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Lina Yu et al.
Molecular pain, 9, 3-3 (2013-02-19)
Resveratrol (3,5,4' - trihydroxy-trans-stilbene), a widely distributed natural stilbenoid, was proposed to account for the unique effects of red wine on life span and health. It has been reported to possess various biological and pharmacological activities, such as anti-oxidant, anti-inflammatory
Yong-Soo Seo et al.
Bioresource technology, 121, 475-479 (2012-07-31)
This study was conducted to reduce off-flavors from sea tangle (Laminaria japonica) extract since the typical odor of seaweed is an impediment to consumption of seaweed products. Fifty-six odor compounds emitted from the extract were identified using a thermal desorbor
Yuka Kimura et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(6), 2451-2457 (2013-02-16)
Accumulating evidence shows that hydrogen sulfide (H2S) has a variety of physiological functions. H2S is produced from cysteine by 3 sulfurtransferases. H2S, in turn, generates polysulfides, the functions of which are not well understood. H2S induces Ca(2+) influx in astrocytes
Santosh K Mishra et al.
Cell reports, 31(1), 107472-107472 (2020-04-09)
Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induces itch in mice
Catherine E Sansom et al.
Journal of agricultural and food chemistry, 63(6), 1833-1838 (2015-01-28)
The traditionally consumed New Zealand native plant nau, Cook's scurvy grass, Lepidium oleraceum, has a pungent wasabi-like taste, with potential for development as a flavor ingredient. The main glucosinolate in this Brassicaceae was identified by LC-MS and NMR spectroscopy as
Arup Bhattacharya et al.
Carcinogenesis, 34(11), 2593-2599 (2013-08-16)
Allyl isothiocyanate (AITC) occurs in cruciferous vegetables that are commonly consumed by humans and has been shown to inhibit urinary bladder cancer growth and progression in previous preclinical studies. However, AITC does not significantly modulate cyclooxygenase-2 (Cox-2), whose oncogenic activity
Eyal Halon et al.
Scientific reports, 5, 17975-17975 (2015-12-15)
Generalist insect can utilize two different modes for regulating their detoxification genes, the constitutive mode and the induced mode. Here, we used the Bemisia tabaci sibling species MEAM1 and MED, as a model system for studying constitutive and induced detoxification
Allyl isothiocyanate.
IARC monographs on the evaluation of carcinogenic risks to humans, 73, 37-48 (2000-05-11)
Anabela Borges et al.
Journal of food science and technology, 52(8), 4737-4748 (2015-08-06)
Plants contain numerous components that are important sources of new bioactive molecules with antimicrobial properties. Isothiocyanates (ITCs) are plant secondary metabolites found in cruciferous vegetables that are arising as promising antimicrobial agents in food industry. The aim of this study
Keita Mizuno et al.
Journal of pharmacological sciences, 125(1), 91-98 (2014-05-03)
The acute peripheral neuropathy induced by oxaliplatin treatment occurs very frequently and is aggravated by exposure to cold. Goshajinkigan (GJG), a traditional Japanese (kampo) medicine, was recently shown to be effective against oxaliplatin-induced acute neuropathy. However, because the effects of
Harrie J M Gijsen et al.
Journal of medicinal chemistry, 53(19), 7011-7020 (2010-09-03)
The TRPA1 channel can be considered as a key biological sensor to irritant chemicals. In this paper, the discovery of 11H-dibenz[b,e]azepines (morphanthridines) and dibenz[b,f][1,4]oxazepines is described as extremely potent agonists of the TRPA1 receptor. This has led to the discovery
Qingli Meng et al.
American journal of physiology. Cell physiology, 309(1), C1-10 (2015-04-24)
To address mechanoreceptive roles of trigeminal ganglion (TG) nerve endings in the inner walls of rat anterior eye chambers, we investigated the mechanotransduction process and mechanosensitive (MS) channel on somata of TG neurons innervating this area in vitro. Rat TG
S R Musk et al.
Carcinogenesis, 14(10), 2079-2083 (1993-10-01)
Allyl isothiocyanate, a constituent of mustard and certain vegetables found in the human diet, was tested for cytotoxic and cytostatic effects in HT29 human colon carcinoma cells in vitro. For an exposure time of 24 h, allyl isothiocyanate exhibited a
Katrien De Clercq et al.
Human reproduction (Oxford, England), 30(6), 1421-1436 (2015-03-31)
Are members of the transient receptor potential (TRP) channel superfamily functionally expressed in the human endometrial stroma? The Ca(2+)-permeable ion channels TRPV2, TRPV4, TRPC6 and TRPM7 are functionally expressed in primary endometrial stromal cells. Intercellular communication between epithelial and stromal
Tetyana Kobets et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 115, 228-243 (2018-03-20)
Genotoxicity of flavor and fragrance materials was assessed in Turkey Egg Genotoxicity Assay (TEGA) using 32P-nucleotide postlabeling (NPL) and comet assays to detect hepatic DNA adducts and strand breaks. Twenty materials having results in GADD45a-Gluc 'BlueScreen HC' genotoxicity assay, and
L Manyes et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 83, 293-299 (2015-07-05)
Isothiocyanates (ITCs) are natural compounds derived from cruciferous vegetables produced by enzymatic conversion of metabolites called glucosinolates. They are potentially useful antimicrobial compounds for food applications have been shown to be promising agents against cancer in human cell culture, animal
Yuesheng Zhang
Molecular nutrition & food research, 54(1), 127-135 (2009-12-05)
Allyl isothiocyanate (AITC), which occurs in many common cruciferous vegetables, is widely and often frequently consumed by humans. Besides antimicrobial activity against a wide spectrum of pathogens, it showed anticancer activity in both cultured cancer cells and animal models, although
Juan Yun et al.
Journal of food science, 78(3), M458-M464 (2013-02-13)
The antimicrobial activity of the essential oils (EOs) from cinnamon bark, oregano, mustard, and of their major components cinnamaldehyde, carvacrol, and allyl isothiocyanate (AIT) was evaluated as a gaseous treatment to reduce Salmonella enterica serovar Typhimurium in vitro and on
Juan M Quiles et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 83, 222-228 (2015-07-07)
Aflatoxins (AFs) are secondary metabolites produced by different species of Aspergillus, such as Aspergillus flavus and Aspergillus parasiticus, which possess mutagenic, teratogenic and carcinogenic activities in humans. In this study, active packaging devices containing allyl isothiocyanate (AITC) or oriental mustard
Enrico Morera et al.
Bioorganic & medicinal chemistry letters, 22(4), 1674-1677 (2012-01-20)
In order to explore the structural determinants for the TRPV1 and TRPA1 agonist properties of gingerols, a series of nineteen analogues (1b-5) of racemic [6]-gingerol (1a) was synthesized and tested on TRPV1 and TRPA1 channels. The exploration of the structure-activity
Michael J M Fischer et al.
Pflugers Archiv : European journal of physiology, 466(12), 2229-2241 (2014-03-20)
Transient receptor potential cation channel, subfamily V, member 1 (TRPV1) plays a key role in sensing environmental hazards and in enhanced pain sensation following inflammation. A considerable proportion of TRPV1-expressing cells also express transient receptor potential cation channel, subfamily A
Eliziane S Patricio et al.
The Journal of investigative dermatology, 135(10), 2484-2491 (2015-05-09)
A role for proteinase-activated receptor-4 (PAR-4) was recently suggested in itch sensation. Here, we investigated the mechanisms underlying the pruriceptive actions of the selective PAR-4 agonist AYPGKF-NH2 (AYP) in mice. Dorsal intradermal (i.d.) administration of AYP elicited intense scratching behavior
Katsunari Ippoushi et al.
Food chemistry, 141(2), 1192-1195 (2013-06-26)
Allyl isothiocyanate, a chief component of mustard oil, exhibits anticancer effects in both cultured cancer cells and animal models. The accumulation of the N-acetylcysteine conjugate of allyl isothiocyanate, the final metabolite of allyl isothiocyanate, in urine was evaluated in rats
J R Daller et al.
Journal of pharmacological and toxicological methods, 66(3), 232-237 (2012-07-17)
Commercial whole-body plethysmography systems used to evaluate the anti-tussive potential of drugs employ sophisticated technology, but these systems may be cost prohibitive for some laboratories. The present study describes an alternative, inexpensive system for evaluating the tussive and anti-tussive potential
Judit Újhelyi et al.
Regulatory peptides, 194-195, 23-29 (2014-09-18)
To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard oil-induced ear edema, ii) neutrophil accumulation, iii) mechanical and iv) thermal touch sensitivity in complete Freund's adjuvant-induced arthritis
Anne Lerbaek et al.
Contact dermatitis, 51(2), 79-83 (2004-09-18)
Allyl isothiocyanate is present in many plants. Allergic contact dermatitis from allyl isothiocyanate is well known but infrequently reported. The aim of this study was to investigate the prevalence of contact allergy to allyl isothiocyanate in patients with suspected contact
Noriyuki Mori et al.
Journal of nutritional science and vitaminology, 59(1), 56-63 (2013-03-29)
We investigated the effects of allyl isothiocyanate (AITC) on the blood glucose levels of mice using an intraperitoneal glucose tolerance test. The intragastric administration of 25 mg/kg body weight AITC reduced the increase in blood glucose level after 2 g/kg
Thomas Voets et al.
Nature chemical biology, 1(2), 85-92 (2006-01-13)
Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photoreceptors. The identification of the trp gene and the search for homologs in
F Mushantaf et al.
Environmental technology, 33(19-21), 2461-2465 (2013-02-12)
This study investigated the potential application of allyl isothiocyanate (AITC) for the disinfection of water by examining the bactericidal effects of this compound against inoculated Escherichia coli in autoclaved, de-chlorinated tap water and against the natural microbiota (heterotrophic plate count
Wenxuan Chen et al.
International journal of food microbiology, 155(3), 165-170 (2012-03-01)
This study investigated the antimicrobial effect of a chitosan coating+allyl isothiocyanate (AIT) and nisin against Salmonella on whole fresh cantaloupes. Cantaloupes were inoculated with a cocktail of three Salmonella strains and treated with chitosan, chitosan+AIT, chitosan+nisin, and chitosan+AIT+nisin coatings. With
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