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Mathieu Quesnel-Vallières et al.
Genes & development, 29(7), 746-759 (2015-04-04)
Alternative splicing (AS) generates vast transcriptomic complexity in the vertebrate nervous system. However, the extent to which trans-acting splicing regulators and their target AS regulatory networks contribute to nervous system development is not well understood. To address these questions, we
Steven Carberry et al.
Biology, 2(4), 1438-1464 (2013-01-01)
In this article, we illustrate the application of difference in-gel electrophoresis for the proteomic analysis of dystrophic skeletal muscle. The mdx diaphragm was used as a tissue model of dystrophinopathy. Two-dimensional gel electrophoresis is a widely employed protein separation method
Bruno Printz et al.
Plant science : an international journal of experimental plant biology, 238, 13-25 (2015-08-11)
The expanding interest for using lignocellulosic biomass in industry spurred the study of the mechanisms underlying plant cell-wall synthesis. Efforts using genetic approaches allowed the disentanglement of major steps governing stem fibre synthesis. Nonetheless, little is known about the relations
Victoria L Smith et al.
Journal of immunology (Baltimore, Md. : 1950), 195(6), 2722-2730 (2015-08-08)
Exosomes are extracellular vesicles of endocytic origin that function in intercellular communication. Our previous studies indicate that exosomes released from Mycobacterium tuberculosis-infected macrophages contain soluble mycobacterial proteins. However, it was unclear how these secreted proteins were targeted to exosomes. In
Paula Martin-Vaquero et al.
Spine, 40(9), 601-612 (2015-06-02)
Prospective study. To identify proteins with differential expression in the cerebrospinal fluid (CSF) from 15 clinically normal (control) dogs and 15 dogs with cervical spondylomyelopathy (CSM). Canine CSM is a spontaneous, chronic, compressive cervical myelopathy similar to human cervical spondylotic
Carla Ritagliati et al.
PLoS neglected tropical diseases, 9(4), e0003725-e0003725 (2015-04-16)
Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets is essential for the development of more efficient therapeutic alternatives. Inhibition
Jennifer Fostel et al.
Pharmacogenomics, 7(3), 441-454 (2006-04-14)
To identify biomarkers of chronic fatigue syndrome (CFS) and related disorders through analysis of microarray data, pathology test results and self-report symptom profiles. To empirically derive the symptom domains of the illnesses, factor analysis was performed on responses to self-report
Petronella E Deetman et al.
Transplantation, 99(5), 1009-1015 (2014-11-14)
Little is known about optimal protein intake after transplantation. The aim of this study was to prospectively investigate associations of urinary urea excretion, a marker for protein intake, with graft failure and mortality in renal transplant recipients (RTR) and potential
Peng Gao et al.
PloS one, 10(7), e0133913-e0133913 (2015-07-29)
Bivalve shell is a biomineralized tissue with various layers/microstructures and excellent mechanical properties. Shell matrix proteins (SMPs) pervade and envelop the mineral crystals and play essential roles in biomineralization. Despite that Mytilus is an economically important bivalve, only few proteomic
Luciana S Oliveira et al.
PloS one, 9(6), e98913-e98913 (2014-06-10)
C57BL/6 mice macrophages innately produce higher levels of NO than BALB/c cells when stimulated with LPS. Here, we investigated the molecular events that account for this intrinsic differential production of NO. We found that the lower production of NO in
Michael Neely et al.
Journal of clinical pharmacology, 55(7), 798-808 (2015-02-17)
Few studies have characterized longitudinal female plasma and genital antiretroviral pharmacokinetics and pharmacodynamics. Among 20 regimen-naive HIV-infected adult women initiating atazanavir-based therapy (n = 9) or efavirenz-based therapy (n = 11), we measured blood CD4+ T lymphocytes, and paired plasma and genital HIV RNA
Stephanie Brown et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3205-3210 (2015-02-13)
The monoterpene indole alkaloids are a large group of plant-derived specialized metabolites, many of which have valuable pharmaceutical or biological activity. There are ∼3,000 monoterpene indole alkaloids produced by thousands of plant species in numerous families. The diverse chemical structures
Yi-Ching Hsueh et al.
Biological chemistry, 396(9-10), 1151-1162 (2015-03-18)
Lipopolysaccharides (LPS) are central components of the outer membrane and consist of Lipid A, the core polysaccharide, and the O-antigen. The synthesis of LPS is initiated at the cytosolic face of the cytoplasmic membrane. The subsequent transport to and across
Yi-Ren Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 150-162 (2014-04-23)
The direct modulation of Antrodia cinnamomea (AC) on the prominent role of liver fibrosis-hepatic stellate cells (HSCs) in situ remains unclear. Firstly, the administration of A. cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation
Mari Akiyama
Analytical and bioanalytical chemistry, 406(24), 5805-5813 (2014-04-04)
Inspection of patient-derived cells used in transplantation is non-invasive. Therefore, proteomics analysis using supernatants of cells cultured before transplantation is informative. In order to investigate the cell niche of bovine periosteal cells, supernatants of these cultured cells were subjected to
Oana A Cuzman et al.
Journal of biotechnology, 214, 49-56 (2015-09-17)
The ureolytic bacteria are one of the most efficient organisms able to produce high amounts of carbonate that easily react with the free calcium ions from the environment. Sporosarcina pasteurii, a robust microbe in alkaline environments, was tested in this
Woo-Sung Kwon et al.
Scientific reports, 5, 13821-13821 (2015-09-09)
The ability to predict male fertility is of paramount importance for animal breeding industries and for human reproduction. Conventional semen analysis generally provides information on the quantitative parameters of spermatozoa, but yields no information concerning its functional competence. Proteomics have
Eugenia Mato et al.
Molecular and cellular endocrinology, 404, 37-45 (2015-01-27)
We investigated the role of VDAC2 in human epithelial thyroid tumours using proteomic 2D-DIGE analysis and qRT-PCR. We found a significant up-regulation of VDAC2 in thyroid tumours and in thyroid tumour cell lines (TPC-1 and CAL-62). We did not detect
Yi-Ping Chuang et al.
Infection and immunity, 83(2), 682-692 (2014-11-26)
Glycerophosphodiester phosphodiesterase (GlpQ) metabolizes glycerophosphorylcholine from the lung epithelium to produce free choline, which is transformed into phosphorylcholine and presented on the surfaces of many respiratory pathogens. Two orthologs of glpQ genes are found in Streptococcus pneumoniae: glpQ, with a
Qiao Wang et al.
Carbohydrate polymers, 111, 393-399 (2014-07-20)
Porous microspheres of regenerated cellulose with size in range of 1-2 μm and composite microspheres of chitosan coated cellulose with size of 1-3 μm were obtained through a two-step spray-assisted approach. The spray coagulating process must combine with a spray
Joydeep Roy et al.
Molecular biology of the cell, 26(9), 1583-1600 (2015-03-06)
Hsp70 aids in protein folding and directs misfolded proteins to the cellular degradation machinery. We describe discrete roles of Hsp70,SSA1 as an important quality-control machinery that switches functions to ameliorate the cellular environment. SSA1 facilitates folding/maturation of newly synthesized protein
Melanie Amort et al.
Nature communications, 6, 7030-7030 (2015-05-09)
Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the vault complex-associated RNAs (vtRNAs) are significantly upregulated in Epstein-Barr virus (EBV)-infected human B cells. Very little is known
Thiago Buno Lima Prando et al.
Journal of ethnopharmacology, 174, 369-378 (2015-09-01)
Although Echinodorus grandiflorus, Cuphea carthagenensis, and Phyllanthus tenellus infusions are used in Brazilian folk medicine due to their possible diuretic effect, none of these species was critically investigated as a diuretic drug. So, the aim of this study was to
Ana Paula Cordeiro et al.
BMC genomics, 16 Suppl 5, S11-S11 (2015-06-05)
Meningitis is the inflammation of the meninges in response to infection or chemical agents. While aseptic meningitis, most frequently caused by enteroviruses, is usually benign with a self-limiting course, bacterial meningitis remains associated with high morbidity and mortality rates, despite
Federica Mori et al.
Oncotarget, 6(16), 13946-13961 (2015-06-13)
High-grade osteosarcoma (OS) is characterized by low incidence, high aggressiveness and moderate 5-years survival rate after aggressive poly-chemotherapy and surgery. Here we used miRNA profiling as a tool to possibly predict and monitor OS's development and therapeutic outcome. First, we
Yuh-Wen Chiu et al.
Journal of environmental biology, 35(4), 667-673 (2014-07-10)
The freshwater golden apple snail, Pomacea canaliculata, is one of the world's 100 worst invasive alien species. The snails' wide distribution, high abundance, and sensitivity to environmental pollution make them a potential bioindicator for environmental contamination. In this study, the
Joaquín Fernández-Irigoyen et al.
Molecular brain, 7, 83-83 (2014-11-20)
The basal ganglia (BG) are a complex network of subcortical nuclei involved in the coordination and integration of the motor activity. Although these independent anatomical structures are functionally related, the proteome present in each isolated nucleus remains largely unexplored. In
Alain Carpentier et al.
Medicine and science in sports and exercise, 47(7), 1519-1522 (2014-10-22)
Recently, dietary supplementation with inorganic nitrate (NO3) has been proposed to endurance athletes to increase their performance. However, it has been suggested that an excess of NO3 might be harmful. The present study analyzed the effect of NO3 supplementation on
Budhaditya Mukherjee et al.
Journal of immunology (Baltimore, Md. : 1950), 195(6), 2731-2742 (2015-08-19)
Infection with antimony-resistant Leishmania donovani (Sb(R)LD) induces aggressive pathology in the mammalian hosts as compared with ones with antimony-sensitive L. donovani (Sb(S)LD) infection. Sb(R)LD, but not Sb(S)LD, interacts with TLR2/TLR6 to induce IL-10 by exploiting p50/c-Rel subunits of NF-κB in
Beata Głowińska et al.
Folia biologica, 61(1-2), 73-77 (2013-06-19)
The study aimed at investigating differences in selected peripheral blood biochemical parameters and hormones in bulls of various genotype: Polish Holstein-Friesians (PHF; group I) and crossbreeds obtained from PHF dams sired by Limousin bulls (LMxPHF; group II). The blood for
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