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Surabi Veeraragavan et al.
Behavioral neuroscience, 125(5), 783-790 (2011-09-29)
Muscarinic acetylcholine receptors (mAChR) are G protein-coupled receptors (M1-M5), grouped together into two functional classes, based on their G protein interaction. Although ubiquitously expressed in the CNS, the M4 protein shows highest expression in the neostriatum, cortex, and hippocampus. Electrophysiological
Wei Wu et al.
Psychopharmacology, 231(21), 4109-4118 (2014-04-05)
Drug addiction represents a pathological usurpation of neural processes involved in learning and memory. Retrieval of drug-related memories can result in drug craving and relapse. Recently, the insula was identified as part of the neuronal circuit responsible for the processing
Yuji Odagaki et al.
Journal of pharmacological sciences, 125(2), 157-168 (2014-05-23)
The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5'-O-(3-[(35)S]thio) triphosphate ([(35)S]GTPγS) binding assay in rat brain membranes. The most efficacious stimulation elicited by acetylcholine or carbachol (CCh) was obtained in striatal
Melis Palamar et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(3), 349-352 (2012-10-16)
This study aims to investigate the effects of tropicamide 1% on the main numerical parameters of anterior segment with the Pentacam rotating Scheimpflug camera in healthy individuals. Pentacam measurements of 50 (25 female and 25 male) healthy individuals before and
Rajendra K Gangalum et al.
Investigative ophthalmology & visual science, 55(11), 7227-7240 (2014-08-30)
The clinical management of cataracts in infancy involves surgical removal of the lens to ensure transmission of light to the retina, which is essential for normal neural development of the infant. This surgery, however, entails a lifelong follow-up and impaired
Hetal D Buckhurst et al.
PloS one, 10(7), e0132902-e0132902 (2015-07-29)
Anterior segment optical coherent tomography (AS-OCT, Visante; Zeiss) is used to examine meridional variation in anterior scleral thickness (AST) and its association with refractive error, ethnicity and gender. Scleral cross-sections of 74 individuals (28 males; 46 females; aged between 18-40
Carla J Abbott et al.
PloS one, 9(12), e114546-e114546 (2014-12-17)
To compare in young and old rats longitudinal measurements of retinal nerve fiber layer thickness (RNFLT) and axonal transport 3-weeks after chronic IOP elevation. IOP was elevated unilaterally in 2- and 9.5-month-old Brown-Norway rats by intracameral injections of magnetic microbeads.
Pittaya Phamonvaechavan et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 95 Suppl 4, S1-S7 (2012-06-16)
To compare the effectiveness and safety of two instillation methods of combined 0.75% tropicamide and 2.5% phenylephrine at 0, 5 minutes (min) with the same combined regimen at 0,30 minutes in preterm infants. A prospective, cross-over, randomized controlled trial was
Ke Jiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), E5716-E5723 (2014-12-17)
Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed
S J Park et al.
Eye (London, England), 29(4), 561-568 (2015-01-17)
To determine intraocular pharmacokinetic properties of intravitreally injected vascular endothelial growth factor (VEGF)-Trap in a rabbit model. VEGF-Trap was intravitreally injected in 18 rabbit eyes. Eyes were enucleated 1 h and 1, 2, 5, 14, and 30 days after injections and
Lian Zhao et al.
EMBO molecular medicine, 7(9), 1179-1197 (2015-07-04)
Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently lacks comprehensive treatment. We discover that retinal microglia contribute non-cell autonomously to rod photoreceptor degeneration by primary phagocytosis of living rods. Using rd10 mice, we found that the initiation of
Anna Bryndis Einarsdottir et al.
Journal of Alzheimer's disease : JAD, 49(1), 79-83 (2015-10-08)
Structural and physiological abnormalities have been reported in the retina in Alzheimer's disease (AD). Retinal oximetry detects changes in retinal oxygen metabolism in many eye diseases, where structural changes are seen. To compare oxygen saturation in retinal blood vessels in
Yan Yan et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(9), 1515-1528 (2015-05-20)
Suprachoroidal-transretinal stimulation (STS) can potentially restore vision. This study investigated the spatial characteristics of cortical electrical evoked potentials (EEPs) elicited by STS. A 4 × 4 thin-film platinum microelectrode stimulating array (200 μm electrode diameter and 400 μm center-to-center distance) was fabricated
Delu Song et al.
The American journal of pathology, 184(10), 2721-2729 (2014-08-05)
Mutations in the RP1 gene can cause retinitis pigmentosa. We identified a spontaneous L66P mutation caused by two adjacent point mutations in the Rp1 gene in a colony of C57BL/6J mice. Mice homozygous for the L66P mutation exhibited slow, progressive
Raghavan Lavanya et al.
Ophthalmology, 119(3), 474-480 (2011-11-29)
To evaluate the risk of primary acute angle closure (AAC), changes in intraocular pressure (IOP), and associated risk factors after pupil dilation in Asian subjects with narrow angles (primary angle-closure suspects [PACS]). Prospective clinical study. A total of 471 subjects
Ahmed S Ibrahim et al.
Biochimica et biophysica acta, 1851(3), 290-298 (2015-01-07)
We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal levels of the vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF).
Peres R Badial et al.
Veterinary ophthalmology, 18(5), 385-392 (2014-10-24)
The aim of this study was to compare ocular dimensions, corneal curvature, and corneal thickness between horses affected with hereditary equine regional dermal asthenia (HERDA) and unaffected horses. Five HERDA-affected quarter horses and five healthy control quarter horses were used.
Srinivas Rao Chennamaneni et al.
Pharmaceutical research, 31(11), 3179-3190 (2014-06-21)
To advance therapy for the treatment of concurrent uveitis and post-cataract surgical inflammation; we evaluated pharmacokinetics and pharmacodynamics of Bioerodible Dexamethasone Implant (BDI) containing 0.3 mg of dexamethasone (DXM) in Concanavalin A (Con A) induced uveitis followed by phacoemulsification in
eComment: Optic nerve blood flow measurements during on-pump heart surgery.
Fani Tsolaki et al.
Interactive cardiovascular and thoracic surgery, 12(5), 722-722 (2011-05-11)
Amany Tawfik et al.
Investigative ophthalmology & visual science, 55(6), 3616-3625 (2014-05-09)
Loss-of-function mutations in hemojuvelin (HJV) cause juvenile hemochromatosis, an iron-overload disease. Deletion of Hjv in mice results in excessive iron accumulation and morphologic changes in the retina. Here, we studied the retinal vasculature in Hjv(-/-) mice. Age-matched wild-type and Hjv(-/-)
Daniel J Salchow et al.
American journal of ophthalmology, 156(5), 1034-1039 (2013-08-27)
To determine the effect of general anesthesia on the accommodative tone in children. Cohort study in an academic practice. In children under 12 years of age who were undergoing general anesthesia, cycloplegic refraction was measured using streak retinoscopy during an
Josef Grünberger et al.
Wiener medizinische Wochenschrift (1946), 162(7-8), 176-181 (2012-03-28)
Pupillometry is a non-invasive investigation based on the concept that pupillary reagibility depends on a number of specific sensory, mental and emotional variables. By means of the receptor test based on the topical application of the cholinergic antagonist tropicamide cognitive
Rui Huang et al.
Molecular vision, 20, 1271-1280 (2014-10-30)
The purpose of this study is to evaluate the functional and morphological changes in subretinal xenografts of human retinal progenitor cells (hRPCs) in B6 mice treated with Cyclosporin A (CsA; 210 mg/l in drinking water). The hRPCs from human fetal
Hilde K Ofte et al.
Cephalalgia : an international journal of headache, 35(6), 469-477 (2014-08-22)
Cluster headache (CH) attacks are accompanied by cranial autonomic symptoms indicative of parasympathetic hyperactivity and sympathetic dysfunction ipsilateral to the pain. We aimed to assess cranial autonomic function in CH patients during the remission phase of cluster headache. During a
Delan Jinapriya et al.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 47(2), 145-149 (2012-05-09)
To evaluate the efficacy of a combination anaesthetic plus dilating gel (ADG) on pupil dilation (PD) and corneal anaesthesia (KA) compared to traditional preoperative pharmacotherapy for cataract surgery. Prospective, noninferiority study. We studied 20 consenting adults who experienced unilateral cataracts
Yu Zhang et al.
Journal of molecular neuroscience : MN, 55(4), 830-835 (2014-10-09)
GABAergic neurons within the ventrolateral preoptic area (VLPO) play an important role in sleep-wakefulness regulation. Propofol, a widely used systemic anesthetic, has lately been reported to excite noradrenaline (NA)-inhibited type of VLPO neurons. Present study tested if acetylcholine system takes
Effect of the single-drop mydriatic combination of 0.8% tropicamide with 5% phenylephrine with multiple applications of the same drop: a randomized controlled trial.
Jitendra Jethani et al.
Indian journal of ophthalmology, 59(4), 323-325 (2011-06-15)
Zhuo Ye et al.
International journal of ophthalmology, 8(4), 653-658 (2015-08-27)
To investigate the pharmacokinetics and distributions of bevacizumab by intravitreal injection of prepared bevacizumab-poly (L-lactic-co-glycolic acid) (PLGA) microspheres in rabbits, to provide evidence for clinical application of this kind of bevacizumab sustained release dosage form. Bevacizumab was encapsulated into PLGA
David Sung Hyeon Baek et al.
Journal of pharmacological and toxicological methods, 71, 77-82 (2014-09-10)
Traditional methods of pre-clinical ocular toxicology require that multiple cohorts of animals be sacrificed over time for terminal histological analysis. By contrast, in vivo techniques capable of following the same cohort prospectively have the potential to be efficient and cost-saving.
Yalong Dang et al.
Drug design, development and therapy, 8, 1441-1449 (2014-09-27)
Our objective was to investigate the efficacy and safety of dexa methasone (DEX) implant for the treatment of pseudophakic cystoid macular edema (PCME) in diabetic patients. This was a prospective, non-randomized, interventional case series of 43 participants. Eighteen patients were
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