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Joaquín Fernández-Irigoyen et al.
Molecular brain, 7, 83-83 (2014-11-20)
The basal ganglia (BG) are a complex network of subcortical nuclei involved in the coordination and integration of the motor activity. Although these independent anatomical structures are functionally related, the proteome present in each isolated nucleus remains largely unexplored. In
Teppei Morita et al.
RNA (New York, N.Y.), 21(8), 1490-1501 (2015-06-25)
The genes encoding Hfq-dependent sRNAs possess a typical Rho-independent transcription terminator. Here, we have studied the molecular events occurring at Rho-independent terminators of sRNA genes, focusing on two well-characterized Hfq-binding sRNAs, SgrS and RyhB. We constructed several hybrid genes in
Beata Głowińska et al.
Folia biologica, 61(1-2), 73-77 (2013-06-19)
The study aimed at investigating differences in selected peripheral blood biochemical parameters and hormones in bulls of various genotype: Polish Holstein-Friesians (PHF; group I) and crossbreeds obtained from PHF dams sired by Limousin bulls (LMxPHF; group II). The blood for
Larry D Cowgill
The Veterinary clinics of North America. Small animal practice, 41(1), 193-225 (2011-01-22)
Hemodialysis improves survival for animals with acute kidney injury beyond what would be expected with conventional management of the same animals. Clinical evidence and experience in human patients suggest a role for earlier intervention with renal replacement to avoid the
Luciana S Oliveira et al.
PloS one, 9(6), e98913-e98913 (2014-06-10)
C57BL/6 mice macrophages innately produce higher levels of NO than BALB/c cells when stimulated with LPS. Here, we investigated the molecular events that account for this intrinsic differential production of NO. We found that the lower production of NO in
Frazer I Heinis et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(4), R368-R377 (2015-05-29)
The hearts of mammalian hibernators maintain contractile function in the face of severe environmental stresses during winter heterothermy. To enable survival in torpor, hibernators regulate the expression of numerous genes involved in excitation-contraction coupling, metabolism, and stress response pathways. Understanding
Yuh-Wen Chiu et al.
Journal of environmental biology, 35(4), 667-673 (2014-07-10)
The freshwater golden apple snail, Pomacea canaliculata, is one of the world's 100 worst invasive alien species. The snails' wide distribution, high abundance, and sensitivity to environmental pollution make them a potential bioindicator for environmental contamination. In this study, the
Hilal Ahmad Parray et al.
International journal of molecular sciences, 16(7), 14441-14463 (2015-06-30)
Previously, galectin-1 (GAL1) was found to be up-regulated in obesity-prone subjects, suggesting that use of a GAL1 inhibitor could be a novel therapeutic approach for treatment of obesity. We evaluated thiodigalactoside (TDG) as a potent inhibitor of GAL1 and identified
Rafael Kramann et al.
The Journal of clinical investigation, 125(8), 2935-2951 (2015-07-21)
Chronic kidney disease is characterized by interstitial fibrosis and proliferation of scar-secreting myofibroblasts, ultimately leading to end-stage renal disease. The hedgehog (Hh) pathway transcriptional effectors GLI1 and GLI2 are expressed in myofibroblast progenitors; however, the role of these effectors during
Alain Carpentier et al.
Medicine and science in sports and exercise, 47(7), 1519-1522 (2014-10-22)
Recently, dietary supplementation with inorganic nitrate (NO3) has been proposed to endurance athletes to increase their performance. However, it has been suggested that an excess of NO3 might be harmful. The present study analyzed the effect of NO3 supplementation on
Michael Neely et al.
Journal of clinical pharmacology, 55(7), 798-808 (2015-02-17)
Few studies have characterized longitudinal female plasma and genital antiretroviral pharmacokinetics and pharmacodynamics. Among 20 regimen-naive HIV-infected adult women initiating atazanavir-based therapy (n = 9) or efavirenz-based therapy (n = 11), we measured blood CD4+ T lymphocytes, and paired plasma and genital HIV RNA
John S Ramsey et al.
PloS one, 10(11), e0140826-e0140826 (2015-11-19)
'Candidatus Liberibacter asiaticus' (CLas), the bacterial pathogen associated with citrus greening disease, is transmitted by Diaphorina citri, the Asian citrus psyllid. Interactions among D. citri and its microbial endosymbionts, including 'Candidatus Profftella armatura', are likely to impact transmission of CLas.
Teslime Atli et al.
JPMA. The Journal of the Pakistan Medical Association, 62(10), 1061-1065 (2013-07-23)
To compare the sensitivity and specificity of C[14] urea breath test with histopathological findings in biopsies obtained through endoscopy. In this cross-sectional study, conducted at the Medical Faculty Ankara University, Ankara, Turkey between January and October 2009, 100 patients aged
Mingliang Zhang et al.
Journal of chromatography. A, 1365, 148-155 (2014-09-25)
One-pot synthesis of surface-confined ionic liquid functionalized silica spheres was proposed using N-(3-aminopropyl)imidazole, γ-isopropyltriethoxysilane and 1-bromooctadecane as starting materials. The surface modification of the silica spheres was successful with a high surface density of octadecylimidazolium, enabling the utilization of this
Sergi Torres-Puig et al.
Nucleic acids research, 43(10), 4923-4936 (2015-05-01)
The Mycoplasma genitalium MG428 protein shows homology to members of the sigma-70 family of sigma factors. Herein, we found that MG428 activates transcription of recA, ruvA and ruvB as well as several genes with unknown function. Deletion of MG_428 or
Dan N Wang et al.
Helicobacter, 20(2), 98-105 (2014-11-11)
The Helicobacter pylori is considered the important causative agent causing biliary diseases, but the H. pylori can be isolated from very few gallbladder specimens with diseases. We studied the formation of H. pylori L-forms in bile in vitro and isolated the H. pylori
QingMing Kong et al.
Molecular bioSystems, 11(5), 1400-1409 (2015-03-31)
Artesunate (ART) has high prophylactic efficacy against Schistosoma japonicum infections and has been used to treat and prevent schistosomiasis in China since 1995. However, the molecular mechanism of ART's effects on S. japonicum remains unclear. Herein, we applied isobaric tagging
Prasada Rao S Kodavanti et al.
Environmental health perspectives, 123(5), 428-436 (2015-01-24)
Polybrominated diphenyl ethers (PBDEs) are structurally similar to polychlorinated biphenyls (PCBs) and have both central (learning and memory deficits) and peripheral (motor dysfunction) neurotoxic effects at concentrations/doses similar to those of PCBs. The cellular and molecular mechanisms for these neurotoxic
Yi-Ren Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 150-162 (2014-04-23)
The direct modulation of Antrodia cinnamomea (AC) on the prominent role of liver fibrosis-hepatic stellate cells (HSCs) in situ remains unclear. Firstly, the administration of A. cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation
Mari Akiyama
Analytical and bioanalytical chemistry, 406(24), 5805-5813 (2014-04-04)
Inspection of patient-derived cells used in transplantation is non-invasive. Therefore, proteomics analysis using supernatants of cells cultured before transplantation is informative. In order to investigate the cell niche of bovine periosteal cells, supernatants of these cultured cells were subjected to
S Kastenbauer et al.
Neurology, 58(2), 186-191 (2002-01-24)
To study reactive nitrogen species-mediated oxidative brain damage and antioxidant defenses in patients with acute bacterial meningitis. Nitrotyrosine (a widely used marker for the formation of reactive nitrogen species, such as peroxynitrite) and the lipid peroxidation product 4-hydroxynonenal were detected
Narges Milani et al.
PloS one, 10(5), e0126275-e0126275 (2015-05-13)
Zinc oxide (ZnO) nanoparticles may provide a more soluble and plant available source of Zn in Zn fertilizers due to their greater reactivity compared to equivalent micron- or millimetre-sized (bulk) particles. However, the effect of soil on solubility, spatial distribution
Ilaria Fiorentino et al.
Experimental cell research, 330(2), 240-247 (2014-09-24)
Nanoparticle (NPs) delivery systems in vivo promises to overcome many obstacles associated with the administration of drugs, vaccines, plasmid DNA and RNA materials, making the study of their cellular uptake a central issue in nanomedicine. The uptake of NPs may
Zhou Liu et al.
Cell transplantation, 24(7), 1265-1281 (2014-05-27)
Transplantation of bone marrow mesenchymal stem cells (MSCs) promotes functional recovery in multiple sclerosis (MS) patients and in a murine model of MS. However, there is only a modicum of information on differentiation of grafted MSCs into oligodendrocyte-like cells in
Dan Shen et al.
The New phytologist, 204(3), 577-594 (2014-08-19)
Verticillium longisporum, a soil-borne pathogenic fungus, causes vascular disease in oilseed rape (Brassica napus). We proposed that plant microRNAs (miRNAs) are involved in the plant-V. longisporum interaction. To identify oilseed rape miRNAs, we deep-sequenced two small RNA libraries made from
Kalyan C Kondapalli et al.
Biochemistry, 47(26), 6917-6927 (2008-06-11)
Frataxin, a mitochondrial protein that is directly involved in regulating cellular iron homeostasis, has been suggested to serve as an iron chaperone during cellular Fe-S cluster biosynthesis. In humans, decreased amounts or impaired function of frataxin causes the autosomal recessive
Dominik Büchi et al.
The international journal of esthetic dentistry, 9(2), 134-145 (2014-04-26)
This case report describes a minimally invasive step-by-step approach to treat a patient with amelogenesis imperfecta. This is a genetic developmental disorder of the dental enamel, which clinically manifests as white and dark discolorations of the teeth. The clinical examination
Tzong-Hsi Lee et al.
Digestive diseases and sciences, 60(2), 454-457 (2014-09-13)
Previous studies demonstrated that the sensitivity of rapid urease test (RUT) for diagnosis of Helicobacter pylori infection decreased during peptic ulcer bleeding. We designed this study and tried to find a better method to improve the detection rate of H.
Luiza Ghila et al.
International journal of molecular sciences, 22(7) (2021-05-01)
The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms governing these processes is, thus, extremely valuable for managing the disease progression. Extracellular
Carla Ritagliati et al.
PLoS neglected tropical diseases, 9(4), e0003725-e0003725 (2015-04-16)
Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets is essential for the development of more efficient therapeutic alternatives. Inhibition
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