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G Ian Gallicano et al.
Gene therapy (2020-11-14)
Covid-19 (SARS CoV-2) has become a deadly, world-wide pandemic. Although most who are infected survive, complications from the virus can be pronounced and long-lasting. To date, of all the respiratory viruses including influenza and coronaviruses, only influenza has had a
Stéphane Pierre et al.
Toxicological sciences : an official journal of the Society of Toxicology, 137(1), 114-124 (2013-10-25)
The contribution of environmental pollutants to liver fibrosis is an important and poorly explored issue. In vitro studies suggest that the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) ligands induce several genes that are known to be
Yi-Jin Tao et al.
International journal of ophthalmology, 12(7), 1075-1082 (2019-07-26)
To determine the effect of pirfenidone on the activated human Müller cells by platelet-derived growth factor-BB (PDGF-BB). The primary human Müller cells were separated from retinal tissues and established the pathogenic model by stimulated with PDGF-BB. The Müller cells behaviour
Isolation and characterization of kidney-derived stem cells.
Gupta S, et al.
Journal of the American Society of Nephrology, 17(11), 3028-3040 (2006)
Hyun-Gyo Lee et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(9), 1153-1160 (2014-02-28)
Dysregulated cyclin-dependent kinases (CDKs) are considered a potential target for cancer therapy. Flavopiridol is a potent CDK inhibitor. In this study, the antiproliferative effect of the flavonoid compound flavopiridol and its mechanism in human uterine leiomyoma cells were investigated. The
Vatsala Maitin et al.
Journal of lipid research, 55(1), 75-84 (2013-10-19)
One mechanism of the lipid-lowering effects of the fish oil n-3 fatty acids [e.g., docosahexaenoic acid (DHA)] in cell and animal models is induced hepatic apolipoprotein B100 (apoB) presecretory degradation. This degradation occurs post-endoplasmic reticulum, but whether DHA induces it
María Alejandra González-González et al.
Scientific reports, 7, 40768-40768 (2017-01-21)
The periventricular zone of cerebellum is a germinative niche during the embryonic development, nevertheless its structural organization and functional implications in adult have not been widely studied. Here we disclose the presence of two novel clusters of cells in that
Mice with cav-1 gene disruption have benign stromal lesions and compromised epithelial differentiation.
Yang G, et al.
Experimental and Molecular Pathology, 84(2), 131-140 (2008)
Christine Wasylyk et al.
International journal of cancer, 127(11), 2542-2553 (2010-02-18)
Prostate cancer is a common cause of death, and an important goal is to establish the pathways and functions of causative genes. We isolated RNAs that are differentially expressed in macrodissected prostate cancer samples. This study focused on 1 identified
Lifeng Yang et al.
Toxicology, 389, 74-84 (2017-07-27)
Both RhoA/ROCK and Raf-1/CK2 pathway play essential roles in cell proliferation, apoptosis, differentiation, and multiple other common cellular functions. We previously reported that vimentin is responsible for TNF-α-induced cell apoptosis. Herein, we investigated the regulation of RhoA/ROCK and Raf-1/CK2 signaling
G Bhuvanalakshmi et al.
Stem cell reviews, 10(6), 856-870 (2014-06-14)
The chick embryo represents an accessible and economical in vivo model, which has long been used in developmental biology, gene expression analysis, and loss/gain of function experiments. In the present study, we assessed and characterized bone marrow derived mesenchymal stem
The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin.
Zhao L, et al.
Journal of Cellular Physiology, 233(3), 2420-2425 (2018)
Anisa Shaker et al.
The Journal of clinical investigation, 120(6), 2081-2093 (2010-05-12)
Epithelial-mesenchymal interactions regulate normal gut epithelial homeostasis and have a putative role in inflammatory bowel disease and colon cancer pathogenesis. Epimorphin is a mesenchymal and myofibroblast protein with antiproliferative, promorphogenic effects in intestinal epithelium. We previously showed that deletion of
Jie Yang et al.
Scientific reports, 6, 38372-38372 (2016-12-03)
Damage to vascular endothelial cells (VECs) is a critical hallmark of hemorrhagic diseases caused by dengue virus (DENV). However, the precise molecular event involved in DENV binding and infection of VECs has yet to be clarified. In this study, vimentin
A novel role of vimentin filaments: binding and stabilization of collagen mRNAs.
Challa AA and Stefanovic B.
Molecular and Cellular Biology, 31, 3773-3789 (2011)
Eliane Moisan et al.
Journal of leukocyte biology, 79(3), 489-498 (2005-12-21)
Neutrophils represent an important source of autoantigens for antineutrophil cytoplasmic antibody associated with vasculitis. To date, two cytoskeletal proteins, vinculin and vimentin, have been reported to be expressed on the cell surfaces of activated macrophages, platelets, and apoptotic T lymphocytes.
Ji Min Yu et al.
Methods in molecular biology (Clifton, N.J.), 702, 219-231 (2010-11-18)
While adult stem cells can be induced to transdifferentiate into multiple lineages of cells or tissues, their plasticity and utility for human therapy remains controversial. In this chapter, we describe methods for the transdifferentiation of human adipose tissue-derived stem cells
Hiroaki Shime et al.
Infection and immunity, 70(11), 6460-6463 (2002-10-16)
To help understand the molecular mechanisms of Pasteurella multocida toxin (PMT) action, we searched for a cellular protein interacting with PMT. The ligand overlay assay revealed a 60-kDa cellular protein that binds to a region from the 840th to 985th
Nawal Bendris et al.
Cellular and molecular life sciences : CMLS, 71(24), 4881-4894 (2014-06-01)
Our previous work showed that Cyclin A2 deficiency promotes cell invasion in fibroblasts. Given that the majority of cancers emerge from epithelia, we explored novel functions for Cyclin A2 by depleting it in normal mammary epithelial cells. This caused an
Benedikt Schwartz et al.
Mechanisms of development, 133, 23-35 (2014-07-16)
Mesoderm formation in the mouse embryo initiates around E6.5 at the primitive streak and continues until the end of axis extension at E12.5. It requires the process of epithelial-to-mesenchymal transition (EMT), wherein cells detach from the epithelium, adopt mesenchymal cell
Catherine H Kaschula et al.
BMC cancer, 19(1), 248-248 (2019-03-22)
Garlic has been used for centuries for its flavour and health promoting properties that include protection against cancer. The vinyl disulfide-sulfoxide ajoene is one of the phytochemicals found in crushed cloves, hypothesised to act by S-thiolating reactive cysteines in target
Ji Hye Jun et al.
Cells, 11(2) (2022-01-22)
Changes in the structure and function of blood vessels are important factors that play a primary role in regeneration of injured organs. WKYMVm has been reported as a therapeutic factor that promotes the migration and proliferation of angiogenic cells. Additionally
Tumor HLA?DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma
Matoba K, et al.
International Journal of Cancer. Journal International Du Cancer, 115(2), 231-240 (2005)
Amy L Howes et al.
PloS one, 9(9), e108283-e108283 (2014-09-24)
3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cell culture and in vivo studies. To benefit anti-cancer drug discovery from 3D models, new techniques are needed that enable their use in high-throughput (HT) screening amenable
Eric Boilard et al.
Blood, 102(8), 2901-2909 (2003-06-28)
One of the most studied secreted phospholipases A2 (sPLA2), the group IIA sPLA2, is found at high levels in inflammatory fluids of patients with autoimmune diseases. A characteristic of group IIA sPLA2 is its preference for negatively charged phospholipids, which
Astrocytes acquire morphological and functional characteristics of ependymal cells following disruption of ependyma in hydrocephalus.
Roales-Bujan R
Acta Neuropathologica, 124, 531-546 (2012)
Sandeep Gupta et al.
Journal of the American Society of Nephrology : JASN, 17(11), 3028-3040 (2006-09-22)
Acute kidney injury is followed by regeneration of damaged renal tubular epithelial cells. The purpose of this study was to test the hypothesis that renal stem cells exist in the adult kidney and participate in the repair process. A unique
Taeyong Lee
Journal of bone metabolism, 26(3), 179-191 (2019-09-27)
Osteolytic metastasis is a common destructive form of metastasis, in which there is an increased bone resorption but impaired bone formation. It is hypothesized that the changed mechanical properties of tumor affected bone cells could inhibit its mechanosensing, thus contributing
Eun Joo Lee et al.
Respirology (Carlton, Vic.), 25(4), 417-426 (2019-08-01)
Mesenchymal stem cells (MSC) have been shown to ameliorate the deleterious effects of bleomycin in murine models. However, the mechanism responsible for protection from pulmonary fibrosis by stem cell therapy is still poorly understood, especially in terms of endoplasmic reticulum
Christiane Fuchs et al.
Biology open, 5(2), 140-153 (2016-01-21)
The transcription factor Nkx2.5 and the intermediate filament protein desmin are simultaneously expressed in cardiac progenitor cells during commitment of primitive mesoderm to the cardiomyogenic lineage. Up-regulation of Nkx2.5 expression by desmin suggests that desmin may contribute to cardiogenic commitment
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