), 89-100 (2014-06-25)
We reported the development of multifunctional liposomes as a dual-modality probe to facilitate targeted magnetic resonance and fluorescent imaging of bone metastasis from advanced cancer. Multifunctional liposomes consisted of liposomes as a carrier, hydrophobic CdSe QDs in phospholipid bilayer, hydrophilic
Holger Pletsch et al.
Nanoscale, 7(5), 1977-1983 (2014-12-24)
The design of networks from polymers and noble metal nanoparticles requires thorough control over topological polymer-particle arrangements. This study explores the interaction between a linear polydentate poly(propylene sulfide) (PPrS) ligand and silver nanoparticles (AgNPs) with an aim to study its
M Zandvliet et al.
Veterinary journal (London, England : 1997), 205(2), 263-271 (2014-12-06)
Canine lymphoma is typically treated with a doxorubicin-based multidrug chemotherapy protocol. Although this is often initially successful, tumour recurrence is common and frequently refractory to treatment. Failure to respond to chemotherapy is thought to represent drug resistance and has been
Toon Verheyen et al.
Nucleic acids research, 43(12), 5771-5784 (2015-05-21)
Protein phosphatase-1 (PP1) is a key regulator of transcription and is targeted to promoter regions via associated proteins. However, the chromatin binding sites of PP1 have never been studied in a systematic and genome-wide manner. Methylation-based DamID profiling in HeLa
Pieter Glibert et al.
Journal of proteome research, 14(2), 839-849 (2014-12-17)
The ability to distinguish between phosphopeptides of high and low stoichiometry is essential to discover the true extent of protein phosphorylation. We here extend the strategy whereby a peptide sample is briefly split in two identical parts and differentially labeled
Monika Avbelj et al.
Blood, 124(26), 3896-3904 (2014-11-02)
Myeloid differentiation 88 (MyD88) is the key signaling adapter of Toll-like and interleukin-1 receptors. Recurrent lymphoma-associated mutations, particularly Leu265Pro (L265P), within the MyD88 Toll/interleukin-1 receptor (TIR) domain sustain lymphoma cell survival due to constitutive nuclear factor κB signaling. We found
S Kittel-Schneider et al.
Pharmacopsychiatry, 48(4-5), 145-149 (2015-05-27)
Disturbances of circadian rhythms occur in all episodes of bipolar disorder (BD). Lithium, as gold-standard in the maintenance treatment of BD, is known to influence circadian processes. In a pilot study lymphoblastoid cell lines (LCLs) were generated from 8 BD
Xiaohe Tian et al.
Scientific reports, 5, 11990-11990 (2015-07-21)
The blood-brain barrier (BBB) is by far the most important target in developing new approaches to improve delivery of drugs and diagnostic tools into the Central Nervous System (CNS). Here we report the engineering of pH- sensitive polymersomes (synthetic vesicles
Jing-Yu Wu et al.
The Journal of organic chemistry, 73(22), 9137-9139 (2008-10-24)
Aziridines underwent cyclization reaction with carbon disulfide and isothiocyanate in the presence of organophosphine to afford thiazolidinone derivatives in good to high yields. The mechanistic study revealed that organophosphine serves as a catalyst in the reaction.
Takashi Sutani et al.
Nature communications, 6, 7815-7815 (2015-07-24)
Chromosome condensation is a hallmark of mitosis in eukaryotes and is a prerequisite for faithful segregation of genetic material to daughter cells. Here we show that condensin, which is essential for assembling condensed chromosomes, helps to preclude the detrimental effects
Marta Moskot et al.
Metabolic brain disease, 30(5), 1257-1267 (2015-07-26)
Natural flavonoids such as genistein, kaempferol and daidzein were previously found to be able to reduce efficiency of glycosaminoglycan synthesis in cells of patients suffering from mucopolysaccharidoses, inherited metabolic diseases with often brain disease symptoms. This feature was employed to
J X Yan et al.
Journal of chromatography. A, 813(1), 187-200 (1998-08-11)
A simple technique is introduced to identify and quantitate cysteine (Cys) after acid hydrolysis of protein. The technique involves using 9-fluorenylmethyl chloroformate (Fmoc)-based amino acid analysis that recovers all of the amino acids (asparagine and glutamine are recovered in their
Yuming Lai et al.
ACS nano, 8(9), 9664-9672 (2014-09-10)
We investigate the origins and magnitude of low-frequency noise in high-mobility nanocrystal field-effect transistors and show the noise is of 1/f-type. Sub-band gap states, in particular, those introduced by nanocrystal surfaces, have a significant influence on the 1/f noise. By
Wies van Roosmalen et al.
The Journal of clinical investigation, 125(4), 1648-1664 (2015-03-17)
Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion remodeling. Using a phagokinetic track assay with migratory H1299 cells, we performed an siRNA screen of almost
Robert Rekawiecki et al.
Theriogenology, 84(3), 348-357 (2015-05-16)
The aim of this study was to examine whether progesterone (P(4)) and its antagonists, onapristone (ZK299) and mifepristone (RU486), affect the levels of PGRA and PGRB messenger RNA (mRNA) and protein in the cow uterus which may be important in
Melanie Piédavent-Salomon et al.
Brain : a journal of neurology, 138(Pt 11), 3263-3274 (2015-09-12)
Recent association studies have linked numerous genetic variants with an increased risk for multiple sclerosis, although their functional relevance remains largely unknown. Here we investigated phenotypical and functional consequences of a genetic variant in the CD226 gene that, among other
Naoki Kusunose et al.
Biochemical and biophysical research communications, 467(1), 157-163 (2015-09-26)
Clock gene regulates the circadian rhythm of various physiological functions. The expression of clock gene has been shown to be attenuated by certain drugs, resulting in a rhythm disorder. Mitomycin C (MMC) is often used in combination with ophthalmic surgery
J Krijt et al.
Clinical chemistry, 47(10), 1821-1828 (2001-09-25)
Aminothiols have been implicated in the pathogenesis of arteriosclerosis, and reliable methods are needed to determine their concentrations in body fluids. We present a comparison of two analytical methods and focus on the reduction of low-molecular weight and protein-mixed disulfides
A Ishiwata et al.
Organic letters, 2(18), 2889-2892 (2000-08-31)
[reaction: see text] Diastereoselective reduction of 6-bromo-6-substituted penicillanate esters has been achieved by treatment with tributylphosphine to give 6-substituted penicillanate esters. This reaction would appear to proceed through a phosphonium beta-lactam enolate species, followed by a diastereoselective protonation. This method
Beata Fuchsova et al.
Experimental cell research, 338(2), 170-182 (2015-08-01)
Adenovirus serotypes have been shown to cause drastic changes in nuclear organization, including the transcription machinery, during infection. This ability of adenovirus to subvert transcription in the host cell facilitates viral replication. Because nuclear actin and nuclear myosin I, myosin
Gajendra Kumar Azad et al.
FEBS letters, 589(1), 59-67 (2014-12-08)
Yeast repressor activator protein (Rap1p) is involved in genomic stability and transcriptional regulation. We explored the function of Rap1p in yeast physiology using Rap1p truncation mutants. Our results revealed that the N-terminal truncation of Rap1p (Rap1ΔN) leads to hypersensitivity towards
Ping Chen et al.
Cancer research, 75(15), 2987-2998 (2015-07-01)
Disseminated high-grade serous ovarian cancer (HGS-OvCa) is an aggressive disease treated with platinum and taxane combination therapy. While initial response can be favorable, the disease typically relapses and becomes resistant to treatment. As genomic alterations in HGS-OvCa are heterogeneous, identification
Kersti B Nilsson et al.
Inorganic chemistry, 45(17), 6912-6921 (2006-08-15)
The coordination chemistry of solvated Ag(I) and Au(I) ions has been studied in some of the most strong electron-pair donor solvents, liquid and aqueous ammonia, and the P donor solvents triethyl, tri-n-butyl, and triphenyl phosphite and tri-n-butylphosphine. The solvated Ag(I)
Renato Cardoso Tudela et al.
Protein and peptide letters, 22(12), 1111-1116 (2015-10-09)
Kinins are important vasoactive peptides, but the role of the B1 receptor subtype in the vascular control is poorly understood. This study analyzed the nitric oxide (NO) release, L-arginine (L-Arg) uptake and the expression of the cationic amino acid transporter
Ay-Huey Huang et al.
PloS one, 10(3), e0118530-e0118530 (2015-03-05)
α-parvin (PARVA) is known to be involved in the linkage of integrins, regulation of actin cytoskeleton dynamics and cell survival. However, the role that PARVA plays in cancer progression remains unclear. Here, using a lung cancer invasion cell line model
Takashi Harayama et al.
Chemical & pharmaceutical bulletin, 50(4), 519-522 (2002-04-20)
A palladium-assisted coupling reaction of aryl triflate with arene was investigated, and a novel Pd reagent prepared from equimolar Pd(OAc)2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P was developed. This method is useful for intramolecular biaryl coupling reactions, not only between aryl triflate
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