Showing 1-10 of 10 results for "U7258"
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation
Mah A L, et al.
The Journal of cell biology, 151(4), 847-862 (2000)
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models
Natunen T, et al.
Neurobiology of Disease, 85(6), 187-205 (2016)
Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease
Sundar P D, et al.
Neurobiology of Aging, 28(6), 856-862 (2007)
Nicola J Rutherford et al.
Brain research, 1524, 62-73 (2013-06-19)
Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions including...
Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin
Massey L K, et al.
The Biochemical Journal, 391(3), 513-525 (2005)
Protein aggregation and degradation mechanisms in neurodegenerative diseases.
Takalo M, et al.
American Journal of Neurodegenerative Disease, 2(1), 1-1 (2013)
Yang Duan et al.
Nature communications, 7, 12648-12648 (2016-08-26)
Whether transcriptional regulators are functionally involved in mitosis is a fundamental question in cell biology. Here we report that the RNF20/40 complex, a major ubiquitin ligase catalysing histone H2B monoubiquitination, interacts with the motor protein Eg5 during mitosis and participates...
Mikko Hiltunen et al.
The Journal of biological chemistry, 281(43), 32240-32253 (2006-09-02)
Ubiquilin 1 (UBQLN1) is a ubiquitin-like protein, which has been shown to play a central role in regulating the proteasomal degradation of various proteins, including the presenilins. We recently reported that DNA variants in UBQLN1 increase the risk for Alzheimer...
Unbiased screen reveals ubiquilin-1 and-2 highly associated with huntingtin inclusions
Rutherford N J, et al.
Brain Research, 1524(6), 62-73 (2013)
Katsuyoshi Mizukami et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 34(1), 11-18 (2013-07-23)
This post mortem immunohistochemical study examined the localization and distribution of ubiquilin-1 (UBL), a shuttle protein which interacts with ubiquitin and the proteasome, in the hippocampus from Alzheimer's disease (AD) dementia cases, and age-matched cases without dementia. In Braak stages...

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