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E O Farombi et al.
Andrologia, 46(8), 893-901 (2013-10-02)
The indiscriminate use, abuse and patients' noncompliance to normal prescription of artemisinin and its derivatives are a common practice during the treatment for drug-resistant malaria parasites in most developing countries. This study investigated the influence of artemisinin on the testicular
Rui Huang et al.
PloS one, 9(4), e94226-e94226 (2014-04-15)
Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-7/LCC9) variants was performed to identify modifiers of endocrine sensitivity in breast cancer. Analysis of the expression of 120 paired phosphorylated and non-phosphorylated epitopes
Ying Zhang et al.
Analytical biochemistry, 484, 40-50 (2015-05-20)
Dendritic cells (DCs) are specialized leukocytes that orchestrate the adaptive immune response. Mass spectrometry (MS)-based proteomic study of these cells presents technical challenges, especially when the DCs are human in origin due to the paucity of available biological material. Here
Han Yao et al.
Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18)
L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles. Critical method attributes, the absorbance
A Sharma et al.
Journal of applied microbiology, 119(1), 162-176 (2015-04-18)
Optimization of traditional processing of soybeans using response surface methodology (RSM) to achieve a minimum level of antinutritional factors (ANFs) in kinema. Central composite rotatable designs were used to optimize the processing stages of kinema preparation. In each stage, the
Tahra Mohamed Leheta et al.
The Journal of dermatological treatment, 25(2), 130-136 (2012-03-09)
Deep peeling using phenol and percutaneous collagen induction (PCI) are used in treating acne scars. To compare deep peeling using phenol and PCI combined with trichloroacetic acid (TCA) 20% in treating atrophic acne scars. 24 patients with post-acne atrophic scars
Anu Singh et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 7-15 (2015-04-29)
Direct electro-deposition of gold nano-aggregates (GNAs) was carried out to fabricate electrochemical DNA biosensor for the detection of Salmonella typhi in urine and blood samples. Size of depositing GNAs was controlled by regulating electro-deposition parameters at physiological pH. This facilitated
Olivia Larne et al.
Carcinogenesis, 36(8), 858-866 (2015-05-15)
Androgen signalling through the androgen receptor (AR) is essential for prostate cancer initiation, progression and transformation to the lethal castration-resistant state. The aim of this study was to characterize the mechanisms by which miR-145 deregulation contribute to prostate cancer progression.
Benjamin Ziehr et al.
Proteomics, 15(12), 1983-1994 (2015-04-22)
Viruses rely on the host translation machinery for the synthesis of viral proteins. Human cells have evolved sensors that recognize viral RNAs and inhibit mRNA translation in order to limit virus replication. Understanding how viruses manipulate the host translation machinery
Mohammad Parwez Ahmad et al.
Pakistan journal of pharmaceutical sciences, 28(2), 509-513 (2015-03-03)
Lipopolysaccharide (LPS) induced oxidative stress and impairment of normal physiological function generally categorized by increased anxiety and reduced mobility. Therefore, the present study was to find out the effect Methanolic extract of Asparagus racemosus (MEAR ) in lipopolysaccharide (LPS)-induced oxidative
Weerapon Sangartit et al.
PloS one, 9(12), e114908-e114908 (2014-12-17)
Cadmium (Cd) is a nonessential heavy metal, causing oxidative damage to various tissues and associated with hypertension. Tetrahydrocurcumin (THU), a major metabolite of curcumin, has been demonstrated to be an antioxidant, anti-diabetic, anti-hypertensive and anti-inflammatory agent. In this study, we
Lise Fismen et al.
Analytical biochemistry, 430(2), 163-170 (2012-09-04)
A simple and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method was developed for the quantification of tetrahydrobiopterin (BH4), dihydrobiopterin (BH2), and biopterin (B) in human umbilical vein endothelial cells (HUVECs). Freshly prepared cell samples were treated with a mixture consisting
Tahra M Leheta et al.
The Journal of dermatological treatment, 25(2), 137-141 (2012-05-30)
There have been no well-controlled studies evaluating the efficacy of combining 1540 nm nonablative fractional laser with percutaneous collagen induction (PCI) and trichloroacetic acid (TCA) 20% in the treatment of atrophic acne scars. We hypothesized that combined alternating sessions of
Yoshinori Ohkura et al.
Journal of cardiovascular pharmacology, 65(5), 500-507 (2015-01-31)
S-equol is known as an estrogenic substance, but its ability to restore vascular endothelial function is unknown. The aim of this study was to investigate the impact of S-equol on endothelial function and intimal thickening under isoflavone- and estrogen-deficient circumstances.
A McCulloch
Chemosphere, 47(7), 667-686 (2002-06-25)
Suppositions that the trichloroacetic acid (TCA, CCl3C(O)OH) found in nature was a consequence solely of the use of chlorinated hydrocarbon solvents prompted this critical review of the literature on its environmental fluxes and occurrences. TCA is widely distributed in forest
Tian Wang et al.
Toxicology mechanisms and methods, 24(8), 560-566 (2014-08-20)
Escin, a natural mixture of triterpenoid saponin isolated from the seed of the horse chestnut, is reported to have a potent antiulcer activity against ethanol-induced gastric mucosal lesions. This study investigated the possible mechanisms underlying the gastroprotective effect of escin
Hong-jin Li et al.
European journal of dermatology : EJD, 22(5), 614-621 (2012-08-04)
Transient receptor potential vanilloid 1 (TRPV1) is a highly polymodal TRP channel activated by various stimuli, including capsaicin, heat and acids. TRPV1 expression can be detected widely but is highest in sensory neurons and its activation alerts the body to
Md Arifur Rahman et al.
Archives of pharmacal research, 37(12), 1522-1529 (2014-11-02)
A chitinase from Streptomyces sp. CS501 was isolated from the Korean soil sample, purified by single-step chromatography, and biochemically characterized. The extracellular chitinase (Ch501) was purified to 4.60 fold with yield of 28.74 % using Sepharose Cl-6B column. The molecular
Haji Bahadar et al.
Environmental toxicology and pharmacology, 39(3), 1161-1169 (2015-05-04)
Benzene (C6H6) is an organic compound used in petrochemicals and numerous other industries. It is abundantly released to our environment as a chemical pollutant causing widespread human exposure. This study mainly focused on benzene induced toxicity on rat pancreatic islets
Niina Tani et al.
Bioorganic & medicinal chemistry, 22(23), 6655-6664 (2014-12-03)
Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by evaluating CYP2A6 inhibitory effect of novel formyl, alkyl amine or carbonitrile
Yanier Nuñez-Figueredo et al.
Neurochemistry international, 81, 41-47 (2015-01-27)
JM-20 (3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepine) is a novel benzodiazepine dihydropyridine hybrid molecule, which has been shown to be a neuroprotective agent in brain disorders involving glutamate receptors. However, the effect of JM-20 on the functionality of the glutamatergic system has not been investigated.
Cristina Díez et al.
Analytica chimica acta, 882, 127-139 (2015-06-05)
In this study, fourteen highly polar aminoglycoside (AGs) antibiotics were selected. Various stationary phases were tested, including Obelisc R, ZIC-HILIC, BEH amide and aminopropyl. The nature of the stationary phase, mobile phase (water or buffer solutions and acetonitrile), pH (percentage
[Trichloroacetic acid and trichloroethanol in urine].
Hideki Igisu et al.
Nihon rinsho. Japanese journal of clinical medicine, 62 Suppl 12, 479-481 (2005-01-22)
M I Dinner et al.
Clinics in plastic surgery, 25(1), 53-62 (1998-03-21)
Despite escalating interest in laser resurfacing techniques, chemical peel procedures remain an integral part of the armamentarium for resurfacing aging, sun-damaged, and diseased skin. Like other chemicals, the advantage of the technique of tricholoracetic (TCA) acid application is that the
Serkan Koldaş et al.
Journal of the science of food and agriculture, 95(4), 786-798 (2014-09-10)
A detailed phytochemical analysis of Origanum vulgare L. ssp. viride (Boiss.) Hayek was carried out and the antioxidant activities of five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time
Javier E Ramirez et al.
Food chemistry, 176, 106-114 (2015-01-28)
The HPLC profiles of six fruits endemic of the VIII region of Chile were investigated using high resolution mass analysis (HR-ToF-ESI-MS). The anthocyanin fingerprints generated for the fruits were compared and the antioxidant capacities measured by the scavenging of the
Hikmat Al-Ahmadie et al.
Cancer discovery, 4(9), 1014-1021 (2014-06-18)
Metastatic solid tumors are almost invariably fatal. Patients with disseminated small-cell cancers have a particularly unfavorable prognosis, with most succumbing to their disease within two years. Here, we report on the genetic and functional analysis of an outlier curative response
Francisco A Guardiola et al.
Fish & shellfish immunology, 47(1), 352-359 (2015-09-20)
Although the skin is one of the main defense barriers of fish to date, very little is known about the immune implications and the properties of the numerous substances present in skin cells. In the present study, terminal carbohydrate composition
Angelica M Merlot et al.
Oncotarget, 6(12), 10374-10398 (2015-04-08)
Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer activity. We previously demonstrated that 14C-Dp44mT enters and targets cells through a carrier/receptor-mediated uptake process. Despite structural similarity, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT) and pyridoxal isonicotinoyl hydrazone (PIH) enter cells via passive diffusion. Considering albumin alters
Amal Lamraoui et al.
Inflammation, 37(5), 1689-1704 (2014-05-27)
The inflammatory response caused by scorpion venoms is a key event in the pathogenesis of scorpion envenomation. This response was assessed in the cardiac, pulmonary, and gastric tissues of envenomed mice. The results reveal an increase of permeability in cardiac
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