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V4638

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L H Elvers et al.
Journal of inherited metabolic disease, 30(4), 609-609 (2007-06-19)
Neonatal screening for congenital disorders like phenylketonuria (PKU), congenital hypothyroidism (CH) and congenital adrenal hyperplasia (CAH) is generally performed in dried blood spots on filter paper. The analytes of interest for testing for PKU, CH and CAH are phenylalanine, thyrotropin
Mary J Burton et al.
The American journal of the medical sciences, 348(6), 455-459 (2014-08-28)
We performed a pilot study examining the safety and tolerability of valacyclovir in veterans with herpes simplex virus type 2 and hepatitis C virus (HCV) coinfection. We performed a randomized double-blind, placebo-controlled, crossover clinical trial in U.S. veterans with genotype
M J McKinley
American journal of physiology. Regulatory, integrative and comparative physiology, 304(12), R1149-R1160 (2013-04-19)
Most ingested sodium is contained in food. The aim was to investigate whether sodium depletion, dehydration, or DOCA alters intakes of salted and unsalted foods by rats given choices of two foods: salted (0.2-0.5% Na) and unsalted food containing either
William McDonald et al.
Biochemistry, 53(27), 4467-4475 (2014-06-18)
Knowing how the protein environment modulates ligand pathways and redox centers in the respiratory heme-copper oxidases is fundamental for understanding the relationship between the structure and function of these enzymes. In this study, we investigated the reactions of O2 and
Hernan Carol et al.
Pediatric blood & cancer, 61(8), 1493-1496 (2014-03-26)
PF-03084014, a γ-secretase inhibitor, was tested against the PPTP in vitro cell line panel (1.0 nM to 10 μM) and against the in vivo xenograft panels (administered orally twice daily on Days 1-7 and 15-21). PF-03084014 demonstrated limited in vitro activity, with
Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <
K J Bär et al.
Neurobiology of aging, 24(2), 333-338 (2002-12-25)
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be
Paul J Kennedy et al.
Psychopharmacology, 232(8), 1357-1371 (2014-10-24)
A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine
Vessela Vitcheva et al.
Oxidative medicine and cellular longevity, 2015, 157876-157876 (2015-11-18)
One of the mechanisms involved in the development of addiction, as well as in brain toxicity, is the oxidative stress. The aim of the current study was to investigate the effects of 7-nitroindazole (7-NI), a selective inhibitor of neuronal nitric
Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia.
Sascha Dietrich et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e300-e303 (2013-05-22)
Xin Zhang et al.
Hypertension (Dallas, Tex. : 1979), 64(1), 87-93 (2014-04-23)
Renovascular hypertension alters cardiac structure and function. Autophagy is activated during left ventricular hypertrophy and linked to adverse cardiac function. The angiotensin II receptor blocker, valsartan, lowers blood pressure and is cardioprotective, but whether it modulates autophagy in the myocardium
Shankar Sachidhanandam et al.
Nature neuroscience, 16(11), 1671-1677 (2013-10-08)
Neocortical activity can evoke sensory percepts, but the cellular mechanisms remain poorly understood. We trained mice to detect single brief whisker stimuli and report perceived stimuli by licking to obtain a reward. Pharmacological inactivation and optogenetic stimulation demonstrated a causal
Nebivolol and valsartan: useful treatment for hypertension?
Bernard Waeber et al.
Lancet (London, England), 383(9932), 1864-1866 (2014-06-03)
Giulia Quattrocolo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5486-5498 (2013-03-29)
Cajal-Retzius cells are a class of neurons believed to play critical roles during cortical development. However, their network computational functions remain poorly understood. Although work in the neocortex and hippocampus has shown that Cajal-Retzius cells receive predominantly, if not exclusively
Mami Otaka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(16), 6753-6758 (2013-04-19)
Medium spiny neurons (MSNs) within the nucleus accumbens shell (NAc) function to gate and prioritize emotional/motivational arousals for behavioral output. The neuronal output of NAc MSNs is mainly determined by the integration of membrane excitability and excitatory/inhibitory synaptic inputs. Whereas
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and
Tatsuo K Sato et al.
Nature neuroscience, 17(1), 30-32 (2013-11-19)
Neurons in different locations across the cortex are connected through polysynaptic networks involving both excitation and inhibition. To probe the functional effect of such networks, we used optogenetic stimulation to trigger antidromic spikes in a local region of primary visual
Junbo Li et al.
Luminescence : the journal of biological and chemical luminescence, 30(5), 643-648 (2014-10-28)
In an HCl medium (pH 1.5), ligustrazine (2,3,5,6-tetramethylpyrazine, TMP) reacted with 12-tungstophosphoric acid (TP) to form a 3 : 1 ion-association complex. As a result, the intensities of resonance Rayleigh scattering (RRS), second-order scattering (SOS) and frequency doubling scattering (FDS) were
T De Smedt et al.
Toxicology letters, 231(3), 344-351 (2014-09-17)
On Saturday May 4, 2013, a train transporting chemicals derailed in the village of Wetteren (Belgium) and caused a leak of acrylonitrile (ACN). To assess the human exposure to acrylonitrile in the local population with the highest suspected exposure. Between
Wilson I Gonsalves et al.
Journal of the National Cancer Institute, 106(7), doi:10-doi:10 (2014-06-14)
KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them. Two thousand three hundred twenty-six of 3397 patients in the N0147 phase III
BRAF V600E mutation identifies a subset of low-grade diffusely infiltrating gliomas in adults.
Andrew S Chi et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(14), e233-e236 (2013-04-03)
Jason Yamada-Hanff et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(38), 15011-15021 (2013-09-21)
Hippocampal CA1 pyramidal neurons are normally quiescent but can fire spontaneously when stimulated by muscarinic agonists. In brain slice recordings from mouse CA1 pyramidal neurons, we examined the ionic basis of this activity using interleaved current-clamp and voltage-clamp experiments. Both
Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma.
Frederic J Kaye et al.
Journal of the National Cancer Institute, 107(1), 378-378 (2014-12-06)
S Ishiwata et al.
The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)
To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The
Airi Sekine et al.
SpringerPlus, 4, 48-48 (2015-02-13)
The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor at endogenous brain concentrations. Recent studies have suggested that increase of brain KYNA levels is involved in psychiatric disorders such as schizophrenia and depression.
S A Wudy et al.
Steroids, 66(10), 759-762 (2001-08-28)
A first assay based on stable isotope dilution/gas chromatography-mass spectrometry has been developed for plasma 17alpha-hydroxypregnenolone, the leading marker of 3beta-hydroxysteroid dehydrogenase deficiency. Equilibration of plasma with internal standard was followed by solid phase extraction. After clean up using Sephadex
Inge Derad et al.
Hypertension (Dallas, Tex. : 1979), 63(4), 762-767 (2014-01-15)
Intranasal administration of angiotensin II (ANGII) affects blood pressure in a mode different from intravenously administered ANGII via a direct access to the brain bypassing the blood-brain barrier. This clinical study investigated blood pressure regulation after intranasal ANGII administration in
Concerns for the heart failure reduction in the NAGOYA HEART Study based on meta-regression from the evidence.
Hisato Takagi et al.
Hypertension (Dallas, Tex. : 1979), 62(5), e31-e32 (2013-09-11)
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