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Regulation of isoleucine and valine biosynthesis.
M Iaccarino et al.
Current topics in cellular regulation, 14, 29-73 (1978-01-01)
Xuejing Yu et al.
The FEBS journal, 281(1), 391-400 (2013-11-12)
Branched-chain amino acid aminotransferase (BCAT) plays a key role in the biosynthesis of hydrophobic amino acids (such as leucine, isoleucine and valine), and its substrate spectrum has not been fully explored or exploited owing to the inescapable restrictions of previous...
Walid Jalabi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(38), 15044-15049 (2013-09-21)
The medial nucleus of the trapezoid body (MNTB) in the superior olivary complex (SOC) is an inhibitory hub considered critical for binaural sound localization. We show that genetic ablation of MNTB neurons in mice only subtly affects this ability by...
Shlomit Schaal et al.
JAMA ophthalmology, 132(7), 881-882 (2014-04-20)
Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history...
Ijin Joo et al.
Radiology, 272(2), 417-426 (2014-04-05)
To evaluate the diagnostic value of intravoxel incoherent motion (IVIM) diffusion-weighted (DW) magnetic resonance (MR) imaging in the quantitative assessment of the therapeutic efficacy of a vascular disrupting agent (VDA) (CKD-516) in rabbit VX2 liver tumors. The institutional animal care...
Maria Szpetnar et al.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 59(2), 91-95 (2005-09-09)
Acute and chronic ischaemic diseases are among the main death reasons and civilized world menace. Branched chain amino acids (BCAAs): valine (Val), leucine (Leu), and isoleucine (Ile) are the main source of nitrogen to glutamine (Gln) and alanine (Ala) synthesis...
Young Il Kim et al.
Anticancer research, 34(4), 1715-1722 (2014-04-03)
To evaluate the anticancer efficacy of CKD-516, a novel vascular-disrupting agent, alone and in combination with doxorubicin in the treatment of hepatocellular carcinoma (HCC). In mice bearing luciferized HCC cells, therapeutic efficacy was assessed for seven days after single administration...
B Leclercq
Poultry science, 77(1), 118-123 (1998-02-20)
Lysine exerts specific effects on body composition at dietary levels higher than that required for maximum growth rate, which also results in an improved feed conversion ratio (FCR). As a consequence of these differences, it becomes apparent that there is...
Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia.
Sascha Dietrich et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e300-e303 (2013-05-22)
S A Wudy et al.
Steroids, 66(10), 759-762 (2001-08-28)
A first assay based on stable isotope dilution/gas chromatography-mass spectrometry has been developed for plasma 17alpha-hydroxypregnenolone, the leading marker of 3beta-hydroxysteroid dehydrogenase deficiency. Equilibration of plasma with internal standard was followed by solid phase extraction. After clean up using Sephadex...
Vessela Vitcheva et al.
Oxidative medicine and cellular longevity, 2015, 157876-157876 (2015-11-18)
One of the mechanisms involved in the development of addiction, as well as in brain toxicity, is the oxidative stress. The aim of the current study was to investigate the effects of 7-nitroindazole (7-NI), a selective inhibitor of neuronal nitric...
Christopher A Bishop et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(7), 9727-9739 (2020-06-09)
Dairy intake, as a source of branched-chain amino acids (BCAA), has been linked to a lower incidence of type-2-diabetes and increased circulating odd-chain fatty acids (OCFA). To understand this connection, we aimed to investigate differences in BCAA metabolism of leucine...
Amino acids: metabolism, functions, and nutrition.
Wu G
Amino Acids, 37(1), 1-17 (2009)
An unusual presenting complaint for herpes zoster.
Michael S Wasserman et al.
The American journal of medicine, 126(6), e3-e4 (2013-04-02)
Peter J Boogaard et al.
Toxicology letters, 231(3), 387-390 (2014-06-03)
During a short incident in an ethylene oxide (EO) producing plant, EO vapour was released under high pressure. Operators wore full respiratory protection during repairs to fix the leak. To check the adequacy of the applied personal protective equipment and...
[Telmisartan and valsartan].
Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec, 10(5), 63-63 (2013-12-24)
Sunita Venkateswaran et al.
Developmental medicine and child neurology, 56(1), 91-94 (2013-12-18)
The phenotype attributed to MECP2 mutations continues to expand. In addition to classic and variant Rett syndrome, phenotypes include non-specific intellectual disability and autism spectrum disorder in females, and fatal neonatal encephalopathy in males. One particular phenotype of parkinsonism, pyramidal...
Chunhui Deng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 775(1), 115-120 (2002-07-09)
A new method for quantifying specific amino acids in small volumes of plasma and whole blood has been developed. Volatile derivatives of amino acids are analyzed by gas chromatography-mass spectrometry. The method only takes a few minutes to perform and...
Davide Bressanello et al.
Journal of chromatography. A, 1361, 265-276 (2014-08-28)
This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse urine. Samples were obtained from a murine model that mimics a typical unhealthy Western diet featuring...
Shih-Chia Tso et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9728-9733 (2013-05-30)
The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes. BCAA homeostasis is controlled by the mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC), which is negatively regulated by...
Nebivolol and valsartan: useful treatment for hypertension?
Bernard Waeber et al.
Lancet (London, England), 383(9932), 1864-1866 (2014-06-03)
Adam J Mead et al.
Blood, 121(20), 4156-4165 (2013-03-29)
The association between somatic JAK2 mutation and myeloproliferative neoplasms (MPNs) is now well established. However, because JAK2 mutations are associated with heterogeneous clinical phenotypes and often occur as secondary genetic events, some aspects of JAK2 mutation biology remain to be...
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio...
Hyungju Park et al.
Neuron, 84(5), 1009-1022 (2014-12-04)
Activation of N-methyl-D-aspartate subtype of glutamate receptors (NMDARs) in postsynaptic dendrites is required for long-term potentiation (LTP) of many excitatory synapses, but the role of presynaptic axonal NMDARs in synaptic plasticity remains to be clarified. Here we report that axonal...
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and...
Tatsuo K Sato et al.
Nature neuroscience, 17(1), 30-32 (2013-11-19)
Neurons in different locations across the cortex are connected through polysynaptic networks involving both excitation and inhibition. To probe the functional effect of such networks, we used optogenetic stimulation to trigger antidromic spikes in a local region of primary visual...
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <...
Mary J Burton et al.
The American journal of the medical sciences, 348(6), 455-459 (2014-08-28)
We performed a pilot study examining the safety and tolerability of valacyclovir in veterans with herpes simplex virus type 2 and hepatitis C virus (HCV) coinfection. We performed a randomized double-blind, placebo-controlled, crossover clinical trial in U.S. veterans with genotype...
William McDonald et al.
Biochemistry, 53(27), 4467-4475 (2014-06-18)
Knowing how the protein environment modulates ligand pathways and redox centers in the respiratory heme-copper oxidases is fundamental for understanding the relationship between the structure and function of these enzymes. In this study, we investigated the reactions of O2 and...
Novartis faces charges in Japan over promotion of valsartan to doctors.
Gavin Blair
BMJ (Clinical research ed.), 348, g287-g287 (2014-01-18)
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