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Michael R Bukowski et al.
Analytical biochemistry, 469, 54-64 (2014-12-03)
Protein S-glutathionylation is a posttranslational modification that links oxidative stimuli to reversible changes in cellular function. Protein-glutathione mixed disulfide (PSSG) is commonly quantified by reduction of the disulfide and detection of the resultant glutathione species. This methodology is susceptible to
Antonio Cuadrado-Lavín et al.
The Journal of antimicrobial chemotherapy, 70(8), 2376-2381 (2015-04-10)
Helicobacter pylori eradication remains a challenge. Non-bismuth-based quadruple regimens (NBQR) have shown high eradication rates (ER) elsewhere that need to be locally confirmed. The objective of this study was to compare the first-line ER of a hybrid therapy (20 mg
L Zou et al.
European journal of clinical nutrition, 68(12), 1288-1293 (2014-08-15)
To explore early (within 72 h) vs delayed enteral nutrition (EN) therapy for patients with acute pancreatitis (AP). A total of 93 patients were allocated to two groups: early enteral nutrition (EEN) group (started within 72 h after onset) and delayed enteral
Thomas L Pannabecker
American journal of physiology. Regulatory, integrative and comparative physiology, 304(7), R488-R503 (2013-02-01)
Comparative studies of renal structure and function have potential to provide insights into the urine-concentrating mechanism of the mammalian kidney. This review focuses on the tubular transport pathways for water and urea that play key roles in fluid and solute
H Younes et al.
Nephrologie, 25(7), 283-285 (2004-12-09)
During the past few decades, considerable attention has been given to the impact of nutrition on kidney disease. Although most dietary attempts to treat chronic renal failure (CRF) and to decrease uremia recommend a protein restriction, another dietetic approach, based
Christian Görgens et al.
Analytical and bioanalytical chemistry, 407(18), 5365-5379 (2015-05-01)
In the field of LC-MS, reversed phase liquid chromatography is the predominant method of choice for the separation of prohibited substances from various classes in sports drug testing. However, highly polar and charged compounds still represent a challenging task in
Lingying Liu et al.
International journal of clinical and experimental pathology, 8(6), 6367-6376 (2015-08-12)
In this study, we will establish a stable and optimized rat model that can meet strictly diagnosed criteria and serve as a tool to investigate the potential of novel therapeutics in this preclinical model through comparative analysis of systemic alterations
Tetsuya Ishikawa et al.
PloS one, 10(4), e0123193-e0123193 (2015-04-16)
Preparing targeted cells for medical applications from human induced pluripotent stem cells (hiPSCs) using growth factors, compounds, or gene transfer has been challenging. Here, we report that human induced hepatic lineage-oriented stem cells (hiHSCs) were generated and expanded as a
Daniel Herkommer et al.
ChemMedChem, 10(3), 470-489 (2015-02-03)
The natural products rhizopodin and bistramide belong to an elite class of highly potent actin binding agents. They show powerful antiproliferative activities against a range of tumor cell lines, with IC50 values in the low-nanomolar range. At the molecular level
Athanasios K Anagnostopoulos et al.
Journal of proteome research, 14(2), 1076-1088 (2014-12-30)
CNS tumors are the leading cause of cancer-related death in children. Medulloblastoma is the commonest pediatric CNS malignancy, wherein, despite multimodal therapy with surgery, radiation, and chemotherapy, 5 year survival rates merely approach 60%. Until present, gene expression and cytogenetic
Ying Zhang et al.
International journal of clinical and experimental medicine, 8(4), 5631-5639 (2015-07-02)
To identify putative biomarkers for ossification of posterior longitudinal ligament (OPLL). Proteomic analysis was performed in 4 ligament samples from OPLL patients and healthy controls. RT-PCR was used to further verify the proteomic analysis results. A total of 50 differentially
Aming Zhang et al.
Biochemistry, 54(10), 1956-1962 (2015-03-03)
Both recombinant and natural human IgG2 antibodies have several different disulfide bond isoforms, which possess different global structures, thermal stabilities, and biological activities. A detailed mapping of the structural difference among IgG2 disulfide isoforms, however, has not been established. In
Jae Jin Hwang et al.
World journal of gastroenterology, 21(26), 8132-8139 (2015-07-18)
To compare the efficacy of 14- and 7-d bismuth-based quadruple therapies as second-line eradication treatment for Helicobacter pylori (H. pylori) infection. Between 2004 and 2014, the medical records of 790 patients who had experienced failure of first-line proton pump inhibitor
Ting Zhang et al.
Investigative ophthalmology & visual science, 54(4), 3072-3081 (2013-04-13)
We characterized the de-epithelialized human amniotic membrane (HAM), and compared cell attachment and proliferation efficiencies. HAM was de-epithelialized by 20% ethanol (AHAM), 1.2 U/mL Dispase (DHAM), 0.02% EDTA (EHAM), 0.25% trypsin-EDTA (THAM), and 5 M urea (UHAM), respectively, followed by
H Nir et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 67(2), 97-102 (2015-04-08)
Acute renal injury may occur after amphotericin B (AmB) administration. The hypothesized injury mechanism is renal vasoconstriction and direct toxic damage. Hyperbaric oxygen therapy (HBO) is indicated for treatment of many ischemic events but not for acute renal failure (ARF).
M Kohnle et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 6(1), 205-208 (2006-01-26)
We investigated prospectively the efficacy of ezetimibe in addition to statin therapy in stable renal transplant patients in whom hypercholesterolemia was not sufficiently treated. Eighteen renal transplant patients received 10 mg ezetimibe once daily in addition to high-dose statin therapy
Chuanyu Yang et al.
PloS one, 10(7), e0133826-e0133826 (2015-07-25)
Huanglongbing (HLB) is the most serious disease affecting the citrus industry worldwide to date. The causal agent, Candidatus Liberibacter asiaticus (Las), resides in citrus phloem, which makes it difficult to effectively treat with chemical compounds. In this study, a transcuticular
Ghana Vasanth et al.
Frontiers in immunology, 6, 409-409 (2015-09-09)
The efficacy of a microbial feed additive (Bactocell(®)) in countering intestinal inflammation in Atlantic salmon was examined in this study. Fish were fed either the additive-coated feed (probiotic) or feed without it (control). After an initial 3-week feeding, an inflammatory
Hiroyuki Yamashita et al.
Pharmaceutical research, 31(8), 1946-1957 (2014-02-14)
The advent of cocrystals has demonstrated a growing need for efficient and comprehensive coformer screening in search of better development forms, including salt forms. Here, we investigated a coformer screening system for salts and cocrystals based on binary phase diagrams
Junjie Zhang et al.
International journal of molecular sciences, 15(9), 16186-16195 (2014-09-16)
Wilms' tumor is one of the most common malignant tumors observed in children, and its early diagnosis is important for late-stage treatment and prognosis. We previously screened and identified protein markers for Wilms' tumor; however, these markers lacked specificity, and
Yang Zhang et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(9), 1901-1907 (2013-05-10)
The inhibitory effect of ozone and hydrogen peroxide (HP) on urea hydrolysis in stored urine was investigated and compared. Ozone showed less effect on urea hydrolysis due to the complicated composition of urine (including a large amount of urease-producing bacteria)
Nan-Yuan Teng et al.
Tissue engineering. Part A, 21(7-8), 1444-1454 (2015-01-28)
In vitro differentiation of stem cells into specific cell lineages provides a stable cell supply for cell therapy and tissue engineering. Therefore, understanding the mechanisms underlying such differentiation processes is critical for generating committed lineage-specific cell progenies effectively. We previously
Teja Celhar et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(45), E6195-E6204 (2015-10-30)
Glomerulonephritis is a common and debilitating feature of systemic lupus erythematosus (SLE). The precise immune mechanisms that drive the progression from benign autoimmunity to glomerulonephritis are largely unknown. Previous investigations have shown that a moderate increase of the innate Toll-like
Estéfani García-Ríos et al.
BMC genomics, 15, 1059-1059 (2014-12-05)
The wine industry needs better-adapted yeasts to grow at low temperature because it is interested in fermenting at low temperature to improve wine aroma. Elucidating the response to cold in Saccharomyces cerevisiae is of paramount importance for the selection or
Hitesh M Soni et al.
Indian journal of pharmacology, 47(1), 80-85 (2015-03-31)
The aim was to investigate the nephroprotective effect of combination of aliskiren (ASK), a direct renin inhibitor and pentoxifylline (PTX), inhibitor of tumor necrotic factor-alpha (TNF-alpha), in rat remnant kidney model of chronic kidney disease (CKD). Nephrectomized (NPX) rats were
Yong Wang et al.
Journal of proteome research, 14(2), 804-813 (2014-12-17)
The Y-box-binding protein 1 (YBX1) plays a critical role in tumorigenesis by promoting cell proliferation, overriding cell-cycle check points, and enhancing genomic instability. In this study, the interactome of YBX1 in renal cell carcinoma (RCC) was analyzed by coimmunoprecipitation and
Feng Wang et al.
Scientific reports, 5, 16323-16323 (2015-11-17)
With an increasing clinical demand for functional therapeutic proteins every year, there is an increasing requirement for the massive production of bioactive recombinant human acidic fibroblast growth factor (r-haFGF). In this present study, we delicately explore a strategy for the
Andris Dishlers et al.
Molecular biotechnology, 57(11-12), 1038-1049 (2015-10-09)
The major immunodominant region (MIR) and N-terminus of the hepatitis B virus (HBV) core (HBc) protein were used to expose foreign insertions on the outer surface of HBc virus-like particles (VLPs). The additions to the HBc positively charged arginine-rich C-terminal
ZhengGang Ren et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(8), 894-900 (2015-02-11)
To assess whether urea-based cream (UBC) has prophylactic benefits on sorafenib-induced hand-foot skin reaction (HFSR) in patients with advanced hepatocellular carcinoma (HCC). In this randomized, open-label trial, 871 patients with advanced HCC throughout China were treated with 10% UBC three
Barbara Fogli et al.
Scientific reports, 9(1), 10095-10095 (2019-07-14)
While axons within the central nervous system (CNS) do not regenerate following injury, those in the peripheral nervous system (PNS) do, although not in a clinically satisfactory manner as only a small proportion of axons exhibit long-distance regeneration. Moreover, functional
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