Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions including...
Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin
Massey L K, et al.
The Biochemical Journal, 391(3), 513-525 (2005)
Protein aggregation and degradation mechanisms in neurodegenerative diseases.
Takalo M, et al.
American Journal of Neurodegenerative Disease, 2(1), 1-1 (2013)
Whether transcriptional regulators are functionally involved in mitosis is a fundamental question in cell biology. Here we report that the RNF20/40 complex, a major ubiquitin ligase catalysing histone H2B monoubiquitination, interacts with the motor protein Eg5 during mitosis and participates...
The Journal of biological chemistry, 281(43), 32240-32253 (2006-09-02)
Ubiquilin 1 (UBQLN1) is a ubiquitin-like protein, which has been shown to play a central role in regulating the proteasomal degradation of various proteins, including the presenilins. We recently reported that DNA variants in UBQLN1 increase the risk for Alzheimer...
Unbiased screen reveals ubiquilin-1 and-2 highly associated with huntingtin inclusions
Neuropathology : official journal of the Japanese Society of Neuropathology, 34(1), 11-18 (2013-07-23)
This post mortem immunohistochemical study examined the localization and distribution of ubiquilin-1 (UBL), a shuttle protein which interacts with ubiquitin and the proteasome, in the hippocampus from Alzheimer's disease (AD) dementia cases, and age-matched cases without dementia. In Braak stages...
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