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V800018

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Shao-Yu Peng et al.
Taiwanese journal of obstetrics & gynecology, 53(2), 151-157 (2014-07-16)
Liver fibrosis results from the wound healing response to chronic liver damage. Advanced liver fibrosis results in cirrhosis and liver failure, and liver transplantation is often the only option for effective therapy; however, the shortage of available donor livers limits...
Jiri Vrba et al.
Journal of pharmaceutical and biomedical analysis, 102, 193-198 (2014-10-07)
In this study, we developed a new liquid chromatography-mass spectrometry (LC-MS) method for analysis of the protoberberine alkaloid palmatine and its metabolites with separation performed on a cyanopropyl-modified stationary phase. Palmatine (10 μM) was metabolized using suspensions of human hepatocytes...
Sungmin Hong et al.
Advanced materials (Deerfield Beach, Fla.), 27(27), 4035-4040 (2015-06-03)
A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogel tougher than natural cartilage. Encapsulated cells maintain high viability over a 7 d culture period and are...
Jae Won Lee et al.
Bioresource technology, 182, 296-301 (2015-02-24)
The objectives of this study were to explore the feasibility of applying sequential dilute acid and alkali pretreatment into the hydrolysis of corn stover and to elucidate the effects of structural changes in the biomass on its enzymatic digestibility. H2SO4...
R W Han et al.
Food chemistry, 181, 119-126 (2015-03-22)
A selective and rapid method has been developed to determine, simultaneously, 38 veterinary antibiotic residues in raw milk by ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). One milliliter of raw milk was diluted with 0.5 mL water and 3 mL acetonitrile...
Guokun Wang et al.
Enzyme and microbial technology, 77, 21-28 (2015-07-04)
The majority of the cysteine residues in the secreted proteins form disulfide bonds via protein disulfide isomerase (PDI)-mediated catalysis, stabilizing the enzyme activity. The role of PDI in cellulase production is speculative, as well as the possibility of PDI as...
Hyun-Gyu Lee et al.
Journal of hazardous materials, 283, 400-409 (2014-10-14)
In this work, a new hybrid nanocatalyst, namely titanium dioxide (TiO2) composite nanowires, encapsulated with graphene (G) and palladium nanoparticles (Pd NPs) (designated as G-Pd@TiO2-CNWs), was prepared. In preparing the nanowires, a combination of electrospinning and hydrothermal approaches was employed....
Jun Deng et al.
The Journal of pharmacology and experimental therapeutics, 355(2), 272-279 (2015-09-12)
Cardiotoxicity is a major dose-limiting adverse effect of doxorubicin (DOX), mediated in part by overproduction of reactive oxygen species and oxidative stress. Abcc1 (Mrp1) mediates the efflux of reduced and oxidized glutathione (GSH, GSSG) and is also a major transporter...
Tanganyika Wilder et al.
American journal of physiology. Heart and circulatory physiology, 309(10), H1720-H1730 (2015-10-04)
S-glutathionylation of cardiac myosin-binding protein C (cMyBP-C) induces Ca(2+) sensitization and a slowing of cross-bridge kinetics as a result of increased oxidative signaling. Although there is evidence for a role of oxidative stress in disorders associated with hypertrophic cardiomyopathy (HCM)...
Supriya S Kanyal et al.
Journal of chromatography. A, 1404, 115-123 (2015-06-13)
Microfabrication of ultrathin-layer chromatography (UTLC) plates via conformal deposition of silicon nitride by low-pressure chemical vapor deposition onto patterned carbon nanotube (CNT) scaffolds was demonstrated. After removal of the CNTs and hydroxylation, the resulting UTLC phase showed no expansion or...
Antoine Larochelle et al.
Brain, behavior, and immunity, 46, 221-231 (2015-03-04)
Excitotoxic cell death is a crucial mechanism through which neurodegeneration occurs in numerous pathologies of the central nervous system (CNS), such as Alzheimer's disease, stroke and spinal cord injury. Toll-like receptors (TLRs) are strongly expressed on microglial cells and are...
Yeon-Ji Hong et al.
Journal of biomaterials science. Polymer edition, 26(12), 766-779 (2015-06-11)
Complexation-triggerable liposomes were prepared by modifying the surface of egg phosphatidylcholine (EPC) liposomes with hydrophobicized silk fibroin (HmSF) and hydrophobicized chitosan (HmCh). Maximum complexation, determined by measuring the diameter of complexation, was found when the ratio of HmSF to HmCh...
Sarita Hebbar et al.
Scientific reports, 5, 15926-15926 (2015-12-08)
Sphingolipid metabolites are involved in the regulation of autophagy, a degradative recycling process that is required to prevent neuronal degeneration. Drosophila blue cheese mutants neurodegenerate due to perturbations in autophagic flux, and consequent accumulation of ubiquitinated aggregates. Here, we demonstrate...
Claudia Grajeda-Iglesias et al.
Food chemistry, 194, 749-757 (2015-10-17)
Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natural bioactive compounds, e.g. polyphenols, which could add value to this under-exploited...
Andoni Lancha et al.
PloS one, 9(5), e98398-e98398 (2014-05-30)
Osteopontin (OPN) is a multifunctional extracellular matrix (ECM) protein involved in multiple physiological processes. OPN expression is dramatically increased in visceral adipose tissue in obesity and the lack of OPN protects against the development of insulin resistance and inflammation in...
Michael J Boundy et al.
Journal of chromatography. A, 1387, 1-12 (2015-02-24)
Routine regulatory monitoring of paralytic shellfish toxins (PST) commonly employs oxidative derivitisation and complex liquid chromatography fluorescence detection methods (LC-FL). The pre-column oxidation LC-FL method is currently implemented in New Zealand and the United Kingdom. When using this method positive...
Gerard H Bode et al.
PloS one, 10(5), e0126136-e0126136 (2015-05-23)
The aim of the current study was to develop a method to detect peptide-linked nanoparticles in blood plasma. A convenient enzyme linked immunosorbent assay (ELISA) was developed for the detection of peptides functionalized with biotin and fluorescein groups. As a...
Akbar Esmaeili et al.
Journal of hazardous materials, 280, 788-796 (2014-09-23)
In this research, a novel fixed-bed reactor was designed with a nanofiber membrane composed of a polyvinyl alcohol (PVA)/chitosan nanofiber blend prepared using an electrospinning technique. The applied voltage, tip-collector distance, and solution flow rate of the electrospinning process were...
Xiaoguang Fan et al.
Carbohydrate polymers, 114, 21-26 (2014-09-30)
Corncob residue is a cellulose-rich byproduct obtained from industrial xylose production via dilute acid hydrolysis processes. Enzymatic hydrolysis of cellulose in acid hydrolysis residue of corncob (AHRC) is often less efficient without further pretreatment. In this work, the process characteristics...
Monika Langmajerová et al.
Electrophoresis, 36(11-12), 1365-1373 (2015-03-05)
A new CE-MS method with enzymatic reaction inside the capillary was developed for the study of drug metabolism by cytochromes P450. This automated method, based on the transverse diffusion of laminar flow profiles methodology, is comprised of the injection of...
Nayara de Carvalho Leite et al.
Metabolism: clinical and experimental, 64(9), 1122-1133 (2015-06-01)
Obesity-induced abnormalities, such as insulin resistance, dyslipidemia and hypertension, are frequently correlated with low-grade inflammation, a process that may depend on normal spleen function. This study investigated the role of the spleen in the obesity induced by monosodium glutamate (MSG)...
Katharine M Hardy et al.
Molecular cancer research : MCR, 13(4), 670-680 (2015-03-15)
Metastatic melanoma is a highly aggressive skin cancer with a poor prognosis. Despite a complete response in fewer than 5% of patients, the chemotherapeutic agent dacarbazine (DTIC) remains the reference drug after almost 40 years. More recently, FDA-approved drugs have...
Abrar Ahmad et al.
Molecular medicine reports, 11(4), 2493-2503 (2014-12-17)
There have been numerous studies on the gene expression of connective tissue growth factor (CTGF) in colorectal cancer, however very few have investigated polymorphisms in this gene. The present study aimed to determine whether single nucleotide polymorphisms (SNPs) in the...
Edita Navratilova et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(18), 7264-7271 (2015-05-08)
Pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (NAc), a part of the mesolimbic reward motivation pathway. How the reward pathway is engaged by pain-relieving treatments is not known. Endogenous opioid signaling...
Jing-Jing Xu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 736-739 (2013-06-04)
To study the efficacy and mechanism of Weiyangning pills against experimental gastric ulcer. The gastric ulcer model were established by acetic acid, water-immersion stress, aspirin induction, pyloric ligation in rats, in order to observe the effect of Weiyangning pills against...
Gaurav Subhash Yeola et al.
Drug delivery and translational research, 4(2), 116-125 (2015-03-20)
A typical breakthrough pain episode is severe, categorized by a fast onset, typically reaches peak intensity instantly, and lasts for an average duration of about 30 min. The research work includes the use of opioid for the treatment of breakthrough pain...
Ji Seon Kim et al.
Cytotechnology, 67(1), 51-65 (2013-11-30)
This study was conducted to expand the use of Lithospermum erythrorhizon, which is a good source of natural dye, in skin whitening and immune activation cosmetics. The goal was to provide cosmeceutical data about the extraction yield and shikonin contents...
C Harkin et al.
Journal of applied microbiology, 118(4), 954-965 (2015-02-04)
To isolate bacteria from soil for microbial pretreatment of brown crab (Cancer pagurus) shell waste and the production of chitin. Isolates were screened for protease enzymes and acid production in order to facilitate the removal of protein and calcium carbonate...
Nadia El-wakiel et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 147, 117-123 (2015-04-02)
A new Schiff base of 2-aminobenzimidazole with 2,4-dihydroybezaldehyde (H₃L), and its Cu(II), Ni(II) and Co(II) complexes have been synthesized and characterized by elemental analyses, molar conductance, thermal analysis (TGA), inductive coupled plasma (ICP), magnetic moment measurements, IR, EI-mass, UV-Vis. and...
Dilek Akyıl et al.
Environmental toxicology, 30(8), 937-945 (2014-02-12)
Potential mutagenic and genotoxic effects of Chlorthiophos, an organophosphate pesticide, were evaluated using four standard assays. Five different concentrations of the pesticide were tested by an Ames test using Salmonella typhimurium strains TA97, TA98, TA100, and TA102, with and without...
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